RU2018125950A - Усиленная ферментация - Google Patents
Усиленная ферментация Download PDFInfo
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- RU2018125950A RU2018125950A RU2018125950A RU2018125950A RU2018125950A RU 2018125950 A RU2018125950 A RU 2018125950A RU 2018125950 A RU2018125950 A RU 2018125950A RU 2018125950 A RU2018125950 A RU 2018125950A RU 2018125950 A RU2018125950 A RU 2018125950A
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- 238000000855 fermentation Methods 0.000 title claims 5
- 230000004151 fermentation Effects 0.000 title claims 5
- 108010053835 Catalase Proteins 0.000 claims 16
- 102000016938 Catalase Human genes 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 244000005700 microbiome Species 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000001131 transforming effect Effects 0.000 claims 2
- 108700026220 vif Genes Proteins 0.000 claims 2
- 239000004382 Amylase Substances 0.000 claims 1
- 102000013142 Amylases Human genes 0.000 claims 1
- 108010065511 Amylases Proteins 0.000 claims 1
- 101710152845 Arabinogalactan endo-beta-1,4-galactanase Proteins 0.000 claims 1
- 102100032487 Beta-mannosidase Human genes 0.000 claims 1
- 108010059892 Cellulase Proteins 0.000 claims 1
- 101710121765 Endo-1,4-beta-xylanase Proteins 0.000 claims 1
- 101710147028 Endo-beta-1,4-galactanase Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 claims 1
- 108010029541 Laccase Proteins 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 108700020962 Peroxidase Proteins 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 108010059820 Polygalacturonase Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 108090000787 Subtilisin Proteins 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 108090000637 alpha-Amylases Proteins 0.000 claims 1
- 235000019418 amylase Nutrition 0.000 claims 1
- -1 arabinases Proteins 0.000 claims 1
- 108010055059 beta-Mannosidase Proteins 0.000 claims 1
- 108010089934 carbohydrase Proteins 0.000 claims 1
- 229940106157 cellulase Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108010005400 cutinase Proteins 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 108010093305 exopolygalacturonase Proteins 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/6408—Serine endopeptidases (3.4.21)
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- C12P21/00—Preparation of peptides or proteins
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
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- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01006—Catalase (1.11.1.6)
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- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
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- General Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Detergent Compositions (AREA)
Claims (21)
1. Способ защиты микробиологически полученного вещества от окисления, включающий
a) трансформацию микроорганизма, способного продуцировать указанное вещество, рекомбинантной нуклеиновой кислотой, содержащей ген каталазы, кодирующий полипептид, функционально связанный с одной или более контрольными последовательностями, которые управляют продуцированием полипептида в хозяине экспрессии, где полипептид представляет собой
i) каталазу, имеющую по меньшей мере 60% идентичность аминокислотной последовательности с SEQ ID NO. 1, или
ii) фрагмент каталазы согласно i), где фрагмент имеет каталазную активность,
или
обеспечение микроорганизма, содержащего в качестве гетерологичного гена, ген каталазы, кодирующий
i) каталазу, имеющую по меньшей мере 60% идентичность аминокислотной последовательности с SEQ ID NO. 1, или
ii) фрагмент каталазы согласно i), где фрагмент имеет каталазную активность,
b) культивирование микроорганизма при условиях, позволяющих экспрессию указанного гена каталазы.
2. Способ ферментации для получения продукта ферментации, включающий стадии
a) трансформации микроорганизма, способного продуцировать указанное вещество, рекомбинантной нуклеиновой кислотой, содержащей ген каталазы, кодирующий полипептид, функционально связанный с одной или более контрольными последовательностями, которые управляют продуцированием полипептида в хозяине экспрессии, где полипептид представляет собой
i) каталазу, имеющую по меньшей мере 60% идентичность аминокислотной последовательности с SEQ ID NO. 1, или
ii) фрагмент каталазы согласно i), где фрагмент имеет каталазную активность, или '
обеспечения микроорганизма, содержащего в качестве гетерологичного гена, ген каталазы, кодирующий
i) каталазу, имеющую по меньшей мере 60% идентичность аминокислотной последовательности с SEQ ID NO. 1, или
ii) фрагмент каталазы согласно i), где фрагмент имеет каталазную активность, и
b) культивирования микроорганизма при условиях, позволяющих экспрессию указанного гена каталазы и также позволяющих продуцирование указанного продукта ферментации.
3. Способ по п. 1 или 2, где полипептид содержит замещение, делецию и/или вставку в одном или более положениях.
4. Способ по п. 1 или 2, где контрольная последовательность представляет собой или содержит индуцируемый промотор, предпочтительно индуцируемый пероксидом водорода промотор.
5. Способ по п. 1 или 2, где нуклеиновая кислота представляет собой конструкцию нуклеиновой кислоты или экспрессионный вектор.
