SG137859A1 - Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same - Google Patents

Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same

Info

Publication number: SG137859A1
Authority: SG; Singapore
Prior art keywords: tiotropium salts; producing; pharmaceutical formulations; same; salts
Prior art date: 2003-11-03

Application number

SG200718011-0A

Other languages

English (en)

Inventor

Rolf Banholzer

Waldemar Pfrengle

Peter Sieger

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-03

Filing date

2004-10-29

Publication date

2007-12-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG137859(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-10-29 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2007-12-28 Publication of SG137859A1 publication Critical patent/SG137859A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG200718011-0A 2003-11-03 2004-10-29 Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same SG137859A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03025075		2003-11-03

Publications (1)

Publication Number	Publication Date
SG137859A1 true SG137859A1 (en)	2007-12-28

Family

ID=34530660

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200718011-0A SG137859A1 (en)	2003-11-03	2004-10-29	Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same

Country Status (34)

Country	Link
US (1)	US8686148B2 (me)
EP (3)	EP2336126A1 (me)
JP (1)	JP5165244B2 (me)
KR (1)	KR20060117334A (me)
CN (3)	CN101407514B (me)
AR (1)	AR046317A1 (me)
AT (1)	ATE460414T1 (me)
AU (1)	AU2004285683C1 (me)
BR (1)	BRPI0416136A (me)
CA (1)	CA2544348A1 (me)
CO (1)	CO5690553A2 (me)
CY (2)	CY1110048T1 (me)
DE (1)	DE502004010885D1 (me)
DK (2)	DK1682541T3 (me)
EA (1)	EA012326B1 (me)
ES (2)	ES2422729T3 (me)
HR (1)	HRP20100149T1 (me)
IL (1)	IL175023A (me)
ME (1)	ME00361B (me)
MX (1)	MXPA06004697A (me)
MY (1)	MY143364A (me)
NO (1)	NO335814B1 (me)
NZ (1)	NZ547276A (me)
PE (1)	PE20050446A1 (me)
PL (2)	PL1682541T3 (me)
PT (2)	PT2067779E (me)
RS (2)	RS20060292A (me)
SG (1)	SG137859A1 (me)
SI (2)	SI2067779T1 (me)
TW (2)	TWI435876B (me)
UA (1)	UA82413C2 (me)
UY (1)	UY28590A1 (me)
WO (1)	WO2005042526A1 (me)
ZA (1)	ZA200602342B (me)

Families Citing this family (12)

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EP2319844A1 (de) *	2003-11-03	2011-05-11	Boehringer Ingelheim International GmbH	Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
RS20060292A (sr)	2003-11-03	2008-08-07	Boehringer Ingelheim International Gmbh.,	Postupak za dobijanje novih soli tiotropijuma, nove soli tiotropijuma kao takve, kao i farmaceutske formulacije koje ih sadrže
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
WO2006134021A2 (en) *	2005-06-15	2006-12-21	Boehringer Ingelheim International Gmbh	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) *	2005-07-27	2007-02-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) *	2005-08-02	2007-10-16	Astrazeneca Ab	New salt
MX2007009988A (es) *	2005-12-19	2008-02-22	Sicor Inc	Formas novedosas de bromuro de tiotropio y procesos para su preparacion.
AU2006334367B2 (en) *	2006-01-04	2012-11-08	Boehringer Ingelheim International Gmbh	Use of tiotropium salts in the treatment of moderate persistent asthma
EP1953156A1 (de) *	2007-01-29	2008-08-06	Boehringer Ingelheim Pharma GmbH & Co. KG	Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs)	2012-01-20	2013-07-31	Zentiva, K.S.	Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
EP2897955B1 (en) *	2012-09-11	2019-11-06	Bilgic, Mahmut	New tiotropium bromide crystalline form
JP6042197B2 (ja) *	2012-12-11	2016-12-14	エア・ウォーター株式会社	肺障害治療剤

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US6908055B2 (en) *	2003-02-27	2005-06-21	Tandberg Data Asa	System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) *	2003-06-27	2005-02-10	Mitch Budniak	Electrical testing device having voice annunciator
RS20060292A (sr)	2003-11-03	2008-08-07	Boehringer Ingelheim International Gmbh.,	Postupak za dobijanje novih soli tiotropijuma, nove soli tiotropijuma kao takve, kao i farmaceutske formulacije koje ih sadrže
US7968717B2 (en) *	2003-11-03	2011-06-28	Boehringer Ingelhein International Gmbh	Crystalline anhydrate with anticholinergic efficacy
EP2319844A1 (de)	2003-11-03	2011-05-11	Boehringer Ingelheim International GmbH	Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
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WO2006134021A2 (en) *	2005-06-15	2006-12-21	Boehringer Ingelheim International Gmbh	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

