AU496854B2 - 6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide - Google Patents

6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide

Info

Publication number: AU496854B2
Authority: AU; Australia
Prior art keywords: pyrazine; piperazinyl; chloro; oxide
Prior art date: 1975-04-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

AU12966/76A

Other versions

AU1296676A (en

Inventor

Walfred Spencer Saari And William Carl Lomma, Jr

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-21

Filing date

1976-04-13

Publication date

1978-11-02

1976-04-13 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1977-10-20 Publication of AU1296676A publication Critical patent/AU1296676A/en

1978-11-02 Application granted granted Critical

1978-11-02 Publication of AU496854B2 publication Critical patent/AU496854B2/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AU12966/76A 1975-04-21 1976-04-13 6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide Expired AU496854B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57005275A	1975-04-21	1975-04-21
USUS570,052		1975-04-21

Publications (2)

Publication Number	Publication Date
AU1296676A AU1296676A (en)	1977-10-20
AU496854B2 true AU496854B2 (en)	1978-11-02

Family

ID=24277994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU12966/76A Expired AU496854B2 (en)	1975-04-21	1976-04-13	6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide

Country Status (36)

Country	Link
JP (1)	JPS51136688A (en)
AR (1)	AR210349A1 (en)
AT (1)	AT353795B (en)
AU (1)	AU496854B2 (en)
BE (1)	BE840904A (en)
BG (1)	BG34185A3 (en)
CA (1)	CA1059128A (en)
CH (1)	CH619462A5 (en)
CS (1)	CS195726B2 (en)
CY (1)	CY1090A (en)
DD (1)	DD124599A5 (en)
DE (1)	DE2617205C3 (en)
DK (1)	DK143899C (en)
EG (1)	EG12387A (en)
ES (4)	ES447150A1 (en)
FI (1)	FI62666C (en)
FR (1)	FR2308367A1 (en)
GB (1)	GB1492528A (en)
GR (1)	GR59900B (en)
HK (1)	HK60380A (en)
HU (1)	HU172684B (en)
IE (1)	IE42979B1 (en)
IL (1)	IL49391A (en)
KE (1)	KE3088A (en)
LU (1)	LU74795A1 (en)
MY (1)	MY8100225A (en)
NL (1)	NL167692C (en)
NO (1)	NO146599C (en)
PH (1)	PH12274A (en)
PL (1)	PL99664B1 (en)
PT (1)	PT65027B (en)
RO (1)	RO73278A (en)
SE (1)	SE421695B (en)
SU (1)	SU638260A3 (en)
YU (1)	YU100676A (en)
ZA (1)	ZA762320B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en)	1978-03-17	1979-08-07	Merck & Co., Inc.	Piperazinylpyrazines
US4252816A (en) *	1979-12-03	1981-02-24	Merck & Co., Inc.	Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en)	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) *	1982-05-06	1985-04-03	American Cyanamid Company	Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) *	1983-03-25	1985-10-15	Degussa Aktiengesellschaft	N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
EP0580465A1 (en) *	1992-06-25	1994-01-26	Sanofi	New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives
EE04588B1 (en)	1997-10-27	2006-02-15	Neurosearch A/S	Heteroaryl diazacycloalkanes as cholinergic ligands for acetylcholine nicotine receptors, their use as pharmaceuticals and pharmaceutical composition containing them
ATE245153T1 (en) *	1999-04-26	2003-08-15	Neurosearch As	HETEROARYL-DIAZACYCLOALKANES, THEIR PREPARATION AND USE
AU783915B2 (en) *	2000-02-16	2005-12-22	Neurogen Corporation	Substituted arylpyrazines
US6825198B2 (en) *	2001-06-21	2004-11-30	Pfizer Inc	5-HT receptor ligands and uses thereof
WO2004009586A1 (en)	2002-07-19	2004-01-29	Biovitrum Ab	Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
SE0202287D0 (en) *	2002-07-19	2002-07-19	Biovitrum Ab	New compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2606906A (en) *	1948-10-14	1952-08-12	American Cyanamid Co	1-(2-pyridyl) piperazine and process of preparing same

1976
- 1976-04-07 SE SE7604093A patent/SE421695B/en not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/en active
- 1976-04-07 DK DK164476A patent/DK143899C/en not_active IP Right Cessation
- 1976-04-08 NO NO761207A patent/NO146599C/en unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/en not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/en not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/en unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 GR GR50538A patent/GR59900B/en unknown
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/en active Granted
- 1976-04-15 CY CY1090A patent/CY1090A/en unknown
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/en unknown
- 1976-04-19 ES ES447150A patent/ES447150A1/en not_active Expired
- 1976-04-19 JP JP51043763A patent/JPS51136688A/en active Granted
- 1976-04-20 CH CH492676A patent/CH619462A5/en not_active IP Right Cessation
- 1976-04-20 ZA ZA762320A patent/ZA762320B/en unknown
- 1976-04-20 AT AT288376A patent/AT353795B/en not_active IP Right Cessation
- 1976-04-20 BG BG032968A patent/BG34185A3/en unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/en unknown
- 1976-04-20 SU SU762346054A patent/SU638260A3/en active
- 1976-04-20 RO RO7685688A patent/RO73278A/en unknown
- 1976-04-20 BE BE166282A patent/BE840904A/en not_active IP Right Cessation
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 DE DE2617205A patent/DE2617205C3/en not_active Expired
- 1976-04-20 AR AR262930A patent/AR210349A1/en active
- 1976-04-20 YU YU01006/76A patent/YU100676A/en unknown
- 1976-04-21 PT PT65027A patent/PT65027B/en unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/en unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
1977
- 1977-06-01 ES ES459407A patent/ES459407A1/en not_active Expired
- 1977-06-01 ES ES459406A patent/ES459406A1/en not_active Expired
- 1977-06-01 ES ES459405A patent/ES459405A1/en not_active Expired
1980
- 1980-10-02 KE KE3088A patent/KE3088A/en unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/en unknown
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/en unknown

