RU2009119717A - Водные фармацевтические суспензии, содержащие ребамипид, и способ их получения - Google Patents
Водные фармацевтические суспензии, содержащие ребамипид, и способ их получения Download PDFInfo
- Publication number
- RU2009119717A RU2009119717A RU2009119717/15A RU2009119717A RU2009119717A RU 2009119717 A RU2009119717 A RU 2009119717A RU 2009119717/15 A RU2009119717/15 A RU 2009119717/15A RU 2009119717 A RU2009119717 A RU 2009119717A RU 2009119717 A RU2009119717 A RU 2009119717A
- Authority
- RU
- Russia
- Prior art keywords
- aqueous suspension
- polyvinyl alcohol
- rebamipide
- stage
- suspension according
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000007971 pharmaceutical suspension Substances 0.000 title 1
- 239000007900 aqueous suspension Substances 0.000 claims abstract 14
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract 10
- ALLWOAVDORUJLA-UHFFFAOYSA-N Rebamipida Chemical compound C=1C(=O)NC2=CC=CC=C2C=1CC(C(=O)O)NC(=O)C1=CC=C(Cl)C=C1 ALLWOAVDORUJLA-UHFFFAOYSA-N 0.000 claims abstract 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract 10
- 229950004535 rebamipide Drugs 0.000 claims abstract 10
- 239000000203 mixture Substances 0.000 claims abstract 6
- 239000007864 aqueous solution Substances 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 2
- 238000003756 stirring Methods 0.000 claims abstract 2
- -1 sodium salt compound Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Водная суспензия, содержащая ребамипид и поливиниловый спирт. ! 2. Водная суспензия по п.1, дополнительно содержащая соединение соли натрия. ! 3. Водная суспензия по п.1 или 2, в которой ребамипид составляет 0,1-30% (мас./об.) и поливиниловый спирт составляет 0,1-4% (мас./об.). ! 4. Водная суспензия по любому из пп.1 или 2, которая представляет собой офтальмологическую композицию. ! 5. Водная суспензия по п.3, которая представляет собой офтальмологическую композицию. ! 6. Способ получения водной суспензии, содержащей ребамипид, который включает в себя ! (1) первую стадию: смешивание воды и поливинилового спирта, с получением водного раствора, содержащего поливиниловый спирт, и ! (2) вторую стадию: добавление ребамипида к водному раствору, содержащему поливиниловый спирт, полученному на первой стадии, и перемешивание смеси, с получением водной суспензии, содержащей ребамипид.
Claims (6)
1. Водная суспензия, содержащая ребамипид и поливиниловый спирт.
2. Водная суспензия по п.1, дополнительно содержащая соединение соли натрия.
3. Водная суспензия по п.1 или 2, в которой ребамипид составляет 0,1-30% (мас./об.) и поливиниловый спирт составляет 0,1-4% (мас./об.).
4. Водная суспензия по любому из пп.1 или 2, которая представляет собой офтальмологическую композицию.
5. Водная суспензия по п.3, которая представляет собой офтальмологическую композицию.
6. Способ получения водной суспензии, содержащей ребамипид, который включает в себя
(1) первую стадию: смешивание воды и поливинилового спирта, с получением водного раствора, содержащего поливиниловый спирт, и
(2) вторую стадию: добавление ребамипида к водному раствору, содержащему поливиниловый спирт, полученному на первой стадии, и перемешивание смеси, с получением водной суспензии, содержащей ребамипид.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006291535 | 2006-10-26 | ||
| JP2006-291535 | 2006-10-26 | ||
| PCT/JP2007/071167 WO2008050896A1 (en) | 2006-10-26 | 2007-10-24 | Aqueous pharmaceutical suspensions containing rebamipide and manufacturing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009119717A true RU2009119717A (ru) | 2010-12-10 |
| RU2467751C2 RU2467751C2 (ru) | 2012-11-27 |
Family
