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PE20181890A1 - Contorsbody - un ligante de diana monocatenario - Google Patents

Contorsbody - un ligante de diana monocatenario

Info

Publication number
PE20181890A1
PE20181890A1 PE2018002250A PE2018002250A PE20181890A1 PE 20181890 A1 PE20181890 A1 PE 20181890A1 PE 2018002250 A PE2018002250 A PE 2018002250A PE 2018002250 A PE2018002250 A PE 2018002250A PE 20181890 A1 PE20181890 A1 PE 20181890A1
Authority
PE
Peru
Prior art keywords
domain
fusion polypeptide
polypeptide
binding domain
spacer
Prior art date
Application number
PE2018002250A
Other languages
English (en)
Inventor
Stefan Dengl
Guy Georges
Friederike Hesse
Sabine Imhof-Jung
Josef Platzer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20181890A1 publication Critical patent/PE20181890A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Referido a un polipeptido de fusion dimerico que comprende una primera parte de un dominio de union, una segunda parte de un dominio de union y un dominio espaciador, en el que el domino espaciador es un polipeptido y comprende por lo menos 25 residuos aminoacidos, la primera parte del dominio de union es un polipeptido que se fusiona, directamente o mediante un primer conector, con el extremo N-terminal del dominio espaciador, la segunda parte del dominio de union es un polipeptido que se fusiona, directamente o mediante un segundo conector, con el extremo C-terminal del dominio espaciador, la primera parte del dominio de union y la segunda parte del dominio de union del mismo polipeptido de fusion monocatenario se asocian y forman un sitio de union funcional que se une especificamente a la diana. El polipeptido de fusion dimerico comprende dos polipeptidos de fusion identicos o diferentes, en el que el dominio espaciador del primer polipeptido de fusion se conjuga covalentemente con el dominio espaciador del segundo polipeptido de fusion. Tambien se refiere a una pareja de acidos nucleicos aislados que conjuntamente codifican el polipeptido de fusion dimerico y un metodo para producir el polipeptido de fusion
PE2018002250A 2016-05-02 2017-05-02 Contorsbody - un ligante de diana monocatenario PE20181890A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16167920 2016-05-02

Publications (1)

Publication Number Publication Date
PE20181890A1 true PE20181890A1 (es) 2018-12-11

Family

ID=56008478

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018002250A PE20181890A1 (es) 2016-05-02 2017-05-02 Contorsbody - un ligante de diana monocatenario

Country Status (18)

Country Link
US (3) US20190389971A1 (es)
EP (2) EP3452502B1 (es)
JP (2) JP6675017B2 (es)
KR (1) KR102523682B1 (es)
CN (1) CN109071635B (es)
AU (1) AU2017259869A1 (es)
BR (1) BR112018069890A2 (es)
CA (1) CA3019524A1 (es)
CL (1) CL2018003007A1 (es)
CR (1) CR20180509A (es)
IL (1) IL262523A (es)
MA (1) MA56474A (es)
MX (1) MX2018013342A (es)
PE (1) PE20181890A1 (es)
RU (1) RU2018141360A (es)
SG (1) SG11201809620UA (es)
UA (1) UA123323C2 (es)
WO (1) WO2017191101A1 (es)

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CN111246885B (zh) 2017-10-20 2024-06-11 豪夫迈·罗氏有限公司 从单特异性抗体生成多特异性抗体的方法
AU2018358883B2 (en) 2017-10-30 2025-09-25 F. Hoffmann-La Roche Ag Method for in vivo generation of multispecific antibodies from monospecific antibodies
BR112020006443A2 (pt) 2017-11-01 2020-09-29 F. Hoffmann-La Roche Ag anticorpos biespecíficos, ácido nucleico isolado, vetor ou célula hospedeira, método para produzir um anticorpo biespecífico e para tratar um indivíduo, composição farmacêutica e uso do anticorpo
CA3079129C (en) * 2017-11-01 2023-02-28 F. Hoffmann-La Roche Ag Trifab-contorsbody
EP3704150A1 (en) 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG The compbody - a multivalent target binder
CN111836630A (zh) 2018-01-05 2020-10-27 希望之城 多特异性配体结合物
CA3106829A1 (en) 2018-08-03 2020-02-06 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing two antigen-binding domains that are linked to each other
CN113260634A (zh) 2018-09-28 2021-08-13 中外制药株式会社 包含改变的抗体可变区的抗原结合分子
CA3168510A1 (en) 2020-02-05 2021-08-12 Chugai Seiyaku Kabushiki Kaisha Methods for producing and/or enriching recombinant antigen-binding molecules
MX2022012091A (es) 2020-03-31 2022-10-13 Chugai Pharmaceutical Co Ltd Moleculas de union al antigeno multiespecificas dirigidas a ligando de tipo delta 3 (dll3) y sus usos.
JP2023540663A (ja) * 2020-07-02 2023-09-26 サノフイ Ｇｌｐ－１ｒアゴニスト／ｆｇｆ２１融合タンパク質
KR20220104423A (ko) 2021-01-18 2022-07-26 성기봉 페달엔진자전거(실용모델)
KR102604934B1 (ko) * 2021-10-27 2023-11-23 주식회사 베르티스 피분석물을 검출 또는 측정하기 위한 조성물
KR20240062555A (ko) 2022-11-02 2024-05-09 성기봉 회전 기어 방식의 적용 도르레

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