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SI2794654T1 - Protitelesa proti PHF-tau njihove uporabe - Google Patents

Protitelesa proti PHF-tau njihove uporabe

Info

Publication number
SI2794654T1
SI2794654T1 SI201231610T SI201231610T SI2794654T1 SI 2794654 T1 SI2794654 T1 SI 2794654T1 SI 201231610 T SI201231610 T SI 201231610T SI 201231610 T SI201231610 T SI 201231610T SI 2794654 T1 SI2794654 T1 SI 2794654T1
Authority
SI
Slovenia
Prior art keywords
phf
tau antibodies
tau
antibodies
Prior art date
Application number
SI201231610T
Other languages
English (en)
Inventor
Christopher Alderfer
Dariusz Janecki
Xuesong Liu
Melissa Murdock
Sheng-Jiun Wu
Marc Mercken
Marc Vandermeeren
Thomas Malia
Original Assignee
Janssen Biotech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech, Inc. filed Critical Janssen Biotech, Inc.
Publication of SI2794654T1 publication Critical patent/SI2794654T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI201231610T 2011-12-20 2012-12-19 Protitelesa proti PHF-tau njihove uporabe SI2794654T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161577817P 2011-12-20 2011-12-20
PCT/US2012/070486 WO2013096380A2 (en) 2011-12-20 2012-12-19 Anti-phf-tau antibodies and their uses
EP12859920.6A EP2794654B1 (en) 2011-12-20 2012-12-19 Anti-phf-tau antibodies and their uses

Publications (1)

Publication Number Publication Date
SI2794654T1 true SI2794654T1 (sl) 2019-08-30

Family

ID=48669693

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201231610T SI2794654T1 (sl) 2011-12-20 2012-12-19 Protitelesa proti PHF-tau njihove uporabe

Country Status (34)

Country Link
US (4) US9371376B2 (sl)
EP (2) EP3578567A1 (sl)
JP (4) JP6306513B2 (sl)
KR (1) KR101991681B1 (sl)
CN (2) CN107226863B (sl)
AU (2) AU2012359039B2 (sl)
BR (1) BR112014015323B1 (sl)
CA (2) CA3234629A1 (sl)
CO (1) CO6980627A2 (sl)
CY (1) CY1121862T1 (sl)
DK (1) DK2794654T3 (sl)
EA (1) EA027975B1 (sl)
EC (1) ECSP14005975A (sl)
ES (1) ES2738007T3 (sl)
GT (1) GT201400127A (sl)
HR (1) HRP20191342T1 (sl)
HU (1) HUE045656T2 (sl)
IL (3) IL233051B (sl)
LT (1) LT2794654T (sl)
MX (2) MX380302B (sl)
MY (2) MY186066A (sl)
NI (1) NI201400061A (sl)
NZ (1) NZ626269A (sl)
PH (1) PH12014501427B1 (sl)
PL (1) PL2794654T3 (sl)
PT (1) PT2794654T (sl)
RS (1) RS59024B1 (sl)
SG (1) SG11201403106SA (sl)
SI (1) SI2794654T1 (sl)
SM (1) SMT201900421T1 (sl)
TR (1) TR201910720T4 (sl)
UA (1) UA114902C2 (sl)
WO (1) WO2013096380A2 (sl)
ZA (1) ZA201405317B (sl)

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US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
CN105939722A (zh) 2014-02-14 2016-09-14 伊皮埃里安股份有限公司 Tau肽,抗Tau抗体,及其使用方法
JP6641305B2 (ja) * 2014-06-26 2020-02-05 ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. 微小管結合タンパク質タウに特異的に結合する抗体及び抗原結合断片
ZA201608812B (en) * 2014-06-26 2019-08-28 Janssen Vaccines & Prevention Bv Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
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WO2016112078A2 (en) * 2015-01-08 2016-07-14 Janssen Biotech, Inc. Anti-phf-tau antibodies and their uses
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JP2018139530A (ja) 2017-02-27 2018-09-13 帝人ファーマ株式会社 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤
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BR112020018112A2 (pt) 2018-03-05 2020-12-22 Janssen Pharmaceutica Nv Anticorpos anti-phf-tau e usos dos mesmos
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KR20200144551A (ko) * 2018-03-28 2020-12-29 악손 뉴로사이언스 에스이 알츠하이머병을 검출하고 치료하는 항체-기반 방법
JP2021530552A (ja) 2018-07-31 2021-11-11 イーライ リリー アンド カンパニー 併用療法
IL297231A (en) * 2020-04-08 2022-12-01 Janssen Biotech Inc Anti-phf-tau antibodies and uses thereof
EP4135841A1 (en) 2020-04-15 2023-02-22 Voyager Therapeutics, Inc. Tau binding compounds
IL299292A (en) 2020-06-25 2023-02-01 Merck Sharp & Dohme Llc High-affinity antibodies to tau phosphorylated at serine 413
CA3205586A1 (en) 2020-12-16 2022-06-23 Voyager Therapeutics, Inc. Tau binding compounds
BR112023016271A2 (pt) * 2021-02-14 2023-11-14 Prothena Biosciences Ltd Métodos para usar anticorpos que reconhecem tau
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EP4314059A1 (en) * 2021-03-26 2024-02-07 Janssen Biotech, Inc. Humanized antibodies against paired helical filament tau and uses thereof
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Also Published As

