CN109566874A - A kind of preparation method of enteric slow release type microelement particle - Google Patents
A kind of preparation method of enteric slow release type microelement particle Download PDFInfo
- Publication number
- CN109566874A CN109566874A CN201811464748.1A CN201811464748A CN109566874A CN 109566874 A CN109566874 A CN 109566874A CN 201811464748 A CN201811464748 A CN 201811464748A CN 109566874 A CN109566874 A CN 109566874A
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- CN
- China
- Prior art keywords
- microelement
- particle
- slow release
- release type
- enteric slow
- Prior art date
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- 239000002245 particle Substances 0.000 title claims abstract description 97
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000000463 material Substances 0.000 claims abstract description 125
- 238000000576 coating method Methods 0.000 claims abstract description 86
- 239000011248 coating agent Substances 0.000 claims abstract description 82
- 238000000034 method Methods 0.000 claims abstract description 38
- 238000010438 heat treatment Methods 0.000 claims abstract description 34
- 238000002844 melting Methods 0.000 claims abstract description 31
- 230000008018 melting Effects 0.000 claims abstract description 31
- 229920003023 plastic Polymers 0.000 claims abstract description 24
- 239000004033 plastic Substances 0.000 claims abstract description 24
- 230000008569 process Effects 0.000 claims abstract description 21
- 230000004927 fusion Effects 0.000 claims abstract description 15
- 238000010008 shearing Methods 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims description 27
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 22
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- 239000011573 trace mineral Substances 0.000 claims description 20
- 235000013619 trace mineral Nutrition 0.000 claims description 20
- 239000003925 fat Substances 0.000 claims description 17
- 239000000945 filler Substances 0.000 claims description 17
- 235000021355 Stearic acid Nutrition 0.000 claims description 16
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 16
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 16
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 16
- 239000003921 oil Substances 0.000 claims description 16
- 235000019198 oils Nutrition 0.000 claims description 16
- 239000008117 stearic acid Substances 0.000 claims description 16
- 238000005469 granulation Methods 0.000 claims description 13
- 230000003179 granulation Effects 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 13
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 12
- 239000000395 magnesium oxide Substances 0.000 claims description 12
- 239000005995 Aluminium silicate Substances 0.000 claims description 11
- 229910021536 Zeolite Inorganic materials 0.000 claims description 11
- 235000012211 aluminium silicate Nutrition 0.000 claims description 11
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 11
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 11
- 239000003995 emulsifying agent Substances 0.000 claims description 11
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 11
- 239000010457 zeolite Substances 0.000 claims description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 10
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 10
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000292 calcium oxide Substances 0.000 claims description 9
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 9
- 239000012767 functional filler Substances 0.000 claims description 9
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- 239000005639 Lauric acid Substances 0.000 claims description 8
- 239000012943 hotmelt Substances 0.000 claims description 8
- 238000012216 screening Methods 0.000 claims description 8
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 7
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 7
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 7
- 239000000347 magnesium hydroxide Substances 0.000 claims description 7
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 7
- 239000000440 bentonite Substances 0.000 claims description 6
- 229910000278 bentonite Inorganic materials 0.000 claims description 6
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 6
- 239000000920 calcium hydroxide Substances 0.000 claims description 6
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 6
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- 239000008172 hydrogenated vegetable oil Substances 0.000 claims description 6
- 239000010775 animal oil Substances 0.000 claims description 5
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 5
- 239000008116 calcium stearate Substances 0.000 claims description 5
- 235000013539 calcium stearate Nutrition 0.000 claims description 5
- 125000005456 glyceride group Chemical group 0.000 claims description 5
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 5
- 239000001095 magnesium carbonate Substances 0.000 claims description 5
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 5
- 235000019359 magnesium stearate Nutrition 0.000 claims description 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 4
- 241000498779 Myristica Species 0.000 claims description 4
- 235000009421 Myristica fragrans Nutrition 0.000 claims description 4
- 239000005642 Oleic acid Substances 0.000 claims description 4
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 4
- 235000019482 Palm oil Nutrition 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 235000011194 food seasoning agent Nutrition 0.000 claims description 4
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 4
- 239000001702 nutmeg Substances 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- 239000002540 palm oil Substances 0.000 claims description 4
- 229940088417 precipitated calcium carbonate Drugs 0.000 claims description 4
- 238000007873 sieving Methods 0.000 claims description 4
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims description 4
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 3
- 150000002313 glycerolipids Chemical class 0.000 claims description 2
- FWRBVROZVUCLNY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O FWRBVROZVUCLNY-UHFFFAOYSA-N 0.000 claims description 2
- 235000003441 saturated fatty acids Nutrition 0.000 claims description 2
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- ZXRRHFSTAFVGOC-UHFFFAOYSA-N [AlH3].[K] Chemical compound [AlH3].[K] ZXRRHFSTAFVGOC-UHFFFAOYSA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 25
- 235000012343 cottonseed oil Nutrition 0.000 abstract description 4
- 235000019629 palatability Nutrition 0.000 abstract description 4
- 230000003247 decreasing effect Effects 0.000 abstract description 3
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- 239000000047 product Substances 0.000 description 39
- 238000004090 dissolution Methods 0.000 description 21
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 8
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- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 5
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- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000004567 concrete Substances 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 239000000109 continuous material Substances 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000012850 discrimination method Methods 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000011507 gypsum plaster Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 150000002603 lanthanum Chemical class 0.000 description 1
- 238000004093 laser heating Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000012778 molding material Substances 0.000 description 1
- 238000000199 molecular distillation Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 244000054334 omnivore Species 0.000 description 1
- 235000020912 omnivore Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- FWFGVMYFCODZRD-UHFFFAOYSA-N oxidanium;hydrogen sulfate Chemical compound O.OS(O)(=O)=O FWFGVMYFCODZRD-UHFFFAOYSA-N 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 244000062645 predators Species 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000012743 protein tagging Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 229910052761 rare earth metal Inorganic materials 0.000 description 1
- 238000003303 reheating Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 1
- 210000004767 rumen Anatomy 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 229960002718 selenomethionine Drugs 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229940110280 zinc methionine Drugs 0.000 description 1
- CNMFGFBWPBBGKX-SCGRZTRASA-L zinc;(2s)-2-amino-4-methylsulfanylbutanoate Chemical compound [Zn+2].CSCC[C@H](N)C([O-])=O.CSCC[C@H](N)C([O-])=O CNMFGFBWPBBGKX-SCGRZTRASA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/22—Compounds of alkali metals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of preparation methods of enteric slow release type microelement particle, comprising: takes powdery microelement, coating material is added and is pre-mixed, premix is obtained；Heating melting is carried out to the premix；Under the conditions of heating melting, the premix is mixed, shearing, fusion, form plastic pug；It under the conditions of heating melting, pelletizes to the plastic pug, obtains enteric slow release type microelement particle.Microelement is due to Cotton seeds under the conditions of heating melting in preparation method provided by the present invention, not only effectively increase the stability of microelement feed itself, also significantly increase the palatability of feed, and make to be isolated in the addition use process of microelement with unclassified stores generation, the shelf-life that feed can significantly be extended, also it is remarkably decreased the incidence of the enterogastric diseases of animal.
