RU2016145066A - Композиция для предотвращения или лечения жировых болезней печени - Google Patents
Композиция для предотвращения или лечения жировых болезней печени Download PDFInfo
- Publication number
- RU2016145066A RU2016145066A RU2016145066A RU2016145066A RU2016145066A RU 2016145066 A RU2016145066 A RU 2016145066A RU 2016145066 A RU2016145066 A RU 2016145066A RU 2016145066 A RU2016145066 A RU 2016145066A RU 2016145066 A RU2016145066 A RU 2016145066A
- Authority
- RU
- Russia
- Prior art keywords
- liver
- pharmaceutical composition
- fatty
- fatty liver
- prevention
- Prior art date
Links
- 210000004185 liver Anatomy 0.000 title claims 4
- 208000010706 fatty liver disease Diseases 0.000 title claims 3
- 230000002265 prevention Effects 0.000 title claims 2
- 208000004930 Fatty Liver Diseases 0.000 title 1
- 206010019708 Hepatic steatosis Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 231100000240 steatosis hepatitis Toxicity 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
- 230000007850 degeneration Effects 0.000 claims 2
- -1 tetrahydropyran-4-yl Chemical group 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 230000036542 oxidative stress Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (6)
1. Фармацевтическая комопзиция для предотвращения или лечения жировой болезни печени, которая содержит (тетрагидропиран-4-ил)-[2-фенил-5-(1,1-диоксо-тиоморфолин-4-ил)метил-1H-индол-7-ил]амин или его фармацевтически приемлемую соль, как активный ингредиент.
2. Фармацевтическая композиция по п. 1, в которой жировая болезнь печени является неалкогольной жировой болезнью печени.
3. Фармацевтическая композиция по п. 2, в которой неалкогольной жировой болезнью печени является неалкогольный стеатогепатит.
4. Фармацевтическая композиция по п. 2, в которой неалкогольная жировая болезнь печени является простой жировой дистрофией печени.
5. Фармацевтическая композиция по п. 1, которая ингибирует накопление жира в печени.
6. Фармацевтическая композиция по п. 1, которая ингибирует воспалительный процесс и фиброз печени, ингибируя оксидативный стресс или воспалительные цитокины, обусловленные жировой дистрофией печени.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140046904 | 2014-04-18 | ||
| KR10-2014-0046904 | 2014-04-18 | ||
| PCT/KR2015/003869 WO2015160213A1 (ko) | 2014-04-18 | 2015-04-17 | 지방간 질환의 예방 또는 치료용 조성물 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016145066A true RU2016145066A (ru) | 2018-05-20 |
| RU2016145066A3 RU2016145066A3 (ru) | 2018-05-20 |
| RU2664696C2 RU2664696C2 (ru) | 2018-08-21 |
Family
ID=54324325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016145066A RU2664696C2 (ru) | 2014-04-18 | 2015-04-17 | Композиция для предотвращения или лечения жировых болезней печени |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9814726B2 (ru) |
| EP (1) | EP3132795B1 (ru) |
| JP (1) | JP6490097B2 (ru) |
| KR (1) | KR102006247B1 (ru) |
| CN (2) | CN106659722A (ru) |
| BR (1) | BR112016024020A8 (ru) |
| ES (1) | ES2851006T3 (ru) |
| MX (1) | MX369571B (ru) |
| RU (1) | RU2664696C2 (ru) |
| WO (1) | WO2015160213A1 (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20241643T1 (hr) * | 2017-12-06 | 2025-02-14 | Basf As | Derivati masnih kiselina za liječenje nealkoholnog steatohepatitisa |
| US20230015691A1 (en) * | 2019-11-26 | 2023-01-19 | Mitsubishi Tanabe Pharma Corporation | Prophylactic or therapeutic agent for non-alcoholic steatohepatitis in humans |
| US20230148589A1 (en) * | 2020-03-31 | 2023-05-18 | Lg Chem, Ltd. | Composition for protecting islet transplantation |
