SK17082000A3 - 1,2,5-trisubstituovan 1,2-dihydro-indazol-3-ny s antiastmatickm, antialergickm, protizpalovm, imunomodulanm a neuroprotektvnym inkom, spsob ich prpravy a ich pouitie - Google Patents

1,2,5-trisubstituovan 1,2-dihydro-indazol-3-ny s antiastmatickm, antialergickm, protizpalovm, imunomodulanm a neuroprotektvnym inkom, spsob ich prpravy a ich pouitie Download PDF

Info

Publication number: SK17082000A3
Authority: SK; Slovakia
Prior art keywords: methoxy; indazol; dihydro; alkyl; formula
Prior art date: 1998-05-11

Application number

SK1708-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Rudolf Schindler

Norbert Hfgen

Hildegard Poppe

Kay Brune

Original Assignee

Arzneimittelwerk Dresden Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-11

Filing date

1999-04-01

Publication date

2001-09-11

1999-04-01 Application filed by Arzneimittelwerk Dresden Gmbh filed Critical Arzneimittelwerk Dresden Gmbh

2001-09-11 Publication of SK17082000A3 publication Critical patent/SK17082000A3/sk

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-1 1,2,5-trisubstituted 1,2-dihydro-indazol-3-ones Chemical class 0.000 title claims abstract description 39
238000000034 method Methods 0.000 title claims abstract description 14
230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 8
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239000000924 antiasthmatic agent Substances 0.000 title claims abstract description 6
230000002519 immonomodulatory effect Effects 0.000 title claims abstract description 6
238000004519 manufacturing process Methods 0.000 title claims abstract 4
239000003814 drug Substances 0.000 title claims description 11
230000000324 neuroprotective effect Effects 0.000 title abstract description 5
150000001875 compounds Chemical class 0.000 claims abstract description 71
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 28
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WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 8
239000002253 acid Substances 0.000 claims description 8
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206010039073 rheumatoid arthritis Diseases 0.000 description 1
229940121392 rotamase inhibitor Drugs 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
238000007789 sealing Methods 0.000 description 1
230000008313 sensitization Effects 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
125000005624 silicic acid group Chemical class 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
LLKGTXLYJMUQJX-UHFFFAOYSA-M sodium;3-[2-carboxyethyl(dodecyl)amino]propanoate Chemical compound [Na+].CCCCCCCCCCCCN(CCC(O)=O)CCC([O-])=O LLKGTXLYJMUQJX-UHFFFAOYSA-M 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
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239000004094 surface-active agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
239000001648 tannin Substances 0.000 description 1
235000018553 tannin Nutrition 0.000 description 1
229920001864 tannin Polymers 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000001302 tertiary amino group Chemical group 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
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239000004034 viscosity adjusting agent Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
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QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

SK1708-2000A 1998-05-11 1999-04-01 1,2,5-trisubstituovan 1,2-dihydro-indazol-3-ny s antiastmatickm, antialergickm, protizpalovm, imunomodulanm a neuroprotektvnym inkom, spsob ich prpravy a ich pouitie SK17082000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19821003A DE19821003A1 (de)	1998-05-11	1998-05-11	Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/002291 WO1999058504A1 (de)	1998-05-11	1999-04-01	Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver wirkung, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number	Publication Date
SK17082000A3 true SK17082000A3 (sk)	2001-09-11

Family

ID=7867363

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1708-2000A SK17082000A3 (sk)	1998-05-11	1999-04-01	1,2,5-trisubstituovan 1,2-dihydro-indazol-3-ny s antiastmatickm, antialergickm, protizpalovm, imunomodulanm a neuroprotektvnym inkom, spsob ich prpravy a ich pouitie

Country Status (23)