Description
Technical field
The invention belongs to feed processing technologies, are related to a kind of preparation method of enteric slow release type microelement particle.
Background technique
Microelement is people and the necessary basic nutrition element of growth of animal；Addition microelement is conducive to improve dynamic in feed
The production performance of object, is reduced or avoided deficiency disease；It has been identified that essential trace element related with human health and life has 18
Kind, that is, there are iron, copper, zinc, cobalt, manganese, chromium, selenium, iodine, nickel, fluorine, molybdenum, vanadium, tin, silicon, strontium, boron, rubidium, arsenic etc., and be proved part lanthanum
Series rare earth element has effect to animal health, the anti-adversity ability of animal can be improved, and improve feed efficiency.It is micro to be applicable in animal
Element and source are mainly the sulfate of metallic element, chlorate, the organic compound of selenium, the compound of iodine and above-mentioned element
Object or protein salt etc..
The addition of feeding microelement is generally using the inorganic salts or organic matter of microelement, the mode directly mixed,
It is processed into applicable high concentration pre-mixing feed additive, is added in Feed Manufacturing；General economic and practical mainly adopts
Improve the utilization rate of microelement with inorganic salts or inorganic, organic composite mode.And the microelement of low dosage addition is general
With high bioavailability；Processing is coated to applicable microelement, can avoid directly contacting with unclassified stores, make
It is continuously discharged with better processing stability, and in enteron aisle low dosage, and the utilization rate of microelement not only can be improved, subtract
Few additive amount, and can reduce and directly add generated negative effect, such as improve feed product palatability, extends the shelf life, reduces
Animal intestinal tract problem reduces discharge, mitigates environmental pressure.
Currently, the coating processing method of existing microelement feed, be generally coated using polyacrylic resin spraying,
The methods of the coating of spraying microcrystalline cellulose, mixing zeins ethanol solution coating are prepared, and there are with high costs, molten
Effect is poor out, some processes the problems such as there are significant security risks, affects the effective use of microelement.
Summary of the invention
To solve the above problems, the present invention provides a kind of preparation method of enteric slow release type microelement particle, comprising:
Powdery microelement is taken, coating material is added and is pre-mixed, premix is obtained；
Heating melting is carried out to the premix；
Under the conditions of heating melting, the premix is mixed, shearing, fusion, form plastic pug；
Under the conditions of heating melting, extruding granulation is carried out to the plastic pug, obtains enteric slow release type microelement
Grain.
Preferably, described " under the conditions of heating melting, extruding granulation to be carried out to the plastic pug, obtains enteric slow release
After type microelement particle ", further includes:
Rotation is carried out to the enteric slow release type microelement particle that hot melt is prepared and throws circle, and is cooled to through air-cooled
No more than 45 DEG C.
Preferably, described " taking powdery microelement, coating material is added and is pre-mixed, premix is obtained " includes:
Powdery microelement is taken, coating material is added and is pre-mixed, also, functionality is added in pre-mixing process and fills out
Material is mixed, and the premix is obtained.
Preferably, the functional filler includes ultra-fine auxiliary material and alkalescent filler；
The ultra-fine auxiliary material includes ultrafine zeolite powder, superfine calcined kaolin, superfine talcum powder, superfine white carbon black, ultra-fine
One or more of aluminum aluminum sulfate, calcium carbonate superfine powder, ultra-fine magnesium carbonate；
The alkalescent filler includes one or more of calcium oxide, magnesia, calcium hydroxide, magnesium hydroxide.
Preferably, before described " taking powdery microelement, coating material is added and is pre-mixed, premix is obtained ", also
Include:
Trace element materials are taken, hydrophilic auxiliary material mixing is added, obtains mixed raw material；Wherein, the hydrophilic auxiliary material includes oxygen
Change one or more of calcium, magnesia, ultrafine zeolite powder and gesso；
70-100 DEG C of hot-air seasoning is carried out to the mixed raw material, sieving obtains the dry powdery microelement.
Preferably, described " under the conditions of heating melting, to pelletize to the plastic pug, it is micro- to obtain enteric slow release type
After secondary element particle ", further includes:
Anticaking agent is added in the enteric slow release type microelement particle.
And be sieved and choose the particle of wherein 0.3-1.5mm, obtain screening particle；
Under the conditions of being heated to 50-80 DEG C, fluidized bed whole grain is carried out to get to particle after whole grain to the sieve powder particles.
Preferably, the anticaking agent includes bentonite, precipitated calcium carbonate, kaolin, calcium stearate, talcum powder and stearic acid
One or more of magnesium；
The anticaking agent is anticaking agent dry and by 325-2000 mesh screen.
Preferably, the coating material includes one of stearic, hydrogenated oil and fat and emulsifier or multiple combinations；
The tristearin includes: long-chain saturated fat in stearic acid, height palm oil, saturation oleic acid, myristic acid, lauric acid etc.
One or more of fat acid；
The hydrogenated oil and fat includes hydrogenated vegetable oil and/or hydrogenated animal oil；
The emulsifier includes stearic acid list glycerolipid, stearic acid diglycerol rouge, nutmeg diand monoglycerides, lauric acid
The combination of one or more of diand monoglycerides.
Preferably, the additional amount of the coating material is the 15-55% for being equivalent to total amount.
Preferably, the temperature of the heating melting is 60-105 DEG C.
The present invention provides a kind of preparation method of enteric slow release type microelement particle, by wrapping to microelement
Clothing reheats melting, and after being mixed respectively under the conditions of heating melting, shear, merge, squeezes and pelletize, thus finally
Obtain enteric slow release type microelement particle.Microelement is due in heating melting condition in preparation method provided by the present invention
Lower Cotton seeds, not only effectively increase the stability of microelement feed itself, also significantly increase the palatability of feed, and
Make to be isolated in the addition use process of microelement with unclassified stores generation, can significantly extend the shelf-life of feed, also make animal
The incidences of enterogastric diseases be remarkably decreased.
