SK15652001A3 - Farmaceutický prípravok obsahujúci inhibítor karboxypeptidázy U a inhibítor trombínu - Google Patents

Farmaceutický prípravok obsahujúci inhibítor karboxypeptidázy U a inhibítor trombínu Download PDF

Info

Publication number: SK15652001A3
Authority: SK; Slovakia
Prior art keywords: inhibitor; thrombin inhibitor; thrombin; carboxypeptidase; group
Prior art date: 1999-05-03

Application number

SK1565-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Tommy Abrahamsson

Viveca Nerme

Magnus Polla

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-03

Filing date

2000-05-03

Publication date

2002-07-02

1999-05-03 Priority claimed from SE9901573A external-priority patent/SE9901573D0/xx

1999-05-03 Priority claimed from SE9901572A external-priority patent/SE9901572D0/xx

1999-08-13 Priority claimed from SE9902902A external-priority patent/SE9902902D0/xx

2000-05-03 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2002-07-02 Publication of SK15652001A3 publication Critical patent/SK15652001A3/sk

Links

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VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
235000019157 thiamine Nutrition 0.000 description 1
239000011721 thiamine Substances 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
229930192474 thiophene Natural products 0.000 description 1
230000002537 thrombolytic effect Effects 0.000 description 1
201000005665 thrombophilia Diseases 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
150000003852 triazoles Chemical class 0.000 description 1
238000007631 vascular surgery Methods 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK1565-2001A 1999-05-03 2000-05-03 Farmaceutický prípravok obsahujúci inhibítor karboxypeptidázy U a inhibítor trombínu SK15652001A3 (sk)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
SE9901573A SE9901573D0 (sv)	1999-05-03	1999-05-03	New compounds
SE9901572A SE9901572D0 (sv)	1999-05-03	1999-05-03	New compounds
SE9902902A SE9902902D0 (sv)	1999-08-13	1999-08-13	New formulation
PCT/SE2000/000847 WO2000066152A1 (en)	1999-05-03	2000-05-03	A pharmaceutical formulation containing an inhibitor of carboxypeptidase u and a thrombin inhibitor

Publications (1)

Publication Number	Publication Date
SK15652001A3 true SK15652001A3 (sk)	2002-07-02

Family

ID=27355973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1565-2001A SK15652001A3 (sk)	1999-05-03	2000-05-03	Farmaceutický prípravok obsahujúci inhibítor karboxypeptidázy U a inhibítor trombínu

Country Status (26)

Country	Link
US (1)	US6974800B1 (is)
EP (1)	EP1181048B1 (is)
JP (1)	JP2002543148A (is)
KR (1)	KR100725206B1 (is)
CN (1)	CN100518820C (is)
AR (1)	AR023819A1 (is)
AT (1)	ATE447964T1 (is)
AU (1)	AU763772B2 (is)
BR (1)	BR0010255A (is)
CA (1)	CA2371217A1 (is)
CZ (1)	CZ20013932A3 (is)
DE (1)	DE60043297D1 (is)
EE (1)	EE200100578A (is)
ES (1)	ES2335383T3 (is)
HK (1)	HK1042442B (is)
HU (1)	HUP0201615A3 (is)
IL (1)	IL145951A0 (is)
IS (1)	IS6140A (is)
MX (1)	MXPA01011044A (is)
MY (1)	MY126962A (is)
NO (1)	NO20015308L (is)
NZ (1)	NZ515063A (is)
SK (1)	SK15652001A3 (is)
TR (1)	TR200103151T2 (is)
TW (1)	TWI232106B (is)
WO (1)	WO2000066152A1 (is)

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SE9901572D0 (sv) *	1999-05-03	1999-05-03	Astra Ab	New compounds
ES2202171T3 (es)	1999-09-14	2004-04-01	Meiji Seika Kaisha, Ltd.	Derivados del acido fosfonico que poseen actividad inhibidora de la carboxipeptidas b.
SE0001803D0 (sv)	2000-05-16	2000-05-16	Astrazeneca Ab	New compounds i
SE0103272D0 (sv)	2001-09-28	2001-09-28	Astrazeneca Ab	Chemical compounds
US6713496B2 (en)	2002-01-22	2004-03-30	Pfizer Inc	3-(imidazolyl)-2-alkoxypropanoic acids
JP2005516972A (ja)	2002-01-22	2005-06-09	ファイザー・インク	血栓疾患の治療のためのｔａｆｉ−ａ阻害剤として使用される３−（イミダゾリル）−２−アミノプロピオン酸
AU2003230698B2 (en)	2002-03-21	2009-03-26	Bayer Schering Pharma Aktiengesellschaft	Plasma carboxypeptidase B inhibitors
DK1896059T3 (da) *	2005-06-24	2013-04-08	Drugrecure Aps	Luftvejsadministration af Tissue Factor Pathway Inhibitor ved inflammatoriske tilstande, der påvirker luftvejene
US9834527B2 (en)	2013-06-10	2017-12-05	Sanofi	Macrocyclic urea derivatives as inhibitors of TAFIa, their preparation and their use as pharmaceuticals
EP3569617A1 (en) *	2018-05-18	2019-11-20	Trion Research GmbH	Pharmaceutical preparation for use in treating epstein- barr virus positive patients with reactivation phenomenon- associated diseases