Also Published As

Publication number	Publication date
DD124599A5 (en)	1977-03-02
IL49391A0 (en)	1976-06-30
EG12387A (en)	1978-12-31
FR2308367B1 (en)	1979-09-21
DK164476A (en)	1976-10-22
DE2617205B2 (en)	1980-05-08
PH12274A (en)	1978-12-12
KE3088A (en)	1980-11-07
FR2308367A1 (en)	1976-11-19
AU1296676A (en)	1977-10-20
NO146599C (en)	1982-11-03
FI760978A7 (en)	1976-10-22
CH619462A5 (en)	1980-09-30
JPS5522475B2 (en)	1980-06-17
DK143899B (en)	1981-10-26
ES459407A1 (en)	1978-08-16
BE840904A (en)	1976-08-16
ES459405A1 (en)	1978-08-16
DE2617205A1 (en)	1976-10-28
ZA762320B (en)	1977-11-30
ATA288376A (en)	1979-05-15
FI62666B (en)	1982-10-29
SU638260A3 (en)	1978-12-15
FI62666C (en)	1983-02-10
NL167692B (en)	1981-08-17
SE421695B (en)	1982-01-25
HU172684B (en)	1978-11-28
NO146599B (en)	1982-07-26
NO761207L (en)	1976-10-22
HK60380A (en)	1980-11-07
PT65027B (en)	1978-04-03
PT65027A (en)	1976-05-01
MY8100225A (en)	1981-12-31
CS195726B2 (en)	1980-02-29
IE42979B1 (en)	1980-11-19
RO73278A (en)	1982-09-09
YU100676A (en)	1982-08-31
GB1492528A (en)	1977-11-23
SE7604093L (en)	1976-10-22
DK143899C (en)	1982-04-13
CY1090A (en)	1980-12-27
GR59900B (en)	1978-03-16
AR210349A1 (en)	1977-07-29
NL7603800A (en)	1976-10-25
IE42979L (en)	1976-10-21
BG34185A3 (en)	1983-07-15
AT353795B (en)	1979-12-10
PL99664B1 (en)	1978-07-31
IL49391A (en)	1979-09-30
NL167692C (en)	1982-01-18
CA1059128A (en)	1979-07-24
ES447150A1 (en)	1977-09-16
DE2617205C3 (en)	1981-01-29
LU74795A1 (en)	1977-02-07
ES459406A1 (en)	1978-08-16
JPS51136688A (en)	1976-11-26

Publication	Publication Date	Title
AU512592B2 (en)	1980-10-16	Diaper
AU1129676A (en)	1977-08-25	Absorbent article and method
IL50478A (en)	1980-01-31	Pyrimidine derivatives their manufacture and nematic mixtutures containing them
AU508123B2 (en)	1980-03-13	Heterocyclic substituted pyrimidones and pyrimidthiones
AU496854B2 (en)	1978-11-02	6-chloro-2(1-piperazinyl)-pyrazine and its n-oxide
AU1050876A (en)	1977-07-28	Benzotriazole derivatives
AU511834B2 (en)	1980-09-11	l-Benzazolylalky1-4-substituted piperazines
AU1418276A (en)	1977-11-24	Flame detection
AU507575B2 (en)	1980-02-21	Griseofulvin tablet
AU509392B2 (en)	1980-05-08	Pyridinecarboxamides
CA1036119A (en)	1978-08-08	Flame and heat-resistant luggage
AU512318B2 (en)	1980-10-02	Diaper
AU507798B2 (en)	1980-02-28	5, 6-alkylene-5, 6-dihyoro-pyrimidin-4(3h)-on derivatives
AU503883B2 (en)	1979-09-27	Aroyl-phenylindene and aroyl-phenylnapthalene derivatives
AU503926B2 (en)	1979-09-27	1, 3-BENZODITHIOLE-2-ONE (and 2-THIONIC) DERIVATIVES
AU501558B2 (en)	1979-06-21	Emulsified gluten
SU640728A1 (en)	1979-01-05	Animal-killing and blood-collecting apparatus
AU1525676A (en)	1978-01-05	Quinoxaline derivatives
GR59830B (en)	1978-03-04	5-substituted sh-dibenzo(b-f)-azepin derivatives and process for the preparation the same
AU503505B2 (en)	1979-09-06	13-ethynyl and 13-halovinyl steroids
AU2538977A (en)	1978-11-30	Quinoxalines
SG13084G (en)	1985-02-15	Pyrimidone and thiopyrimidone derivatives
AU497882B2 (en)	1979-01-18	B-phenyl-4-piperidinores and dihydropyridinones
AU503819B2 (en)	1979-09-20	Desoxystreptamine derivative and salts
CA1013502A (en)	1977-07-12	Adjustable pants