RU2031661C1 - Agent for treatment of wounds and for rendering first medical aid - Google Patents
Agent for treatment of wounds and for rendering first medical aid Download PDFInfo
- Publication number
- RU2031661C1 RU2031661C1 RU93035980/14A RU93035980A RU2031661C1 RU 2031661 C1 RU2031661 C1 RU 2031661C1 RU 93035980/14 A RU93035980/14 A RU 93035980/14A RU 93035980 A RU93035980 A RU 93035980A RU 2031661 C1 RU2031661 C1 RU 2031661C1
- Authority
- RU
- Russia
- Prior art keywords
- agent
- sorbent
- treatment
- medical
- fiber
- Prior art date
Links
- 206010052428 Wound Diseases 0.000 title description 8
- 208000027418 Wounds and injury Diseases 0.000 title description 7
- 238000009877 rendering Methods 0.000 title 1
- 239000002594 sorbent Substances 0.000 claims abstract description 8
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 4
- 150000004676 glycans Chemical class 0.000 claims abstract description 3
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 3
- 239000005017 polysaccharide Substances 0.000 claims abstract description 3
- 239000000835 fiber Substances 0.000 claims abstract 3
- 239000000843 powder Substances 0.000 claims abstract 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract 2
- 102000008186 Collagen Human genes 0.000 claims abstract 2
- 108010035532 Collagen Proteins 0.000 claims abstract 2
- 229920000954 Polyglycolide Polymers 0.000 claims abstract 2
- 229940072056 alginate Drugs 0.000 claims abstract 2
- 229920000615 alginic acid Polymers 0.000 claims abstract 2
- 235000010443 alginic acid Nutrition 0.000 claims abstract 2
- 229920003086 cellulose ether Polymers 0.000 claims abstract 2
- 229920001436 collagen Polymers 0.000 claims abstract 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract 2
- 229920000058 polyacrylate Polymers 0.000 claims abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 229920001222 biopolymer Polymers 0.000 claims 2
- 229920001059 synthetic polymer Polymers 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- -1 polyvinylcaprolactam Polymers 0.000 claims 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical compound [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007590 electrostatic spraying Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 description 1
- 229920003987 resole Polymers 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
FIELD: medicine. SUBSTANCE: proposed agent contains at least one layer being manufactured on the base of fiber and powder medical sorbent. Synthetic and biologic polymers, namely polylactides, polyglycolides, polyvinylpirrolidone, polyvinylcaprolactam, collagen, alginate, hitozan and others may be used as mentioned above fiber. Sorbent on the base of cross-linked polysaccharides, polyacrylates, cellulose ether and derivatives of polyvinyl alcohol may be used as mentioned above powder sorbent. Proposed agent has microfibrous structure which may be prepared directly on the surface of treated wound. Said agent also may be manufactured as multilayer one and may additionally contain medical preparations and proteolytic ferments. EFFECT: improves quality of agent. 3 cl, 1 tbl
Description
Изобретение относится к медицине, а именно к хирургии, и предназначено для лечения ран и оказания первой медицинской помощи. The invention relates to medicine, namely to surgery, and is intended for the treatment of wounds and first aid.
В практике лечения ран различной этиологии и генеза важное значение приобретают лекарственные формы типа медицинских сорбентов, которые обладают гемостатическим, дренирующим действием, обеспечивают отток из раны микробной флоры и благотворно влияют на местные иммунные процессы в ране. In the practice of treating wounds of various etiologies and genesis, dosage forms such as medical sorbents, which have a hemostatic, draining effect, provide an outflow from the wound of the microbial flora, and have beneficial effects on local immune processes in the wound, are of great importance.
Однако при использовании этих порошкообразных лекарственных форм определенную трудность доставляет дозировка их применения и неудобство фиксации на определенных участках тела. However, when using these powdered dosage forms, the dosage of their use and the inconvenience of fixation in certain parts of the body are of particular difficulty.
Известно перевязочное средство, выполненное из биодеструктируемой матрицы с введенным лекарственным препаратом, причем основа матрицы формируется из поливинилого спирта и поливинилпирролидона. A dressing is known made of a biodegradable matrix with an injected drug, the matrix base being formed from polyvinyl alcohol and polyvinylpyrrolidone.
Однако структурные особенности этой повязки не позволяют формировать ее многослойной, в том числе с защитным гидрофобным слоем, вводить в матрицу такие лекарственные формы, как медицинские сорбенты, что значительно снижает диапазон ее функциональных свойств. However, the structural features of this dressing do not allow it to be layered, including with a protective hydrophobic layer, and to introduce such dosage forms as medical sorbents into the matrix, which significantly reduces the range of its functional properties.
Целью изобретения является создание перевязочного средства с комплексом заданных свойств, в том числе гемостатических, сорбционных, защитных. The aim of the invention is the creation of a dressing with a set of desired properties, including hemostatic, sorption, protective.
