SI2121674T1 - Postopki in intermediati za pripravo makrocikličnega proteaznega inhibitorja HCV - Google Patents

Postopki in intermediati za pripravo makrocikličnega proteaznega inhibitorja HCV

Info

Publication number: SI2121674T1
Authority: SI; Slovenia
Prior art keywords: hcv; intermediates; preparing; processes; protease inhibitor
Prior art date: 2007-02-01

Application number

SI200830052T

Other languages

English (en)

Inventor

Andras Horvath

Dominique Paul Michel Depre

Dominic John Ormerod

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-01

Filing date

2008-02-01

Publication date

2010-09-30

2008-02-01 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2010-09-30 Publication of SI2121674T1 publication Critical patent/SI2121674T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

SI200830052T 2007-02-01 2008-02-01 Postopki in intermediati za pripravo makrocikličnega proteaznega inhibitorja HCV SI2121674T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07101571		2007-02-01
EP08708576A EP2121674B1 (en)	2007-02-01	2008-02-01	Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
PCT/EP2008/051269 WO2008092955A1 (en)	2007-02-01	2008-02-01	Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv

Publications (1)

Publication Number	Publication Date
SI2121674T1 true SI2121674T1 (sl)	2010-09-30

Family

ID=38337997

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200830052T SI2121674T1 (sl)	2007-02-01	2008-02-01	Postopki in intermediati za pripravo makrocikličnega proteaznega inhibitorja HCV

Country Status (25)

Country	Link
US (2)	US8212043B2 (sl)
EP (1)	EP2121674B1 (sl)
JP (1)	JP5563830B2 (sl)
KR (1)	KR101598135B1 (sl)
CN (3)	CN105111200A (sl)
AR (1)	AR065137A1 (sl)
AT (1)	ATE467630T1 (sl)
AU (1)	AU2008209697B2 (sl)
BR (1)	BRPI0806853B1 (sl)
CA (1)	CA2677173C (sl)
CL (1)	CL2008000322A1 (sl)
CY (1)	CY1110893T1 (sl)
DE (1)	DE602008001251D1 (sl)
DK (1)	DK2121674T3 (sl)
ES (1)	ES2345857T3 (sl)
HK (1)	HK1217952A1 (sl)
HR (1)	HRP20100429T1 (sl)
IL (1)	IL199276A (sl)
MX (1)	MX2009008271A (sl)
PL (1)	PL2121674T3 (sl)
PT (1)	PT2121674E (sl)
RU (1)	RU2483067C2 (sl)
SI (1)	SI2121674T1 (sl)
TW (1)	TWI455936B (sl)
WO (1)	WO2008092955A1 (sl)

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MY140680A (en)	2002-05-20	2010-01-15	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
RU2483067C2 (ru) *	2007-02-01	2013-05-27	Тиботек Фармасьютикалз Лтд.	Способы и промежуточные продукты для получения макроциклического ингибитора протеазы вируса гепатита с
US8207341B2 (en)	2008-09-04	2012-06-26	Bristol-Myers Squibb Company	Process or synthesizing substituted isoquinolines
EP2382198B1 (en) *	2008-12-23	2013-07-10	Janssen Pharmaceuticals, Inc.	Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
KR101868412B1 (ko) *	2009-02-27	2018-06-18	얀센 파마슈티칼스 인코포레이티드	Ｈｃｖ 마크로사이클릭 저해제의 무정형 염
EP2417134B1 (en)	2009-04-08	2017-05-17	Idenix Pharmaceuticals LLC.	Macrocyclic serine protease inhibitors
CA2769652A1 (en)	2009-08-05	2011-02-10	Idenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
EP2528922B1 (en)	2010-01-27	2017-08-02	AB Pharma Ltd	Polyheterocyclic compounds as hcv inhibitors
AU2011229164B2 (en) *	2010-03-16	2015-11-26	Janssen Pharmaceuticals, Inc.	Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
WO2012109398A1 (en)	2011-02-10	2012-08-16	Idenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating hcv infections
US8957203B2 (en)	2011-05-05	2015-02-17	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8691757B2 (en)	2011-06-15	2014-04-08	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CA2857705A1 (en)	2011-06-16	2012-12-20	AB Pharma Ltd.	Macrocyclic heterocyclic compounds for inhibiting hepatitis c virus and preparation and use thereof
US9227965B2 (en) *	2011-09-22	2016-01-05	Janssen Pharmaceuticals, Inc.	Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV
ES2857649T3 (es)	2012-03-01	2021-09-29	Array Biopharma Inc	Inhibidores de serina/treonina cinasa
JP6158168B2 (ja) *	2012-03-14	2017-07-05	積水メディカル株式会社	光学活性２−ビニルシクロプロパン−１，１−ジカルボン酸エステルの製造法
CN103387509B (zh) *	2012-05-11	2016-06-08	重庆博腾制药科技股份有限公司	一种hcv蛋白酶抑制剂中间体的制备方法
JP6154474B2 (ja)	2012-10-19	2017-06-28	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｃ型肝炎ウイルス阻害剤
EP2914598B1 (en)	2012-11-02	2017-10-18	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
US9598433B2 (en)	2012-11-02	2017-03-21	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US9643999B2 (en)	2012-11-02	2017-05-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
EP2914614B1 (en)	2012-11-05	2017-08-16	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
FR2998892B1 (fr)	2012-12-04	2015-01-02	Pf Medicament	Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments
JP6342922B2 (ja)	2013-03-07	2018-06-13	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｃ型肝炎ウイルス阻害剤
CN105175406B (zh) *	2014-06-09	2019-06-04	深圳翰宇药业股份有限公司	Hcv抑制剂的中间体以及由其制备hcv抑制剂的方法
CN105237528B (zh) *	2014-06-09	2019-06-04	深圳翰宇药业股份有限公司	Hcv抑制剂的中间体以及由其制备hcv抑制剂的方法
MA41812A (fr)	2015-03-27	2018-01-30	Janssen Pharmaceuticals Inc	Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc
CN107098805A (zh) *	2017-05-17	2017-08-29	盐城同泰化工科技有限公司	一种4‑环戊酮‑1，2‑二甲酸的制备方法
CN115850070B (zh) *	2022-12-13	2025-11-21	渭南高新区海泰新型电子材料有限责任公司	一种环己烷二羧酸单酯类化合物的合成方法
CN118652175A (zh) *	2024-08-21	2024-09-17	兰州大学	一种磷酸芳香酯催化ε-己内酯接枝丙烯酸羟乙酯类化合物的方法
CN118652174B (zh) *	2024-08-21	2025-03-14	兰州大学	一种酸性树脂催化ε-己内酯接枝丙烯酸羟乙酯类化合物的方法

