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RU2012127760A - Bcl-2-селективные апоптоз-индуцирующие средства для лечения рака и иммунных заболеваний - Google Patents

Bcl-2-селективные апоптоз-индуцирующие средства для лечения рака и иммунных заболеваний Download PDF

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Publication number
RU2012127760A
RU2012127760A RU2012127760/04A RU2012127760A RU2012127760A RU 2012127760 A RU2012127760 A RU 2012127760A RU 2012127760/04 A RU2012127760/04 A RU 2012127760/04A RU 2012127760 A RU2012127760 A RU 2012127760A RU 2012127760 A RU2012127760 A RU 2012127760A
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Russia
Prior art keywords
methyl
chlorophenyl
yloxy
piperazin
benzamide
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RU2012127760/04A
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English (en)
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RU2542994C2 (ru
Inventor
Милан БРАНКО
Хун ДИН
Джордж А. ДОУЭРТИ
Стивен В. ЭЛМОР
Лиза ХАСВОЛЬД
Лаура ХЕКСАМЕР
Аарон КАНЗЕР
Роберт А. МАНТЕЙ
Уилльям Дж. МАККЛЕЛЛАН
Чанг Х. ПАРК
Чэол-Мин ПАРК
Эндрю М. ПЕТРОС
Сяохун СУН
Эндрю Дж. САУЭРС
Джерард М. САЛЛИВАН
Чжи-фу ТАО
Гари Т. ВАН
Лэ ВАН
Силу ВАН
Майкл Д. УЭНДТ
Тодд М. ХАНСЕН
Original Assignee
Эбботт Лэборетриз
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Abstract

1. Соединение или его терапевтически приемлемая соль, где соединение выбрано из следующих:N-({5-хлор-6-[(4,4-дифторциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;N-({6-[(транс-4-карбамоилциклогексил)метокси]-5-хлорпиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(4-{[(транс-4-цианоциклогексил)метил]амино}-3-нитрофенил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;N-({5-хлор-6-[2-(1Н-имидазол-1-ил)этокси]пиридин-3ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;N-({5-хлор-6-[(1-метил-1Н-имидазол-5-ил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[5-фтор-6-(тетрагидро-2Н-пиран-4-илметокси)пиридин-3-ил]сульфонил}-2-(1Н-индазол-4-илокси)бензамид;N-{[5-хлор-6-(1,4-диоксан-2-илметокси)пиридин-3ил]сульфонил}-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;N-({5-хлор-6-[(4,4-дифтор-1-гидроксициклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;N-({5-хлор-6-[(2,2-дифторциклопропил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;N-({5-хлор-6-[(транс-4-цианоциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]ме

Claims (6)

1. Соединение или его терапевтически приемлемая соль, где соединение выбрано из следующих:
N-({5-хлор-6-[(4,4-дифторциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({6-[(транс-4-карбамоилциклогексил)метокси]-5-хлорпиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(4-{[(транс-4-цианоциклогексил)метил]амино}-3-нитрофенил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[2-(1Н-имидазол-1-ил)этокси]пиридин-3ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(1-метил-1Н-имидазол-5-ил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[5-фтор-6-(тетрагидро-2Н-пиран-4-илметокси)пиридин-3-ил]сульфонил}-2-(1Н-индазол-4-илокси)бензамид;
N-{[5-хлор-6-(1,4-диоксан-2-илметокси)пиридин-3ил]сульфонил}-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(4,4-дифтор-1-гидроксициклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(2,2-дифторциклопропил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(транс-4-цианоциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(цис-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(транс-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({3-хлор-4-[(4-фтортетрагидро-2Н-пиран-4-ил)метокси]фенил}сульфонил)-4-(4-{[4-(4-хлорфенил)-6,6-диметил-5,6-дигидро-2Н-пиран-3-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({4-[(4-фтортетрагидро-2Н-пиран-4-ил)метокси]-3-(трифторметил)фенил}сульфонил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[3-хлор-4-(тетрагидро-2Н-пиран-4-илметокспи)фенил]сульфонил}-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензимидазол-4-илокси)-N-({3-хлор-4-[(4-фтортетрагидро-2Н-пиран-4-ил)метокси]фенил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)бензамид;
