RU2016129283A - Ras opposite (rop) и родственные молекулы нуклеиновых кислот, которые придают устойчивость жесткокрылым и полужесткокрылым насекомым-вредителям - Google Patents
Ras opposite (rop) и родственные молекулы нуклеиновых кислот, которые придают устойчивость жесткокрылым и полужесткокрылым насекомым-вредителям Download PDFInfo
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
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- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
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- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
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- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
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Claims (29)
1. РНК, содержащая по меньшей мере 15 смежных нуклеотидов, обладающая, по всей ее длине по меньшей мере 80% идентичностью с последовательностью ДНК, кодирующей по меньшей мере фрагмент Ras opposite (ROP).
2. РНК по п. 1, где РНК включает двухцепочечную РНК (дцРНК).
3. РНК по п. 1, где нуклеиновая кислота дополнительно содержит последовательность, комплементарную по меньшей мере 15 смежным нуклеотидам.
4. РНК по п. 2, где дцРНК содержит структуру стебель-петля.
5. РНК по п. 4, где по меньшей мере участок структуры стебель-петля экспрессированной РНК образуется связыванием по меньшей мере 15 смежных нуклеотидов с последовательностью, комплементарной по меньшей мере 15 смежным нуклеотидам.
6. РНК по п. 1, где РНК представляет iРНК.
7. РНК по п. 6, где iРНК представляет дцРНК, миРНК, shРНК, микроРНК или hpРНК.
8. РНК по п. 1, где РНК включает аналог нуклеиновой кислоты.
9. РНК по п. 1, где РНК способна ингибировать экспрессию ROP у жесткокрылых или полужесткокрылых насекомых.
10. РНК по п. 9, где ингибирование экспрессии ROP происходит посредством посттранскрипционного сайленсинга генов.
11. РНК по п. 1, где ROP представляет ROP Diabrotica virgifera virgifera или ROP Euschistus heros или ROP Meligethes aeneus.
12. РНК по п. 1, где ROP кодируется SEQ ID NO: 1, SEQ ID NO: 115, SEQ ID NO: 120, SEQ ID NO: 122, SEQ ID NO: 124, SEQ ID NO: 126, SEQ ID NO: 131 или SEQ ID NO: 133.
13. РНК по п. 1, где последовательность, кодирующая, по меньшей мере, фрагмент ROP, выбрана из группы, состоящей из SEQ ID NO: 3, 4, 114, 119 и 128.
14. РНК по п. 1, где по меньшей мере 15 смежных нуклеотидов выбраны из группы, состоящей из 19, 21, 25, 29, 30, 40, 50, 70 и 100 смежных нуклеотидов.
15. РНК по п. 1, где по меньшей мере 80% идентичность выбрана из группы, состоящей из 85%, 90%, 95% и 100% идентичности.
16. Растительная клетка, содержащая РНК по п. 1.
17. Растительная клетка по п. 16, где растение выбрано из группы, состоящей из.
18. Нуклеиновая кислота, кодирующая РНК по п. 1.
19. Нуклеиновая кислота по п. 18, где нуклеиновая кислота содержит последовательность, выбранную из группы, состоящей из SEQ ID NO: 3, 4, 114, 119 и 128.
20. Нуклеиновая кислота по п. 18, где нуклеиновая кислота операбельно связана с промотором.
21. Вектор, содержащий нуклеиновую кислоту по п. 17.
22. Растительная клетка, содержащая нуклеиновую кислоту по п. 17.
23. Растительная клетка по п. 16, где растение выбрано из группы, состоящей из.
24. Растительная клетка по п. 16, где нуклеиновая кислота по п. 17 интегрирована в геном растительной клетки.
25. Способ контроля насекомых-вредителей, где указанный способ включает экспрессию нуклеиновой кислоты по п. 18, в растении.
26. Способ по п. 25, где насекомое-вредитель представляет жесткокрылое или полужесткокрылое насекомое.
27. Способ по п. 25, где насекомое-вредитель выбрано из группы, состоящей из Diabrotica virgifera virgifera, Diabrotica barberi, Diabrotica undecimpunctata howardi, Diabrotica virgifera zeae, Diabrotica balteata, Diabrotica undecimpunctata tenella, Diabrotica undecimpunctata undecimpunctata, Euschistus heros, Nezara viridula, Piezodorus guildinii, Halyomorpha Halys, Acrosternum hilare, Euschistus servus и Meligethes aeneus.
28. Источник корма для насекомых-вредителей, содержащей РНК по п. 1.
