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GB1433774A - Heterocyclic compounds apparatus for conveying articles - Google Patents

Heterocyclic compounds apparatus for conveying articles

Info

Publication number
GB1433774A
GB1433774A GB924973A GB924973A GB1433774A GB 1433774 A GB1433774 A GB 1433774A GB 924973 A GB924973 A GB 924973A GB 924973 A GB924973 A GB 924973A GB 1433774 A GB1433774 A GB 1433774A
Authority
GB
United Kingdom
Prior art keywords
alkyl group
hydrogen atom
group
compounds
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB924973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Priority to GB924973A priority Critical patent/GB1433774A/en
Priority to IE00249/74A priority patent/IE38886B1/en
Priority to ZA740883A priority patent/ZA74883B/en
Priority to SE7401984A priority patent/SE7401984L/xx
Priority to AU65592/74A priority patent/AU474797B2/en
Priority to CH224374A priority patent/CH602707A5/xx
Priority to DE19742407744 priority patent/DE2407744A1/en
Priority to BE141102A priority patent/BE811246A/en
Priority to LU69479A priority patent/LU69479A1/xx
Priority to AT149974A priority patent/AT329562B/en
Priority to JP49022232A priority patent/JPS5029574A/ja
Priority to FR7406327A priority patent/FR2218896B1/fr
Priority to CA193,476A priority patent/CA1025856A/en
Priority to NL7402613A priority patent/NL7402613A/xx
Publication of GB1433774A publication Critical patent/GB1433774A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

1433774 Tetrazole-derived amides ALLEN & HANBURYS 6 Feb 1974 [26 Feb 1973] 9249/73 Heading C2C The invention comprises compounds of formula their 4-oxyquinoline tautomers (when R 4 =H) and pharmaceutically acceptable salts and esters thereof, in which : R 1 and R 2 which may be the same or different represent a hydrogen atom, a halogen atom, or an alkyl, trifluoromethyl or nitro group, or a group OR 3 in which R 3 represents a hydrogen atom, or an alkenyl or alkyl group, which alkyl group may be substituted by alkoxy, aryl, amino, alkylamino, dialkylamino, hydroxy or acyloxy groups; or a group NR 6 R 7 in which R 6 and R 7 which may be the same or different represent a hydrogen atom or an alkyl group, which alkyl group may be substituted with a hydroxy or acyloxy group, or in which R 6 and R 7 together with the nitrogen atom form a 5- or 6-membered ring which may contain additional hetero atoms; R 4 represents a hydrogen atom, an alkenyl or alkyl group, which alkyl group may be substituted with hydroxy, acyloxy, alkoxy, aryl, amino, alkylamino, dialkylamino or alkylaralkylamino groups; and R 5 represents a hydrogen atom or an alkyl group. In examples, these compounds are prepared by reacting the corresponding quinolonecarboxylic acid (A) (or a functional derivative thereof such as the acid chloride or the mixed anhydride with EtOCO 2 H) with 5-aminotetrazole and by the interconversion of functional groups in compounds thus prepared; the acids (A) are made by hydrolysing the corresponding esters. Therapeutic compositions for treating conditions primarily caused by antigen/reaginic antibody combination comprise compounds of the above formula, and may be administered orally or by inhalation.
GB924973A 1973-02-26 1973-02-26 Heterocyclic compounds apparatus for conveying articles Expired GB1433774A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB924973A GB1433774A (en) 1973-02-26 1973-02-26 Heterocyclic compounds apparatus for conveying articles
IE00249/74A IE38886B1 (en) 1973-02-26 1974-02-08 Heterocyclic compounds
ZA740883A ZA74883B (en) 1973-02-26 1974-02-11 Heterocyclic compounds
SE7401984A SE7401984L (en) 1973-02-26 1974-02-14
AU65592/74A AU474797B2 (en) 1973-02-26 1974-02-14 Heterocyclic compounds
CH224374A CH602707A5 (en) 1973-02-26 1974-02-18
DE19742407744 DE2407744A1 (en) 1973-02-26 1974-02-18 QUINOLINE-3-CARBOXAMIDOTETRAZOLE DERIVATIVES, THE PROCESS FOR THEIR PREPARATION AND COMPOUNDS CONTAINING THEIR COMPOUNDS
BE141102A BE811246A (en) 1973-02-26 1974-02-19 QUINOLEINE-3-CARBOXAMIDOTETRAZOLES
LU69479A LU69479A1 (en) 1973-02-26 1974-02-22
AT149974A AT329562B (en) 1973-02-26 1974-02-25 PROCESS FOR THE PRODUCTION OF NEW QUINOLINE-3-CARBOXAMIDOTETRAZOLE DERIVATIVES AND THEIR SALT
JP49022232A JPS5029574A (en) 1973-02-26 1974-02-25
FR7406327A FR2218896B1 (en) 1973-02-26 1974-02-25
CA193,476A CA1025856A (en) 1973-02-26 1974-02-26 Quinoline-3-carboxamidotetrazole derivatives
NL7402613A NL7402613A (en) 1973-02-26 1974-02-26