Specific embodiment
Mode combined with specific embodiments below is described in further detail technical solution of the present invention, but not structure
At any limitation of the invention, the modification of anyone limited times made within the scope of the invention as claimed, still in this hair
Within bright scope of the claims.
The present invention provides a kind of preparation method of enteric slow release type microelement particle, comprising:
Powdery microelement is taken, coating material is added and is pre-mixed, premix is obtained；
Heating melting is carried out to the premix；
Under the conditions of heating melting, the premix is mixed, shearing, fusion, form plastic pug；
Under the conditions of heating melting, extruding granulation is carried out to the plastic pug, obtains enteric slow release type microelement
Grain.
The present invention is to solve problems of the prior art, existing to microelement coating method, it is main to wrap
It includes following several:
1, after composite trace element being added the adhesives granulation such as CMC (sodium cellulose glycolate), xanthan gum, use is medical
The coating of enteric solubility polyacrylic resin surface coating, product is disintegrated release under the conditions of enteron aisle, to realize microelement
In the effect of enteron aisle dissolution.This method technical maturity, but production efficiency is low, it is with high costs, be not able to satisfy feedstuff industry it is low at
Originally, the requirement of large-scale production.
2, by after dry composite trace element mixes, the mode of direct spraying microcrystalline cellulose generates coating effect
Fruit；The easy moisture absorption disintegration of product described in this method, lacks product stability, and can not achieve the enteric slow release performance of requirement.
3, compound microelement is mixed with zeins ethanol solution, ethyl alcohol volatilization make alcohol soluble protein with it is micro
Element, which combines, forms coating, becomes product after volatilize in pelletization ethyl alcohol and moisture, can preferably realize that microelement is protected, and
Realize the isolation effect with unclassified stores；Product described in this method has preferable stability.Main problem is that enteron aisle discharges
Inefficiency, especially young animal utilization rate is lower, and ethyl alcohol volatilization has certain risk.
4, after passing through adhesive mixing granulation by composite trace element, throw circle, be dried to particle, through fluidized bed in particle table
Face sprays the mode of stearic acid or resin and plasticiser, carries out particle surface spraying, realizes coating purpose.This method technique at
It is ripe, but coating process is time-consuming, energy consumption is higher, and production efficiency is low, is difficult to realize large-scale production at present.
And the present embodiment provides a kind of preparation methods of enteric slow release type microelement particle directly by microelement and packet
Clothing material is premixed, and under the conditions of heating melting, after being mixed, sheared, being merged, is directly squeezed granulation, be can be obtained
Enteric slow release type microelement particle.Wherein, coating material of the present invention is mainly using being insoluble in water, stablize in gastric acid, but
A series of stearic, hydrogenated oil and fats and emulsifier that can be digested and assimilated by animal intestinal tract, and wherein any two kinds and two or more
The compatibility of material forms；Such as: stearic acid, hydrogenated vegetable oil, animal tristearin, stearic acid list (double) glyceride, glyceride citrate
Equal fixed oils, other aliphatic esters or emulsifier.
It should be noted that aquatic feeds, rumen-bypass amino acid that the application is readily applicable to sustained release amino acid are ruminated
The production of animal feed.
Wherein, coating material can refer to the compatibility using one or two kinds of and two or more coating materials, realize intestines
In the case where molten sustained release, time range required for controllable realization trace-element slow-release.In the simulated intestinal fluid containing bile acid
In, the time needed for coating microelement release, controllable time range is between 0.5-6.5 hours.
Double pipe heater that is above-mentioned, needing to have mixing, shearing function when preparing plastic pug, is by two different tube diameters
Steel pipe intussusception form；Casing is heated by thermal conductivity oil heating method between pipe；Heater internal diameter is 20-30cm, is installed additional in pipe
Screw extrusion and shearing composite blading form continuous material heating and mixing, and material is pushed and is passed through under motor drive
2.5-5.0 meters of laser heating forms " the warm sludge material " with certain homogenizing effect, and through Squeezinggranulator or waves pelletizer
It is granulated.The double pipe heater can realize 1-5 ton/hours of working ability by adjusting heating power and squeezing the revolving speed of blade.
It is above-mentioned, the extruding granulation, including dry granulation and wet granulation, it is mainly made in the present invention using screw extrusion
Grain machine or wobbler are granulated；" the plastic pug " of heat is the gluey material with good plasticity, can arbitrarily be squeezed as needed
Molding, sizing when molding materials are cooled to 45 degree Celsius or less；After heated again, can still become with good plasticity " can
Molded mud material ".
To sum up, the present embodiment provides a kind of preparation methods of enteric slow release type microelement particle, by microelement
It is coated, melting is reheated, and mixed, sheared, merged and pelletized respectively under the conditions of heating melting, thus finally
Obtain enteric slow release type microelement particle.Microelement is due in heating melting condition in preparation method provided by the present invention
Lower Cotton seeds, not only effectively increase the stability of microelement feed itself, also significantly increase the palatability of feed, and
Make to be isolated in the addition use process of microelement with unclassified stores generation, can significantly extend the shelf-life of feed, also make animal
The incidences of enterogastric diseases be remarkably decreased.
Preferably, described " under the conditions of heating melting, extruding granulation to be carried out to the plastic pug, obtains enteric slow release
After type microelement particle ", further includes:
Rotation is carried out to the enteric slow release type microelement particle that hot melt is prepared and throws circle, and is cooled to through air-cooled
No more than 45 DEG C.
Above-mentioned, heating particle obtained is soft particle, throwing circle is carried out to above-mentioned particle using circle-throw movement machine (wobbler), to reach
To plastotype purpose, while particle being made to keep the intensity that particle can be improved under certain form that can pass through wind while carrying out throwing round
The cold cooling carried out to particle cools down hot melt soft particle obtained rapidly, when temperature is less than or is equal to 45 DEG C,
Grain forming becomes grit.By the rapid wind cooling temperature lowering for heating particle, realize under the premise of guaranteeing particle shape
The intensity of particle is improved rapidly, on the one hand improve the stability of particle to a certain extent.
Preferably, described " taking powdery microelement, coating material is added and is pre-mixed, premix is obtained " includes:
Powdery microelement is taken, coating material is added and is pre-mixed, also, functionality is added in pre-mixing process and fills out
Material is mixed, and the premix is obtained.
