SI1078001T1 - Il-6-antagonisticni peptidi - Google Patents
Il-6-antagonisticni peptidiInfo
- Publication number
- SI1078001T1 SI1078001T1 SI9930940T SI9930940T SI1078001T1 SI 1078001 T1 SI1078001 T1 SI 1078001T1 SI 9930940 T SI9930940 T SI 9930940T SI 9930940 T SI9930940 T SI 9930940T SI 1078001 T1 SI1078001 T1 SI 1078001T1
- Authority
- SI
- Slovenia
- Prior art keywords
- seq
- present
- antagonist peptides
- peptide
- peptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 101150101999 IL6 gene Proteins 0.000 title 1
- 102000004889 Interleukin-6 Human genes 0.000 abstract 2
- 108090001005 Interleukin-6 Proteins 0.000 abstract 2
- 108010067902 Peptide Library Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010396 two-hybrid screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108997A EP0972780A1 (en) | 1998-05-18 | 1998-05-18 | Il-6 antagonist peptides |
| EP99926326A EP1078001B1 (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
| PCT/EP1999/003421 WO1999060013A2 (en) | 1998-05-18 | 1999-05-18 | Il-6 antagonist peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1078001T1 true SI1078001T1 (sl) | 2007-04-30 |
Family
ID=8231951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9930940T SI1078001T1 (sl) | 1998-05-18 | 1999-05-18 | Il-6-antagonisticni peptidi |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6599875B1 (sl) |
| EP (2) | EP0972780A1 (sl) |
| JP (1) | JP4468578B2 (sl) |
| AT (1) | ATE347563T1 (sl) |
| AU (1) | AU749616B2 (sl) |
| CA (2) | CA2332817C (sl) |
| CY (1) | CY1105865T1 (sl) |
| DE (1) | DE69934308T2 (sl) |
| DK (1) | DK1078001T3 (sl) |
| ES (1) | ES2273492T3 (sl) |
| IL (2) | IL139575A0 (sl) |
| PT (1) | PT1078001E (sl) |
| SI (1) | SI1078001T1 (sl) |
| WO (1) | WO1999060013A2 (sl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| ATE348163T1 (de) | 1998-10-23 | 2007-01-15 | Amgen Inc | Thrombopoietin substitute |
| EP1773400A2 (en) | 2004-07-08 | 2007-04-18 | Amgen Inc. | Therapeutic peptides |
| US20070036788A1 (en) * | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| WO2006036834A2 (en) | 2004-09-24 | 2006-04-06 | Amgen Inc. | MODIFIED Fc MOLECULES |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| KR101508019B1 (ko) | 2007-01-23 | 2015-04-06 | 고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 | 만성 거부반응 억제제 |
| CN104906581A (zh) | 2008-06-05 | 2015-09-16 | 国立研究开发法人国立癌症研究中心 | 神经浸润抑制剂 |
| JP5898496B2 (ja) | 2008-11-25 | 2016-04-06 | アルダーバイオ ホールディングス エルエルシー | Ｉｌ−６に対する抗体およびその使用 |
| JP6051049B2 (ja) | 2010-05-28 | 2016-12-21 | 中外製薬株式会社 | 抗腫瘍ｔ細胞応答増強剤 |
| DK2643018T3 (da) | 2010-11-23 | 2021-01-18 | Vitaeris Inc | Anti-il-6-antistoffer til behandling af oral mucositis |
| PL3636274T3 (pl) | 2011-01-18 | 2025-01-20 | Bioniz Therapeutics, Inc. | Kompozycje do modulowania aktywności gamma-c-cytokiny |
| WO2013063229A1 (en) | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| CN103923182A (zh) * | 2014-01-17 | 2014-07-16 | 南通诚信氨基酸有限公司 | 白介素-6多肽抑制剂及其应用 |
| US10030058B2 (en) | 2015-10-09 | 2018-07-24 | Bioniz, Llc | Modulating gamma-C-cytokine activity |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| EP3976182A4 (en) | 2019-05-03 | 2023-01-18 | Bioniz, LLC | MODULATION OF THE EFFECTS OF GAMMA CYTOKINE SIGNALING FOR THE TREATMENT OF ALOPECIA AND ALOPECIA-ASSOCIATED DISORDERS |
