RU2012118228A - HIGHLY STABLE PHARMACEUTICAL COMPOSITION BASED ON THE LYOPHYLISATE OF 3-OXYPRIDINES OR METHYLPYRIDINES OR THEIR PHARMACEUTALLY ACCEPTABLE SALTS - Google Patents
HIGHLY STABLE PHARMACEUTICAL COMPOSITION BASED ON THE LYOPHYLISATE OF 3-OXYPRIDINES OR METHYLPYRIDINES OR THEIR PHARMACEUTALLY ACCEPTABLE SALTS Download PDFInfo
- Publication number
- RU2012118228A RU2012118228A RU2012118228/15A RU2012118228A RU2012118228A RU 2012118228 A RU2012118228 A RU 2012118228A RU 2012118228/15 A RU2012118228/15 A RU 2012118228/15A RU 2012118228 A RU2012118228 A RU 2012118228A RU 2012118228 A RU2012118228 A RU 2012118228A
- Authority
- RU
- Russia
- Prior art keywords
- hydroxypyridine
- ethyl
- succinate
- methylpyridines
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 5
- 150000003839 salts Chemical class 0.000 title claims abstract 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract 6
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical class CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 claims abstract 4
- DCUJJWWUNKIJPH-UHFFFAOYSA-N nitrapyrin Chemical compound ClC1=CC=CC(C(Cl)(Cl)Cl)=N1 DCUJJWWUNKIJPH-UHFFFAOYSA-N 0.000 claims abstract 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract 4
- 239000001103 potassium chloride Substances 0.000 claims abstract 3
- 235000011164 potassium chloride Nutrition 0.000 claims abstract 3
- 239000011780 sodium chloride Substances 0.000 claims abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000008215 water for injection Substances 0.000 claims abstract 3
- KZUIXWYHQJZUOK-UHFFFAOYSA-N 2-ethyl-6-methylpyridin-1-ium-3-ol;chloride Chemical compound Cl.CCC1=NC(C)=CC=C1O KZUIXWYHQJZUOK-UHFFFAOYSA-N 0.000 claims abstract 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 239000013543 active substance Substances 0.000 claims abstract 2
- UERDQPPNWOGLLN-UHFFFAOYSA-N butanedioic acid 3-methylpyridine Chemical compound CC1=CC=CN=C1.OC(=O)CCC(O)=O UERDQPPNWOGLLN-UHFFFAOYSA-N 0.000 claims abstract 2
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 claims abstract 2
- 238000004108 freeze drying Methods 0.000 claims abstract 2
- 238000002347 injection Methods 0.000 claims abstract 2
- 239000007924 injection Substances 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- -1 nitroxy succinate 2-ethyl-6-methyl-3-hydroxypyridine Chemical compound 0.000 claims abstract 2
- GBGXSZXUQWIDNR-UHFFFAOYSA-N oxalic acid;pyridin-3-ol Chemical compound OC(=O)C(O)=O.OC1=CC=CN=C1 GBGXSZXUQWIDNR-UHFFFAOYSA-N 0.000 claims abstract 2
- LQUPGMXVVZSYIV-UHFFFAOYSA-N propanedioic acid;pyridin-3-ol Chemical compound OC(=O)CC(O)=O.OC1=CC=CN=C1 LQUPGMXVVZSYIV-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000003381 stabilizer Substances 0.000 claims abstract 2
- 238000000859 sublimation Methods 0.000 claims abstract 2
- 230000008022 sublimation Effects 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims abstract 2
- IKMNOGHPKNFPTK-UHFFFAOYSA-N 2-ethyl-6-methylpyridin-1-ium-3-ol;4-hydroxy-4-oxobutanoate Chemical compound OC(=O)CCC(O)=O.CCC1=NC(C)=CC=C1O IKMNOGHPKNFPTK-UHFFFAOYSA-N 0.000 claims 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- JPGDYIGSCHWQCC-UHFFFAOYSA-N emoxypine Chemical compound CCC1=NC(C)=CC=C1O JPGDYIGSCHWQCC-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1. Фармацевтический состав для инъекций, содержащий производные 3-окси или метилпиридинов или их фармацевтически приемлемые соли в качестве активного ингредиента, характеризующийся тем, что находится в форме стабильного лиофилизата и содержит активный компонент натрия или калия хлорид в качестве вспомогательного вещества, воду для инъекций при следующем соотношении компонентов, мас.