[go: up one dir, main page]

SG178881A1 - Antibodies against cdcp1 for the treatment of cancer - Google Patents

Antibodies against cdcp1 for the treatment of cancer

Info

Publication number
SG178881A1
SG178881A1 SG2012013272A SG2012013272A SG178881A1 SG 178881 A1 SG178881 A1 SG 178881A1 SG 2012013272 A SG2012013272 A SG 2012013272A SG 2012013272 A SG2012013272 A SG 2012013272A SG 178881 A1 SG178881 A1 SG 178881A1
Authority
SG
Singapore
Prior art keywords
cancer
treatment
antibodies against
cdcp1
against cdcp1
Prior art date
Application number
SG2012013272A
Other languages
English (en)
Inventor
Birgit Bossenmaier
Georg Fertig
Hans-Willi Krell
Reiner Lammers
Alexander Lifke
Gerhard Niederfellner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG178881A1 publication Critical patent/SG178881A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG2012013272A 2009-08-28 2010-08-26 Antibodies against cdcp1 for the treatment of cancer SG178881A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09011047 2009-08-28
PCT/EP2010/005245 WO2011023390A1 (en) 2009-08-28 2010-08-26 Antibodies against cdcp1 for the treatment of cancer

Publications (1)

Publication Number Publication Date
SG178881A1 true SG178881A1 (en) 2012-04-27

Family

ID=41349259

Family Applications (1)

Application Number Title Priority Date Filing Date
SG2012013272A SG178881A1 (en) 2009-08-28 2010-08-26 Antibodies against cdcp1 for the treatment of cancer

Country Status (9)

Country Link
US (1) US8883159B2 (es)
EP (1) EP2470206A1 (es)
JP (1) JP5680646B2 (es)
CN (1) CN102481366A (es)
AR (1) AR077972A1 (es)
CA (1) CA2770141A1 (es)
SG (1) SG178881A1 (es)
TW (1) TW201113037A (es)
WO (1) WO2011023390A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2800583A1 (en) * 2012-01-02 2014-11-12 Novartis AG Cdcp1 and breast cancer
WO2015082446A1 (en) 2013-12-02 2015-06-11 F. Hoffmann-La Roche Ag Treatment of cancer using an anti-cdcp1 antibody and a taxane
MA50134A (fr) 2016-12-16 2020-07-29 Bluefin Biomedicine Inc Anticorps anti-protéine 1 contenant un domaine anti-cub (cdcp1), conjugués anticorps-médicament et leurs méthodes d'utilisation
US10928391B2 (en) * 2017-06-06 2021-02-23 The Cleveland Clinic Foundation CD318 as a marker for, and CD318 inhibition as a treatment for, autoimmune disease
US11603412B2 (en) 2017-10-25 2023-03-14 The Regents Of The University Of California Antibodies against CDCP1 for the treatment and detection of cancer
JP7440509B2 (ja) 2018-11-09 2024-02-28 ベス イスラエル デアコネス メディカル センター Ｃｄｃｐ１－標的化療法
CA3259098A1 (en) * 2022-06-20 2025-04-18 Sichuan Huiyu Seacross Pharmaceutical Technology Co., Ltd. ANTIBODIES AND THEIR USES
KR20240057529A (ko) * 2022-10-24 2024-05-03 주식회사 노벨티노빌리티 신규 항-cdcp1 항체 및 이의 용도
WO2025199124A1 (en) * 2024-03-19 2025-09-25 Tavotek Lab Inc Antibodies targeting cd318 (cdcp1) and uses thereof
WO2025237395A1 (en) * 2024-05-17 2025-11-20 TJ Biopharma (Shanghai) Co., Ltd. Anti-cdcp1 constructs and uses thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US6750334B1 (en) 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
PT1071700E (pt) 1998-04-20 2010-04-23 Glycart Biotechnology Ag Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
ES2601882T5 (es) 1999-04-09 2021-06-07 Kyowa Kirin Co Ltd Procedimiento para controlar la actividad de una molécula inmunofuncional
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
CN1329061A (zh) * 2000-06-19 2002-01-02 上海博德基因开发有限公司 一种新的多肽——人g蛋白亚基9.46和编码这种多肽的多核苷酸
EP1301533A1 (de) 2000-07-07 2003-04-16 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Tumorassoziiertes antigen (b345), gekennzeichnet durch eine aminosäuresequenz wie in seq. id. no. 4
HUP0600342A3 (en) 2001-10-25 2011-03-28 Genentech Inc Glycoprotein compositions
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
DE10242146A1 (de) 2002-09-04 2004-03-18 Eberhard-Karls-Universität Tübingen Universitätsklinikum Antikörper zur Identifizierung und/oder Isolierung von hämatopoetischen Stammzellen
NZ582315A (en) 2003-01-22 2011-01-28 Glycart Biotechnology Ag Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function
ATE473279T1 (de) 2003-02-19 2010-07-15 Novartis Pharma Gmbh In metastatischen menschlichen tumorzellen exprimiertes glycoproteinantigen sima135
JP2007500508A (ja) 2003-07-29 2007-01-18 モルフォテック、インク． 抗体とエフェクター機能が増強された遺伝子組み換え抗体を作成する方法
AU2004266159A1 (en) 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Improved antibodies having altered effector function and methods for making the same
US20050152894A1 (en) 2003-09-05 2005-07-14 Genentech, Inc. Antibodies with altered effector functions
GB0324656D0 (en) 2003-10-22 2003-11-26 Celltech R&D Ltd A protein involved in ovarian cancer
DK2380910T3 (en) 2003-11-05 2015-10-19 Roche Glycart Ag Antigen binding molecules with increased Fc receptor binding affinity and effector function
US20080008719A1 (en) * 2004-07-10 2008-01-10 Bowdish Katherine S Methods and compositions for the treatment of prostate cancer
CA2587766A1 (en) 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
TW200720289A (en) 2005-04-01 2007-06-01 Hoffmann La Roche Antibodies against CCR5 and uses thereof
JP5315489B2 (ja) 2005-04-26 2013-10-16 アール クレア アンド カンパニー エフェクター機能が増強されたヒトＩｇＧ抗体を作製する方法
CA2606102C (en) 2005-04-26 2014-09-30 Medimmune, Inc. Modulation of antibody effector function by hinge domain engineering
WO2007005502A2 (en) 2005-06-30 2007-01-11 Applera Corporation Methods and compositions for treating diseases targeting cdcp1
AR055137A1 (es) 2005-08-26 2007-08-08 Glycart Biotechnology Ag Moleculas de union al antigeno modificadas con actividad de senalizacion celular alterada
JP2007112734A (ja) * 2005-10-19 2007-05-10 Chugai Pharmaceut Co Ltd 抗ｃｄｃｐ１抗体を含有する癌細胞増殖抑制剤
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
TWI412375B (zh) * 2009-08-28 2013-10-21 Roche Glycart Ag 人類化抗ｃｄｃｐ１抗體

