SI20270A - Substituirani 4-okso-naftiridin-3-karboksamidi kot ligandi možganskih GABA receptorjev - Google Patents

Substituirani 4-okso-naftiridin-3-karboksamidi kot ligandi možganskih GABA receptorjev Download PDF

Info

Publication number: SI20270A
Authority: SI; Slovenia
Prior art keywords: oxo; carboxamide; naphthyridine; tetrahydro; compound according
Prior art date: 1997-08-25

Application number

SI9820055A

Other languages

English (en)

Slovenian (sl)

Inventor

Pamela Albaugh

Robert W. Desimone

Gang Liu

Original Assignee

Neurogen Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-25

Filing date

1998-08-24

Publication date

2000-12-31

1998-08-24 Application filed by Neurogen Corporation filed Critical Neurogen Corporation

2000-12-31 Publication of SI20270A publication Critical patent/SI20270A/sl

Links

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125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
235000015277 pork Nutrition 0.000 description 1
230000001242 postsynaptic effect Effects 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
239000002287 radioligand Substances 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
230000001624 sedative effect Effects 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000000344 soap Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229910001467 sodium calcium phosphate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
125000003107 substituted aryl group Chemical group 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
210000000225 synapse Anatomy 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
238000001308 synthesis method Methods 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
GHJRYEQNGTUIFJ-UHFFFAOYSA-N tert-butyl n-[(4-cyanophenyl)methyl]-n-methylcarbamate Chemical compound CC(C)(C)OC(=O)N(C)CC1=CC=C(C#N)C=C1 GHJRYEQNGTUIFJ-UHFFFAOYSA-N 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
125000004953 trihalomethyl group Chemical group 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Anesthesiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SI9820055A 1997-08-25 1998-08-24 Substituirani 4-okso-naftiridin-3-karboksamidi kot ligandi možganskih GABA receptorjev SI20270A (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US91818097A	1997-08-25	1997-08-25
PCT/US1998/017513 WO1999010347A1 (en)	1997-08-25	1998-08-24	Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Publications (1)

Publication Number	Publication Date
SI20270A true SI20270A (sl)	2000-12-31

Family

ID=25439933

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9820055A SI20270A (sl)	1997-08-25	1998-08-24	Substituirani 4-okso-naftiridin-3-karboksamidi kot ligandi možganskih GABA receptorjev

Country Status (24)

Country	Link
EP (1)	EP1007526A1 (is)
JP (1)	JP2001514181A (is)
KR (1)	KR20010023313A (is)
CN (1)	CN1268136A (is)
AP (1)	AP2000001742A0 (is)
AU (1)	AU753800B2 (is)
BG (1)	BG104192A (is)
BR (1)	BR9811362A (is)
CA (1)	CA2301599C (is)
EG (1)	EG21717A (is)
HU (1)	HUP0003258A3 (is)
IL (1)	IL134291A0 (is)
IS (1)	IS5382A (is)
LV (1)	LV12539B (is)
NO (1)	NO20000822L (is)
NZ (1)	NZ502548A (is)
OA (1)	OA11293A (is)
PE (1)	PE130999A1 (is)
PL (1)	PL338783A1 (is)
SI (1)	SI20270A (is)
SK (1)	SK2162000A3 (is)
TW (1)	TW574221B (is)
WO (1)	WO1999010347A1 (is)
YU (1)	YU10500A (is)

