RU2015110511A - PARTICULAR DERIVATIVE ACID PARTICLES FOR DIRECT PRESS - Google Patents
PARTICULAR DERIVATIVE ACID PARTICLES FOR DIRECT PRESS Download PDFInfo
- Publication number
- RU2015110511A RU2015110511A RU2015110511A RU2015110511A RU2015110511A RU 2015110511 A RU2015110511 A RU 2015110511A RU 2015110511 A RU2015110511 A RU 2015110511A RU 2015110511 A RU2015110511 A RU 2015110511A RU 2015110511 A RU2015110511 A RU 2015110511A
- Authority
- RU
- Russia
- Prior art keywords
- propionic acid
- wax
- acid derivative
- compressed tablet
- parts
- Prior art date
Links
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Способ производства прессованной таблетки, включающийплавление производного пропионовой кислоты и воска при перемешивании;диспергирование расплавленной смеси производного пропионовой кислоты/воска в горячей воде;перенос горячей дисперсии производного пропионовой кислоты/воска/воды в другой контейнер, содержащий холодную воду, причем диспергированные капли производного пропионовой кислоты/воска застывают и образуют мелкодисперсные/сферические частицы;фильтрование и высушивание мелкодисперсных/сферических частиц;смешивание отфильтрованных и высушенных мелкодисперсных/сферических частиц с эксципиентами дозированной формы; ипрессование смеси в дозированную форму.2. Способ по п. 1, в котором указанное производное пропионовой кислоты выбрано из группы, состоящей из ибупрофена, напроксена, беноксапрофена, натрия напроксена, флурбипрофена, фенопрофена, фенбупрофена, кетопрофена, индопрофена, пирпрофена, карпофена, оксапрофена, пранопрофена, микропрофена, тиоксапрофена, супропрофена, алминопрофена, тиапрофеновой кислоты, флупрофена и буклоксовой кислоты.3. Способ по п. 1, в котором указанный воск представляет собой глицерилбегенат.4. Способ лечения, включающий введение дозированной формы по п. 1.5. Прессованная таблетка, полученная в соответствии со способом по п. 1, в которой частицы производного пропионовой кислоты содержат от приблизительно 80 частей производного пропионовой кислоты/приблизительно 20 частей воска до приблизительно 95 частей производного пропионовой кислоты/приблизительно 5 частей воска.6. Прессованная таблетка по п. 5, в которой частицы производного пропионовой кислоты содержат приблизительно 951. A method of manufacturing a compressed tablet, comprising melting the propionic acid derivative and wax with stirring; dispersing the molten propionic acid derivative / wax mixture in hot water; transferring the hot dispersion of the propionic acid derivative / wax / water to another container containing cold water, the dispersed drops of the derivative propionic acid / wax solidifies and forms fine / spherical particles; filtering and drying fine / spherical particles; mixing about filtered and dried fine / spherical particles with dosage form excipients; pressing the mixture into a dosage form. 2. The method of claim 1, wherein said propionic acid derivative is selected from the group consisting of ibuprofen, naproxen, benoxaprofen, sodium naproxen, flurbiprofen, phenoprofen, fenbuprofen, ketoprofen, indoprofen, pirprofen, carpofen, oxaprofen, microfrofenoprofenoprofenoprofenoprofenoprofenofenoprofenofenoprofenofenoprofenofenoprofenofenoprofenoprofen fenrofenoprofen , alminoprofen, thiaprofenic acid, fluprofen and bucloxic acid. 3. The method of claim 1, wherein said wax is glyceryl behenate. A method of treatment, including the introduction of a dosage form according to p. 1.5. A compressed tablet prepared according to the method of claim 1, wherein the particles of the propionic acid derivative comprise from about 80 parts of the propionic acid derivative / about 20 parts of the wax to about 95 parts of the propionic acid derivative / about 5 parts of the wax. The compressed tablet according to claim 5, in which the particles of the derivative of propionic acid contain approximately 95
Claims (9)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/228,957 US20140213653A1 (en) | 2012-09-18 | 2014-03-28 | Directly compressible proprionic acid derivative particles |
| US14/228,957 | 2014-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015110511A true RU2015110511A (en) | 2016-10-20 |
Family
ID=52737009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015110511A RU2015110511A (en) | 2014-03-28 | 2015-03-24 | PARTICULAR DERIVATIVE ACID PARTICLES FOR DIRECT PRESS |
Country Status (5)
| Country | Link |
|---|---|
| CN (1) | CN105168155A (en) |
| AU (1) | AU2015201584A1 (en) |
| BR (1) | BR102015007013A2 (en) |
| CA (1) | CA2886478A1 (en) |
| RU (1) | RU2015110511A (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5405617A (en) * | 1991-11-07 | 1995-04-11 | Mcneil-Ppc, Inc. | Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals |
| US20030232097A1 (en) * | 2002-06-17 | 2003-12-18 | Strides Inc. | Oily wax matrix suspension formulation comprising ibuprofen free acid and potassium salt of ibuprofen |
| JP2006518380A (en) * | 2003-01-31 | 2006-08-10 | スミスクライン・ビーチャム・コーポレイション | Solid dispersion composition |
| WO2014047001A1 (en) * | 2012-09-18 | 2014-03-27 | Mcneil-Ppc, Inc. | Low melting propionic acid derivative particles for use in oral dosage forms |
-
2015
- 2015-03-24 RU RU2015110511A patent/RU2015110511A/en not_active Application Discontinuation
- 2015-03-27 CN CN201510140784.2A patent/CN105168155A/en active Pending
- 2015-03-27 AU AU2015201584A patent/AU2015201584A1/en not_active Abandoned
- 2015-03-27 CA CA2886478A patent/CA2886478A1/en not_active Abandoned
- 2015-03-30 BR BR102015007013A patent/BR102015007013A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2886478A1 (en) | 2015-09-28 |
| BR102015007013A2 (en) | 2015-12-15 |
| AU2015201584A1 (en) | 2015-10-15 |
| CN105168155A (en) | 2015-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20180326 |