SI0739199T1 - Estradiol penetration intensifier for transdermal administration - Google Patents
Estradiol penetration intensifier for transdermal administrationInfo
- Publication number
- SI0739199T1 SI0739199T1 SI9530601T SI9530601T SI0739199T1 SI 0739199 T1 SI0739199 T1 SI 0739199T1 SI 9530601 T SI9530601 T SI 9530601T SI 9530601 T SI9530601 T SI 9530601T SI 0739199 T1 SI0739199 T1 SI 0739199T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pct
- estradiol
- transdermal administration
- sec
- active substance
- Prior art date
Links
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title abstract 2
- 229960005309 estradiol Drugs 0.000 title abstract 2
- 229930182833 estradiol Natural products 0.000 title abstract 2
- 230000035515 penetration Effects 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 239000003961 penetration enhancing agent Substances 0.000 abstract 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000010410 layer Substances 0.000 abstract 1
- 239000000583 progesterone congener Substances 0.000 abstract 1
- 239000011241 protective layer Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4400770A DE4400770C1 (de) | 1994-01-13 | 1994-01-13 | Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung |
| PCT/EP1995/000032 WO1995019162A1 (de) | 1994-01-13 | 1995-01-05 | Estradiol-penetrationsverstärker zur transdermalen verabreichung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI0739199T1 true SI0739199T1 (en) | 2002-10-31 |
Family
ID=6507821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9530601T SI0739199T1 (en) | 1994-01-13 | 1995-01-05 | Estradiol penetration intensifier for transdermal administration |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6090404A (xx) |
| EP (1) | EP0739199B1 (xx) |
| JP (1) | JP3980633B2 (xx) |
| KR (1) | KR100374087B1 (xx) |
| AT (1) | ATE215363T1 (xx) |
| AU (1) | AU707963B2 (xx) |
| CZ (1) | CZ287330B6 (xx) |
| DE (2) | DE4400770C1 (xx) |
| DK (1) | DK0739199T3 (xx) |
| ES (1) | ES2174922T3 (xx) |
| FI (1) | FI118719B (xx) |
| HU (1) | HU222499B1 (xx) |
| IL (1) | IL112145A (xx) |
| MY (1) | MY113680A (xx) |
| NO (1) | NO962933L (xx) |
| NZ (1) | NZ278593A (xx) |
| PL (1) | PL184875B1 (xx) |
| PT (1) | PT739199E (xx) |
| SI (1) | SI0739199T1 (xx) |
| SK (1) | SK280530B6 (xx) |
| WO (1) | WO1995019162A1 (xx) |
| ZA (1) | ZA95226B (xx) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| JP2003527310A (ja) * | 1999-04-16 | 2003-09-16 | イエナフアルム ゲーエムベーハー ウント ツェーオー． カーゲー | エストロゲンを局部的に皮内投与するための医薬品組成物または化粧品組成物 |
| US6974588B1 (en) * | 1999-12-07 | 2005-12-13 | Elan Pharma International Limited | Transdermal patch for delivering volatile liquid drugs |
| GB0103046D0 (en) * | 2001-02-07 | 2001-03-21 | Novartis Ag | Organic Compounds |
| CN1578647B (zh) * | 2001-08-29 | 2010-04-07 | 里卡多·A·P·德卡瓦尔霍 | 一种用于单向传送药剂到目标组织的可以手术植入的及可密封的装置 |
| EP1596756A4 (en) * | 2003-01-23 | 2009-11-11 | Supernus Pharmaceuticals Inc | MEANS TO INCREASE ABSORPTION |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| EP1802258A4 (en) | 2004-09-13 | 2015-09-23 | Chrono Therapeutics Inc | BIOSYNCHRONE TRANSDERMAL MEDICINES |
| US20070042026A1 (en) * | 2005-03-17 | 2007-02-22 | Wille John J | Prophylactic and therapeutic treatment of topical and transdermal drug-induced skin reactions |
| US8372040B2 (en) | 2005-05-24 | 2013-02-12 | Chrono Therapeutics, Inc. | Portable drug delivery device including a detachable and replaceable administration or dosing element |