6. Способ по п. 1 или 2, где микробиологически получаемое вещество или продукт ферментации представляет собой белок, предпочтительно фермент, и предпочтительно выбрано из группы, состоящей из протеазы, амилазы, карбогидразы, липазы, целлюлазы, пуллуланазы, кутиназы, пектиназы, маннаназы, арабиназы, галактаназы, ксиланазы, оксидазы, например лакказы, пероксидазы, изомеразы, трансферазы, киназы и фосфатазы, где предпочтительными протеазами являются субтилизин протеаз.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15199815 | 2015-12-14 | ||
| EP15199815.0 | 2015-12-14 | ||
| PCT/EP2016/080171 WO2017102524A1 (en) | 2015-12-14 | 2016-12-08 | Enhanced fermentation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018125950A true RU2018125950A (ru) | 2020-01-16 |
Family
ID=55068759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018125950A RU2018125950A (ru) | 2015-12-14 | 2016-12-08 | Усиленная ферментация |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10676728B2 (ru) |
| EP (1) | EP3390621B1 (ru) |
| JP (1) | JP2018537108A (ru) |
| KR (1) | KR20180086210A (ru) |
| CN (1) | CN108463549A (ru) |
| BR (1) | BR112018011893A2 (ru) |
| CA (1) | CA3007307A1 (ru) |
| DK (1) | DK3390621T3 (ru) |
| MX (1) | MX382752B (ru) |
| RU (1) | RU2018125950A (ru) |
| WO (1) | WO2017102524A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107557438A (zh) * | 2017-10-12 | 2018-01-09 | 江苏省渔业技术推广中心 | 一种基于高通量测序检测青虾肠道乳酸菌的方法 |
| CN115369064B (zh) * | 2022-09-30 | 2023-07-07 | 海南师范大学 | 一种增强生防贝莱斯芽孢杆菌根际定殖和防效的多功能复合菌剂的开发和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7405081B2 (en) * | 2001-02-05 | 2008-07-29 | Pan Shen Q | Methods and kits for identifying scavengers of reactive oxygen species (ROS) |
| KR20040037009A (ko) * | 2002-10-25 | 2004-05-04 | (주) 피엘바이오 | 과산화수소수 분해 능력과 저항성이 이 뛰어난 신규미생물과 이들이 생산하는 카타라아제 |
| JP2005015415A (ja) * | 2003-06-27 | 2005-01-20 | Torisutaa:Kk | 毛髪用化粧料組成物及びその製造方法 |
| WO2010074972A1 (en) | 2008-12-15 | 2010-07-01 | Novozymes, Inc. | Polypeptides having catalase activity and polynucleotides encoding same |
| CN101525601A (zh) * | 2009-04-17 | 2009-09-09 | 江南大学 | 一种添加乙醇和/或过氧化氢胁迫枯草芽孢杆菌发酵产过氧化氢酶的方法 |
| US9637725B2 (en) * | 2011-12-19 | 2017-05-02 | Novozymes Inc. | Polypeptides having catalase activity and polynucleotides encoding same |
-
2016
- 2016-12-08 RU RU2018125950A patent/RU2018125950A/ru not_active Application Discontinuation
- 2016-12-08 MX MX2018007327A patent/MX382752B/es unknown
- 2016-12-08 EP EP16809011.6A patent/EP3390621B1/en active Active
- 2016-12-08 CN CN201680073043.XA patent/CN108463549A/zh active Pending
- 2016-12-08 CA CA3007307A patent/CA3007307A1/en not_active Abandoned
- 2016-12-08 BR BR112018011893-1A patent/BR112018011893A2/pt not_active IP Right Cessation
- 2016-12-08 US US16/062,289 patent/US10676728B2/en active Active
- 2016-12-08 JP JP2018530789A patent/JP2018537108A/ja active Pending
- 2016-12-08 KR KR1020187016599A patent/KR20180086210A/ko not_active Withdrawn
- 2016-12-08 DK DK16809011.6T patent/DK3390621T3/da active
- 2016-12-08 WO PCT/EP2016/080171 patent/WO2017102524A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180086210A (ko) | 2018-07-30 |
| EP3390621A1 (en) | 2018-10-24 |
| US10676728B2 (en) | 2020-06-09 |
| JP2018537108A (ja) | 2018-12-20 |
| CN108463549A (zh) | 2018-08-28 |
| MX2018007327A (es) | 2018-08-24 |
| US20180371444A1 (en) | 2018-12-27 |
| CA3007307A1 (en) | 2017-06-22 |
| BR112018011893A2 (pt) | 2018-12-04 |
| EP3390621B1 (en) | 2021-02-17 |
| DK3390621T3 (da) | 2021-05-10 |
| MX382752B (es) | 2025-03-13 |
| WO2017102524A1 (en) | 2017-06-22 |
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