RU2012146353A - Применение дистантного ишемического кондиционирования для улучшения последствия после инфаркта миокарда - Google Patents
Применение дистантного ишемического кондиционирования для улучшения последствия после инфаркта миокарда Download PDFInfo
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- RU2012146353A RU2012146353A RU2012146353/14A RU2012146353A RU2012146353A RU 2012146353 A RU2012146353 A RU 2012146353A RU 2012146353/14 A RU2012146353/14 A RU 2012146353/14A RU 2012146353 A RU2012146353 A RU 2012146353A RU 2012146353 A RU2012146353 A RU 2012146353A
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- 208000010125 myocardial infarction Diseases 0.000 title claims abstract 23
- 230000003750 conditioning effect Effects 0.000 title claims abstract 17
- 230000000302 ischemic effect Effects 0.000 title claims abstract 14
- 238000000034 method Methods 0.000 claims abstract 44
- 238000002399 angioplasty Methods 0.000 claims abstract 2
- 230000010410 reperfusion Effects 0.000 claims 3
- 208000028867 ischemia Diseases 0.000 claims 2
- 102000008873 Angiotensin II receptor Human genes 0.000 claims 1
- 108050000824 Angiotensin II receptor Proteins 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 238000013176 antiplatelet therapy Methods 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 239000003087 receptor blocking agent Substances 0.000 claims 1
- 230000035488 systolic blood pressure Effects 0.000 claims 1
- 210000001364 upper extremity Anatomy 0.000 claims 1
- 230000001292 preischemic effect Effects 0.000 abstract 3
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- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12009—Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/132—Tourniquets
- A61B17/1322—Tourniquets comprising a flexible encircling member
- A61B17/1327—Tensioning clamps
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/132—Tourniquets
- A61B17/135—Tourniquets inflatable
- A61B17/1355—Automated control means therefor
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00199—Electrical control of surgical instruments with a console, e.g. a control panel with a display
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
- A61B2017/00544—Surgical instruments, devices or methods pneumatically or hydraulically operated pneumatically
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Abstract
1. Способ, включающийпроведение многократных курсов дистантного ишемического кондиционирования (ДИК) субъекту после инфаркта миокарда.2. Способ по п.1, где многократные курсы ДИК начинают в течение 1 недели или в течение 1 месяца от инфаркта миокарда.3. Способ по п.1, где субъект не подвергся предварительному ишемическому кондиционированию перед инфарктом миокарда.4. Способ по п.1, где субъект не подвергся предварительному ишемическому кондиционированию в течение инфаркта миокарда.5. Способ по п.1, где предварительное ишемическое кондиционирование является дистантным или локальным.6. Способ по п. 1, где субъект подвергся предварительному ишемическому кондиционированию.7. Способ по п. 6, где предварительное ишемическое кондиционирование происходило перед инфарктом миокарда.8. Способ по п.1, где субъект испытал ишемическое кондиционирование дистанционно или локально в течение инфаркта миокарда.9. Способ по любому из пп.1-8, где последующие курсы ДИК проводят каждые два дня после первого курса ДИК.10. Способ по любому из пп.1-8, где многократные курсы ДИК проводят каждые три дня, каждые два дня или ежедневно.11. Способ по любому из пп.1-8, где последующие курсы ДИК проводят в течение месяца после инфаркта миокарда.12. Способ по любому из пп.1-8, где многократные курсы ДИК проводят в течение месяца после инфаркта миокарда.13. Способ по любому из пп.1-8, где многократные курсы ДИК включают более одного курса ДИК в день на один или более дней.14. Способ по любому из пп.1-8, где субъект не подвергся баллонной ангиопластике или установке стента.15. Способ по любому из пп.1-8, где субъектом является человек.16. Способ по любому из пп.1-8, где первый курс
Claims (28)
1. Способ, включающий
проведение многократных курсов дистантного ишемического кондиционирования (ДИК) субъекту после инфаркта миокарда.
2. Способ по п.1, где многократные курсы ДИК начинают в течение 1 недели или в течение 1 месяца от инфаркта миокарда.
3. Способ по п.1, где субъект не подвергся предварительному ишемическому кондиционированию перед инфарктом миокарда.
4. Способ по п.1, где субъект не подвергся предварительному ишемическому кондиционированию в течение инфаркта миокарда.