| CN116003530B (zh) * | 2022-12-27 | 2023-12-15 | 西湖大学 | 一种针对白细胞介素-6的d-蛋白抑制剂及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4420782C1 (de) * | 1994-06-15 | 1995-08-17 | Fluegge Ulf Ingo Prof Dr | DNA-Sequenz, kodierend einen 2-Oxoglutarat/Malat-Translokator, Plasmide, Bakterien, Hefen und Pflanzen enthaltend diesen Transporter |
| ATE217344T1 (de) * | 1994-09-21 | 2002-05-15 | Cytogen Corp | Antigen bindende peptide (abtides) aus peptidbibliotheken |
| AU3204895A (en) * | 1995-02-01 | 1996-08-21 | University Of Massachusetts Medical Center | Methods of selecting a random peptide that binds to a target protein |
| CA2220433C (en) * | 1995-05-11 | 2010-02-16 | Applied Research Systems Ars Holding N.V. | Il-6 activity inhibitor |
| DE19628873A1 (de) * | 1995-07-17 | 1997-01-23 | Fraunhofer Ges Forschung | Cyclitol |
| JP3913273B2 (ja) * | 1995-09-28 | 2007-05-09 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | Ｉｌ−６活性を阻害する合成ペプチド |
| AU3193097A (en) * | 1996-06-20 | 1998-01-07 | Koster, Henk W. | Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity |
| EP0972780A1 (en) * | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
-
1998
- 1998-05-18 EP EP98108997A patent/EP0972780A1/en not_active Withdrawn
-
1999
- 1999-05-18 EP EP99926326A patent/EP1078001B1/en not_active Expired - Lifetime
- 1999-05-18 DE DE69934308T patent/DE69934308T2/de not_active Expired - Lifetime
- 1999-05-18 AT AT99926326T patent/ATE347563T1/de active
- 1999-05-18 AU AU43627/99A patent/AU749616B2/en not_active Ceased
- 1999-05-18 CA CA2332817A patent/CA2332817C/en not_active Expired - Fee Related
- 1999-05-18 CA CA2690399A patent/CA2690399C/en not_active Expired - Fee Related
- 1999-05-18 WO PCT/EP1999/003421 patent/WO1999060013A2/en not_active Ceased
- 1999-05-18 SI SI9930940T patent/SI1078001T1/sl unknown
- 1999-05-18 IL IL13957599A patent/IL139575A0/xx active IP Right Grant
- 1999-05-18 DK DK99926326T patent/DK1078001T3/da active
- 1999-05-18 PT PT99926326T patent/PT1078001E/pt unknown
- 1999-05-18 JP JP2000549631A patent/JP4468578B2/ja not_active Expired - Fee Related
- 1999-05-18 ES ES99926326T patent/ES2273492T3/es not_active Expired - Lifetime
-
2000
- 2000-11-09 IL IL139575A patent/IL139575A/en not_active IP Right Cessation
- 2000-11-20 US US09/715,923 patent/US6599875B1/en not_active Expired - Lifetime
-
2003
- 2003-02-04 US US10/357,479 patent/US6838433B2/en not_active Expired - Lifetime
-
2006
- 2006-12-20 CY CY20061101820T patent/CY1105865T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL139575A (en) | 2008-03-20 |
| AU4362799A (en) | 1999-12-06 |
| EP1078001B1 (en) | 2006-12-06 |
| IL139575A0 (en) | 2002-02-10 |
| US6599875B1 (en) | 2003-07-29 |
| US6838433B2 (en) | 2005-01-04 |
| JP4468578B2 (ja) | 2010-05-26 |
| CY1105865T1 (el) | 2011-02-02 |
| PT1078001E (pt) | 2007-01-31 |
| WO1999060013A3 (en) | 2000-03-09 |
| US20030186876A1 (en) | 2003-10-02 |
| JP2002527354A (ja) | 2002-08-27 |
| CA2332817C (en) | 2010-08-31 |
| DK1078001T3 (da) | 2007-02-19 |
| ATE347563T1 (de) | 2006-12-15 |
| EP1078001A2 (en) | 2001-02-28 |
| CA2332817A1 (en) | 1999-11-25 |
| DE69934308D1 (de) | 2007-01-18 |
| CA2690399C (en) | 2015-01-20 |
| DE69934308T2 (de) | 2007-03-29 |
| ES2273492T3 (es) | 2007-05-01 |
| EP0972780A1 (en) | 2000-01-19 |
| CA2690399A1 (en) | 1999-11-25 |
| AU749616B2 (en) | 2002-06-27 |
| WO1999060013A2 (en) | 1999-11-25 |
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