SI1268468T1 - 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylat and polymorphs - Google Patents

4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylat and polymorphs

Info

Publication number: SI1268468T1
Authority: SI; Slovenia
Prior art keywords: mesylat; tetrahydroisoquinol; methanesulfonamido; polymorphs; quinazoline
Prior art date: 2000-03-03

Application number

SI200130064T

Other languages

English (en)

Slovenian (sl)

Inventor

Patricia Ann Pfizer Global Res. and Dev. BASFORD

Paul Blaise Pfizer Global Res. and Dev. HODGSON

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-03

Filing date

2001-02-23

Publication date

2004-04-30

2000-03-03 Priority claimed from GB0005200A external-priority patent/GB0005200D0/en

2000-06-28 Priority claimed from GB0015900A external-priority patent/GB0015900D0/en

2001-02-23 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2004-04-30 Publication of SI1268468T1 publication Critical patent/SI1268468T1/xx

Links

PELLFYXDXSYSSE-UHFFFAOYSA-N n-[2-(4-amino-6,7-dimethoxy-5-pyridin-2-ylquinazolin-2-yl)-3,4-dihydro-1h-isoquinolin-5-yl]methanesulfonamide;methanesulfonic acid Chemical compound CS(O)(=O)=O.COC=1C(OC)=CC2=NC(N3CC4=C(C(=CC=C4)NS(C)(=O)=O)CC3)=NC(N)=C2C=1C1=CC=CC=N1 PELLFYXDXSYSSE-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SI200130064T 2000-03-03 2001-02-23 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylat and polymorphs SI1268468T1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0005200A GB0005200D0 (en)	2000-03-03	2000-03-03	New salt form
GB0015900A GB0015900D0 (en)	2000-06-28	2000-06-28	New salt form
PCT/IB2001/000244 WO2001064672A1 (en)	2000-03-03	2001-02-23	4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylat and polymorphs
EP01908029A EP1268468B1 (en)	2000-03-03	2001-02-23	4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylat and polymorphs

Publications (1)

Publication Number	Publication Date
SI1268468T1 true SI1268468T1 (en)	2004-04-30

Family

ID=26243792

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200130064T SI1268468T1 (en)	2000-03-03	2001-02-23	4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylat and polymorphs

Country Status (39)

Country	Link
US (1)	US6683085B2 (xx)
EP (1)	EP1268468B1 (xx)
JP (1)	JP3857919B2 (xx)
KR (1)	KR100496089B1 (xx)
CN (1)	CN1214029C (xx)
AP (1)	AP2002002611A0 (xx)
AR (1)	AR029482A1 (xx)
AT (1)	ATE253570T1 (xx)
AU (1)	AU779118B2 (xx)
BG (1)	BG106869A (xx)
BR (1)	BR0108910A (xx)
CA (1)	CA2398963C (xx)
CR (1)	CR6731A (xx)
CZ (1)	CZ20022858A3 (xx)
DE (1)	DE60101157T2 (xx)
DK (1)	DK1268468T3 (xx)
EA (1)	EA004748B1 (xx)
EE (1)	EE200200496A (xx)
ES (1)	ES2208565T3 (xx)
GE (1)	GEP20043364B (xx)
HN (1)	HN2001000036A (xx)
HR (1)	HRP20020718A2 (xx)
HU (1)	HUP0300006A3 (xx)
IL (1)	IL150634A0 (xx)
IS (1)	IS6441A (xx)
MA (1)	MA26876A1 (xx)
MX (1)	MXPA02008665A (xx)
NO (1)	NO20024195L (xx)
NZ (1)	NZ519672A (xx)
OA (1)	OA12186A (xx)
PE (1)	PE20011225A1 (xx)
PL (1)	PL365070A1 (xx)
PT (1)	PT1268468E (xx)
SI (1)	SI1268468T1 (xx)
SK (1)	SK12282002A3 (xx)
TN (1)	TNSN01034A1 (xx)
TR (1)	TR200302130T4 (xx)
UA (1)	UA72311C2 (xx)
WO (1)	WO2001064672A1 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0124455D0 (en) *	2001-10-11	2001-12-05	Pfizer Ltd	Pharmaceutical formulations
US7163696B2 (en)	2001-10-11	2007-01-16	Pfizer Inc.	Pharmaceutical formulations
DE10223913A1 (de)	2002-05-29	2003-12-11	Bayer Cropscience Ag	Verfahren zur Herstellung spezifischer Kristallmodifikationen polymorpher Substanzen
GB0221582D0 (en) *	2002-09-17	2002-10-23	Pfizer Ltd	Method of treatment
AR043880A1 (es) *	2003-04-22	2005-08-17	Solvay Pharm Gmbh	Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas
WO2005089804A2 (en) *	2004-03-16	2005-09-29	Pfizer Limited	Combinations of hmg-coa reductase inhibitors and alpha1 adrenergic receptor antagonists
CN101584696A (zh) *	2008-05-21	2009-11-25	上海艾力斯医药科技有限公司	包含喹唑啉衍生物的组合物及制备方法、用途
CN105596301A (zh) *	2016-01-29	2016-05-25	中国药科大学	一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4914114A (en)	1984-05-28	1990-04-03	Merck Patent Gesellschaft Mit Breschrankter Haftung	3-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-5-hydroxy-indole methanesulfonate having sedating and anti-parkinsonism properties
JPH0822859B2 (ja) *	1986-09-16	1996-03-06	メルク・パテント・ゲゼルシヤフトミツト・ベシユレンクテル・ハフツング	ヒドロキシインドール誘導体
GB9700504D0 (en) *	1997-01-11	1997-02-26	Pfizer Ltd	Pharmaceutical compounds

