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EE03904B1 - Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid - Google Patents

Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid

Info

Publication number
EE03904B1
EE03904B1 EEP199900453A EEP9900453A EE03904B1 EE 03904 B1 EE03904 B1 EE 03904B1 EE P199900453 A EEP199900453 A EE P199900453A EE P9900453 A EEP9900453 A EE P9900453A EE 03904 B1 EE03904 B1 EE 03904B1
Authority
EE
Estonia
Prior art keywords
granules
granule
drug
preparation
dosage form
Prior art date
Application number
EEP199900453A
Other languages
English (en)
Inventor
Florent Victor De Cond Valentin
Petrus Gerebern Vandecruys Roger
Marie Victor Gilis Paul
Peeters Jozef
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE9900453A publication Critical patent/EE9900453A/et
Publication of EE03904B1 publication Critical patent/EE03904B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EEP199900453A 1997-03-26 1998-03-18 Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid EE03904B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200914 1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en) 1997-03-26 1998-03-18 Pellets having a core coated with an antifungal and a polymer

Publications (2)

Publication Number Publication Date
EE9900453A EE9900453A (et) 2000-04-17
EE03904B1 true EE03904B1 (et) 2002-12-16

Family

ID=8228147

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900453A EE03904B1 (et) 1997-03-26 1998-03-18 Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid

Country Status (30)

Country Link
EP (1) EP0969821B1 (et)
JP (1) JP3608800B2 (et)
KR (1) KR100520936B1 (et)
CN (1) CN1206984C (et)
AP (1) AP1227A (et)
AT (1) ATE241969T1 (et)
AU (1) AU734248B2 (et)
BG (1) BG64434B1 (et)
BR (1) BR9806174A (et)
CA (1) CA2269501C (et)
CY (1) CY2384B1 (et)
CZ (1) CZ295502B6 (et)
DE (1) DE69815316T2 (et)
DK (1) DK0969821T3 (et)
EE (1) EE03904B1 (et)
ES (1) ES2201485T3 (et)
HU (1) HU224217B1 (et)
ID (1) ID21477A (et)
IL (1) IL129575A (et)
NO (1) NO325102B1 (et)
NZ (1) NZ335364A (et)
OA (1) OA11162A (et)
PL (1) PL190566B1 (et)
PT (1) PT969821E (et)
RU (1) RU2218153C2 (et)
SI (1) SI0969821T1 (et)
SK (1) SK284813B6 (et)
TR (1) TR199900990T2 (et)
UA (1) UA60318C2 (et)
WO (1) WO1998042318A1 (et)

