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SG11202106377XA - Automated production of viral vectors - Google Patents

Automated production of viral vectors

Info

Publication number
SG11202106377XA
SG11202106377XA SG11202106377XA SG11202106377XA SG11202106377XA SG 11202106377X A SG11202106377X A SG 11202106377XA SG 11202106377X A SG11202106377X A SG 11202106377XA SG 11202106377X A SG11202106377X A SG 11202106377XA SG 11202106377X A SG11202106377X A SG 11202106377XA
Authority
SG
Singapore
Prior art keywords
viral vectors
automated production
automated
production
viral
Prior art date
Application number
SG11202106377XA
Inventor
Matthew Hewitt
Young Shin
Bingnan Gu
Caitlin M Guenther
Anandita Seth
Original Assignee
Lonza Walkersville Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Walkersville Inc filed Critical Lonza Walkersville Inc
Publication of SG11202106377XA publication Critical patent/SG11202106377XA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
    • C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11202106377XA 2018-12-21 2019-12-19 Automated production of viral vectors SG11202106377XA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862783589P 2018-12-21 2018-12-21
US201962866092P 2019-06-25 2019-06-25
US201962890904P 2019-08-23 2019-08-23
US201962949848P 2019-12-18 2019-12-18
PCT/US2019/067354 WO2020132177A1 (en) 2018-12-21 2019-12-19 Automated production of viral vectors

Publications (1)

Publication Number Publication Date
SG11202106377XA true SG11202106377XA (en) 2021-07-29

Family

ID=71101856

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106377XA SG11202106377XA (en) 2018-12-21 2019-12-19 Automated production of viral vectors

Country Status (9)

Country Link
US (3) US11718833B2 (en)
EP (1) EP3898994A4 (en)
JP (2) JP7598864B2 (en)
KR (1) KR20210108406A (en)
CN (1) CN113195725A (en)
CA (1) CA3123449A1 (en)
IL (1) IL284217A (en)
SG (1) SG11202106377XA (en)
WO (1) WO2020132177A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10988724B2 (en) 2016-05-05 2021-04-27 Southwest Research Institute Three-dimensional bioreactor for cell expansion and related applications
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
CN112955532A (en) 2018-09-24 2021-06-11 西南研究院 Three-dimensional bioreactor
WO2021041322A1 (en) 2019-08-23 2021-03-04 Lonza Walkersville, Inc. Methods and constructs for production of lentiviral vector
CN114829613A (en) * 2019-12-19 2022-07-29 隆萨沃克斯维尔股份有限公司 Automated production of viral vectors
GB2599212A (en) 2020-07-30 2022-03-30 Shape Therapeutics Inc Stable cell lines for inducible production of rAAV virions
CN114045305B (en) * 2021-10-15 2023-03-24 深圳市深研生物科技有限公司 Multi-swivel subsystem
EP4419696A1 (en) 2021-10-18 2024-08-28 Regeneron Pharmaceuticals, Inc. Eukaryotic cells comprising adenovirus-associated virus polynucleotides

