RU2011120522A - PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DERMATOSIS SUBJECT TO Glucocorticosteroid Therapy, AND METHOD FOR PRODUCING IT - Google Patents
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DERMATOSIS SUBJECT TO Glucocorticosteroid Therapy, AND METHOD FOR PRODUCING IT Download PDFInfo
- Publication number
- RU2011120522A RU2011120522A RU2011120522/15A RU2011120522A RU2011120522A RU 2011120522 A RU2011120522 A RU 2011120522A RU 2011120522/15 A RU2011120522/15 A RU 2011120522/15A RU 2011120522 A RU2011120522 A RU 2011120522A RU 2011120522 A RU2011120522 A RU 2011120522A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- composition according
- ceramides
- methylprednisolone aceponate
- combination
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 17
- 208000017520 skin disease Diseases 0.000 title claims abstract 5
- 206010048768 Dermatosis Diseases 0.000 title 1
- 239000003862 glucocorticoid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229960002037 methylprednisolone aceponate Drugs 0.000 claims abstract 10
- DALKLAYLIPSCQL-YPYQNWSCSA-N methylprednisolone aceponate Chemical compound C1([C@@H](C)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@](C(=O)COC(C)=O)(OC(=O)CC)[C@@]2(C)C[C@@H]1O DALKLAYLIPSCQL-YPYQNWSCSA-N 0.000 claims abstract 10
- 229940106189 ceramide Drugs 0.000 claims abstract 9
- 150000001783 ceramides Chemical class 0.000 claims abstract 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000003125 aqueous solvent Substances 0.000 claims abstract 6
- 238000000034 method Methods 0.000 claims abstract 6
- 230000002209 hydrophobic effect Effects 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims abstract 4
- MWKPHOIHTLQZIY-UHFFFAOYSA-N 2-hexyldecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CCCCCC)CCCCCCCC MWKPHOIHTLQZIY-UHFFFAOYSA-N 0.000 claims abstract 2
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims abstract 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract 2
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000006172 buffering agent Substances 0.000 claims abstract 2
- 239000000919 ceramic Substances 0.000 claims abstract 2
- 229940008099 dimethicone Drugs 0.000 claims abstract 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract 2
- 239000002552 dosage form Substances 0.000 claims abstract 2
- 239000003995 emulsifying agent Substances 0.000 claims abstract 2
- 239000000839 emulsion Substances 0.000 claims abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims abstract 2
- 235000011009 potassium phosphates Nutrition 0.000 claims abstract 2
- 239000003755 preservative agent Substances 0.000 claims abstract 2
- 230000002335 preservative effect Effects 0.000 claims abstract 2
- 229940037001 sodium edetate Drugs 0.000 claims abstract 2
- 239000001488 sodium phosphate Substances 0.000 claims abstract 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Фармацевтическая композиция в виде мягкой лекарственной формы для лечения заболеваний кожи, которая включает метилпреднизолона ацепонат в терапевтически эффективном количестве и вспомогательные вещества, отличающаяся тем, что дополнительно содержит керамиды или керамидный комплекс.2. Фармацевтическая композиция по п.1, отличающаяся тем, что содержит метилпреднизолона ацепонат и керамиды в следующем соотношении, г/на 100 г композиции:3. Фармацевтическая композиция по п.2, отличающаяся тем, что содержит в качестве вспомогательных веществ гидрофобный компонент, гидрофильный компонент, эмульгатор и консервант.4. Фармацевтическая композиция по п.3, отличающаяся тем, что содержит в качестве гидрофобного компонента комбинацию октилдодеканола, гексилдецилстеарата и диметикона.5. Фармацевтическая композиция по п.4, отличающаяся тем, что содержит в качестве гидрофильного компонента комбинацию неводного растворителя и воды.6. Фармацевтическая композиция по п.5, отличающаяся тем, что содержит дополнительно буферное вещество и натрия эдетат.7. Фармацевтическая композиция по п.6, отличающаяся тем, что содержит в качестве неводного растворителя пропиленгликоль и в качестве буферных веществ - комбинацию калия фосфата однозамещенного и натрия фосфата двузамещенного 12-водного.8. Фармацевтическая композиция по п.7, отличающаяся тем, что содержит в качестве керамидов керамиды LS.9. Способ получения композиции для лечения заболеваний кожи, по которому метилпреднизолона ацепонат вводят в эмульсионную основу, содержащую керамиды.10. Способ по п.9, по которому метилпреднизолона ацепонат вводят в виде раствора.11. Способ по п.10, по1. A pharmaceutical composition in the form of a soft dosage form for the treatment of skin diseases, which comprises a therapeutically effective amount of methylprednisolone aceponate and excipients, characterized in that it further comprises ceramides or a ceramic complex. The pharmaceutical composition according to claim 1, characterized in that it contains methylprednisolone aceponate and ceramides in the following ratio, g / per 100 g of composition: 3. The pharmaceutical composition according to claim 2, characterized in that it contains a hydrophobic component, a hydrophilic component, an emulsifier and a preservative as auxiliary substances. The pharmaceutical composition according to claim 3, characterized in that it comprises a combination of octyldodecanol, hexyldecyl stearate and dimethicone as a hydrophobic component. The pharmaceutical composition according to claim 4, characterized in that it comprises, as a hydrophilic component, a combination of a non-aqueous solvent and water. The pharmaceutical composition according to claim 5, characterized in that it further comprises a buffering agent and sodium edetate. The pharmaceutical composition according to claim 6, characterized in that it contains propylene glycol as a non-aqueous solvent and a combination of potassium phosphate monosubstituted and sodium phosphate disubstituted 12-aqueous as a non-aqueous solvent. The pharmaceutical composition according to claim 7, characterized in that it contains LS.9 as ceramides. A method for preparing a composition for treating skin diseases in which methylprednisolone aceponate is introduced into an emulsion base containing ceramides. 10. The method according to claim 9, in which methylprednisolone aceponate is administered in the form of a solution. The method of claim 10,
Claims (11)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2011120522/15A RU2482852C2 (en) | 2011-05-24 | 2011-05-24 | Pharmaceutical composition for treating dermatoses treated by glucocorticosteroids, and method for preparing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2011120522/15A RU2482852C2 (en) | 2011-05-24 | 2011-05-24 | Pharmaceutical composition for treating dermatoses treated by glucocorticosteroids, and method for preparing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2011120522A true RU2011120522A (en) | 2012-11-27 |
| RU2482852C2 RU2482852C2 (en) | 2013-05-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011120522/15A RU2482852C2 (en) | 2011-05-24 | 2011-05-24 | Pharmaceutical composition for treating dermatoses treated by glucocorticosteroids, and method for preparing it |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2482852C2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2548764C2 (en) * | 2013-01-25 | 2015-04-20 | Открытое Акционерное Общество "Татхимфармпрепараты" | Medication for treating dermatosis (versions) |
| RU2553600C2 (en) * | 2013-05-16 | 2015-06-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Pharmaceutical composition for treating skin diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0524962D0 (en) * | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Topical pharmaceutical compositions |
| RU2329837C2 (en) * | 2006-09-13 | 2008-07-27 | ФГУ "Уральский научно-исследовательский институт дерматологии и иммунопатологии Росздрава" (УрНИИДВиИ) | Method of atopic dermatitis treatment |
| RU2321409C1 (en) * | 2006-10-23 | 2008-04-10 | Ольга Александровна Субботина | Remedy for treating primary and secondary infection skin diseases |
-
2011
- 2011-05-24 RU RU2011120522/15A patent/RU2482852C2/en active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2548764C2 (en) * | 2013-01-25 | 2015-04-20 | Открытое Акционерное Общество "Татхимфармпрепараты" | Medication for treating dermatosis (versions) |
| RU2553600C2 (en) * | 2013-05-16 | 2015-06-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Pharmaceutical composition for treating skin diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2482852C2 (en) | 2013-05-27 |
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