SE8102683L - 2-guanidinothiazole derivatives - Google Patents
2-guanidinothiazole derivativesInfo
- Publication number
- SE8102683L SE8102683L SE8102683A SE8102683A SE8102683L SE 8102683 L SE8102683 L SE 8102683L SE 8102683 A SE8102683 A SE 8102683A SE 8102683 A SE8102683 A SE 8102683A SE 8102683 L SE8102683 L SE 8102683L
- Authority
- SE
- Sweden
- Prior art keywords
- optionally substituted
- alkyl
- cyano
- alkoxy
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of the general formula: <IMAGE> (wherein n is an integer from 2 to 4; R is hydrogen, C1-C6 alkyl (optionally substituted by hydroxy, cyano, amino or phenoxy), C3-C6 cycloalkyl, C2-C6 alkenyl (optionally substituted by phenyl or C2-C7 alkoxy-carbonyl), C4-C7 alkadienyl, C6-C12 aryl (optionally substituted by one to three groups selected from halogen, cyano, nitro, amino, C2-C10 dialkylamino, tetrazolyl, hydroxy, C1-C6 alkoxy, benzoyloxy, C2-C7 alkoxycarbonyl, sulfamoyl, C1-C6 alkylsulfonyl, C1-C6 alkanesulfonamido or C1-C6 alkanoyl), or a heterocycle (optionally substituted by halogen, C1-C6 alkyl or phenyl); and X is a single bond or thia), their 5-halo and alkyl derivatives and salts thereof are anti-peptic ulcer agents and histamine H2 receptor antagonists. The preparation of 1-chloro-3-[2- acetamidoethylthio)-2-propanone is described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14494680A | 1980-04-29 | 1980-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8102683L true SE8102683L (en) | 1981-10-30 |
| SE452462B SE452462B (en) | 1987-11-30 |
Family
ID=22510873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8102683A SE452462B (en) | 1980-04-29 | 1981-04-28 | NEW 2-GUANIDINOTIAZOLD DERIVATIVES |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS574977A (en) |
| AR (1) | AR231538A1 (en) |
| AU (1) | AU540239B2 (en) |
| BE (1) | BE888602A (en) |
| CH (1) | CH646964A5 (en) |
| DE (1) | DE3116890A1 (en) |
| DK (1) | DK188881A (en) |
| ES (1) | ES501736A0 (en) |
| FR (1) | FR2481280A1 (en) |
| GB (1) | GB2076397B (en) |
| IE (1) | IE51151B1 (en) |
| IL (1) | IL62747A (en) |
| IT (1) | IT1146750B (en) |
| NL (1) | NL8102099A (en) |
| NZ (1) | NZ196923A (en) |
| SE (1) | SE452462B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2531705B1 (en) * | 1982-08-13 | 1986-12-05 | Sanofi Sa | AMIDOBENZAMIDES, THEIR SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US4501747A (en) * | 1982-05-10 | 1985-02-26 | Sanofi | Certain amide derivatives of 2-guanidino-thiazoles and compositions containing same |
| JPS59104370A (en) * | 1982-12-03 | 1984-06-16 | Kotobuki Seiyaku Kk | Thiazole derivative and its production |
| GB2138803B (en) * | 1983-04-26 | 1986-06-18 | Shionogi & Co | 2-guanidino-4-hydroxymethylthiazole and derivatives thereof |
| US4680300A (en) * | 1985-01-10 | 1987-07-14 | Syntex (U.S.A.) Inc. | Anti-inflammatory guanidines |
| US4837316A (en) * | 1985-08-29 | 1989-06-06 | Fujirebio Kabushiki Kaisha | Alkylamide derivatives with H2 -receptor antagonistic and cytoprotective action |
| EP0385525B1 (en) * | 1989-03-03 | 1994-04-13 | Akzo Nv | Aminoethylthiazole and aminoethyloxazole derivatives. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR62452B (en) * | 1977-04-20 | 1979-04-12 | Ici Ltd | Preparation process of guanidine derivatives |
| US4165378A (en) * | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| DE2961923D1 (en) * | 1978-01-18 | 1982-03-11 | Ici Plc | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| CA1140925A (en) | 1978-10-16 | 1983-02-08 | Derrick F. Jones | Antisecretory branched chain heterocyclic derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| US4309435A (en) * | 1978-10-16 | 1982-01-05 | Imperial Chemical Industries Ltd. | Antisecretory guanidine derivatives and pharmaceutical compositions containing them |
| EP0014057B1 (en) * | 1979-01-18 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| PH16099A (en) * | 1979-03-06 | 1983-06-24 | Yamanouchi Pharma Co Ltd | Guanidinothiazole compounds,process for preparing them and medical composition containing them |