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356794A (en) 1970-11-20 1974-06-12 Defence Secratary Of State For Apparatus and method for the production of a single cell suspen sion from tissue
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
PT84991B (en) 1986-06-06 1990-03-08 Genentech Inc PROCESS FOR THE PRODUCTION OF BIOLOGICALLY ACTIVE PLASMINOGENE ACTIVITY
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US6022742A (en) 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
US5081036A (en) 1987-01-23 1992-01-14 Hoffmann-La Roche Inc. Method and apparatus for cell culture
EP0345588A1 (en) 1988-06-03 1989-12-13 Gesellschaft für Biotechnologische Forschung mbH (GBF) Method and device for monitoring a biological growth process
CA2000181A1 (en) 1988-10-14 1990-04-14 Chung-Faye Chao Process for producing cultured epidermal sheet, product and method of use
JPH02119772A (en) 1988-10-29 1990-05-07 Shimadzu Corp Cell culturing device
US4939151A (en) 1988-10-31 1990-07-03 Baxter International Inc. Adherent cell culture flask
US5240854A (en) 1989-06-05 1993-08-31 Berry Eric S Continuous high-density cell culture system
DE4021123A1 (en) 1989-10-07 1991-04-11 Sartorius Gmbh Cross-flow membrane filtration of cells from liq. - which is propelled by gas pressure from alternately operated containers
ATE154828T1 (en) 1989-10-10 1997-07-15 Aquasearch Inc PROCESS AND APPARATUS FOR PRODUCING PHOTOSYNTHESIZING MICROBE
GB9010356D0 (en) 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
AU667680B2 (en) 1991-08-07 1996-04-04 Albert Einstein College Of Medicine Of Yeshiva University Proliferation of hepatocyte precursors
JPH0654678A (en) 1992-08-07 1994-03-01 Chuo Setsubi Eng Kk Method for automatic feed culture of microorganism
DE4306661C2 (en) 1993-03-03 1995-04-20 Michael Dipl Biol Sittinger Process for producing an implant from cell cultures
JP3453161B2 (en) 1993-03-18 2003-10-06 宇宙開発事業団 Liquid culture unit
US5424209A (en) 1993-03-19 1995-06-13 Kearney; George P. Automated cell culture and testing system
US5478479A (en) 1994-05-20 1995-12-26 Haemonetics Corporation Two-stage cell wash process controlled by optical sensor
US5549134A (en) 1994-05-27 1996-08-27 Marcvalve Corporation Diaphragm valve
JP3549949B2 (en) 1994-06-17 2004-08-04 山陽電子工業株式会社 Low oxygen incubator
US6297046B1 (en) 1994-10-28 2001-10-02 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US5846828A (en) 1995-06-07 1998-12-08 Advanced Tissue Sciences Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments
US6121042A (en) 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
US5792603A (en) 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
US5688687A (en) 1995-06-07 1997-11-18 Aastrom Biosciences, Inc. Bioreactor for mammalian cell growth and maintenance
US6238908B1 (en) 1995-06-07 2001-05-29 Aastrom Biosciences, Inc. Apparatus and method for maintaining and growth biological cells
AU5931896A (en) 1995-06-07 1996-12-30 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, st oring, shipping, and testing replacement cartilage tissue co nstructs
ATE204322T1 (en) 1995-06-07 2001-09-15 Aastrom Biosciences Inc DEVICE AND METHOD FOR STORING AND CULTURING BIOLOGICAL CELLS
US5728581A (en) 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
US6228635B1 (en) 1995-06-07 2001-05-08 Aastrom Bioscience, Inc. Portable cell growth cassette for use in maintaining and growing biological cells
US5985653A (en) 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
US6096532A (en) 1995-06-07 2000-08-01 Aastrom Biosciences, Inc. Processor apparatus for use in a system for maintaining and growing biological cells
WO1997009286A1 (en) 1995-09-01 1997-03-13 Millenium Biologix, Inc. An artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity
DE69633189T2 (en) 1995-10-06 2005-08-11 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Solid support for use in cell culture, in particular for the cultivation of liver cells, bioreactor containing the solid support, and the use thereof in a bio-artificial liver system
WO1997017426A1 (en) 1995-11-08 1997-05-15 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5827729A (en) 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
WO1997015399A1 (en) 1996-04-24 1997-05-01 Claude Fell Cell separation system for biological fluids like blood
US6008010A (en) 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
US6399375B2 (en) 1997-01-08 2002-06-04 Demtek A/S Method and apparatus for culturing cells and tissues
US5928936A (en) 1997-04-09 1999-07-27 Huntington Medical Research Institutes Cell culture container that self-seals after cannula penetration made of porous sheets
US5786207A (en) 1997-05-28 1998-07-28 University Of Pittsburgh Tissue dissociating system and method
US5922604A (en) 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
AU9582398A (en) 1997-09-25 1999-04-12 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
US6197575B1 (en) 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US5882929A (en) 1998-04-07 1999-03-16 Tissue Engineering, Inc. Methods and apparatus for the conditioning of cartilage replacement tissue
US5989913A (en) 1998-07-02 1999-11-23 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using the same
NZ513303A (en) 1999-02-04 2003-03-28 Technion Res & Dev Foundation Three dimensional plug flow bioreactor, and its use for the maintenance and expansion of hemopoietic stem cells and/or progenitor cells
AU5767900A (en) 1999-06-25 2001-01-31 Advanced Tissue Sciences, Inc. Monitorable three-dimensional scaffolds and tissue culture systems
US6632651B1 (en) 1999-07-06 2003-10-14 Ramot At Tel Aviv University Ltd. Tissue maintenance system that applies rhythmic pulses of pressure