%:Производные 3-окси- или метилпиридиновпри этом состав получен путем лиофилизации сублимированием без добавления стабилизаторов типа метабисульфита, натрия бисульфит, трилон Б и с последующим обезвоживанием вакуумом в течение не менее 64 ч.2. Фармацевтический состав по п.1, характеризующийся тем, что в качестве активного вещества содержит: 3-(N,N-диметилкарбомоилокси)-2-этил-6-метилпиридина сукцинат, 3-метилпиридин сукцинат, 2-этил-6-метил-3-гидроксипиридина гидрохлорид, нитроксисукцината 2-этил-6-метил-3-оксипиридин, 3-оксипиридина оксалат, 6-трихлорметил-2-хлорпиридин (нитрапирин), 3-оксипиридина малонат, 2-этил-6-метил-3-гидроксипиридина сукцинат. 1. A pharmaceutical composition for injection containing derivatives of 3-hydroxy or methylpyridines or their pharmaceutically acceptable salts as an active ingredient, characterized in that it is in the form of a stable lyophilisate and contains the active component sodium or potassium chloride as an auxiliary substance, water for injection with the following ratio of components, wt.%: Derivatives of 3-hydroxy- or methylpyridines, while the composition was obtained by freeze-drying by sublimation without the addition of stabilizers such as metabisulfite, nat Ia bisulfite, Trilon B, and followed by dehydration in vacuum for at least 64 p.2. The pharmaceutical composition according to claim 1, characterized in that the active substance contains: 3- (N, N-dimethylcarbomoyloxy) -2-ethyl-6-methylpyridine succinate, 3-methylpyridine succinate, 2-ethyl-6-methyl-3 -hydroxypyridine hydrochloride, nitroxy succinate 2-ethyl-6-methyl-3-hydroxypyridine, 3-hydroxypyridine oxalate, 6-trichloromethyl-2-chloropyridine (nitrapyrin), 3-hydroxypyridine malonate, 2-ethyl-6-methyl-3-hydroxypyridine .
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012118228/15A RU2504376C1 (en) | 2012-05-04 | 2012-05-04 | High-stable pharmaceutical formulation of lyophilisate of 3-oxypyridine and methylpyridine derivatives and pharmaceutically acceptable salts thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012118228/15A RU2504376C1 (en) | 2012-05-04 | 2012-05-04 | High-stable pharmaceutical formulation of lyophilisate of 3-oxypyridine and methylpyridine derivatives and pharmaceutically acceptable salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012118228A true RU2012118228A (en) | 2013-11-10 |
| RU2504376C1 RU2504376C1 (en) | 2014-01-20 |
Family
ID=49516677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012118228/15A RU2504376C1 (en) | 2012-05-04 | 2012-05-04 | High-stable pharmaceutical formulation of lyophilisate of 3-oxypyridine and methylpyridine derivatives and pharmaceutically acceptable salts thereof |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2504376C1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2637168C2 (en) * | 2015-03-12 | 2017-11-30 | Закрытое Акционерное Общество "Фармфирма "Сотекс" | Pharmaceutical composition in form of solute for intravenous and intramuscular injection and its production process |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2205640C1 (en) * | 2002-04-09 | 2003-06-10 | Общество с ограниченной ответственностью "Экофарминвест" | Stable mexidol-containing pharmaceutical composition |
| RU2440132C2 (en) * | 2006-12-27 | 2012-01-20 | Закрытое акционерное общество "Синтез пептидов" | Composition exhibiting neuroprotective, antiamnestic, antihypoxic and antiischemic activity |
| RU2385722C1 (en) * | 2008-07-02 | 2010-04-10 | Тимофей Георгиевич Кожока | Pharmaceutical neuroprotective, antioxidant, antihypoxic, antiapoptotic and membrane protective composition and method of treatment |
| RU2398583C2 (en) * | 2008-10-23 | 2010-09-10 | Республиканское Унитарное производственное предприятие "Белмедпрепараты" | Antioxidant and antihypoxic agent of 6-methyl-2-ethyl-3-hydrohypyridine succinate |
| TR200904159A1 (en) * | 2009-04-17 | 2010-11-22 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Modified release emoxipine formulations. |
-
2012
- 2012-05-04 RU RU2012118228/15A patent/RU2504376C1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2504376C1 (en) | 2014-01-20 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20190505 |