2004
- 2004-10-29 RS YUP-2006/0292A patent/RS20060292A/sr unknown
- 2004-10-29 PL PL04791028T patent/PL1682541T3/pl unknown
- 2004-10-29 UY UY28590A patent/UY28590A1/es not_active Application Discontinuation
- 2004-10-29 US US10/977,753 patent/US8686148B2/en active Active
- 2004-10-29 DK DK04791028.6T patent/DK1682541T3/da active
- 2004-10-29 SI SI200432055T patent/SI2067779T1/sl unknown
- 2004-10-29 RS RS20060292A patent/RS51758B/sr unknown
- 2004-10-29 JP JP2006537207A patent/JP5165244B2/ja not_active Expired - Lifetime
- 2004-10-29 EA EA200600886A patent/EA012326B1/ru not_active IP Right Cessation
- 2004-10-29 PT PT91533794T patent/PT2067779E/pt unknown
- 2004-10-29 SI SI200431403T patent/SI1682541T1/sl unknown
- 2004-10-29 BR BRPI0416136-0A patent/BRPI0416136A/pt not_active IP Right Cessation
- 2004-10-29 PL PL09153379T patent/PL2067779T3/pl unknown
- 2004-10-29 KR KR1020067010832A patent/KR20060117334A/ko not_active Ceased
- 2004-10-29 PT PT04791028T patent/PT1682541E/pt unknown
- 2004-10-29 CN CN2008101664856A patent/CN101407514B/zh not_active Expired - Lifetime
- 2004-10-29 SG SG200718011-0A patent/SG137859A1/en unknown
- 2004-10-29 AT AT04791028T patent/ATE460414T1/de active
- 2004-10-29 EP EP10180163A patent/EP2336126A1/de not_active Withdrawn
- 2004-10-29 DE DE502004010885T patent/DE502004010885D1/de not_active Expired - Lifetime
- 2004-10-29 CA CA002544348A patent/CA2544348A1/en not_active Abandoned
- 2004-10-29 AU AU2004285683A patent/AU2004285683C1/en not_active Expired
- 2004-10-29 HR HR20100149T patent/HRP20100149T1/hr unknown
- 2004-10-29 EP EP09153379.4A patent/EP2067779B9/de not_active Expired - Lifetime
- 2004-10-29 ES ES09153379T patent/ES2422729T3/es not_active Expired - Lifetime
- 2004-10-29 PE PE2004001045A patent/PE20050446A1/es not_active Application Discontinuation
- 2004-10-29 MX MXPA06004697A patent/MXPA06004697A/es active IP Right Grant
- 2004-10-29 CN CN2010105807004A patent/CN102070630B/zh not_active Expired - Lifetime
- 2004-10-29 UA UAA200605764A patent/UA82413C2/uk unknown
- 2004-10-29 ES ES04791028T patent/ES2342468T3/es not_active Expired - Lifetime
- 2004-10-29 WO PCT/EP2004/012268 patent/WO2005042526A1/de not_active Ceased
- 2004-10-29 EP EP04791028A patent/EP1682541B1/de not_active Expired - Lifetime
- 2004-10-29 CN CNB2004800325281A patent/CN100549010C/zh not_active Expired - Lifetime
- 2004-10-29 ME MEP-2008-513A patent/ME00361B/me unknown
- 2004-10-29 NZ NZ547276A patent/NZ547276A/xx not_active IP Right Cessation
- 2004-10-29 DK DK09153379.4T patent/DK2067779T3/da active
- 2004-11-01 MY MYPI20044526A patent/MY143364A/en unknown
- 2004-11-02 TW TW101107080A patent/TWI435876B/zh not_active IP Right Cessation
- 2004-11-02 TW TW093133283A patent/TWI363758B/zh not_active IP Right Cessation
- 2004-11-03 AR ARP040104038A patent/AR046317A1/es unknown
2006
- 2006-03-22 ZA ZA200602342A patent/ZA200602342B/en unknown
- 2006-03-30 NO NO20061440A patent/NO335814B1/no unknown
- 2006-04-20 IL IL175023A patent/IL175023A/en active IP Right Grant
- 2006-05-02 CO CO06041171A patent/CO5690553A2/es not_active Application Discontinuation
2010
- 2010-05-17 CY CY20101100435T patent/CY1110048T1/el unknown
2013
- 2013-07-17 CY CY20131100607T patent/CY1114157T1/el unknown