| JP5162862B2 (ja) * | 2005-09-16 | 2013-03-13 | 株式会社リコー | 感熱性粘着剤及び感熱性粘着材料 |
| US20080200890A1 (en) * | 2006-12-11 | 2008-08-21 | 3M Innovative Properties Company | Antimicrobial disposable absorbent articles |
| US9555167B2 (en) * | 2006-12-11 | 2017-01-31 | 3M Innovative Properties Company | Biocompatible antimicrobial compositions |
| WO2013006643A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
| LT2782584T (lt) | 2011-11-23 | 2021-09-10 | Therapeuticsmd, Inc. | Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
| US10206932B2 (en) | 2014-05-22 | 2019-02-19 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10213586B2 (en) | 2015-01-28 | 2019-02-26 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| JP2019513709A (ja) | 2016-04-01 | 2019-05-30 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | ステロイドホルモン薬学的組成物 |
| CN109310599B (zh) * | 2016-06-15 | 2023-01-13 | 联合利华知识产权控股有限公司 | 用于增强烷基取代的间苯二酚的透皮递送的方法和化妆品组合物 |
| WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| WO2019232077A1 (en) | 2018-05-29 | 2019-12-05 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| CA3119992A1 (en) | 2018-11-16 | 2020-05-22 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| CN115010949B (zh) * | 2022-07-12 | 2024-02-13 | 华熙生物科技股份有限公司 | 促渗物、护肤品组合物以及化妆品 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3637224A (en) * | 1969-02-27 | 1972-01-25 | Fedders Corp | Annular sealing ring |
| US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| AU553343B2 (en) * | 1981-08-10 | 1986-07-10 | Advance Electrode Kabushikikaisya | Absorbent adhesive bandage with medicament release |
| US4624665A (en) * | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
| US4687481A (en) * | 1984-10-01 | 1987-08-18 | Biotek, Inc. | Transdermal drug delivery system |
| ATE95430T1 (de) * | 1984-12-22 | 1993-10-15 | Sanol Arznei Schwarz Gmbh | Wirkstoffpflaster. |
| US4883669A (en) * | 1985-02-25 | 1989-11-28 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration |
| US4732892A (en) * | 1985-07-12 | 1988-03-22 | American Home Products Corporation | L-α-amino acids as transdermal penetration enhancers |
| CN1021196C (zh) * | 1986-12-29 | 1993-06-16 | 新泽西州州立大学(鲁杰斯) | 透皮雌激素/孕激素药剂单元、系统及方法 |
| CH674618A5 (xx) * | 1987-04-02 | 1990-06-29 | Ciba Geigy Ag | |
| DE3743946A1 (de) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung |
| US4906475A (en) * | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
| DE68920109T2 (de) * | 1988-10-11 | 1995-05-11 | Shire Holdings Ltd | Arzneimittelpräparat für perkutane Absorption. |
| AU4745390A (en) * | 1988-12-01 | 1990-06-26 | Schering Corporation | Compositions for transdermal delivery of estradiol |
| DE3843239C1 (xx) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
| DE3933460A1 (de) * | 1989-10-06 | 1991-04-18 | Lohmann Therapie Syst Lts | Oestrogenhaltiges wirkstoffpflaster |
| AR246186A1 (es) * | 1989-11-17 | 1994-07-29 | Beta Pharm Co | Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica. |
| US5252588A (en) * | 1990-04-27 | 1993-10-12 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation |
| US5248676A (en) * | 1990-05-17 | 1993-09-28 | Hisamitsu Pharmaceutical Co., Inc. | Estradiol percutaneous administration preparations |
| US5122382A (en) * | 1990-10-29 | 1992-06-16 | Alza Corporation | Transdermal contraceptive formulations, methods and devices |