Preferably, the functional filler includes ultra-fine auxiliary material and alkalescent filler；
The ultra-fine auxiliary material includes ultrafine zeolite powder, superfine calcined kaolin, superfine talcum powder, superfine white carbon black, ultra-fine
One or more of aluminum aluminum sulfate, calcium carbonate superfine powder, ultra-fine magnesium carbonate；
The alkalescent filler includes one or more of calcium oxide, magnesia, calcium hydroxide, magnesium hydroxide.
Powdered trace element mixture and packaging material is added functional filler mixing, is processed into packet after hot melt mixing
Close the plastic pug of microelement.
It is above-mentioned, it is experimentally confirmed, the material of meta-alkalescence is supplemented in microelement, such as calcium oxide, magnesia, hydroxide
Calcium, magnesium hydroxide etc. are conducive to coating material and preferably mutually merge with microelement, improve stability.
In the present embodiment, alkalescent filler being added in material, premix is prepared.Commercially available coating material is for example
The substances such as hydrogenated oil and fat, aliphatic ester are the mixture for including a large amount of impurity, the addition of alkalescent filler, the alkalescent having
Filler makes a part impurity that not exclusively stable hydride is poor, reactivity is strong in coating material in subsequent reflow process,
Saponification is more readily formed, so that the stability of material is increased, to make coating material melting for powdery microelement
Conjunction is more complete, avoids due to generating bubble in reflow process, and caused fusion embedding is not perfect, and it is steady to influence final products
Qualitative problem.
In addition, can be added in premix has functional alkaline soil plant material when preparing premix.Wherein,
Functional alkaline soil plant material can have the material of a large amount of meta-alkalescence compounds for main components such as gleditsia sinensis, sea Piao sheaths.
For example, may include steps of:
To gleditsia sinensis benevolence low temperature drying, gleditsia sinensis benevolence dried object is obtained；
After alcohol extract concentration, water dissolution is added, stands 24 hours, isolated water layer and the beds of precipitation；
Water intaking layer, after concentration, is eluted by macroporous absorbent resin, discards eluent, main component can be inhaled by macropore
Attached resin adsorption；
Macroporous absorbent resin described in alcohol rinse by high concentration collects the alcohol eluent eluted, after concentration
It dries to get gleditsia sinensis benevolence total saposins are arrived；
Above-mentioned, the gleditsia sinensis benevolence total saposins after drying can further be prepared as particle, specific:
Gleditsia sinensis benevolence total saposins are taken, after water dissolution is added, carry out wet granulation with sticky auxiliary material mixed at high speed；
Gleditsia sinensis benevolence total saposins particle is arrived with dry by whole grain.
Powdery microelement is taken, coating material is added and is pre-mixed, also, in pre-mixing process, above-mentioned soap is added
Gleditsia sinensis benevolence total saposins powder after angle benevolence total saposins particle or drying, is mixed, obtains premix.
The gleditsia sinensis benevolence total saposins being added in premix, on the one hand, can by the alkaline nature of main active saponin(e,
Make premix in subsequent reflow process, make in coating material a part not exclusively stable hydride is poor, reactivity by force
Impurity, it is easier to form calcium soap, to increase the stability of material, reduce bubble, to make coating material for content
The inclusion of object powdery microelement is complete, avoids due to generating a large amount of bubbles, incomplete, the shadow of caused saturation in reflow process
The problem of ringing finished product stability；On the other hand, gleditsia sinensis benevolence has the active effect of certain relax bowel and defecation, bactericidal antiphlogistic, from
And in feed is added, with more certain digestion for helping raise animal, promote to absorb, prevents the function of raising animal diarrhea
Effect.
Preferably, before described " taking powdery microelement, coating material is added and is pre-mixed, premix is obtained ", also
Include:
Trace element materials are taken, hydrophilic auxiliary material mixing is added, obtains mixed raw material；Wherein, the hydrophilic auxiliary material includes oxygen
Change one or more of calcium, magnesia, ultrafine zeolite powder and gesso；
70-100 DEG C of hot-air seasoning is carried out to the mixed raw material, sieving obtains the dry powdery microelement.
Above-mentioned, the microelement of feed, the easy moisture absorption is rotten when exposed to air or is denaturalized, for example, sulfuric acid monohydrate
The ferrous moisture absorption in air forms ferrous sulfate heptahydrate.Rotten, denaturation or changed microelement, are on the one hand unable to reach
The effect of microelement for raising animal supplements；On the other hand there are the microelements of moisture absorption situation will cause flowing
The poor, material of property can not mix completely, and the problem for causing finished product content inhomogenous leads to not realize original biological utilisation
Rate influences the absorption of microelement.
In the present invention, in the raw material of microelement, hydrophilic auxiliary material is added, as there is the auxiliary material of hydration function, example
Such as calcium oxide, magnesia, ultrafine zeolite powder and gesso, by obtaining mixed raw material after being sufficiently mixed, auxiliary material absorbs micro-
The moisture possessed in secondary element forms hydrate or the crystallization water, and removal deliquesces the material of agglomeration, may finally obtain uniform
The dehydrated material of few free water, i.e. powdery microelement.Powdery microelement is dried by pretreatment, thus carrying out
Before premixing obtains premix, the purpose of dehydration is realized, the mixing and coating of dewatered microelement and unclassified stores,
Poor fluidity, incomplete mixing are avoided, or is occurred due to fusion coating instability problem caused by deliquescing, to a certain extent
Improve the stability of finished product.
Preferably, described " under the conditions of heating melting, to pelletize to the plastic pug, it is micro- to obtain enteric slow release type
After secondary element particle ", further includes:
Anticaking agent is added in the enteric slow release type microelement particle.
And be sieved and choose the particle of wherein 0.3-1.5mm, obtain screening particle；
Under the conditions of being heated to 50-80 DEG C, fluidized bed whole grain is carried out to get to particle after whole grain to the sieve powder particles.
Preferably, the anticaking agent includes bentonite, precipitated calcium carbonate, kaolin, calcium stearate, talcum powder and stearic acid
One or more of magnesium；
The anticaking agent is anticaking agent dry and by 325-2000 mesh screen.
Above-mentioned, the anticaking agents such as the added talcum powder of enteric slow release type microelement particle, magnesium stearate (also can be used as smooth
Agent) mobility that increases material afterwards, it is sieved by sieve, chooses the material of wherein 0.3-1.5mm particle, then through fluidized bed
It is warming up to 50-95 degrees Celsius of reheating shaping, to make particle that there is preferable shape and keep intensity, and then can be whole
Cooled down after shape by air-cooled, further increases granule strength and toughness, the micro member with good fluidity can be formed
Plain coated product.
