SI2794654T1 - Protitelesa proti PHF-tau njihove uporabe - Google Patents
Protitelesa proti PHF-tau njihove uporabeInfo
- Publication number
- SI2794654T1 SI2794654T1 SI201231610T SI201231610T SI2794654T1 SI 2794654 T1 SI2794654 T1 SI 2794654T1 SI 201231610 T SI201231610 T SI 201231610T SI 201231610 T SI201231610 T SI 201231610T SI 2794654 T1 SI2794654 T1 SI 2794654T1
- Authority
- SI
- Slovenia
- Prior art keywords
- phf
- tau antibodies
- tau
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577817P | 2011-12-20 | 2011-12-20 | |
| PCT/US2012/070486 WO2013096380A2 (en) | 2011-12-20 | 2012-12-19 | Anti-phf-tau antibodies and their uses |
| EP12859920.6A EP2794654B1 (en) | 2011-12-20 | 2012-12-19 | Anti-phf-tau antibodies and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2794654T1 true SI2794654T1 (sl) | 2019-08-30 |
Family
ID=48669693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231610T SI2794654T1 (sl) | 2011-12-20 | 2012-12-19 | Protitelesa proti PHF-tau njihove uporabe |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US9371376B2 (sl) |
| EP (2) | EP3578567A1 (sl) |
| JP (4) | JP6306513B2 (sl) |
| KR (1) | KR101991681B1 (sl) |
| CN (2) | CN107226863B (sl) |
| AU (2) | AU2012359039B2 (sl) |
| BR (1) | BR112014015323B1 (sl) |
| CA (2) | CA3234629A1 (sl) |
| CO (1) | CO6980627A2 (sl) |
| CY (1) | CY1121862T1 (sl) |
| DK (1) | DK2794654T3 (sl) |
| EA (1) | EA027975B1 (sl) |
| EC (1) | ECSP14005975A (sl) |
| ES (1) | ES2738007T3 (sl) |
| GT (1) | GT201400127A (sl) |
| HR (1) | HRP20191342T1 (sl) |
| HU (1) | HUE045656T2 (sl) |
| IL (3) | IL233051B (sl) |
| LT (1) | LT2794654T (sl) |
| MX (2) | MX380302B (sl) |
| MY (2) | MY186066A (sl) |
| NI (1) | NI201400061A (sl) |
| NZ (1) | NZ626269A (sl) |
| PH (1) | PH12014501427B1 (sl) |
| PL (1) | PL2794654T3 (sl) |
| PT (1) | PT2794654T (sl) |
| RS (1) | RS59024B1 (sl) |
| SG (1) | SG11201403106SA (sl) |
| SI (1) | SI2794654T1 (sl) |
| SM (1) | SMT201900421T1 (sl) |
| TR (1) | TR201910720T4 (sl) |
| UA (1) | UA114902C2 (sl) |
| WO (1) | WO2013096380A2 (sl) |
| ZA (1) | ZA201405317B (sl) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101991681B1 (ko) * | 2011-12-20 | 2019-06-21 | 얀센 바이오테크 인코포레이티드 | 항-phf-타우 항체 및 그의 용도 |
| MY171473A (en) | 2012-07-03 | 2019-10-15 | Univ Washington | Antibodies to tau |
| CA2882034C (en) | 2012-08-16 | 2019-10-29 | Ipierian, Inc. | Methods of treating a tauopathy |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| CN105939722A (zh) | 2014-02-14 | 2016-09-14 | 伊皮埃里安股份有限公司 | Tau肽,抗Tau抗体,及其使用方法 |
| JP6641305B2 (ja) * | 2014-06-26 | 2020-02-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 微小管結合タンパク質タウに特異的に結合する抗体及び抗原結合断片 |
| ZA201608812B (en) * | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| TWI664190B (zh) | 2014-06-27 | 2019-07-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| WO2016112078A2 (en) * | 2015-01-08 | 2016-07-14 | Janssen Biotech, Inc. | Anti-phf-tau antibodies and their uses |
| TWI669314B (zh) | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對tau之抗體及其用途 |
| CR20180013A (es) | 2015-06-05 | 2018-12-06 | Ac Immune Sa | Anticuerpos anti-tau y métodos de uso. |
| MA42380A (fr) | 2015-07-06 | 2018-05-16 | Ucb Biopharma Sprl | Anticorps se liant à tau |
| EP3319983B1 (en) * | 2015-07-06 | 2026-01-28 | UCB Biopharma SRL | Tau-binding antibodies |
| EP3448875A4 (en) * | 2016-04-29 | 2020-04-08 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| CN109562167A (zh) | 2016-08-09 | 2019-04-02 | 伊莱利利公司 | 联合治疗 |
| TWI789371B (zh) | 2016-12-07 | 2023-01-11 | 美商建南德克公司 | 抗-tau抗體及使用方法 |
| IL266911B2 (en) | 2016-12-07 | 2024-10-01 | Genentech Inc | Anti-tau antibodies and uses thereof in treating tauopathy, retaining or increasing cognitive memory capacity or slowing memory loss |
| AU2018221049A1 (en) | 2017-02-17 | 2019-09-19 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
| JP2018139530A (ja) | 2017-02-27 | 2018-09-13 | 帝人ファーマ株式会社 | 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤 |
| JOP20180021A1 (ar) * | 2017-03-16 | 2019-01-30 | Janssen Biotech Inc | الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها |
| PE20210115A1 (es) | 2017-10-16 | 2021-01-19 | Eisai Randd Man Co Ltd | Anticuerpos anti-tau y uso de los mismos |
| BR112020018112A2 (pt) | 2018-03-05 | 2020-12-22 | Janssen Pharmaceutica Nv | Anticorpos anti-phf-tau e usos dos mesmos |
| KR20240150533A (ko) | 2018-03-05 | 2024-10-15 | 얀센 파마슈티카 엔브이 | 신경퇴행을 검출하기 위한 분석 |
| KR20200144551A (ko) * | 2018-03-28 | 2020-12-29 | 악손 뉴로사이언스 에스이 | 알츠하이머병을 검출하고 치료하는 항체-기반 방법 |
| JP2021530552A (ja) | 2018-07-31 | 2021-11-11 | イーライ リリー アンド カンパニー | 併用療法 |
| IL297231A (en) * | 2020-04-08 | 2022-12-01 | Janssen Biotech Inc | Anti-phf-tau antibodies and uses thereof |
| EP4135841A1 (en) | 2020-04-15 | 2023-02-22 | Voyager Therapeutics, Inc. | Tau binding compounds |
| IL299292A (en) | 2020-06-25 | 2023-02-01 | Merck Sharp & Dohme Llc | High-affinity antibodies to tau phosphorylated at serine 413 |
| CA3205586A1 (en) | 2020-12-16 | 2022-06-23 | Voyager Therapeutics, Inc. | Tau binding compounds |
| BR112023016271A2 (pt) * | 2021-02-14 | 2023-11-14 | Prothena Biosciences Ltd | Métodos para usar anticorpos que reconhecem tau |
| KR20230162790A (ko) * | 2021-03-26 | 2023-11-28 | 얀센 바이오테크 인코포레이티드 | 항-타우 항체 및 이의 용도 |
| EP4314059A1 (en) * | 2021-03-26 | 2024-02-07 | Janssen Biotech, Inc. | Humanized antibodies against paired helical filament tau and uses thereof |
| EP4399524A4 (en) | 2021-09-09 | 2025-10-08 | Alzpath Inc | PHOSPHO-TAU ANTIBODIES AND METHODS OF USE |
| US20250243263A1 (en) | 2022-06-22 | 2025-07-31 | Voyager Therapeutics, Inc. | Tau binding compounds |
| CA3266790A1 (en) | 2022-09-15 | 2024-03-21 | Voyager Therapeutics, Inc. | TAU PROTEIN BINDING COMPOUNDS |
| WO2025018933A1 (en) * | 2023-07-20 | 2025-01-23 | Montoliu Gaya Laia | P-tau immunoassay |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0610330B1 (en) | 1991-10-25 | 1997-06-18 | N.V. Innogenetics S.A. | Monoclonal antibodies directed against the microtubule-associated protein tau |
| EP0737208B1 (en) * | 1993-12-21 | 2006-08-02 | Innogenetics N.V. | Monoclonal antibodies specific for phf-tau, hybridomas secreting them, antigen recognition by these antibodies and their applications |
| US6121003A (en) * | 1994-07-29 | 2000-09-19 | Innogentics N.V. | Monoclonal antibodies specific for an epitope of phosphorylated tau, and their use |
| WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
| WO2005056759A2 (en) | 2003-12-04 | 2005-06-23 | Xencor, Inc. | Methods of generating variant proteins with increased host string content and compositions thereof |
| US20070048785A1 (en) | 2004-06-09 | 2007-03-01 | Lin Laura L | Anti-IL-13 antibodies and complexes |
| EP1790664A1 (en) * | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| US20070280935A1 (en) * | 2006-04-07 | 2007-12-06 | Bernd Bohrmann | Antibody that recognizes phosphorylated peptides |
| EP2057193B1 (en) * | 2006-08-04 | 2013-12-18 | Novartis AG | Ephb3-specific antibody and uses thereof |
| JP2010235447A (ja) * | 2007-07-30 | 2010-10-21 | Igaku Seibutsugaku Kenkyusho:Kk | 炎症性サイトカインの抑制剤 |
| US20100261620A1 (en) | 2008-10-14 | 2010-10-14 | Juan Carlos Almagro | Methods of Humanizing and Affinity-Maturing Antibodies |
| US9968574B2 (en) | 2009-05-15 | 2018-05-15 | The University Of Kentucky Research Foundation | Treatment of MCI and Alzheimer's disease |
| US8748386B2 (en) * | 2009-06-10 | 2014-06-10 | New York University | Immunological targeting of pathological Tau proteins |
| US8609097B2 (en) * | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
| US8912355B2 (en) * | 2009-09-29 | 2014-12-16 | University Of Ottawa Heart Institute | Linoleic phospholipids and uses thereof for inhibiting inflammatory and neurodegenerative processes |
| WO2011047146A2 (en) | 2009-10-14 | 2011-04-21 | Centocor Ortho Biotech Inc. | Methods of affinity maturing antibodies |
| WO2012045882A2 (en) * | 2010-10-07 | 2012-04-12 | Ac Immune S.A. | Pharmaceutical composition |
