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Publication number
RU2018141360A3
RU2018141360A3 RU2018141360A RU2018141360A RU2018141360A3 RU 2018141360 A3 RU2018141360 A3 RU 2018141360A3 RU 2018141360 A RU2018141360 A RU 2018141360A RU 2018141360 A RU2018141360 A RU 2018141360A RU 2018141360 A3 RU2018141360 A3 RU 2018141360A3
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RU
Russia
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RU2018141360A
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RU2018141360A (ru
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Publication of RU2018141360A3 publication Critical patent/RU2018141360A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RU2018141360A 2016-05-02 2017-05-02 Contorsbody - одноцепочечный связывающий мишень агент RU2018141360A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16167920.4 2016-05-02
EP16167920 2016-05-02
PCT/EP2017/060354 WO2017191101A1 (en) 2016-05-02 2017-05-02 The contorsbody - a single chain target binder

Publications (2)

Publication Number Publication Date
RU2018141360A RU2018141360A (ru) 2020-06-03
RU2018141360A3 true RU2018141360A3 (ru) 2020-10-16

Family

ID=56008478

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018141360A RU2018141360A (ru) 2016-05-02 2017-05-02 Contorsbody - одноцепочечный связывающий мишень агент

Country Status (18)

Country Link
US (3) US20190389971A1 (ru)
EP (2) EP3889175A1 (ru)
JP (2) JP6675017B2 (ru)
KR (1) KR102523682B1 (ru)
CN (1) CN109071635B (ru)
AU (1) AU2017259869A1 (ru)
BR (1) BR112018069890A2 (ru)
CA (1) CA3019524A1 (ru)
CL (1) CL2018003007A1 (ru)
CR (1) CR20180509A (ru)
IL (1) IL262523A (ru)
MA (1) MA56474A (ru)
MX (1) MX2018013342A (ru)
PE (1) PE20181890A1 (ru)
RU (1) RU2018141360A (ru)
SG (1) SG11201809620UA (ru)
UA (1) UA123323C2 (ru)
WO (1) WO2017191101A1 (ru)

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US11453713B2 (en) * 2014-12-05 2022-09-27 Xyphos Biosciences Inc. Insertable variable fragments of antibodies and modified A1-A2 domains of NKG2D ligands
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CA3078676A1 (en) 2017-10-30 2019-05-09 F. Hoffmann-La Roche Ag Method for in vivo generation of multispecific antibodies from monospecific antibodies
MX2020004196A (es) * 2017-11-01 2020-11-09 Hoffmann La Roche Trifab-contorsbody.
CN111182944B (zh) 2017-11-01 2022-11-22 豪夫迈·罗氏有限公司 双特异性2+1 Contorsbody
EP3704150A1 (en) 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG The compbody - a multivalent target binder
EP3735254A4 (en) 2018-01-05 2021-11-03 City of Hope MULTI-SPECIFIC LIGAND BINDERS
EP3831854A4 (en) 2018-08-03 2022-05-04 Chugai Seiyaku Kabushiki Kaisha ANTIGEN-BINDING MOLECULE CONTAINING TWO ANTIGEN-BINDING DOMAINS LINKED TO EACH OTHER
BR112022012317A2 (pt) 2020-02-05 2022-09-13 Chugai Pharmaceutical Co Ltd Métodos para a produção e/ou enriquecimento de moléculas de ligação a antígeno recombinantes
EP4126969A4 (en) 2020-03-31 2024-05-29 Chugai Seiyaku Kabushiki Kaisha DLL3-TARGETED MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF
US20230265152A1 (en) * 2020-07-02 2023-08-24 Sanofi Glp-1r agonist / fgf21 fusion proteins
KR20220104423A (ko) 2021-01-18 2022-07-26 성기봉 페달엔진자전거(실용모델)
KR102604934B1 (ko) * 2021-10-27 2023-11-23 주식회사 베르티스 피분석물을 검출 또는 측정하기 위한 조성물
KR20240062555A (ko) 2022-11-02 2024-05-09 성기봉 회전 기어 방식의 적용 도르레

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CL2018003007A1 (es) 2019-02-08
AU2017259869A1 (en) 2018-09-27
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RU2018141360A (ru) 2020-06-03
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