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UA74546C2 (en) *	1999-04-06	2006-01-16	Boehringer Ingelheim Ca Ltd	Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US7125845B2 (en)	2003-07-03	2006-10-24	Enanta Pharmaceuticals, Inc.	Aza-peptide macrocyclic hepatitis C serine protease inhibitors
DE602005017582D1 (en) *	2004-01-30	2009-12-24	Medivir Ab	Hcv ns-3 serine protease inhibitoren
PE20070343A1 (es) *	2005-07-29	2007-05-12	Medivir Ab	Inhibidores macrociclicos del virus de la hepatitis c
PE20070211A1 (es) *	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c
RU2483067C2 (ru) *	2007-02-01	2013-05-27	Тиботек Фармасьютикалз Лтд.	Способы и промежуточные продукты для получения макроциклического ингибитора протеазы вируса гепатита с

2008
- 2008-02-01 RU RU2009132673/04A patent/RU2483067C2/ru not_active IP Right Cessation
- 2008-02-01 TW TW097103908A patent/TWI455936B/zh not_active IP Right Cessation
- 2008-02-01 CL CL200800322A patent/CL2008000322A1/es unknown
- 2008-02-01 DK DK08708576.7T patent/DK2121674T3/da active
- 2008-02-01 WO PCT/EP2008/051269 patent/WO2008092955A1/en not_active Ceased
- 2008-02-01 CN CN201510477307.5A patent/CN105111200A/zh active Pending
- 2008-02-01 US US12/441,927 patent/US8212043B2/en not_active Expired - Fee Related
- 2008-02-01 EP EP08708576A patent/EP2121674B1/en active Active
- 2008-02-01 DE DE602008001251T patent/DE602008001251D1/de active Active
- 2008-02-01 MX MX2009008271A patent/MX2009008271A/es active IP Right Grant
- 2008-02-01 SI SI200830052T patent/SI2121674T1/sl unknown
- 2008-02-01 KR KR1020097015349A patent/KR101598135B1/ko not_active Expired - Fee Related
- 2008-02-01 PT PT08708576T patent/PT2121674E/pt unknown
- 2008-02-01 CN CN201310036125.5A patent/CN103145699B/zh not_active Expired - Fee Related
- 2008-02-01 AU AU2008209697A patent/AU2008209697B2/en not_active Ceased
- 2008-02-01 HR HR20100429T patent/HRP20100429T1/hr unknown
- 2008-02-01 AR ARP080100428A patent/AR065137A1/es unknown
- 2008-02-01 PL PL08708576T patent/PL2121674T3/pl unknown
- 2008-02-01 JP JP2009547703A patent/JP5563830B2/ja not_active Expired - Fee Related
- 2008-02-01 BR BRPI0806853-4A patent/BRPI0806853B1/pt not_active IP Right Cessation
- 2008-02-01 CA CA2677173A patent/CA2677173C/en not_active Expired - Fee Related
- 2008-02-01 AT AT08708576T patent/ATE467630T1/de active
- 2008-02-01 CN CN200880003655.7A patent/CN101600713B/zh not_active Expired - Fee Related
- 2008-02-01 ES ES08708576T patent/ES2345857T3/es active Active
2009
- 2009-06-10 IL IL199276A patent/IL199276A/en active IP Right Grant
2010
- 2010-08-09 CY CY20101100740T patent/CY1110893T1/el unknown
2012
- 2012-05-31 US US13/484,881 patent/US8722892B2/en not_active Expired - Fee Related
2016
- 2016-05-26 HK HK16106009.8A patent/HK1217952A1/zh unknown