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CA2371472A1 (en) *	1999-05-06	2000-11-16	Neurogen Corporation	Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
US6448246B1 (en)	1999-05-25	2002-09-10	Neurogen Corporation	Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands
US6562822B2 (en)	2000-07-12	2003-05-13	Pharmacia & Upjohn Company	Heterocyle carboxamides as antiviral agents
US6559145B2 (en)	2000-07-12	2003-05-06	Pharmacia & Upjohn Company	Heterocycle carboxamides as antiviral agents
US6730682B2 (en)	2000-07-12	2004-05-04	Pharmacia & Upjohn Company	Heterocycle carboxamides as antiviral agents
WO2002055079A2 (en)	2000-10-12	2002-07-18	Merck & Co Inc	Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
EP1326611B1 (en)	2000-10-12	2007-06-13	Merck & Co., Inc.	Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
KR20030036922A (ko)	2000-10-12	2003-05-09	머크 앤드 캄파니 인코포레이티드	Ｈｉｖ 인테그라제 억제제로서 유용한 아자- 및폴리아자-나프탈레닐 카복스아미드
US20020151591A1 (en) *	2000-10-17	2002-10-17	Anabella Villalobos	Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
MXPA03007834A (es) *	2001-03-01	2003-12-08	Pfizer Prod Inc	Uso de agonistas inversos de gabaa, en combinacion con agonistas parciales del receptor de nicotina, estrogenos, moduladores selectivos de estrogenos o vitamina e, para el tratamiento de transtornos cognitivos.
AR036256A1 (es)	2001-08-17	2004-08-25	Merck & Co Inc	Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
JP4523281B2 (ja)	2002-01-17	2010-08-11	メルク・シャープ・エンド・ドーム・コーポレイション	Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類
ATE409187T1 (de)	2002-03-15	2008-10-15	Merck & Co Inc	N-(substituierte benzyl)-8-hydroxy-1,6- naphthyridin-7- carbonsäureamide als hiv- integrase-hemmer
WO2004106336A1 (en) *	2003-05-27	2004-12-09	Pfizer Products Inc.	Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) *	2003-05-28	2004-12-09	Pfizer Products Inc.	Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
US8293737B2 (en) *	2006-10-16	2012-10-23	Bionomics Limited	Anxiolytic compounds
LT2083811T (lt) *	2006-11-22	2017-01-25	Clinical Research Associates, Llc	Dauno sindromo, trapiosios x chromosomos sindromo ir autizmo gydymo būdai

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AR204813A1 (es) *	1972-05-08	1976-03-05	Yamanouchi Pharma Co Ltd	Proceso para la preparacion de derivados de ampilicina
GB1433774A (en) *	1973-02-26	1976-04-28	Allen & Hanburys Ltd	Heterocyclic compounds apparatus for conveying articles
US4374138A (en) *	1981-11-13	1983-02-15	Warner-Lambert Company	Antibacterial amide compounds, compositions, and methods of use
DD295360A5 (de) *	1987-07-03	1991-10-31	Akad Wissenschaften	Verfahren zur Herstellung von aktivierten Carbonsäureestern
DD279887A1 (de) *	1987-07-03	1990-06-20	Inst Pharmakologische Forschun	Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD279875A1 (de) *	1987-07-03	1990-06-20	Inst Pharmakologische Forschun	Verfahren zur herstellung von aktivierten carbonsaeureestern
JPS6461461A (en) *	1987-09-01	1989-03-08	Otsuka Pharma Co Ltd	Benzohetero ring derivative