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US3091569A (en)	1960-08-26	1963-05-28	Mead Johnson & Co	Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus
FR1393338A (fr)	1964-01-08	1965-03-26	Rech S Pharma Et Scient	Nouveau dérivé de la cystéine et sa préparation
US3766206A (en)	1971-11-03	1973-10-16	Pfizer	18beta-glycyrrheting acid amides useful as antiulcer agents
FR2266502A1 (en)	1974-04-08	1975-10-31	Synpharm Sa	N-(2-thenoyl)-cysteine and esters - with mucolytic activity, prepd. from cysteine (esters) and thenoyl chloride
US4113715A (en)	1977-01-17	1978-09-12	E. R. Squibb & Sons, Inc.	Amino acid derivatives
US4177277A (en)	1977-01-17	1979-12-04	E. R. Squibb & Sons, Inc.	Method for alleviating hypertension
JPS545949A (en)	1977-06-16	1979-01-17	Hisamitsu Pharmaceut Co Inc	Novel cyclohexanecarboxylic acid and its derivatives
FR2430945A2 (fr)	1978-07-12	1980-02-08	Chauvin Blache Lab	Nouveaux derives de la cysteine, leur procede de fabrication et leur application en therapeutique
US4708965A (en)	1985-09-16	1987-11-24	Morgan Lee R	Method of treating herpes virus infections with N,N'-diacetylcystine and derivatives
DE3838467C2 (de)	1988-11-12	1998-12-10	Agfa Gevaert Ag	Fotografisches Aufzeichnungsmaterial
US5206161A (en) *	1991-02-01	1993-04-27	Genentech, Inc.	Human plasma carboxypeptidase B
IT1249650B (it)	1991-05-29	1995-03-09	Poli Ind Chimica Spa	N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico
SE9103612D0 (sv) *	1991-12-04	1991-12-04	Astra Ab	New peptide derivatives
SE9301916D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
SE9404196D0 (sv) *	1994-12-02	1994-12-02	Astra Ab	New antithrombotic formulation
KR0173034B1 (ko)	1995-04-28	1999-03-30	성재갑	선택적 트롬빈 억제제
GB9525620D0 (en) *	1995-12-15	1996-02-14	Glaxo Group Ltd	Chemical compounds
US5859271A (en) *	1996-04-15	1999-01-12	Virginia Commonwealth University	Cytoprotective compounds
US6126939A (en) *	1996-09-03	2000-10-03	Yeda Research And Development Co. Ltd.	Anti-inflammatory dipeptide and pharmaceutical composition thereof
US5993815A (en) *	1996-11-08	1999-11-30	University Of Vermont	Methods and compositions for inhibiting the activation of thrombin-activatable fibrinolysis inhibitor (TAFI)
US6117911A (en) *	1997-04-11	2000-09-12	Neorx Corporation	Compounds and therapies for the prevention of vascular and non-vascular pathologies