Preferably, the coating material includes one of stearic, hydrogenated oil and fat and emulsifier or multiple combinations；
The tristearin includes: long-chain saturated fat in stearic acid, height palm oil, saturation oleic acid, myristic acid, lauric acid etc.
One or more of fat acid；
The hydrogenated oil and fat includes hydrogenated vegetable oil and/or hydrogenated animal oil；
The emulsifier includes glyceryl monostearate, stearic acid double glyceride, nutmeg diand monoglycerides, lauric acid
The combination of one or more of diand monoglycerides.
Preferably, the additional amount of the coating material is the 15-55% for being equivalent to total amount.
Preferably, the temperature of the heating melting is 60-105 DEG C.
Wherein, the emulsifier, can for by raw material of fatty acid with the various diand monoglycerides of glycerol stroke.It is described
Hydrogenated oil and fat includes hydrogenated vegetable oil and/or hydrogenated animal oil；It can be full for the hydrogenation for the plant and animal material that hydrogenated reaction obtains
And fatty acid.
To facilitate the understanding of the present invention, below with reference to embodiment to further illustrate the technical scheme of the present invention.Applicant
Statement, detailed process equipment and process flow of the invention that the present invention is explained by the above embodiments, but the present invention not office
It is limited to above-mentioned detailed process equipment and process flow, that is, does not mean that the present invention must rely on above-mentioned detailed process equipment and technique
Process could be implemented.It should be clear to those skilled in the art, any improvement in the present invention, each to product of the present invention
The equivalence replacement of raw material and addition, the selection of concrete mode of auxiliary element etc. all fall within protection scope of the present invention and openly
Within the scope of.
Preparation process:
S1, trace element materials are taken, hydrophilic auxiliary material mixing is added, obtains mixed raw material；70- is carried out to the mixed raw material
100 DEG C of hot-air seasonings, sieving obtain the dry powdery microelement；(the hydrophilic auxiliary material include calcium oxide, magnesia,
One or more of ultrafine zeolite powder and gesso)
S2, powdery microelement is taken, coating material is added and is pre-mixed, also, function is added in pre-mixing process
Property filler is mixed, and the premix is obtained.Wherein, the additional amount of the coating material is the 15-55% for being equivalent to total amount.
(functional filler includes ultra-fine auxiliary material and alkalescent filler；The ultra-fine auxiliary material includes ultrafine zeolite powder, superfine calcinated height
One or more of ridge soil, superfine talcum powder, superfine white carbon black, ultra-fine aluminum aluminum sulfate, calcium carbonate superfine powder, ultra-fine magnesium carbonate；
The alkalescent filler includes one or more of calcium oxide, magnesia, calcium hydroxide, magnesium hydroxide) (the coating material
Including one of stearic, hydrogenated oil and fat and emulsifier or multiple combinations；The tristearin includes: stearic acid, height palm oil, saturation
One or more of chain saturated fatty acids in oleic acid, myristic acid, lauric acid etc.；The hydrogenated oil and fat includes hydrogenated vegetable oil
And/or hydrogenated animal oil；The emulsifier includes glyceryl monostearate, stearic acid double glyceride, the single, double glycerol of nutmeg
One or more of ester, lauric acid diand monoglycerides combination)
S3, heating melting is carried out to the premix；
S4, under the conditions of hot melt, by the premix mix, shearing, fusion, form plastic pug；
S5, under the conditions of hot melt, extruding granulation is carried out to the plastic pug, obtains enteric slow release type microelement
Grain.
S6, rotation throwing circle is carried out to the enteric slow release type microelement particle that hot melt is prepared, and through air-cooled cold
But to no more than 45 DEG C.
S7, anticaking agent is added in the enteric slow release type microelement particle；The anticaking agent is dry and passes through
Crossing the anticaking agent of 325-2000 mesh screen, (anticaking agent includes bentonite, precipitated calcium carbonate, kaolin, calcium stearate, talcum
One or more of powder and magnesium stearate).
S8 is simultaneously sieved and chooses the particle of wherein 0.3-1.5mm, obtains screening particle；
S9, under the conditions of being heated to 50-80 DEG C, fluidized bed whole grain is carried out to get to after whole grain to the sieve powder particles
Grain.
Embodiment 1:
The present embodiment provides a kind of enteric slow release type microelement particle (being applied to pig), prepare according to following technique, tool
Body is as follows:
1, trace element materials (mass fraction):
Ferrous sulfate monohydrate: 30 parts；
Cupric sulfate pentahydrate: 10 parts；
Manganese sulfate monohydrate: 8 parts；
Monohydrate zinc sulphate: 15 parts；
1%:4 parts of sodium selenite；
1%:3 parts of Potassiumiodate；
1.2%:2 parts of chromium picolinate；
5%:0.4 parts of sulfuric acid monohydrate cobalt；
In mixing machine after mixing, 80 DEG C of drying, 100% crosses 40 meshes to the above trace element materials, and 90% crosses 80
Mesh to get arrive powdery microelement, it is spare.
2, hydrophilic auxiliary material: 3 parts of calcium oxide；
3, functional filler:
Alkalescent filler: magnesium hydroxide: 5 parts；
Ultra-fine auxiliary material: ultrafine zeolite powder (1000 mesh): 5 parts；Silica (white carbon black): 3 parts；
4, coating material:
Stearic acid: 60 parts；
Hydrogenated oil and fat: 35 parts；
Fatty acid monoglyceride (molecular distillation): 20 parts；
5, fusion coating: sufficiently mixed in mixing machine by above-mentioned powdery microelement and coating material according to above-mentioned technique
It closes uniformly, obtains premix, necessary constituent mass number are as follows:
Powdery microelement: 70 parts；
Coating material: 30 parts；
Based on above-mentioned preparation process, by the above mixture through double pipe heater heating melting to 75-95 degree, become have can
After the plastic pug of plasticity, through extrusion granulation, pelletizer ring moulds aperture 0.6-1.2mm, taken off after granulation temperature be cooled to 45 degree hereinafter,
It is made micro with the stearic bar shaped particle merged.
6, antagonist:
Talcum powder: 2-10 parts；2-10 parts of magnesium stearate；
Particle adds appropriate magnesium stearate and talcum powder does anticaking agent, after wobbler shearing, throwing circle, sieves in selection
1.5mm puts into fluidized bed after lower sieve 0.3mm screening.Fluidized bed air quantity is adjusted to particle fluidized state, adjusts inlet air temperature and is
50-65 degree Celsius, material are kept for 10-60 seconds after reaching predetermined temperature, close heating, and discharging at air-cooled to 45 degree, screening is chosen
20-80 mesh is qualified products, i.e. acquisition product.Obtained product is brighter and cleaner shaped granule, improves the commodity property of product,
With better mobility and mixture homogeneity.
