RU2010137329A - Продукт для ухода за полостью рта и способы его применения и получения - Google Patents
Продукт для ухода за полостью рта и способы его применения и получения Download PDFInfo
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- RU2010137329A RU2010137329A RU2010137329/15A RU2010137329A RU2010137329A RU 2010137329 A RU2010137329 A RU 2010137329A RU 2010137329/15 A RU2010137329/15 A RU 2010137329/15A RU 2010137329 A RU2010137329 A RU 2010137329A RU 2010137329 A RU2010137329 A RU 2010137329A
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- amino acid
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- 210000000214 mouth Anatomy 0.000 title claims abstract 7
- 238000000034 method Methods 0.000 title claims 2
- 239000000203 mixture Substances 0.000 claims abstract 35
- -1 fluorine ions Chemical class 0.000 claims abstract 12
- 150000003839 salts Chemical class 0.000 claims abstract 12
- 150000001413 amino acids Chemical class 0.000 claims abstract 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract 9
- 239000011575 calcium Substances 0.000 claims abstract 9
- 229910052791 calcium Inorganic materials 0.000 claims abstract 6
- 229910019142 PO4 Inorganic materials 0.000 claims abstract 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract 5
- 239000010452 phosphate Substances 0.000 claims abstract 5
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims abstract 4
- 229920006318 anionic polymer Polymers 0.000 claims abstract 4
- 239000003945 anionic surfactant Substances 0.000 claims abstract 4
- 239000003242 anti bacterial agent Substances 0.000 claims abstract 4
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims abstract 4
- 150000004715 keto acids Chemical class 0.000 claims abstract 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims abstract 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims abstract 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims abstract 4
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 3
- 239000011737 fluorine Substances 0.000 claims abstract 3
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000004475 Arginine Substances 0.000 claims abstract 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical group OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000008366 buffered solution Substances 0.000 claims abstract 2
- 239000000551 dentifrice Substances 0.000 claims abstract 2
- 229940091249 fluoride supplement Drugs 0.000 claims abstract 2
- MDQRDWAGHRLBPA-UHFFFAOYSA-N fluoroamine Chemical compound FN MDQRDWAGHRLBPA-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000013618 particulate matter Substances 0.000 claims abstract 2
- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 claims abstract 2
- 235000003270 potassium fluoride Nutrition 0.000 claims abstract 2
- 239000011698 potassium fluoride Substances 0.000 claims abstract 2
- 235000013024 sodium fluoride Nutrition 0.000 claims abstract 2
- 239000011775 sodium fluoride Substances 0.000 claims abstract 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract 2
- 239000000243 solution Substances 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 claims abstract 2
- XROWMBWRMNHXMF-UHFFFAOYSA-J titanium tetrafluoride Chemical compound [F-].[F-].[F-].[F-].[Ti+4] XROWMBWRMNHXMF-UHFFFAOYSA-J 0.000 claims abstract 2
- 229960003500 triclosan Drugs 0.000 claims abstract 2
- 241000894006 Bacteria Species 0.000 claims 3
- 229910021486 amorphous silicon dioxide Inorganic materials 0.000 claims 3
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical group [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 claims 1
- 239000003082 abrasive agent Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 230000001013 cariogenic effect Effects 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000005115 demineralization Methods 0.000 claims 1
- 230000002328 demineralizing effect Effects 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 claims 1
- 210000003298 dental enamel Anatomy 0.000 claims 1
- 210000004268 dentin Anatomy 0.000 claims 1
- 206010013781 dry mouth Diseases 0.000 claims 1
- 230000003628 erosive effect Effects 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 239000004088 foaming agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 208000007565 gingivitis Diseases 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 230000007406 plaque accumulation Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 239000004323 potassium nitrate Substances 0.000 claims 1
- 235000010333 potassium nitrate Nutrition 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000005728 strengthening Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- 239000000606 toothpaste Substances 0.000 claims 1
- 229940034610 toothpaste Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000002087 whitening effect Effects 0.000 claims 1
- 229920006163 vinyl copolymer Polymers 0.000 abstract 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A61K8/34—Alcohols
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract
1. Композиция для ухода за полостью рта, содержащая ! а. эффективное количество соли основной аминокислоты, причем соль имеет рН в незабуференном растворе менее чем приблизительно 7,5; ! b. эффективное количество растворимого источника ионов фтора и ! c. вещество в виде частиц, которое имеет рН в незабуференном растворе менее чем приблизительно 7,5. ! 2. Композиция по п.1, в которой ! а. солью основной аминокислоты является соль неорганической оксокислоты и основной аминокислоты; и ! b. вещество в виде частиц представляет собой соль неорганической оксокислоты и кальция. ! 3. Композиция по п.1, в которой основной аминокислотой является аргинин. ! 4. Композиция по п.1, в которой солью основной аминокислоты является фосфат. ! 5. Композиция по п.1, в которой источник ионов фтора выбран из фторида натрия, фторида олова, фторида калия, фторсиликата натрия, фторсиликата аммония, аминофторида, фторида аммония, фторида титана, гексафторсульфата, монофторфосфата натрия и их комбинации. ! 6. Композиция по п.1, которая представляет собой средство для чистки зубов, содержащее (i) фосфат аргинина, (ii) дикальция фосфата дигидрат и (iii) монофторфосфат натрия. ! 7. Композиция по п.1, дополнительно содержащая анионное поверхностно-активное вещество. ! 8. Композиция по п.7, в которой анионным поверхностно-активным веществом является лаурилсульфат натрия. ! 9. Композиция по п.1, дополнительно содержащая антибактериальный агент. ! 10. Композиция по п.9, в которой антибактериальным агентом является триклозан. ! 11. Композиция по п.1, дополнительно содержащая анионный полимер. ! 12. Композиция по п.11, в которой анионным полимером является сополимер метилвиниловог
Claims (22)
1. Композиция для ухода за полостью рта, содержащая
а. эффективное количество соли основной аминокислоты, причем соль имеет рН в незабуференном растворе менее чем приблизительно 7,5;
b. эффективное количество растворимого источника ионов фтора и
c. вещество в виде частиц, которое имеет рН в незабуференном растворе менее чем приблизительно 7,5.
