SI9620044B - Ternarni radiofarmacevtski kompleksi - Google Patents

Ternarni radiofarmacevtski kompleksi Download PDF

Info

Publication number: SI9620044B
Authority: SI; Slovenia
Prior art keywords: group; substituted; independently selected; occurrence; carbon atom
Prior art date: 1995-04-03

Application number

SI9620044A

Other languages

English (en)

Slovenian (sl)

Other versions

SI9620044A (sl

Inventor

David Scot Edwards

Shuang Liu

Original Assignee

Dupont Pharmaceuticals Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-03

Filing date

1996-04-03

Publication date

1999-02-28

1996-04-03 Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company

1998-06-30 Publication of SI9620044A publication Critical patent/SI9620044A/sl

1999-02-28 Publication of SI9620044B publication Critical patent/SI9620044B/sl

Links

239000012217 radiopharmaceutical Substances 0.000 title claims abstract 21
229940121896 radiopharmaceutical Drugs 0.000 title claims abstract 21
230000002799 radiopharmaceutical effect Effects 0.000 title claims abstract 21
229910052799 carbon Inorganic materials 0.000 claims 27
125000004432 carbon atom Chemical group C* 0.000 claims 27
229910052739 hydrogen Inorganic materials 0.000 claims 21
239000001257 hydrogen Substances 0.000 claims 21
229910006069 SO3H Inorganic materials 0.000 claims 18
125000003118 aryl group Chemical group 0.000 claims 18
125000000623 heterocyclic group Chemical group 0.000 claims 17
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 11
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 11
HRGUSFBJBOKSML-UHFFFAOYSA-N 3',5'-di-O-methyltricetin Chemical compound COC1=C(O)C(OC)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 HRGUSFBJBOKSML-UHFFFAOYSA-N 0.000 claims 10
IDDMFNIRSJVBHE-UHFFFAOYSA-N Piscigenin Natural products COC1=C(O)C(OC)=CC(C=2C(C3=C(O)C=C(O)C=C3OC=2)=O)=C1 IDDMFNIRSJVBHE-UHFFFAOYSA-N 0.000 claims 10
KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 claims 10
BMCJATLPEJCACU-UHFFFAOYSA-N tricin Natural products COc1cc(OC)c(O)c(c1)C2=CC(=O)c3c(O)cc(O)cc3O2 BMCJATLPEJCACU-UHFFFAOYSA-N 0.000 claims 10
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 9
150000002431 hydrogen Chemical class 0.000 claims 9
125000002877 alkyl aryl group Chemical group 0.000 claims 8
239000003446 ligand Substances 0.000 claims 8
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
125000003710 aryl alkyl group Chemical group 0.000 claims 6
125000000753 cycloalkyl group Chemical group 0.000 claims 6
229910052751 metal Inorganic materials 0.000 claims 6
239000002184 metal Substances 0.000 claims 6
102000004196 processed proteins & peptides Human genes 0.000 claims 6
108090000765 processed proteins & peptides Proteins 0.000 claims 6
101100294118 Caenorhabditis elegans nhr-53 gene Proteins 0.000 claims 5
101100516564 Caenorhabditis elegans nhr-71 gene Proteins 0.000 claims 4
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims 4
101710091342 Chemotactic peptide Proteins 0.000 claims 4
125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
-1 p- (2-phenylethyl) phenyl Chemical group 0.000 claims 4
239000002464 receptor antagonist Substances 0.000 claims 4
229940044551 receptor antagonist Drugs 0.000 claims 4
229920006395 saturated elastomer Polymers 0.000 claims 4
229910052723 transition metal Inorganic materials 0.000 claims 4
150000003624 transition metals Chemical class 0.000 claims 4
239000002738 chelating agent Substances 0.000 claims 3
102000009123 Fibrin Human genes 0.000 claims 2
108010073385 Fibrin Proteins 0.000 claims 2
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
102000003800 Selectins Human genes 0.000 claims 2
108090000184 Selectins Proteins 0.000 claims 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
239000003638 chemical reducing agent Substances 0.000 claims 2
229950003499 fibrin Drugs 0.000 claims 2
BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims 2
229960004705 kojic acid Drugs 0.000 claims 2
WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims 2
210000000265 leukocyte Anatomy 0.000 claims 2
125000005647 linker group Chemical group 0.000 claims 2
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 2
125000004344 phenylpropyl group Chemical group 0.000 claims 2
AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 claims 2
150000005299 pyridinones Chemical class 0.000 claims 2
102000005962 receptors Human genes 0.000 claims 2
108020003175 receptors Proteins 0.000 claims 2
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 2
102220519702 Cytosolic phospholipase A2 gamma_R49N_mutation Human genes 0.000 claims 1
102000005157 Somatostatin Human genes 0.000 claims 1
108010056088 Somatostatin Proteins 0.000 claims 1
125000000217 alkyl group Chemical group 0.000 claims 1
239000003153 chemical reaction reagent Substances 0.000 claims 1
150000004820 halides Chemical class 0.000 claims 1
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
239000002773 nucleotide Substances 0.000 claims 1
125000003729 nucleotide group Chemical group 0.000 claims 1
150000003839 salts Chemical class 0.000 claims 1
229960000553 somatostatin Drugs 0.000 claims 1
230000000087 stabilizing effect Effects 0.000 claims 1
HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical group Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 claims 1
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000035473 Communicable disease Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 abstract 1
RBFQJDQYXXHULB-UHFFFAOYSA-N arsane Chemical compound [AsH3] RBFQJDQYXXHULB-UHFFFAOYSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000012216 imaging agent Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
229940056501 technetium 99m Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Optics & Photonics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SI9620044A 1995-04-03 1996-04-03 Ternarni radiofarmacevtski kompleksi SI9620044B (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/415,908 US5744120A (en)	1993-03-30	1995-04-03	Ternary radiopharmaceutical complexes
PCT/US1996/004567 WO1996031243A1 (en)	1995-04-03	1996-04-03	Ternary radiopharmaceutical complexes