It should be noted that product is in canescence to green particles according to the difference of microelement ingredient.Also it may be selected to add
The harmless colorant of oiling dissolubility makes material have special color, to facilitate product identification；Under lower than 45 degree storage conditions of temperature not
Deformation does not soften, with good stability, and do not generate interaction to unclassified stores, and after entering enteron aisle, in neutrality and
It under weak basic condition, acts on through bile acid, gradually dissolves, and release microelement, realize the slow release effect of microelement.
In addition, by adjusting the proportion of coating material, being applicable in different digestion features for different types of animal
Animal；According to the different compatibilities of coating material, the time range being sustained in enteron aisle is adjusted, generally applicable different animals feed
Addition production.
Embodiment 2:
The present embodiment provides a kind of enteric slow release type microelement particle (being applied to the animals such as the omnivorous fish of aquatic products), are based on
Above-mentioned preparation process, specific as follows:
1, trace element materials (mass fraction):
Ferrous sulfate monohydrate: 15 parts；
Cupric sulfate pentahydrate: 4 parts；
Manganese sulfate monohydrate: 10 parts；
Monohydrate zinc sulphate: 10 parts；
Zinc methionine: 7 parts；
1%:4 parts of sodium selenite；
1%:1 parts of selenomethionine；
5%:1 parts of Potassiumiodate；
The above material is uniformly mixed in mixing machine, and material 100% can cross 40 meshes, and 90% can cross 80 meshes to get arriving
Powdery microelement, it is spare；
2, hydrophilic auxiliary material: bentonite and the mixing of magnesia equal proportion: 8 parts；
3, functional filler:
Alkalescent filler: calcium hydroxide: 5 parts；
Ultra-fine auxiliary material: ultra-fine magnesium carbonate (1000 mesh): 10 parts；Ultra-fine aluminum aluminum sulfate: 3 parts；
Cornstarch: 3 parts；
4, coating material:
Hydrogenated plant oil: 50 parts；
Glyceryl monostearate: 40 parts；
Stearic acid: 20 parts
5, antagonist: kaolin (calcining): 2-5 parts；
6, fusion coating:
(1) powdery is micro with coating material parts by weight are as follows:
68 parts of powdery microelement；
32 parts of coating material；
(2) by the above premix, it is mixed and heated to 70-95 degree under heated device stirring condition, after forming plastic pug, is adopted
It is granulated with the Squeezinggranulator of die hole aperture 0.6-1.0mm；
(3) material is cooling through de- temperature after being granulated, and forms bar shaped particle, anticaking agent is added, through wobbler shearing-crushing, ball blast
After machine polishing, fluidized bed is put into；Material fluidized state is kept, when inlet air temperature is increased to 55 degree, is kept for 10-60 seconds, is closed and add
Heat changes to cold wind, and fluidized state is kept to can be taken off when material is cooled to 45 degree or less；It is screened, choose 0.4-1.0mm
(16-40 mesh) partial size obtains product.
(4) microelement particle produced is with the experiment of 0.6-1.0mm particle, in the simulated intestinal fluid for being added with bile salt
Middle release time range is 0.5-2.5 hours.
Embodiment 3:
The present embodiment provides a kind of enteric slow release type microelement particles (to be applied to flesh-eater, as fox racoon dog fur is dynamic
Object, carnivorous fish), it is prepared using following technique, specific as follows:
1, trace element materials (mass fraction):
Ferrous sulfate monohydrate: 25 parts；
Basic copper chloride: 1.5 parts；
Manganese sulfate monohydrate: 10 parts；
Monohydrate zinc sulphate: 15 parts；
5%:0.5 parts of Potassiumiodate；
1%:3 parts of sodium selenite；
1.2%:1.5 parts of chromium picolinate；
1%:1 parts of sulfuric acid monohydrate cobalt；
2, it hydrophilic auxiliary material: boils ultra-fine stone (crossing 1000 mesh): 5 parts；
The plaster of paris (crosses 800 mesh): 5 parts；
3, functional filler:
Alkalescent filler: magnesium hydroxide (crosses 800 mesh): 10 parts；
Ultra-fine auxiliary material: ultrafine zeolite powder (1000 mesh): 3 parts；
Flesh-eater gastric acid generally with higher or stronger endogenous enzymes digestion power, especially to fat digestion energy
Power is better than Omnivore, thus need of coating stability with higher, can be completed by adjusting the proportion of coating material.
4, coating material:
The composition and each component parts by weight of prefabricated coating material, as follows:
Stearic acid: 70 parts；
Hydrogenated oil and fat: 25 parts；
Glyceryl monostearate: 10 parts；
Calcined kaolin: 2 parts；
40 meshes are crossed, it is spare.
5, fusion coating: sufficiently mixed in mixing machine by above-mentioned powdery microelement and coating material according to above-mentioned technique
It closes uniformly, obtains premix, necessary constituent mass number are as follows:
Powdery microelement: 65 parts；
Prefabricated coating material: 35 parts；
65 parts of powdery microelement, 35 parts of prefabricated coating material is pre-mixed；Also, in pre-mixing process, in right amount
Added with alkalescent filler magnesia, the premix is obtained.
6, antagonist:
Bentonite: 7 parts；5 parts of calcium stearate；
(2) by the above premix, heated device is stirred, and is heated to 75-95 degree, plastic pug is formed, using aperture
The Squeezinggranulator of 0.6-1.5mm is granulated.
(3) material is cooling through de- temperature after being granulated, and forms bar shaped particle, adds anticaking agent, through wobbler shearing-crushing, screening
Afterwards, fluidized bed is put into；Material fluidized state is kept, inlet air temperature is increased to 50-65 when spending, and is kept for 5-30 second, closes and heats, changes
Enter cold wind, keeps fluidized state, material is cooling to be can be taken off；It is screened, it chooses 0.3-1.5mm (16-40 mesh) partial size and is produced
Product.
Wherein, preferred fluidized-bed process condition are as follows: highest inlet air temperature is not less than 50 degree, not higher than 75 degree, when holding
Between 5-30 seconds, under the conditions of boiling, in time close heating, switch cold front heavy rain material to 45 degree hereinafter, can discharge；It can after discharging
Add a small amount of kaolin, talcum powder does anticaking agent, through circle-throw movement machine throw justify, screening choose 0.4-1.5mm particles be finished product.