Country	Link
US (1)	US6180637B1 (no)
EP (1)	EP1077948A1 (no)
JP (1)	JP2002514627A (no)
KR (1)	KR20010025011A (no)
CN (1)	CN1309642A (no)
AR (1)	AR018605A1 (no)
AU (1)	AU745796B2 (no)
BG (1)	BG104910A (no)
BR (1)	BR9911772A (no)
CA (1)	CA2271837A1 (no)
CO (1)	CO5021131A1 (no)
DE (1)	DE19821003A1 (no)
HK (1)	HK1038751A1 (no)
HU (1)	HUP0101707A3 (no)
IL (1)	IL139358A0 (no)
NO (1)	NO20005698L (no)
NZ (1)	NZ508646A (no)
PL (1)	PL344254A1 (no)
SK (1)	SK17082000A3 (no)
TR (1)	TR200003302T2 (no)
TW (1)	TW448163B (no)
WO (1)	WO1999058504A1 (no)
ZA (1)	ZA200006151B (no)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7253169B2 (en)	1999-11-12	2007-08-07	Gliamed, Inc.	Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) *	1999-11-12	2002-07-09	Gpi Nil Holdings, Inc.	AZA compounds, pharmaceutical compositions and methods of use
WO2008141385A1 (en) *	2007-05-21	2008-11-27	Biota Scientific Management Pty Ltd	Viral polymerase inhibitors
PE20140976A1 (es)	2011-03-14	2014-08-28	Boehringer Ingelheim Int	Inhibidores de benzodioxano de la producion de leucotrieno
WO2013012844A1 (en)	2011-07-19	2013-01-24	Boehringer Ingelheim International Gmbh	Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase
WO2013134226A1 (en)	2012-03-06	2013-09-12	Boehringer Ingelheim International Gmbh	Benzodioxanes for inhibiting leukotriene production
AR090259A1 (es)	2012-03-06	2014-10-29	Boehringer Ingelheim Int	Inhibidores de benzodioxano de la produccion de leucotrieno para terapia de combinacion
TW201416354A (zh)	2012-07-17	2014-05-01	Boehringer Ingelheim Int	白三烯生成抑制劑
EP3022194B1 (en)	2013-07-15	2017-05-17	Boehringer Ingelheim International GmbH	Inhibitors of leukotriene production
WO2015009609A1 (en)	2013-07-15	2015-01-22	Boehringer Ingelheim International Gmbh	Inhibitors of leukotriene production
NZ749389A (en) *	2016-06-08	2022-12-23	Sunregen Healthcare Ag	Lipids with odd number of carbon atoms and their use as pharmaceutical composition or nutritional supplement
CN113105409B (zh) *	2021-04-06	2023-06-02	四川大学	2-(羟基苄基)苯并[d]异噻唑酮类化合物、其制备方法和用途
CA3221177A1 (en)	2021-11-01	2023-05-04	Meghan Kerrisk Campbell	Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3132916A1 (de) *	1981-08-20	1983-03-03	Kali-Chemie Pharma Gmbh, 3000 Hannover	1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5179112A (en) *	1985-04-17	1993-01-12	Ici Americas Inc.	Heterocyclic amide derivatives and pharmaceutical use
IL84944A (en) *	1987-01-19	1992-02-16	Ici Plc	Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation
US5036083A (en) *	1988-07-15	1991-07-30	Ici Pharma	Heterocyclic agents
US5229408A (en) *	1988-07-15	1993-07-20	Ici Pharma	4-carbamoyl-1,2-dihydro-3H-indazol-3-one derivatives
DE19610882A1 (de) *	1996-03-20	1997-09-25	Dresden Arzneimittel	Neue 1,3,5-trisubstituierte Indazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

1998
- 1998-05-11 DE DE19821003A patent/DE19821003A1/de not_active Withdrawn
1999
- 1999-04-01 SK SK1708-2000A patent/SK17082000A3/sk unknown
- 1999-04-01 NZ NZ508646A patent/NZ508646A/xx unknown
- 1999-04-01 TR TR2000/03302T patent/TR200003302T2/xx unknown
- 1999-04-01 IL IL13935899A patent/IL139358A0/xx unknown
- 1999-04-01 HK HK02100376.2A patent/HK1038751A1/zh unknown
- 1999-04-01 AU AU42576/99A patent/AU745796B2/en not_active Ceased
- 1999-04-01 JP JP2000548308A patent/JP2002514627A/ja active Pending
- 1999-04-01 CN CN99808515A patent/CN1309642A/zh active Pending
- 1999-04-01 PL PL99344254A patent/PL344254A1/xx unknown
- 1999-04-01 EP EP99950343A patent/EP1077948A1/de not_active Withdrawn
- 1999-04-01 WO PCT/EP1999/002291 patent/WO1999058504A1/de not_active Ceased
- 1999-04-01 KR KR1020007012614A patent/KR20010025011A/ko not_active Withdrawn
- 1999-04-01 BR BR9911772-0A patent/BR9911772A/pt not_active IP Right Cessation
- 1999-04-01 HU HU0101707A patent/HUP0101707A3/hu unknown
- 1999-04-23 TW TW088106565A patent/TW448163B/zh not_active IP Right Cessation
- 1999-05-05 US US09/305,602 patent/US6180637B1/en not_active Expired - Fee Related
- 1999-05-07 CO CO99028290A patent/CO5021131A1/es unknown
- 1999-05-11 CA CA002271837A patent/CA2271837A1/en not_active Abandoned
- 1999-05-11 AR ARP990102212A patent/AR018605A1/es not_active Application Discontinuation
2000
- 2000-10-31 ZA ZA200006151A patent/ZA200006151B/en unknown
- 2000-11-03 BG BG104910A patent/BG104910A/xx unknown
- 2000-11-10 NO NO20005698A patent/NO20005698L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR9911772A (pt)	2001-02-06
CO5021131A1 (es)	2001-03-27
AR018605A1 (es)	2001-11-28
US6180637B1 (en)	2001-01-30
EP1077948A1 (de)	2001-02-28
NZ508646A (en)	2002-11-26
NO20005698D0 (no)	2000-11-10
TR200003302T2 (tr)	2001-02-21
HK1038751A1 (zh)	2002-03-28
DE19821003A1 (de)	1999-11-18
AU4257699A (en)	1999-11-29
CA2271837A1 (en)	1999-11-11
ZA200006151B (en)	2000-12-06
HUP0101707A3 (en)	2002-06-28
TW448163B (en)	2001-08-01
WO1999058504A1 (de)	1999-11-18
KR20010025011A (ko)	2001-03-26
NO20005698L (no)	2001-01-08
PL344254A1 (en)	2001-10-22
WO1999058504A9 (de)	2000-02-03
BG104910A (en)	2001-06-29
IL139358A0 (en)	2001-11-25
CN1309642A (zh)	2001-08-22
HUP0101707A2 (hu)	2002-03-28
AU745796B2 (en)	2002-03-28
JP2002514627A (ja)	2002-05-21

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