2000
- 2000-04-28 AR ARP000102084A patent/AR023819A1/es unknown
- 2000-05-02 MY MYPI20001884A patent/MY126962A/en unknown
- 2000-05-03 US US09/600,659 patent/US6974800B1/en not_active Expired - Fee Related
- 2000-05-03 JP JP2000615036A patent/JP2002543148A/ja active Pending
- 2000-05-03 MX MXPA01011044A patent/MXPA01011044A/es active IP Right Grant
- 2000-05-03 TW TW089108401A patent/TWI232106B/zh not_active IP Right Cessation
- 2000-05-03 AT AT00925845T patent/ATE447964T1/de not_active IP Right Cessation
- 2000-05-03 TR TR2001/03151T patent/TR200103151T2/xx unknown
- 2000-05-03 ES ES00925845T patent/ES2335383T3/es not_active Expired - Lifetime
- 2000-05-03 CZ CZ20013932A patent/CZ20013932A3/cs unknown
- 2000-05-03 HK HK02104301.4A patent/HK1042442B/en not_active IP Right Cessation
- 2000-05-03 SK SK1565-2001A patent/SK15652001A3/sk unknown
- 2000-05-03 HU HU0201615A patent/HUP0201615A3/hu unknown
- 2000-05-03 WO PCT/SE2000/000847 patent/WO2000066152A1/en not_active Ceased
- 2000-05-03 EP EP00925845A patent/EP1181048B1/en not_active Expired - Lifetime
- 2000-05-03 CA CA002371217A patent/CA2371217A1/en not_active Abandoned
- 2000-05-03 EE EEP200100578A patent/EE200100578A/xx unknown
- 2000-05-03 DE DE60043297T patent/DE60043297D1/de not_active Expired - Lifetime
- 2000-05-03 IL IL14595100A patent/IL145951A0/xx unknown
- 2000-05-03 BR BR0010255-5A patent/BR0010255A/pt not_active IP Right Cessation
- 2000-05-03 NZ NZ515063A patent/NZ515063A/en not_active IP Right Cessation
- 2000-05-03 AU AU44472/00A patent/AU763772B2/en not_active Ceased
- 2000-05-03 CN CNB008071284A patent/CN100518820C/zh not_active Expired - Fee Related
- 2000-05-03 KR KR1020017014009A patent/KR100725206B1/ko not_active Expired - Fee Related
2001
- 2001-10-30 NO NO20015308A patent/NO20015308L/no not_active Application Discontinuation
- 2001-11-01 IS IS6140A patent/IS6140A/is unknown

Also Published As

Publication number	Publication date
CA2371217A1 (en)	2000-11-02
WO2000066152A1 (en)	2000-11-09
ATE447964T1 (de)	2009-11-15
AU763772B2 (en)	2003-07-31
AR023819A1 (es)	2002-09-04
TWI232106B (en)	2005-05-11
EP1181048B1 (en)	2009-11-11
HK1042442A1 (en)	2002-08-16
BR0010255A (pt)	2002-02-13
KR20020003386A (ko)	2002-01-12
CZ20013932A3 (cs)	2002-04-17
DE60043297D1 (de)	2009-12-24
AU4447200A (en)	2000-11-17
CN100518820C (zh)	2009-07-29
NO20015308D0 (no)	2001-10-30
CN1350463A (zh)	2002-05-22
EP1181048A1 (en)	2002-02-27
HK1042442B (en)	2010-04-09
MY126962A (en)	2006-11-30
EE200100578A (et)	2003-02-17
IS6140A (is)	2001-11-01
KR100725206B1 (ko)	2007-06-07
TR200103151T2 (tr)	2002-04-22
MXPA01011044A (es)	2002-06-04
HUP0201615A2 (en)	2002-09-28
US6974800B1 (en)	2005-12-13
ES2335383T3 (es)	2010-03-26
NO20015308L (no)	2001-12-03
IL145951A0 (en)	2002-07-25
NZ515063A (en)	2003-08-29
HUP0201615A3 (en)	2006-07-28
JP2002543148A (ja)	2002-12-17
PL356119A1 (en)	2004-06-14

Publication	Publication Date	Title
RU2252783C2 (ru)	2005-05-27	Фармацевтический препарат, содержащий низкомолекулярный ингибитор тромбина и его пролекарство
WO2000066557A1 (en)	2000-11-09	New compounds
SK15652001A3 (sk)	2002-07-02	Farmaceutický prípravok obsahujúci inhibítor karboxypeptidázy U a inhibítor trombínu
US6518244B2 (en)	2003-02-11	Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
ZA200108966B (en)	2003-01-30	A pharmaceutical formulation containing an inhibitor of carboxypeptidase U and a thrombin inhibitor.
RU2242992C2 (ru)	2004-12-27	Фармацевтический препарат, содержащий ингибитор карбоксипептидазы u и ингибитор тромбина
AU2001264495B2 (en)	2006-01-05	A combination product comprising melagatran and a factor viia inhibitor
AU2001264495A1 (en)	2002-03-14	A combination product comprising melagatran and a factor VIIa inhibitor
AU2002363023B2 (en)	2007-10-25	A combination product comprising melagatran and dexamethasone
PL203505B1 (pl)	2009-10-30	Preparat farmaceutyczny zawieraj acy inhibitor karboksypeptydazy U i inhibitor trombiny, zestaw sk ladników i zastosowanie preparatu farmaceutycznego
ZA200108544B (en)	2003-01-17	A pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug.

Legal Events

Date	Code	Title	Description
2010-11-08	FD9A	Suspended procedure due to non-payment of fee