| GR71929B (en) * | 1979-11-13 | 1983-08-19 | Ici Ltd | |
| JPS5754177A (en) * | 1980-09-19 | 1982-03-31 | Teikoku Hormone Mfg Co Ltd | CHIKANCHIAZOORUJUDOTAI |
| JPS57102852A (en) * | 1980-12-19 | 1982-06-26 | Shionogi & Co Ltd | Dicarboxylic acid diamide |
-
1981
- 1981-04-24 NZ NZ196923A patent/NZ196923A/en unknown
- 1981-04-28 ES ES501736A patent/ES501736A0/en active Granted
- 1981-04-28 BE BE0/204631A patent/BE888602A/en not_active IP Right Cessation
- 1981-04-28 SE SE8102683A patent/SE452462B/en not_active IP Right Cessation
- 1981-04-28 NL NL8102099A patent/NL8102099A/en not_active Application Discontinuation
- 1981-04-28 FR FR8108468A patent/FR2481280A1/en active Granted
- 1981-04-28 DE DE19813116890 patent/DE3116890A1/en not_active Ceased
- 1981-04-28 DK DK188881A patent/DK188881A/en not_active Application Discontinuation
- 1981-04-28 JP JP6473981A patent/JPS574977A/en active Granted
- 1981-04-29 IE IE956/81A patent/IE51151B1/en unknown
- 1981-04-29 CH CH279381A patent/CH646964A5/en not_active IP Right Cessation
- 1981-04-29 GB GB8113289A patent/GB2076397B/en not_active Expired
- 1981-04-29 IL IL62747A patent/IL62747A/en unknown
- 1981-04-29 IT IT67585/81A patent/IT1146750B/en active
- 1981-04-29 AU AU69966/81A patent/AU540239B2/en not_active Ceased
-
1984
- 1984-01-01 AR AR23153884D patent/AR231538A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| AU6996681A (en) | 1981-11-05 |
| ES8206501A1 (en) | 1982-08-16 |
| JPH027952B2 (en) | 1990-02-21 |
| FR2481280B1 (en) | 1983-10-28 |
| GB2076397B (en) | 1984-02-08 |
| IE51151B1 (en) | 1986-10-15 |
| ES501736A0 (en) | 1982-08-16 |
| CH646964A5 (en) | 1984-12-28 |
| NZ196923A (en) | 1983-12-16 |
| IE810956L (en) | 1981-10-29 |
| FR2481280A1 (en) | 1981-10-30 |
| IT8167585A0 (en) | 1981-04-29 |
| IL62747A0 (en) | 1981-06-29 |
| DE3116890A1 (en) | 1982-03-04 |
| DK188881A (en) | 1981-10-30 |
| GB2076397A (en) | 1981-12-02 |
| AR231538A1 (en) | 1984-12-28 |
| IT1146750B (en) | 1986-11-19 |
| SE452462B (en) | 1987-11-30 |
| BE888602A (en) | 1981-10-28 |
| JPS574977A (en) | 1982-01-11 |
| NL8102099A (en) | 1981-11-16 |
| IL62747A (en) | 1984-10-31 |
| AU540239B2 (en) | 1984-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX154758A (en) | PROCEDURE FOR PREPARATION OF SUCCINIMIDE DERIVATIVES | |
| DK633088A (en) | collagenase | |
| ES8800246A1 (en) | Pesticidal silylmethyl ether compounds. | |
| DE3265802D1 (en) | Anti-hypertensive 1-substituted spiro (piperidine-oxobenzoxazines) | |
| KR860005794A (en) | Method for preparing an imidazole derivative | |
| SE8102683L (en) | 2-guanidinothiazole derivatives | |
| FI874311A0 (en) | 7 - / (META-SUBSTITUERADE) PHENYLGLYSIN / -1-CARBA-1-DETIAKEPHALOSPORINER. | |
| MX9205207A (en) | DERIVATIVES OF DIHYDROPIRIDINE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM | |
| PT89263B (en) | PROCESS FOR THE PREPARATION OF DERIVATIVES TIOL-CETONE OR TIOL-ALDEIDO | |
| ES2009757B3 (en) | PROCEDURE FOR OBTAINING GAMMA-BUTIROLACTAMAS. | |
| FI844185L (en) | N-SUBSTITUERADE ISOKINOLINDERIVAT OCH FOERFARANDE FOER FRAMSTAELLNING DAERAV. | |
| ES531933A0 (en) | A PROCEDURE FOR PREPARING AN IMIDAZOLINONE DERIVATIVE | |
| ATE23147T1 (en) | UNSATURATED COMPOUNDS, THEIR PRODUCTION AND APPLICATION. | |
| DK61191A (en) | METHOD FOR PREPARING 1ALFA-SILYLOXY-4ALFA-HYDROXY-3BETA- (3ALFA-HYDROXY-4-PHENOXY-BUTEN-1-YL) -CYCLOPENT-2ALFA-YL-ALKINE DERIVATIVES | |
| JPS5271478A (en) | Synthesis of novel derivatives of kanamycin b | |
| ES2068620T3 (en) | PROCEDURE FOR THE PREPARATION OF SULFONILISOCIANATOS. | |
| SE8701524D0 (en) | NEW SULPHONAMIDS AND THEIR PREPARATION PROCEDURE | |
| ES8707936A1 (en) | A METHOD FOR PREPARING A BENZO (H) CINOLINE COMPOUND | |
| GR76302B (en) | ||
| ES2038672T3 (en) | PURINE HTA ANTAGONISTS OF HISTAMINE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| PT88468A (en) | PROCESS FOR THE PREPARATION OF MACROLIDE COMPOUNDS | |
| ES483138A1 (en) | A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF TIENO-TIACINA |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8102683-3 Effective date: 19921108 Format of ref document f/p: F |