| LT2627672T (lt) * | 2010-10-11 | 2018-12-10 | Biogen International Neuroscience Gmbh | Žmogaus antikūnai prieš tau baltymą |
| KR101991681B1 (ko) * | 2011-12-20 | 2019-06-21 | 얀센 바이오테크 인코포레이티드 | 항-phf-타우 항체 및 그의 용도 |
| JOP20180021A1 (ar) * | 2017-03-16 | 2019-01-30 | Janssen Biotech Inc | الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها |
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2012
- 2012-12-19 KR KR1020147019911A patent/KR101991681B1/ko active Active
- 2012-12-19 CA CA3234629A patent/CA3234629A1/en active Pending
- 2012-12-19 RS RS20190932A patent/RS59024B1/sr unknown
- 2012-12-19 US US14/363,888 patent/US9371376B2/en active Active
- 2012-12-19 UA UAA201408042A patent/UA114902C2/uk unknown
- 2012-12-19 EP EP19173615.6A patent/EP3578567A1/en active Pending
- 2012-12-19 AU AU2012359039A patent/AU2012359039B2/en active Active
- 2012-12-19 CA CA2859665A patent/CA2859665C/en active Active
- 2012-12-19 MX MX2017011111A patent/MX380302B/es unknown
- 2012-12-19 MX MX2014007476A patent/MX350311B/es active IP Right Grant
- 2012-12-19 EA EA201491224A patent/EA027975B1/ru not_active IP Right Cessation
- 2012-12-19 LT LT12859920T patent/LT2794654T/lt unknown
- 2012-12-19 EP EP12859920.6A patent/EP2794654B1/en active Active
- 2012-12-19 TR TR2019/10720T patent/TR201910720T4/tr unknown
- 2012-12-19 HU HUE12859920A patent/HUE045656T2/hu unknown
- 2012-12-19 PT PT12859920T patent/PT2794654T/pt unknown
- 2012-12-19 SM SM20190421T patent/SMT201900421T1/it unknown
- 2012-12-19 JP JP2014548811A patent/JP6306513B2/ja active Active
- 2012-12-19 HR HRP20191342 patent/HRP20191342T1/hr unknown
- 2012-12-19 PL PL12859920T patent/PL2794654T3/pl unknown
- 2012-12-19 SI SI201231610T patent/SI2794654T1/sl unknown
- 2012-12-19 ES ES12859920T patent/ES2738007T3/es active Active
- 2012-12-19 BR BR112014015323-0A patent/BR112014015323B1/pt active IP Right Grant
- 2012-12-19 SG SG11201403106SA patent/SG11201403106SA/en unknown
- 2012-12-19 NZ NZ626269A patent/NZ626269A/en unknown
- 2012-12-19 DK DK12859920.6T patent/DK2794654T3/da active
- 2012-12-19 WO PCT/US2012/070486 patent/WO2013096380A2/en not_active Ceased
- 2012-12-19 MY MYPI2017000364A patent/MY186066A/en unknown
- 2012-12-19 CN CN201710472573.8A patent/CN107226863B/zh active Active
- 2012-12-19 CN CN201280062971.8A patent/CN104024274B/zh active Active
- 2012-12-19 MY MYPI2014701643A patent/MY178142A/en unknown
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2014
- 2014-06-10 IL IL233051A patent/IL233051B/en active IP Right Grant
- 2014-06-19 NI NI201400061A patent/NI201400061A/es unknown
- 2014-06-20 PH PH12014501427A patent/PH12014501427B1/en unknown
- 2014-06-20 EC ECIEPI20145975A patent/ECSP14005975A/es unknown
- 2014-06-20 CO CO14134449A patent/CO6980627A2/es unknown
- 2014-06-20 GT GT201400127A patent/GT201400127A/es unknown
- 2014-07-18 ZA ZA2014/05317A patent/ZA201405317B/en unknown
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2016
- 2016-04-26 US US15/138,635 patent/US9745371B2/en active Active
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2017
- 2017-07-11 US US15/646,865 patent/US10000559B2/en active Active
- 2017-11-20 AU AU2017264975A patent/AU2017264975B2/en active Active
- 2017-12-21 JP JP2017245019A patent/JP6695317B2/ja active Active
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2018
- 2018-05-21 US US15/984,772 patent/US10196440B2/en active Active
- 2018-11-14 IL IL263021A patent/IL263021B/en active IP Right Grant
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2019
- 2019-06-10 JP JP2019108147A patent/JP6987809B2/ja active Active
- 2019-08-06 CY CY20191100834T patent/CY1121862T1/el unknown
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2020
- 2020-02-10 JP JP2020020482A patent/JP6987904B2/ja active Active
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2021
- 2021-03-03 IL IL281250A patent/IL281250A/en unknown
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