5. Способ по п.1, где предварительное ишемическое кондиционирование является дистантным или локальным.
6. Способ по п. 1, где субъект подвергся предварительному ишемическому кондиционированию.
7. Способ по п. 6, где предварительное ишемическое кондиционирование происходило перед инфарктом миокарда.
8. Способ по п.1, где субъект испытал ишемическое кондиционирование дистанционно или локально в течение инфаркта миокарда.
9. Способ по любому из пп.1-8, где последующие курсы ДИК проводят каждые два дня после первого курса ДИК.
10. Способ по любому из пп.1-8, где многократные курсы ДИК проводят каждые три дня, каждые два дня или ежедневно.
11. Способ по любому из пп.1-8, где последующие курсы ДИК проводят в течение месяца после инфаркта миокарда.
12. Способ по любому из пп.1-8, где многократные курсы ДИК проводят в течение месяца после инфаркта миокарда.
13. Способ по любому из пп.1-8, где многократные курсы ДИК включают более одного курса ДИК в день на один или более дней.
14. Способ по любому из пп.1-8, где субъект не подвергся баллонной ангиопластике или установке стента.
15. Способ по любому из пп.1-8, где субъектом является человек.
16. Способ по любому из пп.1-8, где первый курс ДИК проводят в течение ишемии, связанной с инфарктом миокарда.
17. Способ по любому из пп.1-8, где первый курс ДИК проводят в течение реперфузии после ишемии, связанной с инфарктом миокарда.
18. Способ по любому из пп.1-8, где по меньшей мере один курс ДИК из многократных курсов ДИК включает по меньшей мере четыре цикла, при этом каждый цикл включает окклюзирующее давление и реперфузию.
19. Способ по любому из пп.1-8, где по меньшей мере один курс ДИК из многократных курсов ДИК включает более одного цикла, включающего 5 минут окклюзирующего давления и 5 минут реперфузии.
20. Способ по п.19, где окклюзирующим давлением является давление, которое по меньшей мере на 15 мм рт.ст. выше систолического давления, или составляет 200 мм рт.ст.
21. Способ по любому из пп.1-8, где каждый из курсов ДИК в многократных курсах ДИК проводят на том же месте.
22. Способ по любому из пп.1-8, где многократные курсы ДИК проводят на верхней конечности.
23. Способ по любому из пп.1-8, дополнительно включающий введение субъекту ингибитора ангиотензин-превращающего фермента (АПФ).
24. Способ по любому из пп.1-8, дополнительно включающий введение субъекту блокатора рецепторов ангиотензина II.
25. Способ по любому из пп.1-8, дополнительно включающий введение субъекту антитромбоцитарной терапии.
26. Способ уменьшения заболеваемости, отсрочки возникновения и/или уменьшения тяжести сердечной дисфункции и/или сердечной недостаточности, включающий
проведение многократных курсов дистантного ишемического кондиционирования (ДИК) субъекту в течение и после инфаркта миокарда.
27. Способ, включающий
проведение многократных курсов дистантного ишемического кондиционирования (ДИК) субъекту, испытывающему инфаркт миокарда, где первый курс ДИК проводят в течение инфаркта миокарда, и последующие курсы ДИК проводят, по меньшей мере, каждые три дня после первого курса ДИК.
