AR046317A1 - Sales de tiotropio, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. - Google Patents
Sales de tiotropio, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.Info
- Publication number
- AR046317A1 AR046317A1 ARP040104038A ARP040104038A AR046317A1 AR 046317 A1 AR046317 A1 AR 046317A1 AR P040104038 A ARP040104038 A AR P040104038A AR P040104038 A ARP040104038 A AR P040104038A AR 046317 A1 AR046317 A1 AR 046317A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- salts
- pharmaceutical compositions
- compositions containing
- tiotropium salts
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 abstract 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
- 150000001450 anions Chemical class 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000001768 cations Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000013583 drug formulation Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El presente se refiere a un procedimiento para la preparación de nuevas sales de tiotropio, a estas nuevas sales de tiotropio como tales, a las formulaciones medicamentosas que las contienen, así como a su utilización para la preparación de un medicamento para el tratamiento de enfermedades de las vías respiratorias, especialmente para el tratamiento de COPD (chronic obstructive pulmonary disease = enfermedades pulmonares crónicas obstructivas) y asma. Sales de tiotropio como tales y composiciones farmacéuticas que las contienen. Reivindicación 1: Procedimiento para la preparación de nuevas sales de tiotropio de la fórmula (1), en donde X- significa un anión, caracterizado porque una sal de tiotropio de la fórmula (2), en donde, Y- significa un anión diferente a X- seleccionado del grupo constituido por halogenuro, alquil(C1-10)sulfonato, alquil-(C1-10)sulfato, aril(C6-10)sulfonato, se hace reaccionar en un disolvente adecuado con una fuente de iones Kat-X, en la Kat representa un catión y X puede tener los significados anteriormente citados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03025075 | 2003-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046317A1 true AR046317A1 (es) | 2005-11-30 |
Family
ID=34530660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104038A AR046317A1 (es) | 2003-11-03 | 2004-11-03 | Sales de tiotropio, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US8686148B2 (es) |
| EP (3) | EP1682541B1 (es) |
| JP (1) | JP5165244B2 (es) |
| KR (1) | KR20060117334A (es) |
| CN (3) | CN100549010C (es) |
| AR (1) | AR046317A1 (es) |
| AT (1) | ATE460414T1 (es) |
| AU (1) | AU2004285683C1 (es) |
| BR (1) | BRPI0416136A (es) |
| CA (1) | CA2544348A1 (es) |
| CO (1) | CO5690553A2 (es) |
| CY (2) | CY1110048T1 (es) |
| DE (1) | DE502004010885D1 (es) |
| DK (2) | DK2067779T3 (es) |
| EA (1) | EA012326B1 (es) |
| ES (2) | ES2342468T3 (es) |
| HR (1) | HRP20100149T1 (es) |
| IL (1) | IL175023A (es) |
| ME (1) | ME00361B (es) |
| MX (1) | MXPA06004697A (es) |
| MY (1) | MY143364A (es) |
| NO (1) | NO335814B1 (es) |
| NZ (1) | NZ547276A (es) |
| PE (1) | PE20050446A1 (es) |
| PL (2) | PL2067779T3 (es) |
| PT (2) | PT1682541E (es) |
| RS (2) | RS51758B (es) |
| SG (1) | SG137859A1 (es) |
| SI (2) | SI2067779T1 (es) |
| TW (2) | TWI435876B (es) |
| UA (1) | UA82413C2 (es) |
| UY (1) | UY28590A1 (es) |
| WO (1) | WO2005042526A1 (es) |
| ZA (1) | ZA200602342B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA82414C2 (uk) * | 2003-11-03 | 2008-04-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Солі тіотропію, спосіб їх одержання, а також лікарські композиції, які їх містять |
| ES2342468T3 (es) | 2003-11-03 | 2010-07-07 | Boehringer Ingelheim International Gmbh | Procedimiento para la preparacion de sales de tiotropio. |
| US20060079544A1 (en) * | 2004-08-13 | 2006-04-13 | Boehringer Ingelheim International Gmbh | Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic |
| MX2007015997A (es) * | 2005-06-15 | 2008-03-07 | Boehringer Ingelheim Int | Procedimiento para preparar nuevas sales de tiotropio, nuevas sales de tiotropio como tales y composiciones farmaceuticas de las mismas. |
| DE102005035112A1 (de) * | 2005-07-27 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen |
| TW200738634A (en) * | 2005-08-02 | 2007-10-16 | Astrazeneca Ab | New salt |
| CN102731494A (zh) * | 2005-12-19 | 2012-10-17 | 西科尔公司 | 噻托溴铵的新形式及其制备方法 |
| BRPI0620886A2 (pt) * | 2006-01-04 | 2011-11-29 | Boehringer Ingelheim Int | uso de sais de tiotrópio no tratamento de asma persistente moderada |