Кроме того, целью изобретения является возможность формирования микроволокнистого перевязочного средства непосредственно на раневой поверхности методом электростатического напыления, регулирования композиции соответственно с характером травы (ожог, открытая рана) и течением раневого процесса. In addition, the aim of the invention is the possibility of forming a microfiber dressing directly on the wound surface by electrostatic spraying, adjusting the composition accordingly with the nature of the grass (burn, open wound) and the course of the wound process.
Использовали сшитый поливиниловый спирт (гелевин), выпускаемый по ТУ 6-05-05-279-88; поливинилпирролидон (ПВП), мол.м. 35000-50000; поливинилкапролактам (ПВК), мол.м. 40000-1000000; клей БФ-2 (15%-ный этанольный раствор поливинилбутираля и фенолформальдегидной смолы марки Резол в соотношении 1:1), выпускаемый по ГОСТУ 12-172-74; поли-d,l-лактид; хитозан, используемый в изобретении, представляет собой полисахарид, выделяемый из панциря камчатского краба. Used cross-linked polyvinyl alcohol (gelatin), manufactured according to TU 6-05-05-279-88; polyvinylpyrrolidone (PVP), mol.m. 35,000-50000; polyvinylcaprolactam (PVC), mol.m. 40000-1000000; BF-2 glue (15% ethanol solution of polyvinyl butyral and phenol-formaldehyde resin of the Resol brand in the ratio 1: 1), produced according to GOST 12-172-74; poly-d, l-lactide; chitosan used in the invention is a polysaccharide secreted from the crab shell.
Результаты испытаний данного средства (в различных модификациях) представлены в таблице. The test results of this tool (in various versions) are presented in the table.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93035980/14A RU2031661C1 (en) | 1993-07-16 | 1993-07-16 | Agent for treatment of wounds and for rendering first medical aid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU93035980/14A RU2031661C1 (en) | 1993-07-16 | 1993-07-16 | Agent for treatment of wounds and for rendering first medical aid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2031661C1 true RU2031661C1 (en) | 1995-03-27 |
| RU93035980A RU93035980A (en) | 1997-03-27 |
Family
ID=20144957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93035980/14A RU2031661C1 (en) | 1993-07-16 | 1993-07-16 | Agent for treatment of wounds and for rendering first medical aid |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2031661C1 (en) |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003267A1 (en) * | 1996-07-23 | 1998-01-29 | Electrosols Ltd. | A dispensing device and method for forming material |
| WO1998029142A1 (en) * | 1996-12-27 | 1998-07-09 | Everest-Todd Research And Development Limited | Improved surgical dressings and method of preparation |
| WO1999004738A1 (en) * | 1997-07-28 | 1999-02-04 | Tatiyana Sergeevna Vasilieva | Bandage cloth having an extended therapeutic action |
| RU2127609C1 (en) * | 1996-07-30 | 1999-03-20 | Игнатюк Татьяна Евгеньевна | Dressing material |
| RU2138294C1 (en) * | 1999-02-04 | 1999-09-27 | Гаврилюк Борис Карпович | Wound coating |
| RU2180856C1 (en) * | 2001-02-08 | 2002-03-27 | Гаврилюк Борис Карпович | Agent for wound healing |
| US6386195B1 (en) | 1992-12-22 | 2002-05-14 | Electrosols Ltd. | Dispensing device |
| WO2002040242A1 (en) * | 2000-11-17 | 2002-05-23 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen |
| US6592623B1 (en) | 1999-08-31 | 2003-07-15 | Virginia Commonwealth University Intellectual Property Foundation | Engineered muscle |
| WO2003063922A1 (en) * | 2002-01-31 | 2003-08-07 | Aesculap Ag & Co. Kg | Haemostatic agent containing polyvinyl alcohol and provision of the same for medical use |
| EP1435247A1 (en) * | 2003-01-06 | 2004-07-07 | Acordis Speciality Fibres Limited | Wound dressings comprising an alginate fabric and a superabsorbent |
| RU2240830C1 (en) * | 2003-12-26 | 2004-11-27 | ФГУП Государственный научно-исследовательский институт особо чистых биопрепаратов | Wound coating and method for its preparing |
| RU2245723C1 (en) * | 2003-07-24 | 2005-02-10 | Вилесов Александр Дмитриевич | Method and means for treating the cases of pyoinflammatory diseases of soft tissues |
| RU2268751C2 (en) * | 2003-04-25 | 2006-01-27 | Алексей Алексеевич Белов | Medical bandage containing proteolytic enzyme complex including collagenolytic proteases from crab hepatopancreas |
| US7193124B2 (en) | 1997-07-22 | 2007-03-20 | Battelle Memorial Institute | Method for forming material |
| US7309498B2 (en) | 2001-10-10 | 2007-12-18 | Belenkaya Bronislava G | Biodegradable absorbents and methods of preparation |