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB924973A GB1433774A (en) 1973-02-26 1973-02-26 Heterocyclic compounds apparatus for conveying articles

Publications (1)

Publication Number Publication Date
GB1433774A true GB1433774A (en) 1976-04-28

Family

ID=9868317

Family Applications (1)

Application Number Title Priority Date Filing Date
GB924973A Expired GB1433774A (en) 1973-02-26 1973-02-26 Heterocyclic compounds apparatus for conveying articles

Country Status (14)

Country Link
JP (1) JPS5029574A (en)
AT (1) AT329562B (en)
AU (1) AU474797B2 (en)
BE (1) BE811246A (en)
CA (1) CA1025856A (en)
CH (1) CH602707A5 (en)
DE (1) DE2407744A1 (en)
FR (1) FR2218896B1 (en)
GB (1) GB1433774A (en)
IE (1) IE38886B1 (en)
LU (1) LU69479A1 (en)
NL (1) NL7402613A (en)
SE (1) SE7401984L (en)
ZA (1) ZA74883B (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186201A (en) 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4377579A (en) 1981-12-03 1983-03-22 Minnesota Mining And Manufacturing Company N-(Tetrazol-5-yl)phenazine-1-carboxamides
US4390541A (en) 1980-12-19 1983-06-28 Lilly Industries Limited Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease
US4959363A (en) * 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
US4965266A (en) * 1987-01-20 1990-10-23 Dainippon Pharmaceutical Co., Ltd. Heteroarylcarboxamide derivatives, process for preparing the same and pharmaceutical composition containing the same
US7488739B2 (en) 2003-07-24 2009-02-10 Astellas Pharma Inc. Quinolone derivative or salt thereof
WO2013129622A1 (en) 2012-03-02 2013-09-06 武田薬品工業株式会社 Heterocyclic compound and use therefor
RU2556984C2 (en) * 2004-06-24 2015-07-20 Вертекс Фармасьютикалз Инкорпорейтед Modulators of atp-binding cassette transporters
CN105330602A (en) * 2015-12-07 2016-02-17 江南大学 Decoquinate analogue and application thereof
US9670163B2 (en) 2005-12-28 2017-06-06 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
US9751839B2 (en) 2009-03-20 2017-09-05 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
US9777005B2 (en) 2012-11-19 2017-10-03 Takeda Pharmaceutical Company Limited Bicyclic heterocyclic compound containing a substituted pyrrole ring
US10272046B2 (en) 2012-02-27 2019-04-30 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US10646481B2 (en) 2008-08-13 2020-05-12 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US10662192B2 (en) 2004-06-24 2020-05-26 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2324304A2 (en) * 1975-09-22 1977-04-15 Roussel Uclaf Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine
US4264604A (en) 1977-07-01 1981-04-28 Ciba-Geigy Corporation Quinolonecarboxylic acid derivatives as bactericides
FR2509728A1 (en) * 1981-07-17 1983-01-21 Roussel Uclaf NOVEL QUINOLINE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
FR2537140B1 (en) * 1982-12-07 1986-07-18 Roussel Uclaf NOVEL 4-HYDROXY-3-QUINOLEINE CARBOXAMIDE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, AND COMPOSITIONS CONTAINING THEM
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
CN1268136A (en) * 1997-08-25 2000-09-27 纽罗根公司 Substituted 4-oxo-naphthyridine-3-carboxamides as ligands for gamma-aminobutyric acid brain receptors
US6143760A (en) 1997-08-25 2000-11-07 Neurogen Corporation Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
ES2243046T3 (en) 1998-02-26 2005-11-16 Neurogen Corporation CICLOALQUIL-4-OXONICOTINIC CARBOXAMIDS REPLACED; GABA BRAIN RECEPTORS LIGANDOS.
WO2003097564A2 (en) * 2002-05-14 2003-11-27 The Regents Of The University Of California Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
EP2502913A3 (en) * 2004-06-24 2013-11-27 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1383088A (en) * 1972-07-03 1975-02-05 Allen & Hanburys Ltd Pharmacologically active quinaldamide derivatives