| EP1953156A1 (de) * | 2007-01-29 | 2008-08-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Scopiniumsalzen |
| CZ201241A3 (cs) * | 2012-01-20 | 2013-07-31 | Zentiva, K.S. | Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy |
| WO2014042605A1 (en) * | 2012-09-11 | 2014-03-20 | Mahmut Bilgic | New tiotropium bromide crystalline form |
| JP6042197B2 (ja) * | 2012-12-11 | 2016-12-14 | エア・ウォーター株式会社 | 肺障害治療剤 |
Family Cites Families (48)
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|---|---|---|---|---|
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| US3551492A (en) * | 1967-10-31 | 1970-12-29 | Ciba Geigy Corp | N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof |
| US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
| JPS6165885A (ja) * | 1984-09-07 | 1986-04-04 | Tanabe Seiyaku Co Ltd | 新規合成中間体及びその製法 |
| FR2585563B1 (fr) | 1985-07-30 | 1993-11-12 | Glaxo Group Ltd | Dispositif pour administrer des medicaments a des patients |
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| US5610163A (en) | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| JP3302647B2 (ja) * | 1992-04-24 | 2002-07-15 | 小野薬品工業株式会社 | フェニルアルカン酸エステルの塩酸塩、およびその製造方法 |
| DE4318455A1 (de) | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Kapselhalterung |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| JP4023086B2 (ja) | 1999-12-27 | 2007-12-19 | 和光純薬工業株式会社 | スルホニウム塩化合物 |
| US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
| UA75375C2 (en) | 2000-10-12 | 2006-04-17 | Boehringer Ingelheim Pharma | Method for producing powdery preparations for inhaling |
| IL155335A0 (en) | 2000-10-12 | 2003-11-23 | Boehringer Ingelheim Pharma | Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament |
| EP1430887A1 (de) | 2000-10-12 | 2004-06-23 | Boehringer Ingelheim Pharma GmbH & Co.KG | Tiotropium-haltige Inhalationspulver |
| IL155538A0 (en) * | 2000-10-31 | 2003-11-23 | Boehringer Ingelheim Pharma | Inhalative solution formulation containing a tiotropium salt |
| US20020193393A1 (en) | 2001-03-07 | 2002-12-19 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| US20020183292A1 (en) | 2000-10-31 | 2002-12-05 | Michel Pairet | Pharmaceutical compositions based on anticholinergics and corticosteroids |
| US20020137764A1 (en) | 2000-10-31 | 2002-09-26 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
| US20020111363A1 (en) | 2000-10-31 | 2002-08-15 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
| US20020193392A1 (en) | 2000-11-13 | 2002-12-19 | Christel Schmelzer | Pharmaceutical compositions based on tiotropium salts of salts of salmeterol |
| DE10056104A1 (de) * | 2000-11-13 | 2002-05-23 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols |
| DE10061877A1 (de) * | 2000-12-12 | 2002-06-13 | Basf Ag | Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung |
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| US20020193394A1 (en) | 2001-03-13 | 2002-12-19 | Bernd Disse | Compounds for treating inflammatory diseases |
| DE10111843A1 (de) * | 2001-03-13 | 2002-09-19 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von inflammatorischen Erkrankungen |
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| US6919325B2 (en) | 2001-09-14 | 2005-07-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts |
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| GB0203193D0 (en) | 2002-02-11 | 2002-03-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
| WO2003068233A1 (en) | 2002-02-11 | 2003-08-21 | Pfizer Limited | Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases |
| US20030229227A1 (en) * | 2002-03-16 | 2003-12-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions |
| DE10212264A1 (de) | 2002-03-20 | 2003-10-02 | Boehringer Ingelheim Pharma | Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
| JP2005526103A (ja) | 2002-04-04 | 2005-09-02 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 吸入に適した粉末製剤 |
| US20030235538A1 (en) | 2002-04-09 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the administration of an anticholinergic by inhalation |
| UA80123C2 (en) | 2002-04-09 | 2007-08-27 | Boehringer Ingelheim Pharma | Inhalation kit comprising inhalable powder of tiotropium |
| DE10216036A1 (de) | 2002-04-11 | 2003-10-23 | Boehringer Ingelheim Pharma | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
| US6908055B2 (en) | 2003-02-27 | 2005-06-21 | Tandberg Data Asa | System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel |
| US20050030040A1 (en) * | 2003-06-27 | 2005-02-10 | Mitch Budniak | Electrical testing device having voice annunciator |
| UA82414C2 (uk) | 2003-11-03 | 2008-04-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Солі тіотропію, спосіб їх одержання, а також лікарські композиції, які їх містять |
| ES2342468T3 (es) | 2003-11-03 | 2010-07-07 | Boehringer Ingelheim International Gmbh | Procedimiento para la preparacion de sales de tiotropio. |
| US7968717B2 (en) * | 2003-11-03 | 2011-06-28 | Boehringer Ingelhein International Gmbh | Crystalline anhydrate with anticholinergic efficacy |
| SE0303270L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | Metod för administration av tiotropium |
| SE0303570L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
| DE102004041253A1 (de) * | 2004-08-26 | 2006-03-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen |
| MX2007015997A (es) | 2005-06-15 | 2008-03-07 | Boehringer Ingelheim Int | Procedimiento para preparar nuevas sales de tiotropio, nuevas sales de tiotropio como tales y composiciones farmaceuticas de las mismas. |
-
2004
- 2004-10-29 ES ES04791028T patent/ES2342468T3/es not_active Expired - Lifetime
- 2004-10-29 RS RS20060292A patent/RS51758B/sr unknown
- 2004-10-29 EP EP04791028A patent/EP1682541B1/de not_active Expired - Lifetime
- 2004-10-29 BR BRPI0416136-0A patent/BRPI0416136A/pt not_active IP Right Cessation
- 2004-10-29 MX MXPA06004697A patent/MXPA06004697A/es active IP Right Grant
- 2004-10-29 RS YUP-2006/0292A patent/RS20060292A/sr unknown
- 2004-10-29 UY UY28590A patent/UY28590A1/es not_active Application Discontinuation
- 2004-10-29 EA EA200600886A patent/EA012326B1/ru not_active IP Right Cessation
- 2004-10-29 ES ES09153379T patent/ES2422729T3/es not_active Expired - Lifetime
- 2004-10-29 JP JP2006537207A patent/JP5165244B2/ja not_active Expired - Lifetime
- 2004-10-29 DK DK09153379.4T patent/DK2067779T3/da active
- 2004-10-29 SI SI200432055T patent/SI2067779T1/sl unknown
- 2004-10-29 CN CNB2004800325281A patent/CN100549010C/zh not_active Expired - Lifetime
- 2004-10-29 AT AT04791028T patent/ATE460414T1/de active
- 2004-10-29 PE PE2004001045A patent/PE20050446A1/es not_active Application Discontinuation
- 2004-10-29 EP EP09153379.4A patent/EP2067779B9/de not_active Expired - Lifetime
- 2004-10-29 DK DK04791028.6T patent/DK1682541T3/da active
- 2004-10-29 DE DE502004010885T patent/DE502004010885D1/de not_active Expired - Lifetime
- 2004-10-29 KR KR1020067010832A patent/KR20060117334A/ko not_active Ceased
- 2004-10-29 PL PL09153379T patent/PL2067779T3/pl unknown
- 2004-10-29 EP EP10180163A patent/EP2336126A1/de not_active Withdrawn
- 2004-10-29 AU AU2004285683A patent/AU2004285683C1/en not_active Expired
- 2004-10-29 HR HR20100149T patent/HRP20100149T1/hr unknown
- 2004-10-29 WO PCT/EP2004/012268 patent/WO2005042526A1/de not_active Ceased
- 2004-10-29 PT PT04791028T patent/PT1682541E/pt unknown
- 2004-10-29 US US10/977,753 patent/US8686148B2/en active Active
- 2004-10-29 CN CN2008101664856A patent/CN101407514B/zh not_active Expired - Lifetime
- 2004-10-29 CA CA002544348A patent/CA2544348A1/en not_active Abandoned
- 2004-10-29 ME MEP-2008-513A patent/ME00361B/me unknown
- 2004-10-29 PT PT91533794T patent/PT2067779E/pt unknown
- 2004-10-29 UA UAA200605764A patent/UA82413C2/uk unknown
- 2004-10-29 PL PL04791028T patent/PL1682541T3/pl unknown
- 2004-10-29 SG SG200718011-0A patent/SG137859A1/en unknown
- 2004-10-29 NZ NZ547276A patent/NZ547276A/xx not_active IP Right Cessation
- 2004-10-29 CN CN2010105807004A patent/CN102070630B/zh not_active Expired - Lifetime
- 2004-10-29 SI SI200431403T patent/SI1682541T1/sl unknown
- 2004-11-01 MY MYPI20044526A patent/MY143364A/en unknown
- 2004-11-02 TW TW101107080A patent/TWI435876B/zh not_active IP Right Cessation
- 2004-11-02 TW TW093133283A patent/TWI363758B/zh not_active IP Right Cessation
- 2004-11-03 AR ARP040104038A patent/AR046317A1/es unknown
-
2006
- 2006-03-22 ZA ZA200602342A patent/ZA200602342B/en unknown
- 2006-03-30 NO NO20061440A patent/NO335814B1/no unknown
- 2006-04-20 IL IL175023A patent/IL175023A/en active IP Right Grant
- 2006-05-02 CO CO06041171A patent/CO5690553A2/es not_active Application Discontinuation
-
2010
- 2010-05-17 CY CY20101100435T patent/CY1110048T1/el unknown
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2013
- 2013-07-17 CY CY20131100607T patent/CY1114157T1/el unknown
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