SE7604093L - ANOREX ASSOCIATIONS - Google Patents
ANOREX ASSOCIATIONSInfo
- Publication number
- SE7604093L SE7604093L SE7604093A SE7604093A SE7604093L SE 7604093 L SE7604093 L SE 7604093L SE 7604093 A SE7604093 A SE 7604093A SE 7604093 A SE7604093 A SE 7604093A SE 7604093 L SE7604093 L SE 7604093L
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- anorex
- associations
- prepared
- appropriate
- Prior art date
Links
- XXEPPPIWZFICOJ-UHFFFAOYSA-N diethylpropion Chemical compound CCN(CC)C(C)C(=O)C1=CC=CC=C1 XXEPPPIWZFICOJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- HCGFLVDMFDHYJD-UHFFFAOYSA-N 2-piperazin-1-ylpyrazine Chemical class C1CNCCN1C1=CN=CC=N1 HCGFLVDMFDHYJD-UHFFFAOYSA-N 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000578 anorexic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novel piperazinylpyrazines of the formula <IMAGE> in which the substituents are defined in Claim 1, and their N-oxides are prepared. These compounds are obtained by reacting an appropriate pyrazine or its N-oxide, which contains an easily removable group in the 2-position, which is defined in Claim 1, with an appropriate piperazine. The compounds III are also prepared as acid addition salts. The compounds obtained can be used in pharmaceutical compositions having anorexic action.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57005275A | 1975-04-21 | 1975-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7604093L true SE7604093L (en) | 1976-10-22 |
| SE421695B SE421695B (en) | 1982-01-25 |
Family
ID=24277994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7604093A SE421695B (en) | 1975-04-21 | 1976-04-07 | SET TO MAKE PIPERAZINYL PYRAZINES |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS51136688A (en) |
| AR (1) | AR210349A1 (en) |
| AT (1) | AT353795B (en) |
| AU (1) | AU496854B2 (en) |
| BE (1) | BE840904A (en) |
| BG (1) | BG34185A3 (en) |
| CA (1) | CA1059128A (en) |
| CH (1) | CH619462A5 (en) |
| CS (1) | CS195726B2 (en) |
| CY (1) | CY1090A (en) |
| DD (1) | DD124599A5 (en) |
| DE (1) | DE2617205C3 (en) |
| DK (1) | DK143899C (en) |
| EG (1) | EG12387A (en) |
| ES (4) | ES447150A1 (en) |
| FI (1) | FI62666C (en) |
| FR (1) | FR2308367A1 (en) |
| GB (1) | GB1492528A (en) |
| GR (1) | GR59900B (en) |
| HK (1) | HK60380A (en) |
| HU (1) | HU172684B (en) |
| IE (1) | IE42979B1 (en) |
| IL (1) | IL49391A (en) |
| KE (1) | KE3088A (en) |
| LU (1) | LU74795A1 (en) |
| MY (1) | MY8100225A (en) |
| NL (1) | NL167692C (en) |
| NO (1) | NO146599C (en) |
| PH (1) | PH12274A (en) |
| PL (1) | PL99664B1 (en) |
| PT (1) | PT65027B (en) |
| RO (1) | RO73278A (en) |
| SE (1) | SE421695B (en) |
| SU (1) | SU638260A3 (en) |
| YU (1) | YU100676A (en) |
| ZA (1) | ZA762320B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| US4163849A (en) | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| US4252816A (en) * | 1979-12-03 | 1981-02-24 | Merck & Co., Inc. | Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents |
| US4339579A (en) | 1980-12-29 | 1982-07-13 | American Home Products Corporation | 2,6-Bis-(pyrrolopyrazinyl)pyrazines |
| EP0094498A3 (en) * | 1982-05-06 | 1985-04-03 | American Cyanamid Company | Antiatherosclerotic 1-piperazine derivatives |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| US4788290A (en) * | 1987-12-11 | 1988-11-29 | American Home Products Corporation | Serotonergic pyrazine derivatives |
| EP0580465A1 (en) * | 1992-06-25 | 1994-01-26 | Sanofi | New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives |
| EE04588B1 (en) | 1997-10-27 | 2006-02-15 | Neurosearch A/S | Heteroaryl diazacycloalkanes as cholinergic ligands for acetylcholine nicotine receptors, their use as pharmaceuticals and pharmaceutical composition containing them |
| ATE245153T1 (en) * | 1999-04-26 | 2003-08-15 | Neurosearch As | HETEROARYL-DIAZACYCLOALKANES, THEIR PREPARATION AND USE |
| AU783915B2 (en) * | 2000-02-16 | 2005-12-22 | Neurogen Corporation | Substituted arylpyrazines |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| WO2004009586A1 (en) | 2002-07-19 | 2004-01-29 | Biovitrum Ab | Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders |
| SE0202287D0 (en) * | 2002-07-19 | 2002-07-19 | Biovitrum Ab | New compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2606906A (en) * | 1948-10-14 | 1952-08-12 | American Cyanamid Co | 1-(2-pyridyl) piperazine and process of preparing same |
