SK169699A3 - Farnesyl transferase inhibitors in combination with hmg coa reductase inhibitors for the treatment of cancer - Google Patents

Farnesyl transferase inhibitors in combination with hmg coa reductase inhibitors for the treatment of cancer Download PDF

Info

Publication number: SK169699A3
Authority: SK; Slovakia
Prior art keywords: alkyl; phenyl; coa reductase; inhibitor; hmg coa
Prior art date: 1997-06-16

Application number

SK1696-99A

Other languages

English (en)

Slovak (sk)

Inventor

Shama Mohammed Kajiji

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-16

Filing date

1998-06-05

Publication date

2000-06-12

1998-06-05 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2000-06-12 Publication of SK169699A3 publication Critical patent/SK169699A3/sk

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title claims abstract description 33
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title claims abstract description 33
206010028980 Neoplasm Diseases 0.000 title claims abstract description 25
201000011510 cancer Diseases 0.000 title claims abstract description 21
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title description 4
239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 claims abstract description 46
238000000034 method Methods 0.000 claims abstract description 38
241000124008 Mammalia Species 0.000 claims abstract description 19
-1 nitro , cyano, phenyl Chemical group 0.000 claims description 48
150000001875 compounds Chemical class 0.000 claims description 41
125000000217 alkyl group Chemical group 0.000 claims description 32
239000008194 pharmaceutical composition Substances 0.000 claims description 29
229910052739 hydrogen Inorganic materials 0.000 claims description 28
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
239000000203 mixture Substances 0.000 claims description 20
229910052736 halogen Inorganic materials 0.000 claims description 19
150000002367 halogens Chemical class 0.000 claims description 19
230000002159 abnormal effect Effects 0.000 claims description 18
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239000001257 hydrogen Substances 0.000 claims description 17
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 16
125000001424 substituent group Chemical group 0.000 claims description 15
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 13
230000002062 proliferating effect Effects 0.000 claims description 13
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
150000002431 hydrogen Chemical class 0.000 claims description 10
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QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 9
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125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 claims description 6
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ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 5
XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims description 5
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims description 5
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 5
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
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GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 5
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125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 4
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OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
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125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims description 3
125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 3
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK1696-99A 1997-06-16 1998-06-05 Farnesyl transferase inhibitors in combination with hmg coa reductase inhibitors for the treatment of cancer SK169699A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4963897P	1997-06-16	1997-06-16
PCT/IB1998/000881 WO1998057633A1 (en)	1997-06-16	1998-06-05	FARNESYL TRANSFERASE INHIBITORS IN COMBINATION WITH HMG CoA REDUCTASE INHIBITORS FOR THE TREATMENT OF CANCER

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Publication Number	Publication Date
SK169699A3 true SK169699A3 (en)	2000-06-12

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SK1696-99A SK169699A3 (en)	1997-06-16	1998-06-05	Farnesyl transferase inhibitors in combination with hmg coa reductase inhibitors for the treatment of cancer

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EP (1)	EP0986387B1 (is)
JP (1)	JP3713051B2 (is)
KR (1)	KR100392573B1 (is)
CN (1)	CN1259868A (is)
AP (1)	AP9801261A0 (is)
AR (1)	AR013090A1 (is)
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BG (1)	BG103946A (is)
BR (1)	BR9810616A (is)
CA (1)	CA2294399C (is)
CO (1)	CO4950607A1 (is)
DE (1)	DE69812933T2 (is)
DK (1)	DK0986387T3 (is)
DZ (1)	DZ2518A1 (is)
EA (1)	EA199901043A1 (is)
ES (1)	ES2196559T3 (is)
GT (1)	GT199800081A (is)
HN (1)	HN1998000091A (is)
HR (1)	HRP980328B1 (is)
HU (1)	HUP0004624A3 (is)
ID (1)	ID23014A (is)
IL (1)	IL132765A0 (is)
IS (1)	IS5259A (is)
MA (1)	MA24569A1 (is)
NO (1)	NO996206L (is)
NZ (1)	NZ500662A (is)
OA (1)	OA11231A (is)
PA (1)	PA8453601A1 (is)
PE (1)	PE82899A1 (is)
PL (1)	PL337651A1 (is)
PT (1)	PT986387E (is)
SK (1)	SK169699A3 (is)
TN (1)	TNSN98088A1 (is)
TR (1)	TR199903074T2 (is)
UA (1)	UA57081C2 (is)
WO (1)	WO1998057633A1 (is)
ZA (1)	ZA985182B (is)