28. Способ по п.27, где первый курс ДИК проводят в течение инфаркта миокарда, и последующие курсы ДИК проводят ежедневно после первого курса ДИК.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31959710P | 2010-03-31 | 2010-03-31 | |
| US61/319,597 | 2010-03-31 | ||
| PCT/IB2011/000368 WO2011121402A2 (en) | 2010-03-31 | 2011-02-04 | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012146353A true RU2012146353A (ru) | 2014-05-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2012146353/14A RU2012146353A (ru) | 2010-03-31 | 2011-06-04 | Применение дистантного ишемического кондиционирования для улучшения последствия после инфаркта миокарда |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20110240043A1 (ru) |
| EP (1) | EP2552331B1 (ru) |
| JP (2) | JP2013523240A (ru) |
| KR (2) | KR20190000368A (ru) |
| CN (1) | CN102939054A (ru) |
| AU (1) | AU2011234189B2 (ru) |
| CA (1) | CA2795053A1 (ru) |
| IL (1) | IL222284A0 (ru) |
| RU (1) | RU2012146353A (ru) |
| SG (3) | SG10201502031XA (ru) |
| WO (1) | WO2011121402A2 (ru) |
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| CA2761633A1 (en) * | 2009-05-13 | 2010-11-18 | Andrew Redington | Performance enhancement |
| US9801780B2 (en) | 2009-06-23 | 2017-10-31 | Lifecuff Technologies Inc. | Methods and devices for remote ischemic conditioning via partial limb occlusion |
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| WO2011005538A2 (en) | 2009-06-23 | 2011-01-13 | Boris Leschinsky | Methods and devices for remote ischemic preconditioning and near-continuous blood pressure monitoring |
| US8974491B2 (en) | 2009-06-23 | 2015-03-10 | Infarct Reduction Technologies Inc. | Methods for adaptive limb occlusion |
| WO2011094730A2 (en) * | 2010-02-01 | 2011-08-04 | The Hospital For Sick Children | Remote ischemic conditioning for treatment and reventon of restenosis |
| CN103354733B (zh) | 2010-04-08 | 2017-02-22 | 儿童医院 | 用于外伤性损伤的远端缺血处理的用途 |
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| USD708338S1 (en) | 2012-08-15 | 2014-07-01 | CellAegis Devices Inc. | Cuff for remote ischemic conditioning |
| US10252052B2 (en) | 2013-03-15 | 2019-04-09 | The Hospital For Sick Children | Methods relating to the use of remote ischemic conditioning |
| AU2013203746B2 (en) | 2013-03-15 | 2015-05-07 | Cellaegis Devices, Inc. | Gas Powered System for Performing Remote Ischemic Conditioning |
| WO2014167423A2 (en) | 2013-03-15 | 2014-10-16 | The Hospital For Sick Children | Methods for modulating autophagy using remote ischemic conditioning |
| CA2907025A1 (en) * | 2013-03-15 | 2014-09-18 | The Hospital For Sick Children | Diagnostic and therapeutic methods relating to microrna-144 |
| WO2014140832A2 (en) | 2013-03-15 | 2014-09-18 | The Hospital For Sick Children | Treatment of erectile dysfunction using remote ischemic conditioning |
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| RU2609059C2 (ru) * | 2015-07-06 | 2017-01-30 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт комплексных проблем гигиены и профессиональных заболеваний" | Способ оценки приспособительно-компенсаторной реакции у здоровых лиц на дистанционное прекондиционирование |
| KR20180030601A (ko) * | 2015-07-08 | 2018-03-23 | 셀에이지스 디바이시스 인크. | 대상에 대해 원격 허혈 조절(ric)을 수행하기 위한 구성 가능한 시스템 |
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2011
- 2011-02-04 CN CN201180026015XA patent/CN102939054A/zh active Pending
- 2011-02-04 EP EP11762079.9A patent/EP2552331B1/en active Active
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- 2011-02-04 KR KR1020127028461A patent/KR20130040851A/ko not_active Ceased
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- 2011-02-04 CA CA 2795053 patent/CA2795053A1/en not_active Abandoned
- 2011-02-04 US US13/021,649 patent/US20110240043A1/en not_active Abandoned
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| AU2011234189B2 (en) | 2015-12-03 |
| US20190269410A1 (en) | 2019-09-05 |
| SG10201908570RA (en) | 2019-11-28 |
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| EP2552331A4 (en) | 2015-10-21 |
| SG184353A1 (en) | 2012-11-29 |
| US20110240043A1 (en) | 2011-10-06 |
| WO2011121402A2 (en) | 2011-10-06 |
| SG10201502031XA (en) | 2015-05-28 |
| EP2552331B1 (en) | 2020-01-08 |
| AU2011234189A9 (en) | 2015-12-03 |
| CA2795053A1 (en) | 2011-10-06 |
| CN102939054A (zh) | 2013-02-20 |
| AU2011234189A1 (en) | 2012-11-01 |
| WO2011121402A9 (en) | 2012-01-05 |
| JP2016052600A (ja) | 2016-04-14 |
| EP2552331A2 (en) | 2013-02-06 |
| IL222284A0 (en) | 2012-12-31 |
| US20160038147A1 (en) | 2016-02-11 |
| KR20130040851A (ko) | 2013-04-24 |
| JP2013523240A (ja) | 2013-06-17 |
| US10136895B2 (en) | 2018-11-27 |
| KR20190000368A (ko) | 2019-01-02 |
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