RU2015104649A - Системы и способы доставки сухих порошковых лекарств - Google Patents
Системы и способы доставки сухих порошковых лекарств Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract 6
- 239000000843 powder Substances 0.000 claims abstract 20
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 claims abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000013543 active substance Substances 0.000 claims abstract 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000002894 organic compounds Chemical class 0.000 claims abstract 4
- 229940079593 drug Drugs 0.000 claims abstract 3
- 229940112141 dry powder inhaler Drugs 0.000 claims abstract 3
- 239000012634 fragment Substances 0.000 claims abstract 3
- 239000005526 vasoconstrictor agent Substances 0.000 claims abstract 3
- 229940124549 vasodilator Drugs 0.000 claims abstract 3
- 239000003071 vasodilator agent Substances 0.000 claims abstract 3
- 125000000349 (Z)-3-carboxyprop-2-enoyl group Chemical group O=C([*])/C([H])=C([H])\C(O[H])=O 0.000 claims abstract 2
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- 108090001061 Insulin Proteins 0.000 claims abstract 2
- 239000000556 agonist Substances 0.000 claims abstract 2
- 239000005557 antagonist Substances 0.000 claims abstract 2
- 230000001088 anti-asthma Effects 0.000 claims abstract 2
- 239000000924 antiasthmatic agent Substances 0.000 claims abstract 2
- 230000002124 endocrine Effects 0.000 claims abstract 2
- -1 glutaryl Chemical group 0.000 claims abstract 2
- 229940088597 hormone Drugs 0.000 claims abstract 2
- 239000005556 hormone Substances 0.000 claims abstract 2
- 229940125396 insulin Drugs 0.000 claims abstract 2
- 125000000346 malonyl group Chemical group C(CC(=O)*)(=O)* 0.000 claims abstract 2
- 229940035363 muscle relaxants Drugs 0.000 claims abstract 2
- 239000003158 myorelaxant agent Substances 0.000 claims abstract 2
- 102000039446 nucleic acids Human genes 0.000 claims abstract 2
- 108020004707 nucleic acids Proteins 0.000 claims abstract 2
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 2
- 125000003431 oxalo group Chemical group 0.000 claims abstract 2
- 229920001184 polypeptide Polymers 0.000 claims abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 150000003384 small molecules Chemical class 0.000 claims abstract 2
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 claims abstract 2
- 229960005486 vaccine Drugs 0.000 claims abstract 2
- ZISSAWUMDACLOM-UHFFFAOYSA-N triptane Chemical compound CC(C)C(C)(C)C ZISSAWUMDACLOM-UHFFFAOYSA-N 0.000 claims 4
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 102400000321 Glucagon Human genes 0.000 claims 1
- 108060003199 Glucagon Proteins 0.000 claims 1
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 1
- 101800000224 Glucagon-like peptide 1 Proteins 0.000 claims 1
- 229940084576 Neurotransmitter agonist Drugs 0.000 claims 1
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- 102400000050 Oxytocin Human genes 0.000 claims 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 1
- 101800000989 Oxytocin Proteins 0.000 claims 1
- 102000003982 Parathyroid hormone Human genes 0.000 claims 1
- 108090000445 Parathyroid hormone Proteins 0.000 claims 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
- 229960004666 glucagon Drugs 0.000 claims 1
- PXZWGQLGAKCNKD-DPNMSELWSA-N molport-023-276-326 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 PXZWGQLGAKCNKD-DPNMSELWSA-N 0.000 claims 1
- 229940127240 opiate Drugs 0.000 claims 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 1
- 229960001723 oxytocin Drugs 0.000 claims 1
- 239000000199 parathyroid hormone Substances 0.000 claims 1
- 229960001319 parathyroid hormone Drugs 0.000 claims 1
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims 1
- 229960003708 sumatriptan Drugs 0.000 claims 1
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Abstract
