RU2012121055A - PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DISEASES ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION - Google Patents
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DISEASES ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION Download PDFInfo
- Publication number
- RU2012121055A RU2012121055A RU2012121055/15A RU2012121055A RU2012121055A RU 2012121055 A RU2012121055 A RU 2012121055A RU 2012121055/15 A RU2012121055/15 A RU 2012121055/15A RU 2012121055 A RU2012121055 A RU 2012121055A RU 2012121055 A RU2012121055 A RU 2012121055A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- methylpyridine
- ethyl
- succinate
- composition according
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 9
- 206010048554 Endothelial dysfunction Diseases 0.000 title claims abstract 3
- 201000010099 disease Diseases 0.000 title claims abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract 3
- 230000008694 endothelial dysfunction Effects 0.000 title claims abstract 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims abstract 9
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims abstract 4
- 229930010555 Inosine Natural products 0.000 claims abstract 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims abstract 4
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960003786 inosine Drugs 0.000 claims abstract 4
- DCUJJWWUNKIJPH-UHFFFAOYSA-N nitrapyrin Chemical compound ClC1=CC=CC(C(Cl)(Cl)Cl)=N1 DCUJJWWUNKIJPH-UHFFFAOYSA-N 0.000 claims abstract 4
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical class CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- IKMNOGHPKNFPTK-UHFFFAOYSA-N 2-ethyl-6-methylpyridin-1-ium-3-ol;4-hydroxy-4-oxobutanoate Chemical compound OC(=O)CCC(O)=O.CCC1=NC(C)=CC=C1O IKMNOGHPKNFPTK-UHFFFAOYSA-N 0.000 claims abstract 2
- KZUIXWYHQJZUOK-UHFFFAOYSA-N 2-ethyl-6-methylpyridin-1-ium-3-ol;chloride Chemical compound Cl.CCC1=NC(C)=CC=C1O KZUIXWYHQJZUOK-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims abstract 2
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 239000013543 active substance Substances 0.000 claims abstract 2
- 229960005305 adenosine Drugs 0.000 claims abstract 2
- UERDQPPNWOGLLN-UHFFFAOYSA-N butanedioic acid 3-methylpyridine Chemical compound CC1=CC=CN=C1.OC(=O)CCC(O)=O UERDQPPNWOGLLN-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 239000002552 dosage form Substances 0.000 claims abstract 2
- 239000007902 hard capsule Substances 0.000 claims abstract 2
- 239000007924 injection Substances 0.000 claims abstract 2
- 238000002347 injection Methods 0.000 claims abstract 2
- -1 lyophilisate Substances 0.000 claims abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims abstract 2
- 239000000829 suppository Substances 0.000 claims abstract 2
- 239000003826 tablet Substances 0.000 claims abstract 2
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Фармацевтический состав для лечения заболеваний, связанных с эндотелиальной дисфункцией, характеризующийся тем, что в качестве активного ингредиента содержит производное метилпиридина или его фармацевтически приемлемую соль, пурин и вспомогательные вещества, находится в виде стабильной лекарственной формы при следующем соотношении компонентов, мас.%:2. Фармацевтический состав по п.1, характеризующийся тем, что в качестве активного вещества, содержит соединения из группы: 3-(N,N-диметилкарбомоилокси)-2-этил-6-метилпиридина сукцинат, 3-метилпиридин сукцинат, 2-этил-6-метил-3-гидроксипиридина гидрохлорид, 6-трихлорметил-2-хлорпиридин (нитрапирин), 2-этил-6-метил-3-гидроксипиридина сукцинат.3. Фармацевтический состав по п.1, характеризующийся тем, что в качестве пурина содержит инозин, аденозин, гипоксантин, преимущественно инозин.4. Фармацевтический состав по п.1, характеризующийся тем, что находится в виде инъекций, лиофилизата, твердых капсул, таблеток, суппозиторий.1. The pharmaceutical composition for the treatment of diseases associated with endothelial dysfunction, characterized in that the active ingredient contains a methylpyridine derivative or its pharmaceutically acceptable salt, purine and excipients, is in the form of a stable dosage form in the following ratio, wt.%: 2. The pharmaceutical composition according to claim 1, characterized in that, as an active substance, contains compounds from the group: 3- (N, N-dimethylcarbomoyloxy) -2-ethyl-6-methylpyridine succinate, 3-methylpyridine succinate, 2-ethyl-6 -methyl-3-hydroxypyridine hydrochloride, 6-trichloromethyl-2-chloropyridine (nitrapyrin), 2-ethyl-6-methyl-3-hydroxypyridine succinate. 3. The pharmaceutical composition according to claim 1, characterized in that as purine contains inosine, adenosine, hypoxanthine, mainly inosine. The pharmaceutical composition according to claim 1, characterized in that it is in the form of injections, lyophilisate, hard capsules, tablets, suppository.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012121055/15A RU2504375C1 (en) | 2012-05-23 | 2012-05-23 | Pharmaceutical formulation for treating diseases associated with endothelial dysfunction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012121055/15A RU2504375C1 (en) | 2012-05-23 | 2012-05-23 | Pharmaceutical formulation for treating diseases associated with endothelial dysfunction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012121055A true RU2012121055A (en) | 2013-11-27 |
| RU2504375C1 RU2504375C1 (en) | 2014-01-20 |
Family
ID=49624994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012121055/15A RU2504375C1 (en) | 2012-05-23 | 2012-05-23 | Pharmaceutical formulation for treating diseases associated with endothelial dysfunction |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2504375C1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2657416C1 (en) * | 2017-02-20 | 2018-06-13 | Общество с ограниченной ответственностью "АЛВИЛС" | Method of treatment of endothelial dysfunction |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2905936B1 (en) * | 1979-02-16 | 1980-04-30 | Degussa | Process for lightening and deodorising sulfate pulp |
| RU2095350C1 (en) * | 1993-10-13 | 1997-11-10 | Центр по химии лекарственных средств (ЦХЛС-ВНИХФИ) | 3-(n,n-dimethylcarbamoylhydroxy)-2-ethyl-6-methylpyridine succinate showing antihypoxic activity |
| RU2280455C2 (en) * | 2004-02-05 | 2006-07-27 | Галина Викторовна Сукоян | Medicinal agent for arresting syndrome of systemic inflammatory response |
-
2012
- 2012-05-23 RU RU2012121055/15A patent/RU2504375C1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2504375C1 (en) | 2014-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20190524 |