Publications (2)

Publication Number	Publication Date
SI9620044A SI9620044A (sl)	1998-06-30
SI9620044B true SI9620044B (sl)	1999-02-28

Family

ID=23647726

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9620044A SI9620044B (sl)	1995-04-03	1996-04-03	Ternarni radiofarmacevtski kompleksi

Country Status (32)

Country	Link
US (2)	US5744120A (es)
EP (2)	EP0820312B1 (es)
JP (1)	JPH11503166A (es)
KR (1)	KR100417558B1 (es)
CN (1)	CN1080127C (es)
AR (1)	AR006077A1 (es)
AT (1)	ATE220335T1 (es)
AU (1)	AU719529B2 (es)
BR (1)	BR9608065A (es)
CA (1)	CA2216423C (es)
CZ (1)	CZ291658B6 (es)
DE (1)	DE69622267T2 (es)
DK (1)	DK0820312T3 (es)
EA (1)	EA000636B1 (es)
EE (1)	EE9700250A (es)
ES (1)	ES2179196T3 (es)
HR (1)	HRP960148A2 (es)
HU (1)	HU225674B1 (es)
IL (1)	IL117642A (es)
LT (1)	LT4391B (es)
LV (1)	LV12039B (es)
MX (1)	MX9707430A (es)
NO (1)	NO317177B1 (es)
NZ (2)	NZ333276A (es)
PL (1)	PL185325B1 (es)
PT (1)	PT820312E (es)
SI (1)	SI9620044B (es)
SK (1)	SK283276B6 (es)
TW (1)	TW503110B (es)
UA (1)	UA56127C2 (es)
WO (1)	WO1996031243A1 (es)
ZA (1)	ZA962672B (es)