2001
- 2001-02-23 IL IL15063401A patent/IL150634A0/xx unknown
- 2001-02-23 HU HU0300006A patent/HUP0300006A3/hu unknown
- 2001-02-23 GE GE4907A patent/GEP20043364B/en unknown
- 2001-02-23 AP APAP/P/2002/002611A patent/AP2002002611A0/en unknown
- 2001-02-23 NZ NZ519672A patent/NZ519672A/en unknown
- 2001-02-23 MX MXPA02008665A patent/MXPA02008665A/es active IP Right Grant
- 2001-02-23 DE DE60101157T patent/DE60101157T2/de not_active Expired - Lifetime
- 2001-02-23 ES ES01908029T patent/ES2208565T3/es not_active Expired - Lifetime
- 2001-02-23 AT AT01908029T patent/ATE253570T1/de not_active IP Right Cessation
- 2001-02-23 UA UA2002097181A patent/UA72311C2/uk unknown
- 2001-02-23 CZ CZ20022858A patent/CZ20022858A3/cs unknown
- 2001-02-23 JP JP2001563512A patent/JP3857919B2/ja not_active Expired - Fee Related
- 2001-02-23 CN CNB018052304A patent/CN1214029C/zh not_active Expired - Fee Related
- 2001-02-23 KR KR10-2002-7011506A patent/KR100496089B1/ko not_active Expired - Fee Related
- 2001-02-23 PL PL01365070A patent/PL365070A1/xx unknown
- 2001-02-23 WO PCT/IB2001/000244 patent/WO2001064672A1/en not_active Ceased
- 2001-02-23 OA OA1200200266A patent/OA12186A/fr unknown
- 2001-02-23 EP EP01908029A patent/EP1268468B1/en not_active Expired - Lifetime
- 2001-02-23 PT PT01908029T patent/PT1268468E/pt unknown
- 2001-02-23 SK SK1228-2002A patent/SK12282002A3/sk unknown
- 2001-02-23 AU AU35888/01A patent/AU779118B2/en not_active Ceased
- 2001-02-23 BR BR0108910-2A patent/BR0108910A/pt not_active Application Discontinuation
- 2001-02-23 EA EA200200826A patent/EA004748B1/ru not_active IP Right Cessation
- 2001-02-23 SI SI200130064T patent/SI1268468T1/xx unknown
- 2001-02-23 TR TR2003/02130T patent/TR200302130T4/xx unknown
- 2001-02-23 HR HR20020718A patent/HRP20020718A2/xx not_active Application Discontinuation
- 2001-02-23 CA CA002398963A patent/CA2398963C/en not_active Expired - Fee Related
- 2001-02-23 DK DK01908029T patent/DK1268468T3/da active
- 2001-02-23 EE EEP200200496A patent/EE200200496A/xx unknown
- 2001-02-28 HN HN2001000036A patent/HN2001000036A/es unknown
- 2001-02-28 PE PE2001000202A patent/PE20011225A1/es not_active Application Discontinuation
- 2001-03-01 US US09/797,112 patent/US6683085B2/en not_active Expired - Fee Related
- 2001-03-01 AR ARP010100977A patent/AR029482A1/es unknown
- 2001-03-02 TN TNTNSN01034A patent/TNSN01034A1/fr unknown
2002
- 2002-06-24 BG BG106869A patent/BG106869A/bg unknown
- 2002-06-25 IS IS6441A patent/IS6441A/is unknown
- 2002-08-15 MA MA26776A patent/MA26876A1/fr unknown
- 2002-08-19 CR CR6731A patent/CR6731A/es not_active Application Discontinuation
- 2002-09-03 NO NO20024195A patent/NO20024195L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PE20011225A1 (es)	2001-12-08