| WO2008010199A3 (en) * | 2006-07-18 | 2008-03-20 | Nanopeutics S R O | A nanofibre product |
| RU2323748C2 (en) * | 2006-02-21 | 2008-05-10 | Алексей Алексеевич Белов | Medical bandage containing exzyme complex from hepatopancreas of crab, and method of its preparation |
| US7374774B2 (en) | 1999-08-31 | 2008-05-20 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed material made by simultaneously electroprocessing a natural protein polymer and two synthetic polymers |
| US7615373B2 (en) | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
| US7759082B2 (en) | 1999-02-25 | 2010-07-20 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed fibrin-based matrices and tissues |
| RU2621114C2 (en) * | 2011-10-05 | 2017-05-31 | Юниверсити Оф Болтон | Polysaccharide fibers for wound dressings |
| RU2824974C2 (en) * | 2011-03-11 | 2024-08-19 | Медтрейд Продактс Лимитед | Haemostatic material |
-
1993
- 1993-07-16 RU RU93035980/14A patent/RU2031661C1/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Патент США N 4470962, кл. A 61L 15/03, 1984. * |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6386195B1 (en) | 1992-12-22 | 2002-05-14 | Electrosols Ltd. | Dispensing device |
| US6457470B1 (en) | 1992-12-22 | 2002-10-01 | Electrosols Ltd. | Dispensing device |
| WO1998003267A1 (en) * | 1996-07-23 | 1998-01-29 | Electrosols Ltd. | A dispensing device and method for forming material |
| RU2127609C1 (en) * | 1996-07-30 | 1999-03-20 | Игнатюк Татьяна Евгеньевна | Dressing material |
| WO1998029142A1 (en) * | 1996-12-27 | 1998-07-09 | Everest-Todd Research And Development Limited | Improved surgical dressings and method of preparation |
| US7193124B2 (en) | 1997-07-22 | 2007-03-20 | Battelle Memorial Institute | Method for forming material |
| WO1999004738A1 (en) * | 1997-07-28 | 1999-02-04 | Tatiyana Sergeevna Vasilieva | Bandage cloth having an extended therapeutic action |
| RU2138294C1 (en) * | 1999-02-04 | 1999-09-27 | Гаврилюк Борис Карпович | Wound coating |
| US7615373B2 (en) | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
| US7759082B2 (en) | 1999-02-25 | 2010-07-20 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed fibrin-based matrices and tissues |
| US6592623B1 (en) | 1999-08-31 | 2003-07-15 | Virginia Commonwealth University Intellectual Property Foundation | Engineered muscle |
| US7374774B2 (en) | 1999-08-31 | 2008-05-20 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed material made by simultaneously electroprocessing a natural protein polymer and two synthetic polymers |
| WO2002040242A1 (en) * | 2000-11-17 | 2002-05-23 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen |
| RU2180856C1 (en) * | 2001-02-08 | 2002-03-27 | Гаврилюк Борис Карпович | Agent for wound healing |
| US7309498B2 (en) | 2001-10-10 | 2007-12-18 | Belenkaya Bronislava G | Biodegradable absorbents and methods of preparation |
| WO2003063922A1 (en) * | 2002-01-31 | 2003-08-07 | Aesculap Ag & Co. Kg | Haemostatic agent containing polyvinyl alcohol and provision of the same for medical use |
| EP1435247B1 (en) * | 2003-01-06 | 2006-11-02 | Speciality Fibres and Materials Limited | Wound dressings comprising an alginate fabric and a superabsorbent |
| EP1435247A1 (en) * | 2003-01-06 | 2004-07-07 | Acordis Speciality Fibres Limited | Wound dressings comprising an alginate fabric and a superabsorbent |
| RU2268751C2 (en) * | 2003-04-25 | 2006-01-27 | Алексей Алексеевич Белов | Medical bandage containing proteolytic enzyme complex including collagenolytic proteases from crab hepatopancreas |
| RU2245723C1 (en) * | 2003-07-24 | 2005-02-10 | Вилесов Александр Дмитриевич | Method and means for treating the cases of pyoinflammatory diseases of soft tissues |
| RU2240830C1 (en) * | 2003-12-26 | 2004-11-27 | ФГУП Государственный научно-исследовательский институт особо чистых биопрепаратов | Wound coating and method for its preparing |
| RU2323748C2 (en) * | 2006-02-21 | 2008-05-10 | Алексей Алексеевич Белов | Medical bandage containing exzyme complex from hepatopancreas of crab, and method of its preparation |
| WO2008010199A3 (en) * | 2006-07-18 | 2008-03-20 | Nanopeutics S R O | A nanofibre product |
| RU2824974C2 (en) * | 2011-03-11 | 2024-08-19 | Медтрейд Продактс Лимитед | Haemostatic material |
| RU2621114C2 (en) * | 2011-10-05 | 2017-05-31 | Юниверсити Оф Болтон | Polysaccharide fibers for wound dressings |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20060717 |