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US6346547B1 (en)	1999-02-08	2002-02-12	Checkpoint, Genetics, Inc.	N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith
US6844425B1 (en) *	1999-02-24	2005-01-18	Mallinckrodt Inc.	Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
WO2000057787A2 (en) *	1999-03-26	2000-10-05	Du Pont Pharmaceuticals Company	Method for localization of blood clots
US6808698B1 (en)	1999-03-26	2004-10-26	Bristol-Myers Squibb Pharma Company	Method for localization of blood clots
US6806363B1 (en)	1999-04-16	2004-10-19	Mayo Foundation For Medical Education & Research	Cobalamin conjugates useful as antitumor agents
US7591995B2 (en)	1999-10-15	2009-09-22	Mayo Foundation For Medical Education And Research	Cobalamin conjugates useful as imaging and therapeutic agents
MXPA02003772A (es)	1999-10-15	2005-04-28	Mayo Foundation	Conjugados de cobalamina, utiles como agentes para obtencion de imagen y como agentes terapeuticos.
US6534038B2 (en) *	2000-04-07	2003-03-18	Bristol-Myers Squibb Pharma Company	Ternary ligand complexes useful as radiopharmaceuticals
AU2001261728A1 (en)	2000-05-17	2001-11-26	Bristol-Myers Squibb Pharma Company	Use of small molecule radioligands for diagnostic imaging
HK1049333A1 (zh)	2000-06-01	2003-05-09	Bristol-Myers Squibb Pharma Company	以环状琥珀酸酯代替内酰胺，作为制造Aβ蛋白质的抑制剂
CA2427146A1 (en)	2000-10-25	2002-07-18	Mayo Foundation For Medical Education And Research	Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
EP1347784A2 (en)	2000-11-03	2003-10-01	Bristol-Myers Squibb Pharma Company	Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
JP2005506952A (ja)	2000-11-27	2005-03-10	ブリストル−マイヤーズ・スクイブ・メディカル・イメージング・インコーポレイテッド	心臓潅流およびビトロネクチンレセプター標的造影剤の同時造影
US6517814B2 (en)	2001-01-09	2003-02-11	Bristol-Myers Squibb Pharma Company	Macrocyclic chelants useful for metallopharmaceuticals
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US20020094316A1 (en) *	2001-01-09	2002-07-18	Shuang Liu	Polypodal chelants for metallopharmaceuticals
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1995
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- 1996-04-03 DE DE69622267T patent/DE69622267T2/de not_active Expired - Fee Related
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1997
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Also Published As

Publication number	Publication date
EP1195168A3 (en)	2007-05-30
EP1195168A2 (en)	2002-04-10
IL117642A0 (en)	1996-07-23
AR006077A1 (es)	1999-08-11
LV12039B (en)	1998-10-20
DK0820312T3 (da)	2002-09-02
HU225674B1 (en)	2007-06-28
TW503110B (en)	2002-09-21
LT4391B (lt)	1998-10-26
SK283276B6 (sk)	2003-05-02
NO974549L (no)	1997-12-02
EA000636B1 (ru)	1999-12-29
HUP9801949A2 (hu)	1999-02-01
NZ333276A (en)	2000-07-28
CN1080127C (zh)	2002-03-06
KR100417558B1 (ko)	2004-03-19
SK132997A3 (en)	1999-01-11
PL322583A1 (en)	1998-02-02
CN1185116A (zh)	1998-06-17
DE69622267D1 (de)	2002-08-14
LT97157A (en)	1998-05-25
DE69622267T2 (de)	2003-02-20
HRP960148A2 (en)	1997-10-31
US6010679A (en)	2000-01-04
KR19980703560A (ko)	1998-11-05
EE9700250A (et)	1998-04-15
CZ302797A3 (cs)	1998-11-11
JPH11503166A (ja)	1999-03-23
HUP9801949A3 (en)	2000-09-28
EA199700291A1 (ru)	1998-04-30
CA2216423C (en)	2004-03-09
ATE220335T1 (de)	2002-07-15
NZ308284A (en)	1999-05-28
AU5787496A (en)	1996-10-23
MX9707430A (es)	1997-12-31
LV12039A (lv)	1998-05-20
BR9608065A (pt)	1999-06-29
PT820312E (pt)	2002-10-31
WO1996031243A1 (en)	1996-10-10
US5744120A (en)	1998-04-28
SI9620044A (sl)	1998-06-30
PL185325B1 (pl)	2003-04-30
IL117642A (en)	2003-04-10
EP0820312B1 (en)	2002-07-10
EP0820312A4 (en)	1998-03-18
ES2179196T3 (es)	2003-01-16
NO974549D0 (no)	1997-10-02
NO317177B1 (no)	2004-09-06
CA2216423A1 (en)	1996-10-10
UA56127C2 (uk)	2003-05-15
ZA962672B (en)	1997-10-03
AU719529B2 (en)	2000-05-11
CZ291658B6 (cs)	2003-04-16
EP0820312A1 (en)	1998-01-28

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