-
1976
- 1976-04-07 SE SE7604093A patent/SE421695B/en not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/en active
- 1976-04-07 DK DK164476A patent/DK143899C/en not_active IP Right Cessation
- 1976-04-08 NO NO761207A patent/NO146599C/en unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/en not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/en not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/en unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 GR GR50538A patent/GR59900B/en unknown
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/en active Granted
- 1976-04-15 CY CY1090A patent/CY1090A/en unknown
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/en unknown
- 1976-04-19 ES ES447150A patent/ES447150A1/en not_active Expired
- 1976-04-19 JP JP51043763A patent/JPS51136688A/en active Granted
- 1976-04-20 CH CH492676A patent/CH619462A5/en not_active IP Right Cessation
- 1976-04-20 ZA ZA762320A patent/ZA762320B/en unknown
- 1976-04-20 AT AT288376A patent/AT353795B/en not_active IP Right Cessation
- 1976-04-20 BG BG032968A patent/BG34185A3/en unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/en unknown
- 1976-04-20 SU SU762346054A patent/SU638260A3/en active
- 1976-04-20 RO RO7685688A patent/RO73278A/en unknown
- 1976-04-20 BE BE166282A patent/BE840904A/en not_active IP Right Cessation
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 DE DE2617205A patent/DE2617205C3/en not_active Expired
- 1976-04-20 AR AR262930A patent/AR210349A1/en active
- 1976-04-20 YU YU01006/76A patent/YU100676A/en unknown
- 1976-04-21 PT PT65027A patent/PT65027B/en unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/en unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
-
1977
- 1977-06-01 ES ES459407A patent/ES459407A1/en not_active Expired
- 1977-06-01 ES ES459406A patent/ES459406A1/en not_active Expired
- 1977-06-01 ES ES459405A patent/ES459405A1/en not_active Expired
-
1980
- 1980-10-02 KE KE3088A patent/KE3088A/en unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/en unknown
-
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE7604093L (en) | ANOREX ASSOCIATIONS | |
| MX9202996A (en) | DIAZABICICLO- (3-3-1) NONANOS. | |
| FR2275210A1 (en) | NEW DERIVATIVES OF BENZIMIDAZOLINONE | |
| ES462065A1 (en) | Thiazolidine derivatives | |
| BG30324A3 (en) | METHOD FOR PREPARING 4-SUBSTITUTED THIAZOLOXAMIC ACIDS, THEIR SALTS AND ESTERS | |
| SE7604476L (en) | PROCEDURE FOR PREPARING 1- (3,3,3-TRIARYLPROPYL) -4-PHENYL-4-PIPERIDINEMETHANOL COMPOUNDS | |
| SE7602049L (en) | NEW BUTYROPHENONE ASSOCIATIONS | |
| BG34036A3 (en) | METHOD FOR THE PREPARATION OF PROPARGYL-2- PHENYLAMINO-IMIDAZOLINES-(2) AND THEIR ACID-ADDITION SALTS | |
| SE7901493L (en) | NEW AMIDE DERIVATIVES OF 5-PYRIMIDINE CARBONIC ACIDS AND METHODS FOR THEIR PREPARATION AND USE AS MEDICINES | |
| GB1539473A (en) | N-aryl-n-(1-l-4-piperidinyl)-arylacetamides | |
| SE7811455L (en) | 2-IMINO-IMIDAZOLIDINE DERIVATIVE | |
| ES454085A1 (en) | Procedure for the preparation of N- (r-tetrahydrofurfuril) -noroximorphone and N- (s-tetrahydrofurfuril) -noroximorphone new. (Machine-translation by Google Translate, not legally binding) | |
| GB1471847A (en) | Dibenzofuran derivatives | |
| ES414955A1 (en) | Halogenated 4-(4'-bisphenylyl)-butanols | |
| SE7608608L (en) | PROCEDURE FOR MAKING NEW DIAMINO ANDROSTANES | |
| FR2329279A1 (en) | PENICILLINS | |
| SE7612961L (en) | TIENAMYCIN DERIVATIVES | |
| BG34037A3 (en) | METHOD FOR OBTAINING SUBSTITUTED N-METHYLENE DERIVATIVES OF THIENAMYCIN | |
| SE7701834L (en) | 4-HYDROXY-2-QUINOLINONE-3-CARBOXYLIC ACID ESTERS | |
| GB1479239A (en) | Acylated 2-hydrazono formyl quinoxaline-1,4-dioxides | |
| ES378206A1 (en) | 2-(imidazolid inylidence-(2)-amino)-5-nitro-thiazoles and salts thereof | |
| ES398080A1 (en) | 1-(1,2-diphenyl-2-formylvinyl)-4-methylpiperazine and salts thereof with physiologically tolerated acids | |
| GB936366A (en) | Methylsulphonyl-phenyl compounds | |
| IT1053288B (en) | I THIADIAZOLYL 5 ACYLIMIDIDAZOLIDINONES SUBSTITUTED RELEVANT PRODUCTION PROCESS AND WEEDING COMPOSITIONS THAT CONTAIN THEM AS ACTIVE COMPOUNDS | |
| SE7700962L (en) | ORGANIC ASSOCIATIONS, THEIR PREPARATION AND USE |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7604093-0 Effective date: 19911108 Format of ref document f/p: F |