Also Published As

Publication number	Publication date
CA2677173A1 (en)	2008-08-07
HRP20100429T1 (hr)	2010-09-30
CN101600713A (zh)	2009-12-09
DE602008001251D1 (de)	2010-06-24
US20100041889A1 (en)	2010-02-18
IL199276A (en)	2014-12-31
RU2483067C2 (ru)	2013-05-27
US20120238746A1 (en)	2012-09-20
RU2009132673A (ru)	2011-03-10
PL2121674T3 (pl)	2010-10-29
HK1186458A1 (zh)	2014-03-14
TWI455936B (zh)	2014-10-11
CN103145699B (zh)	2015-09-09
CN103145699A (zh)	2013-06-12
HK1217952A1 (zh)	2017-01-27
ATE467630T1 (de)	2010-05-15
BRPI0806853A2 (pt)	2014-04-29
MX2009008271A (es)	2009-08-12
KR20090107038A (ko)	2009-10-12
KR101598135B1 (ko)	2016-02-26
EP2121674A1 (en)	2009-11-25
CL2008000322A1 (es)	2008-09-05
TW200846346A (en)	2008-12-01
WO2008092955A1 (en)	2008-08-07
EP2121674B1 (en)	2010-05-12
US8212043B2 (en)	2012-07-03
AR065137A1 (es)	2009-05-20
HK1137442A1 (en)	2010-07-30
BRPI0806853B1 (pt)	2018-03-20
US8722892B2 (en)	2014-05-13
ES2345857T3 (es)	2010-10-04
CY1110893T1 (el)	2015-06-10
PT2121674E (pt)	2010-09-03
AU2008209697A1 (en)	2008-08-07
JP2010517972A (ja)	2010-05-27
CN105111200A (zh)	2015-12-02
AU2008209697B2 (en)	2014-02-20
DK2121674T3 (da)	2010-09-13
JP5563830B2 (ja)	2014-07-30
CA2677173C (en)	2017-12-12
CN101600713B (zh)	2014-11-12

Publication	Publication Date	Title
PL2121674T3 (pl)	2010-10-29	Sposoby i związki pośrednie do wytwarzania makrocyklicznego inhibitora proteazy HCV
IL213246A0 (en)	2011-07-31	Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
ZA200905377B (en)	2010-10-27	Polymorphic forms of a macrocyclic inhibitor of HCV
IL195515A0 (en)	2011-08-01	Macrocyclic oximyl hepatitis c protease inhibitors
IL219123A0 (en)	2012-06-28	Combinations of a specific hcv ns5a inhibitor and an hcv ns3 protease inhibitor
HUS1500020I1 (hu)	2018-12-28	Makrociklusos Hepatitis C szerin proteáz inhibitorok
EP2219454A4 (en)	2012-05-30	HEMMER OF MACROCYCLIC TETRAZOLYL HEPATITIS C SERIN PROTEASE
EP2224920A4 (en)	2012-05-09	PROCESS FOR THE PREPARATION OF MACROCYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS
ZA201202631B (en)	2012-12-27	Hcv protease inhibitors
EP2224801A4 (en)	2011-09-28	MACROCYCLIC INHIBITORS OF THE OXIMYL TYPE OF HEPATITIS C VIRUS SERINE PROTEASE
EP2432318A4 (en)	2012-11-21	NS3 PROTEASE INHIBITORS OF BIPACROCYCLIC HEPATITIS C VIRUS
IL221242A0 (en)	2012-10-31	Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
IL231024A (en)	2017-09-28	Processes and intermediates for the preparation of macrocyclic protease inhibitor for jaundice virus c
ZA200810235B (en)	2009-10-28	Macrocyclic oximyl hepatitis C protease inhibitors
SG2014011258A (en)	2014-07-30	Hcv protease inhibitors