Publication number Publication date
SMT201900421T1 (it) 2019-09-09
PH12014501427A1 (en) 2014-09-22
MX380302B (es) 2025-03-12
US20180305445A1 (en) 2018-10-25
CN107226863B (zh) 2021-06-01
TR201910720T4 (tr) 2019-08-21
US10196440B2 (en) 2019-02-05
MX350311B (es) 2017-09-01
KR20140107493A (ko) 2014-09-04
JP6987809B2 (ja) 2022-01-05
EA201491224A1 (ru) 2014-11-28
JP6695317B2 (ja) 2020-05-20
EA027975B1 (ru) 2017-09-29
US9745371B2 (en) 2017-08-29
AU2017264975B2 (en) 2019-09-12
MY186066A (en) 2021-06-18
JP2018078897A (ja) 2018-05-24
NZ626269A (en) 2016-06-24
GT201400127A (es) 2015-03-23
LT2794654T (lt) 2019-11-11
US9371376B2 (en) 2016-06-21
US20170355758A1 (en) 2017-12-14
KR101991681B1 (ko) 2019-06-21
HUE045656T2 (hu) 2020-01-28
US20150307600A1 (en) 2015-10-29
CN104024274A (zh) 2014-09-03
CN107226863A (zh) 2017-10-03
CO6980627A2 (es) 2014-06-27
US20160304593A1 (en) 2016-10-20
CA3234629A1 (en) 2013-06-27
JP6306513B2 (ja) 2018-04-04
DK2794654T3 (da) 2019-08-05
NI201400061A (es) 2016-12-02
BR112014015323A2 (pt) 2020-10-27
NZ720141A (en) 2017-09-29
AU2012359039B2 (en) 2017-08-24
CY1121862T1 (el) 2020-07-31
EP3578567A1 (en) 2019-12-11
IL263021A (en) 2018-12-31
ZA201405317B (en) 2016-05-25
RS59024B1 (sr) 2019-08-30
HRP20191342T1 (hr) 2019-11-01
JP2020105179A (ja) 2020-07-09
CN104024274B (zh) 2017-07-18
HK1203520A1 (en) 2015-10-30
WO2013096380A2 (en) 2013-06-27
IL263021B (en) 2021-03-25
AU2017264975A1 (en) 2017-12-21
PH12014501427B1 (en) 2014-09-22
MY178142A (en) 2020-10-05
MX2014007476A (es) 2014-07-28
CA2859665C (en) 2024-05-21
IL281250A (en) 2021-04-29
IL233051B (en) 2019-02-28
PL2794654T3 (pl) 2019-11-29
ECSP14005975A (es) 2015-07-31
PT2794654T (pt) 2019-09-10
EP2794654B1 (en) 2019-05-22
JP2015500879A (ja) 2015-01-08
EP2794654A4 (en) 2015-09-30
SG11201403106SA (en) 2014-12-30
WO2013096380A3 (en) 2013-08-22
JP2019176866A (ja) 2019-10-17
US10000559B2 (en) 2018-06-19
BR112014015323B1 (pt) 2022-09-27
ES2738007T3 (es) 2020-01-17
UA114902C2 (uk) 2017-08-28
EP2794654A2 (en) 2014-10-29
JP6987904B2 (ja) 2022-01-05
IL233051A0 (en) 2014-07-31
HK1244490A1 (zh) 2018-08-10
CA2859665A1 (en) 2013-06-27
AU2012359039A1 (en) 2014-07-03

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