2. Композиция по п.1, в которой
а. солью основной аминокислоты является соль неорганической оксокислоты и основной аминокислоты; и
b. вещество в виде частиц представляет собой соль неорганической оксокислоты и кальция.
3. Композиция по п.1, в которой основной аминокислотой является аргинин.
4. Композиция по п.1, в которой солью основной аминокислоты является фосфат.
5. Композиция по п.1, в которой источник ионов фтора выбран из фторида натрия, фторида олова, фторида калия, фторсиликата натрия, фторсиликата аммония, аминофторида, фторида аммония, фторида титана, гексафторсульфата, монофторфосфата натрия и их комбинации.
6. Композиция по п.1, которая представляет собой средство для чистки зубов, содержащее (i) фосфат аргинина, (ii) дикальция фосфата дигидрат и (iii) монофторфосфат натрия.
7. Композиция по п.1, дополнительно содержащая анионное поверхностно-активное вещество.
8. Композиция по п.7, в которой анионным поверхностно-активным веществом является лаурилсульфат натрия.
9. Композиция по п.1, дополнительно содержащая антибактериальный агент.
10. Композиция по п.9, в которой антибактериальным агентом является триклозан.
11. Композиция по п.1, дополнительно содержащая анионный полимер.
12. Композиция по п.11, в которой анионным полимером является сополимер метилвинилового эфира и малеинового ангидрида.
13. Композиция по п.1, в которой истирание радиоактивного дентина (RDA) композиции составляет меньше 150.
14. Композиция по п.1 в форме зубной пасты, дополнительно содержащая одно или несколько из воды, абразивов, поверхностно-активных веществ, пенообразователей, витаминов, полимеров, ферментов, увлажнителей, загустителей, противомикробных агентов, консервантов, вкусовых добавок, красителей и/или их комбинаций.
15. Композиция по п.1, дополнительно включающая источник кальция и фосфата.
16. Композиция по п.15, где указанный источник кальция и фосфата выбран из комплекса кальция и аморфной двуокиси кремния и комплекса кальция и белка.
17. Композиция по п.16, где указанный источник кальция и фосфата представляет собой комплекс кальция и аморфной двуокиси кремния.
18. Композиция по п.17, где указанный комплекс кальция и аморфной двуокиси кремния содержит кальций-натриевый фосфосиликат.
19. Композиция по п.1, дополнительно включающая соль калия.
20. Композиция по п.19, где указанная соль калия выбрана из нитрата калия и хлорида калия.
21. Композиция по п.1, где указанный источник ионов фтора обеспечивает от 25 до 25000 м.д. ионов фтора.
22. Способ, включающий нанесение эффективного количества композиции для полости рта по любому из пп.1-21 на поверхность полости рта для:
а. уменьшения или ингибирования образования зубного кариеса,
b. уменьшения, восстановления или ингибирования ранних поражений эмали,
c. уменьшения или ингибирования деминерализации и усиления реминерализации зубов,
d. уменьшения гиперчувствительности зубов,
e. уменьшения или ингибирования гингивита,
f. стимуляции заживления язвочек или порезов во рту,
g. уменьшения уровня продуцирующих кислоту бактерий,
h. увеличения относительного уровня аргинолитических бактерий,
i. ингибирования образования бактериальной биопленки в полости рта,
j. повышения и/или сохранения рН налета на уровне, по меньшей мере, рН 5,5 после потребления сахара,
k. уменьшения накопления налета,
l. лечения, ослабления или уменьшения сухости во рту,
m. защиты зубов от кариогенных бактерий,
n. отбеливания зубов,
o. уменьшения эрозии,
p. очистки зубов и полости рта и/или
q. укрепления общего состояния здоровья, включая состояние сердечно-сосудистой системы.
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| PCT/US2008/058696 WO2009099453A1 (en) | 2008-02-08 | 2008-03-28 | Oral care product and methods of use and manufacture thereof |
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| RU2010137329/15A RU2471475C2 (ru) | 2008-02-08 | 2008-03-28 | Продукт для ухода за полостью рта и способы его применения и получения |
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| AR (3) | AR065886A1 (ru) |
| AU (3) | AU2008349849B2 (ru) |
| BR (3) | BRPI0821974B1 (ru) |
| CA (4) | CA2828861A1 (ru) |
| CL (3) | CL2008000894A1 (ru) |
| CO (3) | CO6382103A2 (ru) |
| MX (4) | MX2010006371A (ru) |
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| TW (5) | TWI426924B (ru) |
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