ID=39324676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009119717/15A RU2467751C2 (ru) | 2006-10-26 | 2007-10-24 | Водные фармацевтические суспензии, содержащие ребамипид, и способ их получения |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8772317B2 (ru) |
| EP (1) | EP2077840A4 (ru) |
| JP (1) | JP5250551B2 (ru) |
| KR (2) | KR101491965B1 (ru) |
| CN (1) | CN101528229B (ru) |
| AR (1) | AR063366A1 (ru) |
| AU (1) | AU2007309968B2 (ru) |
| BR (1) | BRPI0718429A2 (ru) |
| CA (1) | CA2665024C (ru) |
| IL (1) | IL197950A0 (ru) |
| MX (1) | MX2009004433A (ru) |
| MY (1) | MY148303A (ru) |
| NZ (1) | NZ576224A (ru) |
| RU (1) | RU2467751C2 (ru) |
| SG (1) | SG175628A1 (ru) |
| TW (1) | TWI415629B (ru) |
| UA (1) | UA95989C2 (ru) |
| WO (1) | WO2008050896A1 (ru) |
| ZA (1) | ZA200902778B (ru) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200808375A (en) | 2006-05-12 | 2008-02-16 | Otsuka Pharma Co Ltd | Hydrogel suspension and manufacturing process thereof |
| US20110124682A1 (en) * | 2008-06-19 | 2011-05-26 | Sumida Shun-Ichiro | Pharmaceutical composition comprising rebamipide |
| EP2688552A1 (en) * | 2011-03-24 | 2014-01-29 | Otsuka Pharmaceutical Co., Ltd. | A pharmaceutical composition for treating a disease in the oral cavity comprising rebamipide |
| CN102240260B (zh) * | 2011-05-17 | 2012-05-23 | 山东省医疗器械研究所 | 一种治疗阴道干涩症的药物及其制备方法 |
| TW201322982A (zh) | 2011-11-01 | 2013-06-16 | Otsuka Pharma Co Ltd | 用於治療前眼疾病之藥劑，該藥劑包含瑞巴派特及眼淚保持劑 |
| US8835387B2 (en) * | 2012-02-16 | 2014-09-16 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
| AR090775A1 (es) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| TW201536287A (zh) * | 2013-09-05 | 2015-10-01 | Otsuka Pharma Co Ltd | 瑞巴派特的局部止血用途 |
| CN104586762A (zh) * | 2014-04-11 | 2015-05-06 | 广州仁恒医药科技有限公司 | 含有瑞巴派特的药物组合物及其制备方法 |
| CN103976946A (zh) * | 2014-05-20 | 2014-08-13 | 广州艾格生物科技有限公司 | 一种含有水溶性高分子聚合物的瑞巴派特混悬滴眼液及其制备方法 |
| JP6854587B2 (ja) * | 2015-04-17 | 2021-04-07 | ロート製薬株式会社 | 医薬製剤 |
| CN107614018A (zh) * | 2015-05-28 | 2018-01-19 | 乐敦制药株式会社 | 水性眼科组合物 |
| CN105147606A (zh) * | 2015-08-18 | 2015-12-16 | 广州仁恒医药科技有限公司 | 一种瑞巴派特水悬浮液的制备方法 |
| KR101718733B1 (ko) | 2015-08-21 | 2017-03-22 | 국제약품 주식회사 | 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제 |
| KR20170039347A (ko) * | 2015-10-01 | 2017-04-11 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
| KR102307958B1 (ko) | 2015-10-01 | 2021-10-05 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
| JP2017109996A (ja) * | 2015-12-11 | 2017-06-22 | 日本合成化学工業株式会社 | 結晶成長抑制剤 |
| CN107349181B (zh) * | 2016-05-09 | 2021-02-19 | 四川科伦药物研究院有限公司 | 含有瑞巴派特和聚维酮的眼科水悬浮液及其制备方法 |
| KR101923519B1 (ko) * | 2018-06-26 | 2019-02-27 | 대우제약 주식회사 | 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법 |
| KR20200019451A (ko) | 2018-08-14 | 2020-02-24 | 대우제약 주식회사 | 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법 |
| WO2021199813A1 (ja) * | 2020-03-31 | 2021-10-07 | 参天製薬株式会社 | レバミピドまたはその塩および高分子を含有する水性懸濁液 |
| KR102659338B1 (ko) | 2023-05-18 | 2024-04-19 | 국제약품 주식회사 | 안구건조증 치료용 약제학적 조성물 |
| KR102857592B1 (ko) * | 2024-12-06 | 2025-09-09 | 피투케이바이오 주식회사 | 사이클로스포린 및 레바미피드를 포함하는 점안액 조성물 및 이의 제조 방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0313000B1 (de) * | 1987-10-21 | 1998-05-06 | Siemens Aktiengesellschaft | Verfahren zum Herstellen eines Bipolartransistors mit isolierter Gateelektrode |
| US5188826A (en) * | 1988-02-08 | 1993-02-23 | Insite Vision Incorporated | Topical ophthalmic suspensions |
| DE69123248T2 (de) * | 1991-03-27 | 1997-03-13 | Senju Pharma Co | Verfahren zur herstellung einer wässrigen suspension |
| US5540930A (en) * | 1993-10-25 | 1996-07-30 | Pharmos Corporation | Suspension of loteprednol etabonate for ear, eye, or nose treatment |