1. Ингалятор сухого порошка, содержащий:a) первый элемент, содержащий мундштук;b) второй элемент, содержащий контейнер; иc) по меньшей мере, два жестких воздушных канала;при этом один из, по меньшей мере, двух жестких воздушных каналов при использовании выполнен с возможностью содержания дефлектора или стержня для направления движения сухого порошка внутри контейнера для порошка.2. Ингалятор по п. 1, имеющий значение сопротивления воздушному потоку от приблизительно 0,065 до, приблизительно, 0,200 √кПа/(л/мин).3. Ингалятор по п. 1, в котором сухой порошок является препаратом для пероральной ингаляции и содержит количество сухого порошка от приблизительно 1 до приблизительно 50 мг.4. Ингалятор по п. 1, в котором сухой порошок содержит дикетопиперазин или фармацевтически допустимую соль дикетопиперазина.5. Ингалятор по п. 4, в котором дикетопиперазин имеет формулу 2,5-дикето-3,6-бис(N-X-4-аминобутил)пиперазин, где X выбрано из группы, состоящей из фумарила, сукцинила, малеила, малонила, оксалила и глутарила.6. Ингалятор по п. 5, в котором дикетопиперазин является бис-3,6-(N-фумарил-4-аминобутил)-2,5-дикето-дикетопиперазином.7. Ингалятор по п. 3, в котором сухой порошок содержит лекарство или активное средство.8. Ингалятор по п. 7, в котором активное вещество является эндокринным гормоном, вакцинами, низкомолекулярными соединениями, включая антиастматические средства, вазодилататоры, вазоконстрикторы, миорелаксанты, агонисты и антагонисты нейтротрансмиттеров и т.п.9. Ингалятор по п. 3, в котором сухой порошок содержит пептид, полипептид или их фрагменты, низкомолекулярное органическое соединение или молекулу нуклеиновой кислоты.10. Ингалятор по п. 9, в котором упомянутый пептид является инсулином,
Claims (18)
1. Ингалятор сухого порошка, содержащий:
a) первый элемент, содержащий мундштук;
b) второй элемент, содержащий контейнер; и
c) по меньшей мере, два жестких воздушных канала;
при этом один из, по меньшей мере, двух жестких воздушных каналов при использовании выполнен с возможностью содержания дефлектора или стержня для направления движения сухого порошка внутри контейнера для порошка.
2. Ингалятор по п. 1, имеющий значение сопротивления воздушному потоку от приблизительно 0,065 до, приблизительно, 0,200 √кПа/(л/мин).
3. Ингалятор по п. 1, в котором сухой порошок является препаратом для пероральной ингаляции и содержит количество сухого порошка от приблизительно 1 до приблизительно 50 мг.
4. Ингалятор по п. 1, в котором сухой порошок содержит дикетопиперазин или фармацевтически допустимую соль дикетопиперазина.
5. Ингалятор по п. 4, в котором дикетопиперазин имеет формулу 2,5-дикето-3,6-бис(N-X-4-аминобутил)пиперазин, где X выбрано из группы, состоящей из фумарила, сукцинила, малеила, малонила, оксалила и глутарила.
6. Ингалятор по п. 5, в котором дикетопиперазин является бис-3,6-(N-фумарил-4-аминобутил)-2,5-дикето-дикетопиперазином.
7. Ингалятор по п. 3, в котором сухой порошок содержит лекарство или активное средство.
8. Ингалятор по п. 7, в котором активное вещество является эндокринным гормоном, вакцинами, низкомолекулярными соединениями, включая антиастматические средства, вазодилататоры, вазоконстрикторы, миорелаксанты, агонисты и антагонисты нейтротрансмиттеров и т.п.
9. Ингалятор по п. 3, в котором сухой порошок содержит пептид, полипептид или их фрагменты, низкомолекулярное органическое соединение или молекулу нуклеиновой кислоты.
10. Ингалятор по п. 9, в котором упомянутый пептид является инсулином, глюкагоном, глюкагоноподобным пептидом-1, паратиреоидным гормоном, дезоксирибонуклеазой, окситоцином, оксинтомодулином, пептидом YY, экзендином, их аналогами или их фрагментами.
11. Ингалятор по п. 9, в котором низкомолекулярное органическое соединение является вазодилататором, вазоконстриктором, агонистом нейротрансмиттера или антагонистом нейротрансмиттера.
12. Ингалятор по п. 1, в котором контейнер встроен в корпус контейнера и наполнен сухим порошком.
13. Ингалятор по п. 1, в котором ингалятор не содержит контейнер.
14. Ингалятор по п. 1, в котором контейнер обеспечен отдельно от ингалятора и наполнен сухим порошком.
15. Ингалятор по п. 1, в котором порошок является аморфным порошком.
16. Ингалятор по п. 11, в котором низкомолекулярное органическое соединение является триптаном или опиатом.
17. Ингалятор по п. 16, в котором триптан является суматриптаном или ризатриптаном.
18. Способ доставки сухого порошка субъекту, содержащий введение субъекту эффективного количества аморфного порошкового лекарственного препарата с помощью ингалятора сухого порошка по п. 1.
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