Also Published As

Publication number	Publication date
CA2544348A1 (en)	2005-05-12
KR20060117334A (ko)	2006-11-16
CN101407514A (zh)	2009-04-15
HK1129111A1 (en)	2009-11-20
EP1682541B1 (de)	2010-03-10
TWI363758B (en)	2012-05-11
CN102070630A (zh)	2011-05-25
AU2004285683B2 (en)	2011-04-21
NO335814B1 (no)	2015-02-23
CN102070630B (zh)	2013-04-17
AR046317A1 (es)	2005-11-30
EP2067779B9 (de)	2013-10-16
HK1099748A1 (zh)	2007-08-24
TWI435876B (zh)	2014-05-01
IL175023A (en)	2011-02-28
NO20061440L (no)	2006-07-12
EP1682541A1 (de)	2006-07-26
TW201231465A (en)	2012-08-01
DK2067779T3 (da)	2013-07-29
CN101407514B (zh)	2013-05-29
EA012326B1 (ru)	2009-08-28
ATE460414T1 (de)	2010-03-15
WO2005042526A1 (de)	2005-05-12
PT2067779E (pt)	2013-07-25
EP2067779A1 (de)	2009-06-10
SI1682541T1 (sl)	2010-06-30
MEP51308A (en)	2011-05-10
DK1682541T3 (da)	2010-06-28
TW200526653A (en)	2005-08-16
ES2422729T3 (es)	2013-09-13
AU2004285683A1 (en)	2005-05-12
CY1114157T1 (el)	2016-08-31
CN1882582A (zh)	2006-12-20
PT1682541E (pt)	2010-04-14
JP5165244B2 (ja)	2013-03-21
DE502004010885D1 (de)	2010-04-22
US8686148B2 (en)	2014-04-01
RS20060292A (sr)	2008-08-07
US20050131007A1 (en)	2005-06-16
CO5690553A2 (es)	2006-10-31
ZA200602342B (en)	2007-06-27
UA82413C2 (uk)	2008-04-10
RS51758B (sr)	2011-12-31
UY28590A1 (es)	2005-06-30
MXPA06004697A (es)	2006-07-05
BRPI0416136A (pt)	2007-01-02
NZ547276A (en)	2009-08-28
PL1682541T3 (pl)	2010-08-31
CN100549010C (zh)	2009-10-14
MY143364A (en)	2011-04-29
CY1110048T1 (el)	2015-01-14
ES2342468T3 (es)	2010-07-07
SI2067779T1 (sl)	2013-08-30
EA200600886A1 (ru)	2006-10-27
ME00361B (me)	2011-10-10
PE20050446A1 (es)	2005-08-02
JP2007509893A (ja)	2007-04-19
PL2067779T3 (pl)	2013-09-30
EP2067779B1 (de)	2013-04-24
AU2004285683C1 (en)	2011-09-08
EP2336126A1 (de)	2011-06-22
IL175023A0 (en)	2006-08-20
HRP20100149T1 (hr)	2010-04-30
HK1153409A1 (en)	2012-03-30

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UA83813C2 (ru)	2008-08-26	Порошковое лекарственное средство, которое содержит соль тиотропия и ксинафоат салметерола
HUS1900056I1 (hu)	2020-02-28	Légzési rendellenességek kezelésére alkalmas, glikopirrolát tartalmú száraz porkészítményt tartalmazó inhaláló készülék és alkalmazása
MY123544A (en)	2006-05-31	New inhalable powder containing tiotropium
SG167657A1 (en)	2011-01-28	Novel medicament compositions based on tiotropium salts and on salmeterol salts
WO2004045618A3 (de)	2004-09-30	Neue arzneimittel zur behandlung von chronisch obstruktiver lungenerkrankung
ATE330589T1 (de)	2006-07-15	Pharmazeutische zusammensetzung enthaltend resveratrol zur behandlung von entzündlichen erkrankungen der atemwege
CY1114157T1 (el)	2016-08-31	Αλατα του τιοτροπιου, μεθοδος για την παραγωγη τους και φαρμακευτικα σκευασματα που τα περιεχουν
UA85708C2 (ru)	2009-02-25	Лекарственные комбинации, содержащие бензоксазины, для лечения заболеваний дыхательных путей
MY143517A (en)	2011-05-31	Formoterol superfine formulation
WO2004037807A3 (en)	2004-06-24	Medicinal arylethanolamine compounds
MY146628A (en)	2012-09-14	Novel crystalline anhydride with anticholinergic effect
SG149876A1 (en)	2009-02-27	Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
WO2003087049A3 (de)	2004-02-05	Arzneimittelkombinationen enthaltend heterocyclische verbindungen und ein neues anticholinergikum
CY1108420T1 (el)	2014-04-09	Προτοτυπο τιοτροπιουχο κονιωδες σκευασμα για εισπνοη
MXPA03011702A (es)	2004-03-19	Composicion que comprende un inhibidor de fosodiesterasa 4 y un antagonista de receptor h1 y el uso de los mismos para la elaboracion de un medicamento para el tratamiento de enfermedades respiratorias.
MXPA04002401A (es)	2004-05-31	Nuevos medicamentos para inhalacion.
MXPA04007294A (es)	2004-10-29	Composicion para inhalacion.
WO2005007134A8 (de)	2006-06-15	Pulverformulierungen für die inhalation enthaltend ein neues anticholinergikum
ATE452639T1 (de)	2010-01-15	Arzneimittelkompositionen aus tiotropiumsalzen und epinastin zur therapie von atemswegserkrankungen
ATE339951T1 (de)	2006-10-15	Pulverzubereitungen zur inhalation
DK1581224T3 (da)	2008-03-25	Tiotropiumholdig lægemiddelsammensætning til inhalation