Also Published As

Publication number Publication date
US8883159B2 (en) 2014-11-11
WO2011023390A1 (en) 2011-03-03
EP2470206A1 (en) 2012-07-04
TW201113037A (en) 2011-04-16
CA2770141A1 (en) 2011-03-03
JP2013502905A (ja) 2013-01-31
AR077972A1 (es) 2011-10-05
JP5680646B2 (ja) 2015-03-04
US20110070246A1 (en) 2011-03-24
CN102481366A (zh) 2012-05-30

Similar Documents

Publication Publication Date Title
SG178881A1 (en) Antibodies against cdcp1 for the treatment of cancer
MY162791A (en) Anti-il-23 antibodies
SG178886A1 (en) Humanized anti-cdcp1 antibodies
MY155950A (en) Anti-cd40 antibodies
EA201200999A1 (ru) Способы лечения рака молочной железы
MX2020012426A (es) Anticuerpos anti-cd38.
MX2013009362A (es) Anticuerpo contra el csf-1r.
MX336682B (es) Anticuerpos contra csf-1r humanos y usos de los mismos.
TW201129381A (en) Antibodies against human CSF-1R and uses thereof
SG184310A1 (en) Antibodies that bind human cd27 and uses thereof
AU2011338480A8 (en) Humanized antibodies to LIV-1 and use of same to treat cancer
MX2018009945A (es) Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad.
SG194701A1 (en) Anti-cd40 antibodies and methods of use
PH12013500933A1 (en) Methods and compositions for neural disease immunotherapy
TN2012000466A1 (en) Humanized anti cxcr4 antibodies for the treatment of cancer
MY163502A (en) Antibodies specifically binding to the epidermal growth factor receptor
MX2013001267A (es) ANTICUERPOS A IL-1ß E EIL-18 PARA TRATAMIENTO DE ENFERMEDAD.
MX2014001766A (es) Anticuerpos de neuregulina y sus usos.
MX2010004546A (es) Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina.
MX2012010443A (es) Proceso para la preparacion de 1-alquiltetrazoles 5-sustituidos.
TN2013000186A1 (en) Anti-il-23 antibodies
HK1181057A (en) Monoclonal antibodies for treatment of cancer
AU2011316657A8 (en) Methods of treating giardiasis
PH12013501424B1 (en) Anti-cd38 antibodies
IN2012DN02721A (es)