| US5518734A (en) * | 1991-09-25 | 1996-05-21 | Beta Pharmaceuticals Co. | Transdermal delivery system for estradiol and process for manufacturing said device |
| JP2960832B2 (ja) * | 1992-05-08 | 1999-10-12 | ペルマテック テクノロジー アクチェンゲゼルシャフト | エストラジオールの投与システム |
| DE4223360C1 (xx) * | 1992-07-16 | 1993-04-08 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
| JPH06100439A (ja) * | 1992-09-18 | 1994-04-12 | Sekisui Chem Co Ltd | 経皮吸収貼付剤 |
-
1994
- 1994-01-13 DE DE4400770A patent/DE4400770C1/de not_active Expired - Fee Related
- 1994-12-26 IL IL11214594A patent/IL112145A/xx not_active IP Right Cessation
-
1995
- 1995-01-05 JP JP51881395A patent/JP3980633B2/ja not_active Expired - Fee Related
- 1995-01-05 AU AU14552/95A patent/AU707963B2/en not_active Ceased
- 1995-01-05 DK DK95906300T patent/DK0739199T3/da active
- 1995-01-05 KR KR1019960703800A patent/KR100374087B1/ko not_active Expired - Fee Related
- 1995-01-05 NZ NZ278593A patent/NZ278593A/en not_active IP Right Cessation
- 1995-01-05 SI SI9530601T patent/SI0739199T1/xx unknown
- 1995-01-05 WO PCT/EP1995/000032 patent/WO1995019162A1/de not_active Ceased
- 1995-01-05 DE DE59510142T patent/DE59510142D1/de not_active Expired - Lifetime
- 1995-01-05 ES ES95906300T patent/ES2174922T3/es not_active Expired - Lifetime
- 1995-01-05 CZ CZ19962053A patent/CZ287330B6/cs not_active IP Right Cessation
- 1995-01-05 PT PT95906300T patent/PT739199E/pt unknown
- 1995-01-05 HU HU9601872A patent/HU222499B1/hu not_active IP Right Cessation
- 1995-01-05 AT AT95906300T patent/ATE215363T1/de active
- 1995-01-05 EP EP95906300A patent/EP0739199B1/de not_active Expired - Lifetime
- 1995-01-05 US US08/682,511 patent/US6090404A/en not_active Expired - Fee Related
- 1995-01-05 SK SK915-96A patent/SK280530B6/sk unknown
- 1995-01-05 PL PL95315527A patent/PL184875B1/pl not_active IP Right Cessation
- 1995-01-09 MY MYPI95000041A patent/MY113680A/en unknown
- 1995-01-12 ZA ZA95226A patent/ZA95226B/xx unknown
-
1996
- 1996-06-28 FI FI962702A patent/FI118719B/fi not_active IP Right Cessation
- 1996-07-12 NO NO962933A patent/NO962933L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2174922T3 (es) | 2002-11-16 |
| PL184875B1 (pl) | 2003-01-31 |
| JP3980633B2 (ja) | 2007-09-26 |
| EP0739199B1 (de) | 2002-04-03 |
| KR100374087B1 (ko) | 2003-04-23 |
| HUT74455A (en) | 1996-12-30 |
| WO1995019162A1 (de) | 1995-07-20 |
| DE59510142D1 (de) | 2002-05-08 |
| DE4400770C1 (de) | 1995-02-02 |
| PL315527A1 (en) | 1996-11-12 |
| HU9601872D0 (en) | 1996-09-30 |
| HU222499B1 (hu) | 2003-07-28 |
| KR970700021A (ko) | 1997-01-08 |
| FI962702L (fi) | 1996-08-27 |
| PT739199E (pt) | 2002-09-30 |
| NO962933D0 (no) | 1996-07-12 |
| AU707963B2 (en) | 1999-07-22 |
| SK91596A3 (en) | 1997-03-05 |
| CZ287330B6 (en) | 2000-10-11 |
| NO962933L (no) | 1996-09-12 |
| FI962702A0 (fi) | 1996-06-28 |
| EP0739199A1 (de) | 1996-10-30 |
| MY113680A (en) | 2002-04-30 |
| DK0739199T3 (da) | 2002-07-29 |
| JPH09511229A (ja) | 1997-11-11 |
| US6090404A (en) | 2000-07-18 |
| CZ205396A3 (en) | 1996-10-16 |
| ATE215363T1 (de) | 2002-04-15 |
| IL112145A (en) | 2000-10-31 |
| NZ278593A (en) | 1997-12-19 |
| FI118719B (fi) | 2008-02-29 |
| AU1455295A (en) | 1995-08-01 |
| ZA95226B (en) | 1996-02-07 |
| IL112145A0 (en) | 1995-03-15 |
| SK280530B6 (sk) | 2000-03-13 |
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