EA200200826A1 (ru)	2003-02-27
WO2001064672A1 (en)	2001-09-07
NO20024195D0 (no)	2002-09-03
JP3857919B2 (ja)	2006-12-13
HUP0300006A3 (en)	2006-01-30
CA2398963C (en)	2006-10-24
UA72311C2 (uk)	2005-02-15
ATE253570T1 (de)	2003-11-15
HN2001000036A (es)	2001-07-09
EA004748B1 (ru)	2004-08-26
AU3588801A (en)	2001-09-12
DK1268468T3 (da)	2004-02-09
US20020010188A1 (en)	2002-01-24
CN1432010A (zh)	2003-07-23
SK12282002A3 (sk)	2003-10-07
AP2002002611A0 (en)	2002-09-30
IS6441A (is)	2002-06-25
AU779118B2 (en)	2005-01-06
PT1268468E (pt)	2004-01-30
US6683085B2 (en)	2004-01-27
TR200302130T4 (tr)	2004-01-21
TNSN01034A1 (fr)	2005-11-10
NZ519672A (en)	2004-06-25
OA12186A (en)	2006-05-09
NO20024195L (no)	2002-09-03
JP2003525289A (ja)	2003-08-26
HRP20020718A2 (en)	2004-02-29
CN1214029C (zh)	2005-08-10
BR0108910A (pt)	2002-12-24
MA26876A1 (fr)	2004-12-20
BG106869A (bg)	2002-12-29
MXPA02008665A (es)	2003-02-24
EE200200496A (et)	2004-02-16
EP1268468A1 (en)	2003-01-02
EP1268468B1 (en)	2003-11-05
PL365070A1 (en)	2004-12-27
KR100496089B1 (ko)	2005-06-17
IL150634A0 (en)	2003-02-12
CZ20022858A3 (cs)	2003-09-17
AR029482A1 (es)	2003-07-02
CR6731A (es)	2004-03-11
GEP20043364B (en)	2004-03-10
KR20020080463A (ko)	2002-10-23
DE60101157T2 (de)	2004-09-02
HUP0300006A2 (en)	2003-05-28
CA2398963A1 (en)	2001-09-07
ES2208565T3 (es)	2004-06-16
HK1053655A1 (en)	2003-10-31
DE60101157D1 (de)	2003-12-11

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DK1341774T3 (da)	2006-06-12	Kondenserede heteroaromatiske glucokinase-aktivatorer
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DK1480983T3 (da)	2006-03-27	Heteroarylsubstituerede 2-pyridinyl- og 2-pyrimidinyl- 6,7,8,9-tetrahydropyrimido[1,2a]pyrimidin-4-onderivater
MXPA03004136A (es)	2003-08-19	Derivados de pirimidina y su uso como ligandos del receptor de neuropeptido y (npy).
PL365070A1 (en)	2004-12-27	4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline mesylat and polymorphs
IL160969A0 (en)	2004-08-31	Pharmaceutical formulations for the controlled release of 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl) quinazoline
ZA200207409B (en)	2003-01-02	Drilling and anchor setting arrangement.
ZA200304436B (en)	2004-05-10	Substituted 1,3,5-triazines and pyrimidines as abca-1 elevating compounds against coronatry artery disease or atherosclerosis.
ZA200100906B (en)	2001-08-08	Uracil compounds and use thereof.
AU2002256260A1 (en)	2002-11-05	Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
HK1062439A (en)	2004-11-05	Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
GB0030989D0 (en)	2001-01-31	Quinazoline derivatives
GB0015376D0 (en)	2000-08-16	Quinazoline derivatives