| WO2022039506A1 (ko) | 2020-08-19 | 2022-02-24 | 주식회사 미토이뮨테라퓨틱스 | Ｍabc-r 감염에 의한 병적 염증 치료제로서의 미토콘드리아 표적 항산화제 |
| CN114470217B (zh) * | 2020-11-24 | 2023-06-20 | 深圳微芯生物科技股份有限公司 | 预防和治疗代谢异常或炎症引起的组织损伤的药物组合物 |
| EP4324829A4 (en) | 2021-04-12 | 2025-04-23 | MitoImmune Therapeutics Inc. | 5-[(1,1-DIOXIDO-4-THIOMORPHOLINYL)METHYL]-2-PHENYL-N-(TETRAHYDRO-2H-PYRAN-4-YL)-1H-INDOL-7-AMINE SULFATE AND A NEW CRYSTALLINE FORM THEREOF |
| CN117136185A (zh) | 2021-04-12 | 2023-11-28 | 水疗免疫疗法有限公司 | 5-[（1,1-二氧化-4-硫代吗啉基）甲基]-2-苯基-n-（四氢-2h-吡喃-4-基）-1h-吲哚-7-胺的新晶型 |
| US20250289785A1 (en) | 2021-08-02 | 2025-09-18 | Mitoimmune Therapeutics Inc. | Indole derivative, method for preparing same, and use thereof |
| CN117794917A (zh) | 2021-08-02 | 2024-03-29 | 水疗免疫疗法有限公司 | 新型吲哚衍生物、包含其的药物组合物及其用途 |
| WO2025188159A1 (ko) * | 2024-03-06 | 2025-09-12 | 주식회사 미토이뮨테라퓨틱스 | 신장 섬유증 예방 또는 치료용 약학적 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8957070B2 (en) | 2005-04-20 | 2015-02-17 | Takeda Pharmaceutical Company Limited | Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity |
| US20070161578A1 (en) * | 2005-12-21 | 2007-07-12 | Hwa Joyce J | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist |
| BRPI0815154B1 (pt) * | 2007-08-17 | 2024-01-30 | Lg Chem, Ltd | Compostos de indol, composição, e, método de preparação da mesma |
| KR20100091219A (ko) * | 2007-11-30 | 2010-08-18 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 시스테아민 산물을 이용한 비-알코올성 지방성간염(ｎａｓｈ) 치료 방법 |
| KR101098583B1 (ko) * | 2008-01-04 | 2011-12-26 | 주식회사 엘지생명과학 | 세포, 조직 및 장기 보존 효과를 갖는 인돌 및 인다졸 유도체 |
| PL2460403T3 (pl) * | 2009-07-31 | 2019-11-29 | Smc Global Asset Inc | Mysi model stłuszczeniowego zapalenia wątroby-raka wątroby |
| TWI535440B (zh) * | 2009-10-26 | 2016-06-01 | Ｌｇ生命科學有限公司 | 包括吲哚化合物之醫藥組成物 |
| KR101404151B1 (ko) | 2011-11-25 | 2014-06-05 | 가톨릭대학교 산학협력단 | 안과 질환의 예방 및 치료용 약학 조성물 |
| KR20130087283A (ko) * | 2012-01-27 | 2013-08-06 | 재단법인 의약바이오컨버젼스연구단 | 인돌 및 인다졸 유도체를 유효성분으로 포함하는 암 전이 억제용 조성물 |
| KR101413207B1 (ko) | 2012-06-14 | 2014-07-01 | 부산대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 및 건강기능식품 |
-
2015
- 2015-04-17 KR KR1020150054307A patent/KR102006247B1/ko active Active
- 2015-04-17 RU RU2016145066A patent/RU2664696C2/ru active
- 2015-04-17 EP EP15779540.2A patent/EP3132795B1/en active Active
- 2015-04-17 ES ES15779540T patent/ES2851006T3/es active Active
- 2015-04-17 US US15/304,715 patent/US9814726B2/en active Active
- 2015-04-17 CN CN201580030073.8A patent/CN106659722A/zh active Pending
- 2015-04-17 MX MX2016013575A patent/MX369571B/es active IP Right Grant
- 2015-04-17 WO PCT/KR2015/003869 patent/WO2015160213A1/ko not_active Ceased
- 2015-04-17 BR BR112016024020A patent/BR112016024020A8/pt not_active Application Discontinuation
- 2015-04-17 CN CN202111251896.7A patent/CN113967215A/zh active Pending
- 2015-04-17 JP JP2016563061A patent/JP6490097B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2664696C2 (ru) | 2018-08-21 |
| ES2851006T3 (es) | 2021-09-02 |
| EP3132795A1 (en) | 2017-02-22 |
| BR112016024020A2 (pt) | 2017-08-15 |
| CN113967215A (zh) | 2022-01-25 |
| KR20150120877A (ko) | 2015-10-28 |
| RU2016145066A3 (ru) | 2018-05-20 |
| WO2015160213A1 (ko) | 2015-10-22 |
| JP2017511373A (ja) | 2017-04-20 |
| US20170035776A1 (en) | 2017-02-09 |
| EP3132795A4 (en) | 2017-11-29 |
| MX369571B (es) | 2019-11-12 |
| KR102006247B1 (ko) | 2019-08-01 |
| CN106659722A (zh) | 2017-05-10 |
| MX2016013575A (es) | 2017-06-08 |
| US9814726B2 (en) | 2017-11-14 |
| BR112016024020A8 (pt) | 2021-07-20 |
| EP3132795B1 (en) | 2020-10-21 |
| JP6490097B2 (ja) | 2019-03-27 |
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