2-(1Н-бензимидазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[5-хлор-6-(тетрагидро-2Н-пиран-4-илметокси)пиридин-3-ил]сульфонил}бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({3-циано-4-[(4-фтортетрагидро-2Н-пиран-4-ил)метокси]фенил}сульфонил)-2-(1Н-индазол-4-илокси)бензамид;
N-{[3-хлор-4-(1,4-диоксан-2-илметокси)фенил]сульфонил}-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензимидазол-4-илокси)-N-[(5-хлор-6-{[(2S)-4-циклопропилморфолин-2-ил]метокси}пиридин-3-ил)сульфонил]-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)бензамид;
N-[(5-хлор-6-{[(2S)-4-циклопропилморфолин-2-ил]метокси}пиридин-3-ил)сульфонил]-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
метил 2-{[(4-{[4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензоил]сульфамоил}-2-нитрофенил)амино]метил}морфолин-4-карбоксилат;
2-{[(4-{[4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензоил]сульфамоил}-2-нитрофенил)амино]метил}-N-этил-N-метилморфолин-4-карбоксамид;
2-{[(4-{[2-(1Н-бензимидазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)бензоил]сульфамоил}-2-нитрофенил)амино]метил}-N-этил-N-метилморфолин-4-карбоксамид;
N-({5-хлор-6-[(транс-4-этил-4-гидроксициклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(цис-4-этил-4-гидроксициклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
5-хлор-N-({5-хлор-6-[(4-фтортетрагидро-2Н-пиран-4-ил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
5-хлор-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(4-{[(4-фтортетрагидро-2Н-пиран-4-ил)метил]амино}-3-нитрофенил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(цис-1-фтор-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илоксил) бензамид;
N-({5-хлор-6-[(транс-1-фтор-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси) бензамид;
2-(1Н-бензотриазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(4-{[(4-фтортетрагидро-2Н-пиран-4-ил)метил]амино}-3-нитрофенил)сульфонил]бензамид;
2-(1Н-бензотриазол-4-илокси)-N-({5-хлор-6-[(4-фтортетрагидро-2Н-пиран-4-ил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)бензамид;
2-(1Н-бензимидазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[3-хлор-4-(тетрагидро-2Н-пиран-4-илметокси)фенил]сульфонил}бензамид;
N-[(3-хлор-4-{[4-фтор-1-(оксетан-3-ил)пиперидин-4-ил]метокси}фенил)сульфонил]-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(цис-1-фтор-4-гидроксициклогекси)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензотриазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({4-[(4-фтортетрагидро-2Н-пиран-4-ил)метокси]-3-нитрофенил}сульфонил)бензамид;
N-[(5-хлор-6-{[(1R,2R,4R,5R)-5-гидрокси-5-метилбицикло[2,2,1]гепт-2-ил]метокси}пиридин-3-ил)сульфонил]-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(4-фтортетрагидро-2Н-пиран-4-ил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-5,5-дифторциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-[(5-хлор-6-{[4-фтор-1-(оксетан-3-ил)пиперидин-4-ил]метокси}пиридин-3-ил)сульфонил]-4-(4-{[2-(4-хлорфенил)-5,5-дифторциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензотриазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({3-нитро-4-[(тетрагидро-2Н-пиран-4-илметил)амино]фенил}сульфонил)бензамид;
4-(4-{[2-(4-хлорфенил)-5,5-дифторциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)-N-({3-нитро-4-[(тетрагидро-2Н-пиран-4-илметил)амино]фенил}сульфонил)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(4-{[(транс-4-гидрокси-4-метилциклогексил)метил]амино}-3-нитрофенил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(4-{[(цис-4-гидрокси-4-метилциклогексил)метил]амино}-3-нитрофенил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензотриазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[4-({[(2S)-4-циклопропилморфолин-2-ил]метил}амино)-3-нитрофенил]сульфонил}бензамид;