This product is in the simulated intestinal fluid of addition bile acid or bile salt, time model needed for trace-element slow-release dissolution
Enclosing is 1.0-4.5 hours, suitable for there is the use of the carnivore feed addition of stronger digestion power.
Embodiment 4:
The present embodiment provides a kind of enteric slow release type microelement particle, (single microelement is applied to for single micro-
The feed of secondary element), it is prepared using above-mentioned technique, specific as follows:
Needed for the single microelement of different animals, can any coating material one or two it is compound, to single
Or two or more microelements carry out fusion coating；With the omnivorous animal coating of single trace copper.
1, trace element materials (mass fraction):
30 parts of powdery cupric sulfate pentahydrate (trace element materials) is dried 1 hour through 105 degree, obtains three brochanite powder
(powdery microelement).Copper effective content is 30%.
2, hydrophilic auxiliary material: 5 parts of gesso；
3, functional filler:
Alkalescent filler: calcium hydroxide: 5 parts；
Ultra-fine auxiliary material: ultra-fine aluminum aluminum sulfate (1000 mesh): 5 parts；Silica (white carbon black): 5 parts；
4, coating material:
Hydrogenated oil and fat: 25 parts；
5, fusion coating: sufficiently mixed in mixing machine by above-mentioned powdery microelement and coating material according to above-mentioned technique
It closes uniformly, obtains premix, necessary constituent mass number are as follows:
Powdery microelement (crosses 80 meshes): 75 parts；
Coating material: 13 parts；
6, antagonist:
Kaolin: 8 parts；
It in addition to hydrogenated oil and fat, after the above material was both needed to 80 meshes, is uniformly mixed, heated device mixes under agitation to be added
Heat obtains plastic pug to 75 degree；
The plastic pug is used into 0.6 ring moulds aperture, is granulated through Squeezinggranulator, de- temperature can form bar shaped particle；
It is sieved after being waved crusher machine, throwing circle, chooses the particle of 1mm partial size as finished product.The product is widely portable to
The production and application of concentrated feed.
Above method is equally applicable to the Cotton seeds of crystal amino acid, for aquatic products sustained release amino acid and ruminant mistake
The production of cud amino acid.Such as: aquatic products is sustained the art for coating of amino acid, further illustrates by way of example.
Comparative experiments based on embodiment 1-5:
It is micro that enteric slow release is carried out to the obtained enteric slow release type microelement particle of embodiment 1-5 in the application respectively
The measurement of element result of extraction.
Enteric solubility slowly releasing trace element is the slow-release microelement using intestinal sustained releasing as main feature；To different animals institute
The slow-release time and condition needed is different；For pig, need to keep relative stability under gastric fluid conditions, in enteron aisle condition
Lower holding sustained release, and the microelement of slow-release time release no less than 80% in 2-3 hours；For aquatic fish, feeding disappears
The change time is short, then requires no matter to require sustained release dissolution under the conditions of aqueous or simulated intestinal fluid, general to require to release in 2 hours
It discharges into；And for ruminant, then require PH5-6.5 it is slightly sour under the conditions of keep stablizing, and when having longer stable
Between, to realize the requirement of rumen bypass；Thus different testing conditions are needed to adapt to the different detections for being applicable in animal product, and
Whether meet that enteric slow release is micro or the discrimination method of amino acid as product.
Different coated products are compared with the micro identification detection of enteric slow release below by way of pig, aquatic products, ruminant
Compared with to further illustrate the necessity of the method for the invention
One, experiment: (stability of the comparative sample in gastric juice) is dissolved out in simulate the gastric juice
Laboratory sample:
1, enteric slow release type microelement particle prepared in embodiment 1-5；
2, it the test sample compareed: takes in this comparative experiments and is obtained prepared by two kinds of preparation processes used in the prior art
Product is as test sample:
(1) the microelement particle of polyacrylamide resin spraying coating；
(2) zeins fusion coating.
Experimental method: 500ML triangular flask is taken, is coated microelement in the test sample and the embodiment of the present application 1-5 of control
Grain；1.00 grams of laboratory samples are accurately weighed, are placed in 250ml simulate the gastric juice (according to Chinese Pharmacopoeia 2015 editions configurations), Yu Hengwen
It in water-bath, 37.5 DEG C of water temperature, 60 beats/min of oscillation frequency, after sixty minutes, is filtered through filter paper, detects microelement in solution
Content calculates dissolution.
Calculation method: total iron contains in trace elements iron (mg)/1.00 gram coated product in microelement dissolution rate=solution
It measures (mg) × 100%
The gastric juice dissolution rate of 1 embodiment 1-5 of table and control sample compares
Compare it is found that micro based on the enteric slow release type in embodiment 1-5 prepared by coating method provided herein
Element particle all has preferable gastric juice resistant, wherein the gastric juice dissolution rate of the particle of the embodiment of the present application 1-5 is close
Different test samples is indicated without significant difference in the gastric juice dissolution rate of test sample 1 (polyacrylamide resin spraying coating)
Preferable stability can be kept without largely discharging dissolution in gastric juice.
Two, the result of extraction in simulated intestinal fluid:
Laboratory sample:
1, enteric slow release type microelement particle prepared in embodiment 1-5；
2, it the test sample compareed: takes in this comparative experiments and is obtained prepared by two kinds of preparation processes used in the prior art
Product is as test sample:
(1) the microelement particle of polyacrylamide resin spraying coating；
(2) zeins fusion coating.
Experimental method: taking 500ML triangular flask, take respectively be coated in the test sample and the embodiment of the present application 1-5 of control it is micro
It 1.00 grams of element, is placed in simulated intestinal fluid (Chinese Pharmacopoeia) 250mL added with 2.0 grams of bile acid, in 37.5 DEG C of waters bath with thermostatic control
In pot, after 60 beats/min of frequency, concussion 180 minutes, after filtering, micronutrient levels in clear liquid, or detection iron content are detected,
Calculate dissolution rate.
Calculation method: iron (mg) in microelement dissolution rate=solution/1.0g coating microelement total iron content ×
100%；
The intestinal juice dissolution rate of 2 embodiment 1-5 of table and control sample compares
It is shown by experimental result in table 2, dissolution efficiency of the embodiment of the present application 1-4 in simulated intestinal fluid and polyacrylic acid tree
Rouge spraying coating is close, and there was no significant difference, keeps higher intestinal juice dissolution rate, and coating is merged with zeins
Compared to significant difference.Prove that particle prepared by embodiment 1-4 can meet growth of animal needs in the application, reach expected
Effect.