29. Способ борьбы с насекомыми-вредителями, где указанный способ включает скармливание насекомому-вредителю источника корма по п. 28.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919322P | 2013-12-20 | 2013-12-20 | |
| US61/919,322 | 2013-12-20 | ||
| PCT/US2014/071628 WO2015095774A1 (en) | 2013-12-20 | 2014-12-19 | Ras opposite (rop) and related nucleic acid molecules that confer resistance to coleopteran and/or hemipteran pests |
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| Publication Number | Publication Date |
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| RU2016129283A true RU2016129283A (ru) | 2018-01-25 |
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| RU2016129283A RU2016129283A (ru) | 2013-12-20 | 2014-12-19 | Ras opposite (rop) и родственные молекулы нуклеиновых кислот, которые придают устойчивость жесткокрылым и полужесткокрылым насекомым-вредителям |
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| US (2) | US10647994B2 (ru) |
| EP (1) | EP3082404A4 (ru) |
| JP (1) | JP2017510245A (ru) |
| KR (1) | KR20160093727A (ru) |
| CN (2) | CN111088255A (ru) |
| AP (1) | AP2016009318A0 (ru) |
| AR (1) | AR098918A1 (ru) |
| AU (1) | AU2014368952B2 (ru) |
| BR (1) | BR102014031844A2 (ru) |
| CA (1) | CA2933362C (ru) |
| CL (1) | CL2016001533A1 (ru) |
| IL (1) | IL246283A0 (ru) |
| MX (1) | MX2016008261A (ru) |
| PH (1) | PH12016501191A1 (ru) |
| RU (1) | RU2016129283A (ru) |
| UY (1) | UY35912A (ru) |
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| WO2017136331A1 (en) * | 2016-02-03 | 2017-08-10 | Dow Agrosciences Llc | Gawky (gw) nucleic acid molecules to control insect pests |
| CA3013199A1 (en) * | 2016-02-03 | 2017-08-10 | Dow Agrosciences Llc | Rpb7 nucleic acid molecules to control insect pests |
| EP3342780A1 (en) | 2016-12-30 | 2018-07-04 | Dow AgroSciences LLC | Pre-mrna processing factor 8 (prp8) nucleic acid molecules to control insect pests |
| CN111132552A (zh) * | 2017-02-24 | 2020-05-08 | 旗舰创业创新五公司 | 用于调节内共生体的组合物和相关方法 |
| CN110662840A (zh) * | 2017-03-21 | 2020-01-07 | 美国陶氏益农公司 | 突触融合蛋白7核酸分子用来控制鞘翅目和半翅目害虫 |
| CN107858405B (zh) * | 2017-10-12 | 2021-09-24 | 华南农业大学 | 一种测定外源dsRNA对瓢虫毒性影响的方法 |
| GB201719680D0 (en) | 2017-11-27 | 2018-01-10 | Devgen Nv | Improvements in or relating to gene silencing |
| WO2020081486A1 (en) * | 2018-10-15 | 2020-04-23 | Greenlight Biosciences, Inc. | Control of insect infestation |
| CN112640774B (zh) * | 2021-01-10 | 2023-04-25 | 贵州省旱粮研究所 | 一种阶梯式改良策略选育温热玉米自交系方法 |
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-
2014
- 2014-12-18 BR BR102014031844A patent/BR102014031844A2/pt not_active Application Discontinuation
- 2014-12-19 EP EP14870760.7A patent/EP3082404A4/en not_active Withdrawn
- 2014-12-19 CN CN201911165408.3A patent/CN111088255A/zh active Pending
- 2014-12-19 MX MX2016008261A patent/MX2016008261A/es unknown
- 2014-12-19 AP AP2016009318A patent/AP2016009318A0/en unknown
- 2014-12-19 AU AU2014368952A patent/AU2014368952B2/en not_active Ceased
- 2014-12-19 JP JP2016541168A patent/JP2017510245A/ja active Pending
- 2014-12-19 WO PCT/US2014/071628 patent/WO2015095774A1/en not_active Ceased
- 2014-12-19 RU RU2016129283A patent/RU2016129283A/ru unknown
- 2014-12-19 US US14/577,811 patent/US10647994B2/en active Active
- 2014-12-19 CN CN201480075840.2A patent/CN106028796A/zh active Pending
- 2014-12-19 CA CA2933362A patent/CA2933362C/en active Active
- 2014-12-19 KR KR1020167019581A patent/KR20160093727A/ko not_active Withdrawn
- 2014-12-22 AR ARP140104862A patent/AR098918A1/es not_active Application Discontinuation
- 2014-12-22 UY UY0001035912A patent/UY35912A/es not_active Application Discontinuation
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2016
- 2016-06-16 IL IL246283A patent/IL246283A0/en unknown
- 2016-06-16 CL CL2016001533A patent/CL2016001533A1/es unknown
- 2016-06-17 PH PH12016501191A patent/PH12016501191A1/en unknown
- 2016-07-01 ZA ZA2016/04497A patent/ZA201604497B/en unknown
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| IL246283A0 (en) | 2016-07-31 |
| KR20160093727A (ko) | 2016-08-08 |
| US20150176025A1 (en) | 2015-06-25 |
| PH12016501191A1 (en) | 2016-07-25 |
| EP3082404A1 (en) | 2016-10-26 |
| AR098918A1 (es) | 2016-06-22 |
| WO2015095774A1 (en) | 2015-06-25 |
| US10647994B2 (en) | 2020-05-12 |
| AU2014368952A1 (en) | 2016-07-07 |
| ZA201604497B (en) | 2017-09-27 |
| CL2016001533A1 (es) | 2016-10-28 |
| UY35912A (es) | 2015-07-31 |
| AU2014368952B2 (en) | 2017-12-21 |
| MX2016008261A (es) | 2017-05-09 |
| BR102014031844A2 (pt) | 2015-10-06 |
| CA2933362C (en) | 2022-08-30 |
| AP2016009318A0 (en) | 2016-07-31 |
| JP2017510245A (ja) | 2017-04-13 |
| US20210115467A1 (en) | 2021-04-22 |
| CN111088255A (zh) | 2020-05-01 |
| CA2933362A1 (en) | 2015-06-25 |
| EP3082404A4 (en) | 2017-05-31 |
| CN106028796A (zh) | 2016-10-12 |
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