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IL137665A0 (en) * 1998-07-17 2001-10-31 Janssen Pharmaceutica Nv Pellets having core coated with an antifungal and a polymer
ES2157731B1 (es) 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
WO2000056726A1 (en) 1999-03-24 2000-09-28 Fmc Corporation Improved aqueous solubility pharmaceutical formulations
KR100432949B1 (ko) * 2000-06-13 2004-05-31 코오롱제약주식회사 생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
MXPA03007236A (es) 2001-02-14 2003-12-04 Tibotec Pharm Ltd 2-(amino sustituido)-benzotiazol sulfonamidas inhibidoras de proteasa de vih de amplio espectro.
CN100491360C (zh) 2001-04-09 2009-05-27 泰博特克药品有限公司 广谱2-(取代的-氨基)-苯并唑磺酰胺hiv蛋白酶抑制剂
EE05307B1 (et) 2001-05-11 2010-06-15 Tibotec Pharmaceuticals Ltd. Laiaspektrilised 2-aminobensoksasoolsulfoonamiidid kui HIV proteaasi inhibiitorid, nende kasutamine, farmatseutiline kompositsioon ja meetod retroviiruse replikatsiooni inhibeerimiseks
WO2002100407A1 (en) * 2001-06-12 2002-12-19 Smartrix Technologies Inc. Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
HUP0500164A3 (en) 2001-12-21 2009-03-30 Tibotec Pharm Ltd Heterocyclic substituted benzenesulfonamides as hiv protease inhibitors and pharmaceutical compositions containing them
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
IL165043A0 (en) 2002-05-17 2005-12-18 Tibotec Pharm Ltd broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
CA2493940C (en) 2002-08-14 2011-11-22 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
KR100557680B1 (ko) * 2002-11-23 2006-03-07 한국유나이티드제약 주식회사 이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
PT1438960E (pt) * 2003-01-14 2007-06-19 Cimex Pharma Ag Composição de itraconazole disperso num polímero hidrofílico possuindo biodisponibilidade melhorada
ATE357235T1 (de) * 2003-01-14 2007-04-15 Cimex Pharma Ag Bioaequivalente zusammensetzung in der form einer festen dispersion enthaltend itraconazol und ein hydrophiles polymer
CN1845725A (zh) 2003-08-06 2006-10-11 尼马尔·穆利耶 包含水溶性药物的药物组合物
NZ544980A (en) 2003-09-11 2009-02-28 Tibotec Pharm Ltd Entry inhibitors of the HIV virus
EP1568369A1 (en) 2004-02-23 2005-08-31 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
CA2566340C (en) 2004-05-07 2014-05-06 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
AP2006003791A0 (en) 2004-05-17 2006-10-31 Tibotec Pharm Ltd 1-Heterocyclyl-1,5-dihydro-pyridoÄ3,2-BÜindol-2-ones
WO2005111044A1 (en) 2004-05-17 2005-11-24 Tibotec Pharmaceuticals Ltd. 4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones
JP2007538050A (ja) 2004-05-17 2007-12-27 テイボテク・フアーマシユーチカルズ・リミテツド 抗感染薬剤として有用な６，７，８，９−置換１−フェニル−１，５−ジヒドロ−ピリド［３，２−ｂ］インドール−２−オン
BRPI0709940A2 (pt) 2006-04-03 2011-08-02 Tibotec Pharm Ltd 3,4-diidro-imidazo[4,5-b]piridin-5-onas para inibição do hiv
CN101511346B (zh) * 2006-09-04 2012-07-04 万能药生物有限公司 可编制的漂浮递送技术
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
WO2009070744A1 (en) 2007-11-28 2009-06-04 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome p450 2d6
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
US8313527B2 (en) 2007-11-05 2012-11-20 Allergan, Inc. Soft prosthesis shell texturing method
US8906647B2 (en) 2008-02-21 2014-12-09 Sequoia Pharmaceuticals, Inc. Diamide inhibitors of cytochrome P450
US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
US8877822B2 (en) 2010-09-28 2014-11-04 Allergan, Inc. Porogen compositions, methods of making and uses
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
US9205577B2 (en) 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
GB2479213B (en) 2010-04-01 2013-07-10 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
WO2011143213A1 (en) * 2010-05-11 2011-11-17 Allergan, Inc. Porogen compositions, methods of making and uses
US11202853B2 (en) 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
US8679279B2 (en) 2010-11-16 2014-03-25 Allergan, Inc. Methods for creating foam-like texture
CN102100678B (zh) * 2011-02-18 2012-10-17 天津力生制药股份有限公司 伊曲康唑硫酸盐微丸及其制备方法
EP2962662A1 (en) 2012-12-13 2016-01-06 Allergan, Inc. Variable surface breast implant
US10092392B2 (en) 2014-05-16 2018-10-09 Allergan, Inc. Textured breast implant and methods of making same
DK3405191T3 (da) 2016-01-20 2025-05-19 Theravida Inc Sammensætninger til anvendelse ved behandling af hyperhidrose
LT3781132T (lt) * 2018-04-16 2024-04-25 Bristol-Myers Squibb Company Apiksabano vaisto formos
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Also Published As

Publication number Publication date
NZ335364A (en) 2000-08-25
HUP0002056A2 (hu) 2000-12-28
IL129575A0 (en) 2000-02-29
PT969821E (pt) 2003-10-31
CZ139899A3 (cs) 1999-10-13
JP3608800B2 (ja) 2005-01-12
IL129575A (en) 2004-06-20
RU2218153C2 (ru) 2003-12-10
JP2001520663A (ja) 2001-10-30
AP1227A (en) 2003-11-24
KR20000052971A (ko) 2000-08-25
NO992114L (no) 1999-08-26
CY2384B1 (en) 2004-06-04
TR199900990T2 (xx) 1999-10-21
PL335542A1 (en) 2000-04-25
ID21477A (id) 1999-06-17
BG103356A (en) 2000-03-31
AU7210798A (en) 1998-10-20
HU224217B1 (hu) 2005-06-28
NO992114D0 (no) 1999-04-30
CN1206984C (zh) 2005-06-22
WO1998042318A1 (en) 1998-10-01
BR9806174A (pt) 1999-10-19
AP9901516A0 (en) 1999-06-30
PL190566B1 (pl) 2005-12-30
CA2269501A1 (en) 1998-10-01
DE69815316T2 (de) 2004-04-29
EP0969821A1 (en) 2000-01-12
DE69815316D1 (de) 2003-07-10
OA11162A (en) 2003-04-16
ES2201485T3 (es) 2004-03-16
CZ295502B6 (cs) 2005-08-17
ATE241969T1 (de) 2003-06-15
UA60318C2 (uk) 2003-10-15
EP0969821B1 (en) 2003-06-04
BG64434B1 (en) 2005-02-28
EE9900453A (et) 2000-04-17
SI0969821T1 (en) 2003-10-31
HK1022840A1 (en) 2000-08-25
CA2269501C (en) 2005-11-08
DK0969821T3 (da) 2003-09-15
HUP0002056A3 (en) 2001-01-29
SK54499A3 (en) 2000-01-18
KR100520936B1 (ko) 2005-10-17
NO325102B1 (no) 2008-02-04
SK284813B6 (sk) 2005-12-01
AU734248B2 (en) 2001-06-07
CN1244796A (zh) 2000-02-16

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