To sum up, (polyacrylamide resin spraying is coated and jade with test sample is compareed for product prepared by the embodiment of the present application 1-4
Rice alcohol soluble protein fusion coating) dissolution rate experiment and dissolution rate experiment in intestinal juice in gastric juice have been carried out respectively, it compares.Pass through
Gastric juice and intestinal juice dissolution rate experimental result in Tables 1 and 2 it is found that product prepared by the embodiment of the present application 1-4 in the equal table of gastric juice
Preferable stability, the production that dissolution rate is prepared close to the spraying coating of high molecular material polyacrylamide resin are revealed
The sustained release performance of product；And in intestinal juice, product prepared by the embodiment of the present application 1-4 shows preferably to discharge result of extraction,
Its intestinal juice dissolution rate is close with the spraying coating of high molecular material polyacrylamide resin, and zeins fusion coating
Then due to coating method and packaging material itself the problem of, causes in gastric juice and can not dissolve out in intestinal juice, carries out four as feed
Dimension, which can be expelled directly out, causes cost to waste and be unable to reach expectation function.
To sum up, the embodiment 1-4 according to the preparation method preparation of enteric slow release type microelement particle in the application is made
Standby product can reach in the case where raw material and production cost is greatly lowered close to even more than high molecular material polypropylene
The effect of amide resin spraying coating, thus to solve agricultural animal trace element feeding in the complete effective premise of assurance function
Under provide low-cost new way.
Claims (10)
1. a kind of preparation method of enteric slow release type microelement particle characterized by comprising
Powdery microelement is taken, coating material is added and is pre-mixed, premix is obtained；
Heating melting is carried out to the premix；
Under the conditions of heating melting, the premix is mixed, shearing, fusion, form plastic pug；
Under the conditions of heating melting, extruding granulation is carried out to the plastic pug, obtains enteric slow release type microelement particle.
2. the preparation method of enteric slow release type microelement particle as described in claim 1, which is characterized in that described " to heat
Under melting condition, extruding granulation is carried out to the plastic pug, obtains enteric slow release type microelement particle " after, further includes:
Rotation is carried out to the enteric slow release type microelement particle that hot melt is prepared and throws circle, and is cooled to less through air-cooled
In 45 DEG C.
3. the preparation method of enteric slow release type microelement particle as described in claim 1, which is characterized in that described " to take powdery
Microelement is added coating material and is pre-mixed, obtains premix " include:
Take powdery microelement, coating material be added and is pre-mixed, also, be added in pre-mixing process functional filler into
Row mixing, obtains the premix.
4. the preparation method of enteric slow release type microelement particle as claimed in claim 3, which is characterized in that the functionality is filled out
Material includes ultra-fine auxiliary material and alkalescent filler；
The ultra-fine auxiliary material includes ultrafine zeolite powder, superfine calcined kaolin, superfine talcum powder, superfine white carbon black, ultra-fine sulfuric acid
One or more of aluminium potassium, calcium carbonate superfine powder, ultra-fine magnesium carbonate；
The alkalescent filler includes one or more of calcium oxide, magnesia, calcium hydroxide, magnesium hydroxide.
5. the preparation method of enteric slow release type microelement particle as described in claim 1, which is characterized in that described " to take powdery
Microelement is added coating material and is pre-mixed, obtains premix " before, further includes:
Trace element materials are taken, hydrophilic auxiliary material mixing is added, obtains mixed raw material；Wherein, the hydrophilic auxiliary material include calcium oxide,
One or more of magnesia, ultrafine zeolite powder and gesso；
70-100 DEG C of hot-air seasoning is carried out to the mixed raw material, sieving obtains the dry powdery microelement.
6. the preparation method of enteric slow release type microelement particle as described in claim 1, which is characterized in that described " to heat
Under melting condition, pelletize to the plastic pug, obtain enteric slow release type microelement particle " after, further includes:
Anticaking agent is added in the enteric slow release type microelement particle.
And be sieved and choose the particle of wherein 0.3-1.5mm, obtain screening particle；
Under the conditions of being heated to 50-80 DEG C, fluidized bed whole grain is carried out to get to particle after whole grain to the sieve powder particles.
7. the preparation method of enteric slow release type microelement particle as claimed in claim 6, which is characterized in that the anticaking agent packet
Include one or more of bentonite, precipitated calcium carbonate, kaolin, calcium stearate, talcum powder and magnesium stearate；
The anticaking agent is anticaking agent dry and by 325-2000 mesh screen.
8. the preparation method of enteric slow release type microelement particle as described in claim 1, which is characterized in that the coating material
Including one of stearic, hydrogenated oil and fat and emulsifier or multiple combinations；
The tristearin includes: chain saturated fatty acids in stearic acid, height palm oil, saturation oleic acid, myristic acid, lauric acid etc.
One or more of；
The hydrogenated oil and fat includes hydrogenated vegetable oil and/or hydrogenated animal oil；
The emulsifier includes that stearic acid list glycerolipid, stearic acid diglycerol rouge, nutmeg diand monoglycerides, lauric acid are single, double
The combination of one or more of glyceride.
9. the preparation method of enteric slow release type microelement particle as described in claim 1, which is characterized in that the coating material
Additional amount be the 15-55% for being equivalent to total amount.
10. the preparation method of enteric slow release type microelement particle as described in claim 1, which is characterized in that the heating is molten
The temperature melted is 60-105 DEG C.
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| GB1457643A (en) * | 1974-08-06 | 1976-12-08 | Sarap Cedia | Method of preparing granulated vitaminized coated mineral food complements for animals and products thus obtained |
| CN104721148A (en) * | 2013-12-18 | 2015-06-24 | 江苏豪森药业股份有限公司 | Enteric-coated slow release pellet or particle solid preparation and production method thereof |
| CN106333086A (en) * | 2016-10-31 | 2017-01-18 | 福建深纳生物工程有限公司 | Slow-release microelement premix and preparation method thereof |
| CN108185155A (en) * | 2018-01-24 | 2018-06-22 | 卢亮 | A kind of preparation method of feeding composite trace element coating pre-mixing agent |
| CN108402312A (en) * | 2018-03-08 | 2018-08-17 | 卢亮 | A kind of feeder acidulant coating method |
| CN108456108A (en) * | 2018-03-14 | 2018-08-28 | 湖北丰乐生态肥业有限公司 | The preparation method of micro- bio-feritlizer in a kind of supplement type |
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| CN113170894A (en) * | 2021-05-14 | 2021-07-27 | 南昌大学 | A device and method for preparing granular probiotics that can be delivered in the gastrointestinal tract |
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