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186201A (en) 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4390541A (en) 1980-12-19 1983-06-28 Lilly Industries Limited Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease
US4377579A (en) 1981-12-03 1983-03-22 Minnesota Mining And Manufacturing Company N-(Tetrazol-5-yl)phenazine-1-carboxamides
US4965266A (en) * 1987-01-20 1990-10-23 Dainippon Pharmaceutical Co., Ltd. Heteroarylcarboxamide derivatives, process for preparing the same and pharmaceutical composition containing the same
US4959363A (en) * 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
US7488739B2 (en) 2003-07-24 2009-02-10 Astellas Pharma Inc. Quinolone derivative or salt thereof
US7879878B2 (en) 2003-07-24 2011-02-01 Astellas Pharma Inc. Quinolone derivative or salt thereof
US10662192B2 (en) 2004-06-24 2020-05-26 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
RU2556984C2 (en) * 2004-06-24 2015-07-20 Вертекс Фармасьютикалз Инкорпорейтед Modulators of atp-binding cassette transporters
US10537565B2 (en) 2005-12-28 2020-01-21 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9931334B2 (en) 2005-12-28 2018-04-03 Vertex Pharmaceuticals Incorporated Solid forms of N[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9670163B2 (en) 2005-12-28 2017-06-06 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US11291662B2 (en) 2005-12-28 2022-04-05 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US10646481B2 (en) 2008-08-13 2020-05-12 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US11564916B2 (en) 2008-08-13 2023-01-31 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US9751839B2 (en) 2009-03-20 2017-09-05 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
US12214083B2 (en) 2012-02-27 2025-02-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US10272046B2 (en) 2012-02-27 2019-04-30 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US11752106B2 (en) 2012-02-27 2023-09-12 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US11147770B2 (en) 2012-02-27 2021-10-19 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US9403802B2 (en) 2012-03-02 2016-08-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use therefor
WO2013129622A1 (en) 2012-03-02 2013-09-06 武田薬品工業株式会社 Heterocyclic compound and use therefor
US9777005B2 (en) 2012-11-19 2017-10-03 Takeda Pharmaceutical Company Limited Bicyclic heterocyclic compound containing a substituted pyrrole ring
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
CN105330602A (en) * 2015-12-07 2016-02-17 江南大学 Decoquinate analogue and application thereof
CN105330602B (en) * 2015-12-07 2018-02-09 江南大学 A kind of deccox analog and its application

Also Published As

Publication number Publication date
JPS5029574A (en) 1975-03-25
CA1025856A (en) 1978-02-07
ATA149974A (en) 1975-08-15
AT329562B (en) 1976-05-25
FR2218896A1 (en) 1974-09-20
ZA74883B (en) 1974-12-24
IE38886B1 (en) 1978-06-21
IE38886L (en) 1974-08-26
NL7402613A (en) 1974-08-28
CH602707A5 (en) 1978-07-31
FR2218896B1 (en) 1977-09-09
AU6559274A (en) 1975-08-14
AU474797B2 (en) 1976-08-05
SE7401984L (en) 1974-08-27
DE2407744A1 (en) 1974-08-29
LU69479A1 (en) 1975-05-21
BE811246A (en) 1974-08-19

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee