RU2010149497A - PHARMACEUTICAL COMPOSITION FOR TREATMENT OF INFECTIOUS INFLAMMATORY DISEASES IN GYNECOLOGY AND METHOD FOR PRODUCING IT - Google Patents
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF INFECTIOUS INFLAMMATORY DISEASES IN GYNECOLOGY AND METHOD FOR PRODUCING IT Download PDFInfo
- Publication number
- RU2010149497A RU2010149497A RU2010149497/15A RU2010149497A RU2010149497A RU 2010149497 A RU2010149497 A RU 2010149497A RU 2010149497/15 A RU2010149497/15 A RU 2010149497/15A RU 2010149497 A RU2010149497 A RU 2010149497A RU 2010149497 A RU2010149497 A RU 2010149497A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- composition according
- butoconazole
- clindamycin
- corrector
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 25
- 208000015181 infectious disease Diseases 0.000 title 1
- 230000002458 infectious effect Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract 21
- 229960005074 butoconazole Drugs 0.000 claims abstract 9
- SWLMUYACZKCSHZ-UHFFFAOYSA-N butoconazole Chemical compound C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 SWLMUYACZKCSHZ-UHFFFAOYSA-N 0.000 claims abstract 9
- 239000000203 mixture Substances 0.000 claims abstract 9
- 229920000642 polymer Polymers 0.000 claims abstract 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 7
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical class CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims abstract 6
- 239000003995 emulsifying agent Substances 0.000 claims abstract 6
- 150000002148 esters Chemical class 0.000 claims abstract 6
- 230000002209 hydrophobic effect Effects 0.000 claims abstract 6
- UFUVLHLTWXBHGZ-MGZQPHGTSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 UFUVLHLTWXBHGZ-MGZQPHGTSA-N 0.000 claims abstract 4
- 229960002291 clindamycin phosphate Drugs 0.000 claims abstract 4
- 239000004615 ingredient Substances 0.000 claims abstract 4
- 229960002227 clindamycin Drugs 0.000 claims abstract 3
- 229910002651 NO3 Inorganic materials 0.000 claims abstract 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910019142 PO4 Inorganic materials 0.000 claims abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract 2
- 230000000843 anti-fungal effect Effects 0.000 claims abstract 2
- 229960002120 butoconazole nitrate Drugs 0.000 claims abstract 2
- ZHPWRQIPPNZNML-UHFFFAOYSA-N butoconazole nitrate Chemical compound O[N+]([O-])=O.C1=CC(Cl)=CC=C1CCC(SC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 ZHPWRQIPPNZNML-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000002552 dosage form Substances 0.000 claims abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract 2
- 239000010452 phosphate Substances 0.000 claims abstract 2
- 239000008213 purified water Substances 0.000 claims abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 3
- 229960003511 macrogol Drugs 0.000 claims 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 229960005323 phenoxyethanol Drugs 0.000 claims 2
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- 229940100524 ethylhexylglycerin Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Фармацевтическая композиция в виде мягкой лекарственной формы, обладающая антибактериальной и антифунгальной активностью, которая включает соль или эфир клиндамицина и основу, являющуюся комбинацией гидрофобного компонента, гидрофильного компонента и эмульгатора, отличающаяся тем, что дополнительно содержит бутоконазол. ! 2. Фармацевтическая композиция по п.1, отличающаяся тем, что дополнительно содержит гелеобразующий полимер. ! 3. Фармацевтическая композиция по п.2, отличающаяся тем, что содержит в качестве эфира клиндамицина клиндамицина фосфат. ! 4. Фармацевтическая композиция по п.3, отличающаяся тем, что содержит в качестве бутоконазола бутоконазола нитрат. ! 5. Фармацевтическая композиция по п.4, отличающаяся тем, что содержит в качестве гелеобразующего полимера гидроксипропилкрахмала фосфат. !6. Фармацевтическая композиция по п.5, отличающаяся тем, что содержит ингредиенты в следующем соотношении, г/на 100 г композиции: ! Клиндамицина фосфат 1,0-3,0 Бутоконазола нитрат 1,0-3,0 Гелеобразующий полимер 3,0-12,0 Основа Остальное ! 7. Фармацевтическая композиция по п.6, отличающаяся тем, что содержит ингредиенты основы в следующем соотношении, г/на 100 г композиции: ! Гидрофобный компонент 3,0-15,0 Гидрофильный компонент 50,0-90,0 Эмульгатор 3,0-15,0 ! 8. Фармацевтическая композиция по п.7, отличающаяся тем, что содержит в качестве гидрофильного компонента пропиленгликоль, воду и корректор рН. ! 9. Фармацевтическая композиция по п.8, отличающаяся тем, что содержит пропиленгликоль, воду и корректор рН в следующем соотношении, г/на ! 100 г композиции: ! Пропиленгликоль 2,0-15,0 Вода очищенная 48,0-75,0 Корректор рН д 1. A pharmaceutical composition in the form of a soft dosage form having antibacterial and antifungal activity, which includes a clindamycin salt or ester and a base, which is a combination of a hydrophobic component, a hydrophilic component and an emulsifier, characterized in that it further comprises butoconazole. ! 2. The pharmaceutical composition according to claim 1, characterized in that it further comprises a gelling polymer. ! 3. The pharmaceutical composition according to claim 2, characterized in that it contains clindamycin clindamycin phosphate as an ester. ! 4. The pharmaceutical composition according to claim 3, characterized in that it contains nitrate as butoconazole butoconazole. ! 5. The pharmaceutical composition according to claim 4, characterized in that it contains phosphate as a gelling polymer. ! 6. The pharmaceutical composition according to claim 5, characterized in that it contains the ingredients in the following ratio, g / 100 g of the composition:! Clindamycin Phosphate 1.0-3.0 Butoconazole Nitrate 1.0-3.0 Gelling Polymer 3.0-12.0 Basis Else! 7. The pharmaceutical composition according to claim 6, characterized in that it contains the ingredients of the base in the following ratio, g / 100 g of the composition:! Hydrophobic component 3.0-15.0 Hydrophilic component 50.0-90.0 Emulsifier 3.0-15.0! 8. The pharmaceutical composition according to claim 7, characterized in that it contains propylene glycol, water and a pH corrector as a hydrophilic component. ! 9. The pharmaceutical composition according to claim 8, characterized in that it contains propylene glycol, water and a pH corrector in the following ratio, g / per! 100 g of composition:! Propylene glycol 2.0-15.0 Purified water 48.0-75.0 Corrector pH d
Claims (17)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010149497/15A RU2479305C2 (en) | 2010-12-06 | 2010-12-06 | Pharmaceutical composition for treating infectious inflammatory diseases and method for preparing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010149497/15A RU2479305C2 (en) | 2010-12-06 | 2010-12-06 | Pharmaceutical composition for treating infectious inflammatory diseases and method for preparing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010149497A true RU2010149497A (en) | 2012-06-20 |
| RU2479305C2 RU2479305C2 (en) | 2013-04-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010149497/15A RU2479305C2 (en) | 2010-12-06 | 2010-12-06 | Pharmaceutical composition for treating infectious inflammatory diseases and method for preparing it |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2479305C2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2538703C2 (en) * | 2013-03-12 | 2015-01-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Pharmaceutical composition for treating vaginal candidiasis and method for preparing it |
| EA023024B1 (en) * | 2012-11-23 | 2016-04-29 | Общество с ограниченной ответственностью "НПК "Трифарма" | Pharmaceutical composition containing nalbuphine hydrochloride, use thereof to treat moderate to severe pain and method for producing said pharmaceutical composition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6899890B2 (en) * | 2002-03-20 | 2005-05-31 | Kv Pharmaceutical Company | Bioadhesive drug delivery system |
| RU2205011C1 (en) * | 2002-05-16 | 2003-05-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Pharmaceutical composition eliciting antibacterial activity |
-
2010
- 2010-12-06 RU RU2010149497/15A patent/RU2479305C2/en active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA023024B1 (en) * | 2012-11-23 | 2016-04-29 | Общество с ограниченной ответственностью "НПК "Трифарма" | Pharmaceutical composition containing nalbuphine hydrochloride, use thereof to treat moderate to severe pain and method for producing said pharmaceutical composition |
| RU2538703C2 (en) * | 2013-03-12 | 2015-01-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Pharmaceutical composition for treating vaginal candidiasis and method for preparing it |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2479305C2 (en) | 2013-04-20 |
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