US6402941B1 (en) 2000-02-07 2002-06-11 Wastewater Biological Solutions, Corp Apparatus for biological treatment of environmental contaminants and waste
JP3865354B2 (en) 2000-03-02 2007-01-10 高木産業株式会社 Cell or tissue culture method
JP4402249B2 (en) 2000-03-31 2010-01-20 正仁 田谷 Cell culture method, cell culture apparatus and recording medium
GB0009960D0 (en) 2000-04-25 2000-06-14 Oncoprobe Limited Electrochemical sensing
US7585323B2 (en) 2000-05-05 2009-09-08 Medlden, Llc In vitro mechanical loading of musculoskeletal tissues
US6485963B1 (en) 2000-06-02 2002-11-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof
WO2002014539A1 (en) 2000-08-14 2002-02-21 University Of Maryland Baltimore County Bioreactor and bioprocessing technique
US6864084B2 (en) 2000-08-18 2005-03-08 Levitronix Llc Bioreactor and method for fluidly suspending a product
AU2001294922A1 (en) 2000-10-02 2002-04-15 Thomas F. Cannon Automated bioculture and bioculture experiments system
US20020146817A1 (en) 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
DE10049437A1 (en) 2000-10-06 2002-04-25 Fraunhofer Ges Forschung Bioreactor for growing phototropic microorganisms comprises trough of transparent material fitted with septa that create meandering flow path
US7198940B2 (en) 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
EP1355860A1 (en) 2001-01-09 2003-10-29 Wastewater Biological Solutions Corp. Apparatus and method for biological treatment of environmental contaminants and waste
US20050130297A1 (en) 2001-04-26 2005-06-16 Societe Nouvelle Cell Tissue Progress Cell and tissue culture device with temperature regulation
FR2824071B1 (en) 2001-04-26 2003-08-01 Cell Tissue Progress THERMAL REGULATION CELL AND TISSUE CULTURE DEVICE
US7169578B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US6673595B2 (en) 2001-08-27 2004-01-06 Biocrystal, Ltd Automated cell management system for growth and manipulation of cultured cells
GB0121986D0 (en) 2001-09-11 2001-10-31 Isis Innovation Method and structure for growing living organic tissue
US7348175B2 (en) 2002-03-15 2008-03-25 St3 Development Corporation Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products
ES2713559T3 (en) 2002-04-08 2019-05-22 Octane Biotech Inc Automated tissue engineering system
US20030215935A1 (en) 2002-05-14 2003-11-20 Coon David James Apparatus and method for isolating living cells from an encapsulated organ tissue sample
EP1649056A1 (en) 2003-07-02 2006-04-26 Caliper Life Sciences, Inc. Methods for amplifying and detecting nucleic acids in microfluidic devices under continuous and non-continuous flow conditions.
ATE428994T1 (en) 2004-03-19 2009-05-15 Nokia Corp DETECTOR LOGIC AND RADIO IDENTIFICATION DEVICE AND METHOD FOR IMPROVING TERMINAL OPERATION
AU2005247967B2 (en) 2004-05-26 2011-09-01 Octane Biotech, Inc. Advanced tissue engineering system
EP3338896B1 (en) 2007-12-07 2025-11-12 Miltenyi Biotec B.V. & Co. KG Sample processing systems and methods
CA2833001C (en) 2010-04-21 2020-06-23 Yves Larcher Automated cell culture system
EP2997134B1 (en) 2013-05-14 2020-06-24 Board of Regents, The University of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
US20150344844A1 (en) 2014-02-04 2015-12-03 Marc Better Methods for producing autologous t cells useful to treat b cell malignancies and other cancers and compositions thereof
RU2763795C2 (en) 2014-04-23 2022-01-11 Джуно Терапьютикс, Инк. Methods of isolating, culturing and genetic engineering cell populations of the immune system for adoptive therapy
JP6661544B2 (en) 2014-04-24 2020-03-11 ミルテニイ バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング Automatic generation of genetically modified T cells
SI3134095T1 (en) 2014-04-25 2020-08-31 Bluebird Bio, Inc. Improved methods for manufacturing adoptive cell therapies
US11471487B2 (en) 2014-10-31 2022-10-18 The Trustees Of The University Of Pennsylvania Compositions and methods of stimulating and expanding T cells
ES2805674T3 (en) 2014-11-05 2021-02-15 Juno Therapeutics Inc Methods for cell transduction and processing
KR20250075716A (en) 2014-12-29 2025-05-28 노파르티스 아게 Methods of making chimeric antigen receptor-expressing cells
JP6734283B2 (en) 2015-01-21 2020-08-05 フレッド ハッチンソン キャンサー リサーチ センター Point of care and/or portable platform for gene therapy
JP6885876B2 (en) 2015-04-13 2021-06-16 マックスサイト インコーポレーティッド Methods and Compositions for Modifying Genomic DNA
GB201508752D0 (en) 2015-05-21 2015-07-01 Mason Christopher And Veraitch Farlan S Cell culture device, system and methods of use thereof
MA45489A (en) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh CELL CULTURE PROCESSES, ASSOCIATED KITS AND APPARATUS
IL260655B2 (en) * 2016-01-29 2023-03-01 Sirion Biotech Gmbh Aav-based conditional expression system
GB201603374D0 (en) * 2016-02-26 2016-04-13 Ucl Business Plc Packaging cell
CA3031152A1 (en) 2016-07-21 2018-01-25 Celyad Method and apparatus for automated independent parallel batch-processing of cells
KR102402037B1 (en) 2016-08-21 2022-05-24 아드바 바이오테크놀로지 리미티드 Bioreactor and method of use thereof
CN110234756A (en) 2017-01-18 2019-09-13 F1肿瘤医学公司 The method and application thereof of transduction and amplification immunocyte
CN110785495A (en) * 2017-04-18 2020-02-11 葛兰素史克知识产权开发有限公司 Method for producing adeno-associated virus vector
PL3645719T3 (en) 2017-06-30 2022-06-20 Inscripta, Inc. Automated cell processing methods, modules, instruments, and systems
WO2019046766A2 (en) 2017-09-01 2019-03-07 Lonza Walkersville, Inc. End-to-end cell therapy automation
US11603527B2 (en) 2017-12-27 2023-03-14 Global Life Sciences Solutions Usa Llc Method and kit for viral vector isolation

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