N-[(5-хлор-6-{[4-фтор-1-(оксетан-3-ил)пиперидин-4-ил]метокси}пиридин-3-ил)сульфонил]-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[4-({[(2S)-4-циклопропилморфолин-2-ил]метил}амино)-3-нитрофенил]сульфонил}-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензимидазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[4-({[(2S)-4-циклопропилморфолин-2-ил]метил}амино)-3-нитрофенил]сульфонил}бензамид;
N-({5-хлор-6-[(транс-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-5,5-дифторциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({4-[(цис-4-гидрокси-4-метилциклогексил)метокси]-3-нитрофенил}сульфонил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({4-[(транс-4-гидрокси-4-метилциклогексил)метокси]-3-нитрофенил}сульфонил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(3-циано-4-{[4-фтор-1-(оксетан-3-ил)пиперидин-4-ил]метокси}фенил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)-N-{[3-нитро-4-(2-оксаспиро[3.5]нон-7-илметокси)фенил]сульфонил}бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[5-хлор-6-(5,6,7,8-тетрагидроимидазо[1,2-а]пиридин-6-илметокси)пиридин-3-ил]сульфонил}-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензимидазол-4-илокси)-N-({5-хлор-6-[(транс-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(5-циано-6-{[4-фтор-1-(оксетан-3-ил)пиперидин-4-ил]метокси}пиридин-3-ил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(транс-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-5-(метоксиметил)-5-метилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)-N-{[3-нитро-4-({[(2S)-4-(оксетан-3-ил)морфолин-2-ил]метил}амино)фенил]сульфонил}бензамид;
2-(1Н-бензимидазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-{[3-нитро-4-({[(2S)-4-(оксетан-3-ил)морфолин-2-ил]метил}амино)фенил]сульфонил}бензамид;
N-[(5-хлор-6-{[транс-4-(2-гидроксипропан-2-ил)циклогексил]метокси}пиридин-3-ил)сульфонил]-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({3-циано-4-[(транс-4-гидрокси-4-метилциклогексил)метокси]фенил}сульфонил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({5-циано-6-[(транс-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)-N-({5-нитро-6-[(тетрагидро-2Н-пиран-4-илметил)амино]пиридин-3-ил-}сульфонил)бензамид;
2-(1Н-бензотриазол-4-илокси)-N-({5-хлор-6-[(транс-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)бензамид;
N-({3-хлор-4-[(цис-4-циано-1-фторциклогексил)метокси]фенил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({3-хлор-4-[(транс-4-циано-1-фторциклогексил)метокси]фенил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(цис-4-циано-1-фторциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(транс-4-циано-1-фторциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
N-({5-хлор-6-[(транс-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[4-(4-хлорфенил)-6,6-диметил-5,6-дигидро-2Н-пиран-3-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензимидазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(4-{[(транс-4-гидрокси-4-метилциклогексил)метил]амино}-3-нитрофенил)сульфонил]бензамид;
N-({5-хлор-6-[(транс-4-гидрокси-4-метилциклогексил)метокси]пиридин-3-ил}сульфонил)-4-(4-{[2-(4-хлорфенил)-5-метокси-5-метилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(5-хлор-6-{[1-(1,3-тиазол-2-ил)пиперидин-4-ил]метокси}пиридин-3-ил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(6-{[(цис-4-гидрокси-4-метилциклогексил)метил]амино}-5-нитропиридин-3-ил)сульфонил]-2-(1Н-индазол-4-илокси)бензамид;
4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-({6-[(транс-4-гидрокси-4-метилциклогексил)метокси]-5-(трифторметил)пиридин-3-ил-}сульфонил)-2-(1Н-индазол-4-илокси)бензамид;
2-(1Н-бензимидазол-4-илокси)-4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-N-[(4-{[(цис-4-гидрокси-4-метилциклогексил)метил]амино}-3-нитрофенил)сульфонил]бензамид;
N-(4-{[4-(4-{[2-(4-хлорфенил)-4,4-диметилциклогекс-1-ен-1-ил]метил}пиперазин-1-ил)-2-(1Н-индазол-4-илокси)бензоил]сульфамоил}-2-нитрофенил)-4-цианопиперидин-1-карбоксамид.
