RU2010142822A - MEANS OF PREPARING CARDIOPROTECTIVE ACTION AND METHOD OF ITS PRODUCTION - Google Patents
MEANS OF PREPARING CARDIOPROTECTIVE ACTION AND METHOD OF ITS PRODUCTION Download PDFInfo
- Publication number
- RU2010142822A RU2010142822A RU2010142822/15A RU2010142822A RU2010142822A RU 2010142822 A RU2010142822 A RU 2010142822A RU 2010142822/15 A RU2010142822/15 A RU 2010142822/15A RU 2010142822 A RU2010142822 A RU 2010142822A RU 2010142822 A RU2010142822 A RU 2010142822A
- Authority
- RU
- Russia
- Prior art keywords
- surfactant
- echinochrome
- associate
- water
- molecularly encapsulated
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract 20
- 230000003293 cardioprotective effect Effects 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- NCFUWNUATANZPH-UHFFFAOYSA-N echinochrome A Natural products OC1=C(O)C(O)=C2C(=O)C(CC)=C(O)C(=O)C2=C1O NCFUWNUATANZPH-UHFFFAOYSA-N 0.000 claims abstract 16
- 239000004094 surface-active agent Substances 0.000 claims abstract 15
- 229930190208 echinochrome Natural products 0.000 claims abstract 14
- 239000000654 additive Substances 0.000 claims abstract 8
- 230000000087 stabilizing effect Effects 0.000 claims abstract 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 4
- 230000000996 additive effect Effects 0.000 claims abstract 4
- 239000008346 aqueous phase Substances 0.000 claims abstract 4
- 239000000243 solution Substances 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims abstract 4
- 241000257465 Echinoidea Species 0.000 claims abstract 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims abstract 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims abstract 2
- 239000007864 aqueous solution Substances 0.000 claims abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract 2
- 229960005070 ascorbic acid Drugs 0.000 claims abstract 2
- 239000011668 ascorbic acid Substances 0.000 claims abstract 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims abstract 2
- 229940045200 cardioprotective agent Drugs 0.000 claims abstract 2
- 239000012659 cardioprotective agent Substances 0.000 claims abstract 2
- 230000008020 evaporation Effects 0.000 claims abstract 2
- 238000001704 evaporation Methods 0.000 claims abstract 2
- 238000000265 homogenisation Methods 0.000 claims abstract 2
- 239000000155 melt Substances 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 4
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 1
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Средство, обладающее кардиопротекторным действием, на основе эхинохрома - 2,3,5,6,8-пентагидрокси-7-этил-1,4-нафтохинона, который получают из природного источника (плоских морских ежей) или синтетическим путем, отличающееся тем, что оно представляет собой водный раствор эхинохрома в молекулярно-капсулированной форме в виде водорастворимого ассоциата. ! 2. Способ получения средства, обладающего кардиопротекторным действием, на основе эхинохрома, отличающийся тем, что получение молекулярно-капсулированной формы водорастворимого ассоциата осуществляют путем гомогенизации эхинохрома и поверхностно-активного вещества в общем растворителе, например этаноле, с последующим переводом такого раствора в водную фазу и концентрированием путем испарения растворителя и воды. ! 3. Способ по п.2, отличающийся тем, что в раствор готовой молекулярно-капсулированной формы вводят стабилизирующие добавки. ! 4. Способ по п.2, отличающийся тем, что в качестве стабилизирующей добавки используют аскорбиновую кислоту. ! 5. Способ по п.2, отличающийся тем, что процесс осуществляют путем гомогенизации эхинохрома в расплаве поверхностно-активного вещества при соотношении поверхностно-активного вещества к эхинохрому 4-5:1 в диапазоне температур 40-60°С. ! 6. Способ по п.2, отличающийся тем, что в расплав поверхностно-активного вещества дополнительно вводят добавки для стабилизации эхинохрома в форме молекулярно-капсулированного ассоциата в водной фазе. ! 7. Способ по п.2, отличающийся тем, что в качестве стабилизирующей добавки используют аскорбилпальмитат. ! 8. Способ по п.2, отличающийся тем, что в качестве поверхностно-активного вещества испо 1. A tool with a cardioprotective effect, based on echinochrome - 2,3,5,6,8-pentahydroxy-7-ethyl-1,4-naphthoquinone, which is obtained from a natural source (flat sea urchins) or synthetically, characterized in that it is an aqueous solution of echinochrome in molecularly encapsulated form in the form of a water-soluble associate. ! 2. A method for producing an echinochrome-based cardioprotective agent, characterized in that the molecularly encapsulated form of the water-soluble associate is obtained by homogenizing the echinochrome and surfactant in a common solvent, for example ethanol, followed by transferring such a solution to the aqueous phase and concentration by evaporation of the solvent and water. ! 3. The method according to claim 2, characterized in that stabilizing additives are introduced into the solution of the finished molecularly encapsulated form. ! 4. The method according to claim 2, characterized in that ascorbic acid is used as a stabilizing additive. ! 5. The method according to claim 2, characterized in that the process is carried out by homogenization of echinochrome in a melt of a surfactant with a ratio of surfactant to echinochrome 4-5: 1 in the temperature range 40-60 ° C. ! 6. The method according to claim 2, characterized in that additives are added to the surfactant melt to stabilize the echinochrome in the form of a molecularly encapsulated associate in the aqueous phase. ! 7. The method according to claim 2, characterized in that ascorbyl palmitate is used as a stabilizing additive. ! 8. The method according to claim 2, characterized in that as a surfactant is used
Claims (13)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010142822/15A RU2500396C2 (en) | 2010-10-20 | 2010-10-20 | Agent showing cardioprotective action, and method for preparing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010142822/15A RU2500396C2 (en) | 2010-10-20 | 2010-10-20 | Agent showing cardioprotective action, and method for preparing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010142822A true RU2010142822A (en) | 2012-04-27 |
| RU2500396C2 RU2500396C2 (en) | 2013-12-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010142822/15A RU2500396C2 (en) | 2010-10-20 | 2010-10-20 | Agent showing cardioprotective action, and method for preparing it |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2500396C2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2651042C1 (en) * | 2017-06-05 | 2018-04-18 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Histochrome dosage form for oral administration and prolonged action |
| GR1010730B (en) | 2022-12-07 | 2024-07-25 | Εθνικο Και Καποδιστριακο Πανεπιστημιο Αθηνων, | A pharmaceutical formulation comprising polymeric micro-/nanofibers incorporating echinochrome a |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2139935C1 (en) * | 1997-07-17 | 1999-10-20 | Сотников Павел Степанович | Method of preparing water-soluble vitamin preparation and method of preparing vitamin preparation |
| RU2137472C1 (en) * | 1998-10-12 | 1999-09-20 | Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН | Medicinal preparation "gistokhrom" for treatment of patients with acute myocardium infarction and heart ischemic disease |
| EA003994B1 (en) * | 1999-01-20 | 2003-12-25 | Общество с ограниченной ответственностью "МДТ" | Vitamin preparation, aqueous vitamin preparation and method for producing the same |
| RU2388491C2 (en) * | 2007-12-12 | 2010-05-10 | Закрытое акционерное общество "Центр новых технологий и бизнеса" | Production method of water-soluble forms of biologically active substances |
| RU2360683C1 (en) * | 2008-04-16 | 2009-07-10 | Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) | Corrective composition for pathologic carbohydrate, lipid disbolism and antioxidant organism state involvement |
-
2010
- 2010-10-20 RU RU2010142822/15A patent/RU2500396C2/en active
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| Publication number | Publication date |
|---|---|
| RU2500396C2 (en) | 2013-12-10 |
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