1998
- 1998-08-24 AU AU91173/98A patent/AU753800B2/en not_active Ceased
- 1998-08-24 WO PCT/US1998/017513 patent/WO1999010347A1/en not_active Ceased
- 1998-08-24 NZ NZ502548A patent/NZ502548A/en unknown
- 1998-08-24 IL IL13429198A patent/IL134291A0/xx unknown
- 1998-08-24 CN CN98808578A patent/CN1268136A/zh active Pending
- 1998-08-24 KR KR1020007001948A patent/KR20010023313A/ko not_active Withdrawn
- 1998-08-24 JP JP2000507675A patent/JP2001514181A/ja active Pending
- 1998-08-24 CA CA002301599A patent/CA2301599C/en not_active Expired - Fee Related
- 1998-08-24 HU HU0003258A patent/HUP0003258A3/hu unknown
- 1998-08-24 PL PL98338783A patent/PL338783A1/xx unknown
- 1998-08-24 BR BR9811362-3A patent/BR9811362A/pt not_active Application Discontinuation
- 1998-08-24 YU YU10500A patent/YU10500A/sh unknown
- 1998-08-24 SI SI9820055A patent/SI20270A/sl unknown
- 1998-08-24 EP EP98943352A patent/EP1007526A1/en not_active Withdrawn
- 1998-08-24 SK SK216-2000A patent/SK2162000A3/sk unknown
- 1998-09-29 EG EG118098A patent/EG21717A/xx active
- 1998-10-23 TW TW87117597A patent/TW574221B/zh active
- 1998-11-13 PE PE1998001100A patent/PE130999A1/es not_active Application Discontinuation
2000
- 2000-02-01 AP APAP/P/2000/001742A patent/AP2000001742A0/en unknown
- 2000-02-18 OA OA1200000044A patent/OA11293A/en unknown
- 2000-02-18 NO NO20000822A patent/NO20000822L/no not_active Application Discontinuation
- 2000-02-22 IS IS5382A patent/IS5382A/is unknown
- 2000-02-25 BG BG104192A patent/BG104192A/xx unknown
- 2000-03-16 LV LVP-00-29A patent/LV12539B/en unknown

Also Published As

Publication number	Publication date
OA11293A (en)	2002-11-19
CA2301599C (en)	2003-03-25
BG104192A (en)	2001-05-31
EG21717A (en)	2002-02-27
PL338783A1 (en)	2000-11-20
CN1268136A (zh)	2000-09-27
AP2000001742A0 (en)	2000-02-24
LV12539B (en)	2001-01-20
BR9811362A (pt)	2000-08-22
PE130999A1 (es)	1999-12-16
AU753800B2 (en)	2002-10-31
YU10500A (sh)	2002-10-18
HUP0003258A3 (en)	2001-05-28
IL134291A0 (en)	2001-04-30
NO20000822L (no)	2000-04-13
WO1999010347A1 (en)	1999-03-04
IS5382A (is)	2000-02-22
KR20010023313A (ko)	2001-03-26
NO20000822D0 (no)	2000-02-18
AU9117398A (en)	1999-03-16
EP1007526A1 (en)	2000-06-14
NZ502548A (en)	2002-06-28
TW574221B (en)	2004-02-01
JP2001514181A (ja)	2001-09-11
LV12539A (en)	2000-10-20
CA2301599A1 (en)	1999-03-04
SK2162000A3 (en)	2001-03-12
HUP0003258A2 (en)	2001-03-28

Publication	Publication Date	Title
US6646124B2 (en)	2003-11-11	Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
US6103903A (en)	2000-08-15	4-(4-piperidylmethyhlamino) substituted heteroaryl fused pyridines: GABA brain receptor ligands
US6166203A (en)	2000-12-26	Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
US6156898A (en)	2000-12-05	Substituted 1,4-dihydro-4-oxonicotinic carboxamides; GABA brain receptor ligands
AU754716B2 (en)	2002-11-21	Amide derivatives and nociceptin antagonists
SI20270A (sl)	2000-12-31	Substituirani 4-okso-naftiridin-3-karboksamidi kot ligandi možganskih GABA receptorjev
US6177569B1 (en)	2001-01-23	Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
US5840888A (en)	1998-11-24	Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
JPH06502639A (ja)	1994-03-24	特定のイミダゾキノキサリン；新種のｇａｂａ脳受容体リガンド
MXPA01011173A (es)	2002-04-24	4-0x0-quinolin-3-carboxamidas sustituidas: ligandos del receptor cerebro de gaba.
US6194427B1 (en)	2001-02-27	Substituted cycloalkyl-4-Oxonicotinic carboxamides; gaba brain receptor ligands
EP0650964A1 (en)	1995-05-03	1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives
EP1107966B1 (en)	2005-07-27	Oxo-pyridoimidazole-carboxamides: gaba brain receptor ligands
MXPA00001598A (en)	2001-03-05	Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands
MXPA01001991A (en)	2002-03-05	Oxo-pyridoimidazole-carboxamides:gaba brain receptor ligands