2. Композиция для лечения рака мочевого пузыря, рака головного мозга, рака молочной железы, рака костного мозга, цервикального рака, хронического лимфоцитарного лейкоза, колоректального рака, эзофагеального рака, гепатоцеллюлярного рака, лимфобластного лейкоза, фолликулярной лимфомы, лимфоидной опухоли Т-клеточного или В-клеточного происхождения, меланомы, миелогенного лейкоза, миеломы, орального рака, рака яичника, немелкоклеточного рака легкого, рака предстательной железы, мелкоклеточного рака легкого или рака селезенки, где указанная композиция включает эксципиент и терапевтически эффективное количество соединения по п.1.
3. Соединение по п.1 или его терапевтически приемлемая соль для применения в лечении рака мочевого пузыря, рака головного мозга, рака молочной железы, рака костного мозга, цервикального рака, хронического лимфоцитарного лейкоза, колоректального рака, эзофагеального рака, гепатоцеллюлярного рака, лимфобластного лейкоза, фолликулярной лимфомы, лимфоидной опухоли Т-клеточного или В-клеточного происхождения, меланомы, миелогенного лейкоза, миеломы, орального рака, рака яичника, немелкоклеточного рака легкого, рака предстательной железы, мелкоклеточного рака легкого или рака селезенки у пациента.
4. Соединение по п.1 или его терапевтически приемлемая соль и одно дополнительное терапевтическое средство или несколько дополнительных терапевтических средств для применения в лечении рака мочевого пузыря, рака головного мозга, рака молочной железы, рака костного мозга, цервикального рака, хронического лимфоцитарного лейкоза, колоректального рака, эзофагеального рака, гепатоцеллюлярного рака, лимфобластного лейкоза, фолликулярной лимфомы, лимфоидной опухоли Т-клеточного или В-клеточного происхождения, меланомы, миелогенного лейкоза, миеломы, орального рака, рака яичника, немелкоклеточного рака легкого, рака предстательной железы, мелкоклеточного рака легкого или рака селезенки у пациента.
5. Применение соединения по п.1 или его терапевтически приемлемой соли для получения лекарственного средства для лечения рака мочевого пузыря, рака головного мозга, рака молочной железы, рака костного мозга, цервикального рака, хронического лимфоцитарного лейкоза, колоректального рака, эзофагеального рака, гепатоцеллюлярного рака, лимфобластного лейкоза, фолликулярной лимфомы, лимфоидной опухоли Т-клеточного или В-клеточного происхождения, меланомы, миелогенного лейкоза, миеломы, орального рака, рака яичника, немелкоклеточного рака легкого, рака предстательной железы, мелкоклеточного рака легкого или рака селезенки у пациента.
6. Применение соединения по п.1 или его терапевтически приемлемой соли и одного дополнительного терапевтического средства или нескольких дополнительных терапевтических средств для получения лекарственного средства для лечения рака мочевого пузыря, рака головного мозга, рака молочной железы, рака костного мозга, цервикального рака, хронического лимфоцитарного лейкоза, колоректального рака, эзофагеального рака, гепатоцеллюлярного рака, лимфобластного лейкоза, фолликулярной лимфомы, лимфоидной опухоли Т-клеточного или В-клеточного происхождения, меланомы, миелогенного лейкоза, миеломы, орального рака, рака яичника, немелкоклеточного рака легкого, рака предстательной железы, мелкоклеточного рака легкого или рака селезенки у пациента.
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