SK14992000A3 - Spôsob inhibície mrpi - Google Patents

Spôsob inhibície mrpi Download PDF

Info

Publication number: SK14992000A3
Authority: SK; Slovakia
Prior art keywords: phenyl; alkyl; alkoxy; compound; formula
Prior art date: 1998-04-08

Application number

SK1499-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Joseph Michael Gruber

Bryan Hurst Norman

Sean Patrick Hollinshead

Joseph Wendell Wilson

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-08

Filing date

1999-04-07

Publication date

2001-06-11

1999-04-07 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

2001-06-11 Publication of SK14992000A3 publication Critical patent/SK14992000A3/sk

Links

230000002401 inhibitory effect Effects 0.000 title claims abstract description 11
238000000034 method Methods 0.000 title claims description 34
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102100021339 Multidrug resistance-associated protein 1 Human genes 0.000 claims abstract 2
108010066052 multidrug resistance-associated protein 1 Proteins 0.000 claims abstract 2
-1 thiophenylmethyl Chemical group 0.000 claims description 74
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 52
239000000203 mixture Substances 0.000 claims description 50
239000000824 cytostatic agent Substances 0.000 claims description 37
230000001085 cytostatic effect Effects 0.000 claims description 33
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 27
150000003839 salts Chemical class 0.000 claims description 27
229910052739 hydrogen Inorganic materials 0.000 claims description 26
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 24
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 18
239000001257 hydrogen Substances 0.000 claims description 17
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK1499-2000A 1998-04-08 1999-04-07 Spôsob inhibície mrpi SK14992000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8108898P	1998-04-08	1998-04-08
PCT/US1999/007615 WO1999051236A1 (en)	1998-04-08	1999-04-07	Methods for inhibiting mrp1

Publications (1)

Publication Number	Publication Date
SK14992000A3 true SK14992000A3 (sk)	2001-06-11

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Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1499-2000A SK14992000A3 (sk)	1998-04-08	1999-04-07	Spôsob inhibície mrpi

Country Status (17)

Country	Link
US (1)	US6221876B1 (no)
EP (1)	EP1067932A4 (no)
JP (1)	JP2002510632A (no)
KR (1)	KR20010042481A (no)
CN (1)	CN1296410A (no)
AU (1)	AU3550299A (no)
BR (1)	BR9909446A (no)
CA (1)	CA2327452A1 (no)
EA (1)	EA200001035A1 (no)
HU (1)	HUP0102548A2 (no)
ID (1)	ID26804A (no)
IL (1)	IL138393A0 (no)
NO (1)	NO20005041L (no)
PL (1)	PL343320A1 (no)
SK (1)	SK14992000A3 (no)
TR (1)	TR200002804T2 (no)
WO (1)	WO1999051236A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002522425A (ja)	1998-08-07	2002-07-23	カイロンコーポレイション	エストロゲンレセプターモジュレーターとしての置換イソオキサゾール
DE60016039T2 (de) *	1999-12-22	2005-08-11	Eli Lilly And Co., Indianapolis	Verfahren und verbindungen für die hemmung von mrp1
US6743794B2 (en)	1999-12-22	2004-06-01	Eli Lilly And Company	Methods and compounds for inhibiting MRP1
CA2411813A1 (en)	2000-06-14	2001-12-20	Eli Lilly And Company	Tricyclic compounds as mrp1-inhibitors
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1999
- 1999-04-07 KR KR1020007011101A patent/KR20010042481A/ko not_active Withdrawn
- 1999-04-07 ID IDW20002006A patent/ID26804A/id unknown
- 1999-04-07 CN CN99804797A patent/CN1296410A/zh active Pending
- 1999-04-07 PL PL99343320A patent/PL343320A1/xx not_active Application Discontinuation
- 1999-04-07 IL IL13839399A patent/IL138393A0/xx unknown
- 1999-04-07 WO PCT/US1999/007615 patent/WO1999051236A1/en not_active Ceased
- 1999-04-07 HU HU0102548A patent/HUP0102548A2/hu unknown
- 1999-04-07 US US09/646,063 patent/US6221876B1/en not_active Expired - Fee Related
- 1999-04-07 BR BR9909446-0A patent/BR9909446A/pt not_active IP Right Cessation
- 1999-04-07 AU AU35502/99A patent/AU3550299A/en not_active Abandoned
- 1999-04-07 SK SK1499-2000A patent/SK14992000A3/sk unknown
- 1999-04-07 TR TR2000/02804T patent/TR200002804T2/xx unknown
- 1999-04-07 EP EP99917359A patent/EP1067932A4/en not_active Withdrawn
- 1999-04-07 EA EA200001035A patent/EA200001035A1/ru unknown
- 1999-04-07 CA CA002327452A patent/CA2327452A1/en not_active Abandoned
- 1999-04-07 JP JP2000542007A patent/JP2002510632A/ja not_active Withdrawn
2000
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Also Published As

Publication number	Publication date
WO1999051236A1 (en)	1999-10-14
EP1067932A1 (en)	2001-01-17
PL343320A1 (en)	2001-08-13
US6221876B1 (en)	2001-04-24
NO20005041D0 (no)	2000-10-06
TR200002804T2 (tr)	2001-02-21
CN1296410A (zh)	2001-05-23
HUP0102548A2 (hu)	2001-11-28
EP1067932A4 (en)	2001-11-14
NO20005041L (no)	2000-10-06
BR9909446A (pt)	2000-12-12
CA2327452A1 (en)	1999-10-14
JP2002510632A (ja)	2002-04-09
IL138393A0 (en)	2001-10-31
AU3550299A (en)	1999-10-25
ID26804A (id)	2001-02-08
KR20010042481A (ko)	2001-05-25
EA200001035A1 (ru)	2001-04-23

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