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YU68900A (sh) *	1998-05-12	2002-12-10	Warner-Lambert Company	Kombinacije inhibitora protein farnesiltransferaze i hmg coa reduktaze i njihova upotreba u tretmanu raka
WO2000016778A1 (en) *	1998-09-24	2000-03-30	Merck & Co., Inc.	A method of treating cancer
EP1006113A1 (en) *	1998-12-02	2000-06-07	Pfizer Products Inc.	Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
WO2000067737A2 (en) *	1999-05-07	2000-11-16	The Brigham And Women's Hospital, Inc.	USE OF HMGCoA REDUCTASE INHIBITORS IN THE PREVENTION OF DISEASES WHOSE PATHOGENESIS IS DEPENDENT ON NEOVASCULARIZATION
US6710058B2 (en)	2000-11-06	2004-03-23	Bristol-Myers Squibb Pharma Company	Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
JP2004516287A (ja)	2000-12-19	2004-06-03	ファイザー・プロダクツ・インク	６−［（４−クロロ−フェニル）−ヒドロキシ−（３−メチル−３ｈ−イミダゾール−４−イル）−メチル］−４−（３−エチニル−フェニル）−１−メチル−１ｈ−キノリン−２−オン，２，３−ジヒドロキシブタン二酸塩の結晶形および製造方法
EP1406609B1 (en)	2000-12-21	2006-09-06	Nitromed, Inc.	Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
US20020151563A1 (en) *	2001-03-29	2002-10-17	Pfizer Inc.	Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the inhibition of abnormal cell growth
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1998
- 1998-05-06 UA UA99126842A patent/UA57081C2/uk unknown
- 1998-06-05 KR KR10-1999-7011860A patent/KR100392573B1/ko not_active Expired - Fee Related
- 1998-06-05 CA CA002294399A patent/CA2294399C/en not_active Expired - Fee Related
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- 1998-06-05 DE DE69812933T patent/DE69812933T2/de not_active Expired - Fee Related
- 1998-06-05 CN CN98805968A patent/CN1259868A/zh active Pending
- 1998-06-05 ES ES98921688T patent/ES2196559T3/es not_active Expired - Lifetime
- 1998-06-05 JP JP50403099A patent/JP3713051B2/ja not_active Expired - Fee Related
- 1998-06-05 EP EP98921688A patent/EP0986387B1/en not_active Expired - Lifetime
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- 1998-06-05 HU HU0004624A patent/HUP0004624A3/hu unknown
- 1998-06-05 PL PL98337651A patent/PL337651A1/xx unknown
- 1998-06-05 DK DK98921688T patent/DK0986387T3/da active
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- 1998-06-05 BR BR9810616-3A patent/BR9810616A/pt not_active Application Discontinuation
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- 1998-06-15 DZ DZ980128A patent/DZ2518A1/xx active
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- 1998-06-15 MA MA25114A patent/MA24569A1/fr unknown
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1999
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Also Published As

Publication number	Publication date
AP9801261A0 (en)	1999-12-11
IL132765A0 (en)	2001-03-19
HN1998000091A (es)	1999-09-29
CA2294399C (en)	2004-03-16
HUP0004624A2 (hu)	2001-10-28
DZ2518A1 (fr)	2003-02-01
CA2294399A1 (en)	1998-12-23
PA8453601A1 (es)	2000-05-24
BG103946A (bg)	2000-07-31
JP3713051B2 (ja)	2005-11-02
HRP980328A2 (en)	1999-04-30
DK0986387T3 (da)	2003-07-14
BR9810616A (pt)	2000-09-12
AR013090A1 (es)	2000-12-13
TR199903074T2 (xx)	2000-05-22
ID23014A (id)	1999-12-30
ES2196559T3 (es)	2003-12-16
CO4950607A1 (es)	2000-09-01
OA11231A (en)	2003-05-26
NZ500662A (en)	2001-10-26
PT986387E (pt)	2003-06-30
DE69812933D1 (de)	2003-05-08
DE69812933T2 (de)	2003-11-06
PE82899A1 (es)	1999-08-26
EP0986387A1 (en)	2000-03-22
CN1259868A (zh)	2000-07-12
GT199800081A (es)	1999-12-07
KR20010013839A (ko)	2001-02-26
ATE235905T1 (de)	2003-04-15
UA57081C2 (uk)	2003-06-16
MA24569A1 (fr)	1998-12-31
HRP980328B1 (en)	2002-06-30
WO1998057633A1 (en)	1998-12-23
IS5259A (is)	1999-11-19
EP0986387B1 (en)	2003-04-02
TNSN98088A1 (fr)	2005-03-15
ZA985182B (en)	1999-12-17
NO996206D0 (no)	1999-12-15
KR100392573B1 (ko)	2003-07-23
HUP0004624A3 (en)	2002-11-28
JP2000513031A (ja)	2000-10-03
AU724676B2 (en)	2000-09-28
AU7445998A (en)	1999-01-04
NO996206L (no)	2000-02-15
PL337651A1 (en)	2000-08-28
EA199901043A1 (ru)	2000-06-26

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