| JP3781792B2 (ja) * | 1993-12-27 | 2006-05-31 | 千寿製薬株式会社 | ジフルプレドナート含有点眼用懸濁液剤 |
| US5556848A (en) | 1993-12-27 | 1996-09-17 | Senju Pharmaceutical Co., Ltd. | Ophthalmic suspension containing diflupredonate |
| US5576311A (en) * | 1994-11-30 | 1996-11-19 | Pharmos Corporation | Cyclodextrins as suspending agents for pharmaceutical suspensions |
| JP3093661B2 (ja) * | 1995-10-12 | 2000-10-03 | 大塚製薬株式会社 | 眼疾患治療剤 |
| AR004214A1 (es) | 1995-10-12 | 1998-11-04 | Otsuka Pharma Co Ltd | Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| JP3402195B2 (ja) * | 1997-05-14 | 2003-04-28 | 千寿製薬株式会社 | 再分散性の良い水性懸濁液剤 |
| KR20010012188A (ko) | 1997-05-14 | 2001-02-15 | 요시다 쇼지 | 재분산성이 양호한 수성 현탁액제 |
| US6884768B2 (en) * | 2001-06-14 | 2005-04-26 | Otsuka Pharmaceutical Co., Ltd. | Medicinal compositions |
| US20050255144A1 (en) * | 2003-04-09 | 2005-11-17 | Directcontact Llc | Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases |
| JP2005008625A (ja) | 2003-05-23 | 2005-01-13 | Santen Pharmaceut Co Ltd | キノロン系抗菌化合物を含有する点眼液 |
| WO2004103373A1 (ja) | 2003-05-23 | 2004-12-02 | Santen Pharmaceutical Co.,Ltd. | キノロン系抗菌化合物を含有する点眼液 |
| TW200613006A (en) | 2004-09-10 | 2006-05-01 | Otsuka Pharma Co Ltd | Rebamipide preparation for rectal administration to be prepared before using |
| TWI363626B (en) * | 2004-11-15 | 2012-05-11 | Otsuka Pharma Co Ltd | Aqueous ophthalmic suspension of crystalline rebamipide |
| TW200808375A (en) | 2006-05-12 | 2008-02-16 | Otsuka Pharma Co Ltd | Hydrogel suspension and manufacturing process thereof |
-
2007
- 2007-10-01 TW TW096136705A patent/TWI415629B/zh not_active IP Right Cessation
- 2007-10-24 CN CN2007800400591A patent/CN101528229B/zh active Active
- 2007-10-24 EP EP07830901A patent/EP2077840A4/en not_active Withdrawn
- 2007-10-24 RU RU2009119717/15A patent/RU2467751C2/ru not_active IP Right Cessation
- 2007-10-24 NZ NZ576224A patent/NZ576224A/en unknown
- 2007-10-24 AU AU2007309968A patent/AU2007309968B2/en not_active Ceased
- 2007-10-24 KR KR1020147016857A patent/KR101491965B1/ko active Active
- 2007-10-24 MY MYPI20091347A patent/MY148303A/en unknown
- 2007-10-24 CA CA2665024A patent/CA2665024C/en not_active Expired - Fee Related
- 2007-10-24 UA UAA200905226A patent/UA95989C2/ru unknown
- 2007-10-24 SG SG2011074945A patent/SG175628A1/en unknown
- 2007-10-24 AR ARP070104698A patent/AR063366A1/es unknown
- 2007-10-24 BR BRPI0718429-8A2A patent/BRPI0718429A2/pt not_active IP Right Cessation
- 2007-10-24 WO PCT/JP2007/071167 patent/WO2008050896A1/en not_active Ceased
- 2007-10-24 JP JP2009518660A patent/JP5250551B2/ja active Active
- 2007-10-24 MX MX2009004433A patent/MX2009004433A/es active IP Right Grant
- 2007-10-24 KR KR1020097010624A patent/KR20090073248A/ko not_active Ceased
- 2007-10-24 US US12/447,065 patent/US8772317B2/en not_active Expired - Fee Related
-
2009
- 2009-04-05 IL IL197950A patent/IL197950A0/en not_active IP Right Cessation
- 2009-04-16 ZA ZA2009/02778A patent/ZA200902778B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200902778B (en) | 2010-02-24 |
| AR063366A1 (es) | 2009-01-21 |
| CN101528229A (zh) | 2009-09-09 |
| EP2077840A4 (en) | 2010-08-11 |
| TW200822936A (en) | 2008-06-01 |
| KR20090073248A (ko) | 2009-07-02 |
| AU2007309968B2 (en) | 2012-09-06 |
| IL197950A0 (en) | 2009-12-24 |
| EP2077840A1 (en) | 2009-07-15 |
| CA2665024A1 (en) | 2008-05-02 |
| MY148303A (en) | 2013-03-29 |
| AU2007309968A1 (en) | 2008-05-02 |
| NZ576224A (en) | 2010-12-24 |
| WO2008050896A1 (en) | 2008-05-02 |
| HK1133188A1 (en) | 2010-03-19 |
| TWI415629B (zh) | 2013-11-21 |
| MX2009004433A (es) | 2009-05-08 |
| US20100029714A1 (en) | 2010-02-04 |
| RU2467751C2 (ru) | 2012-11-27 |
| SG175628A1 (en) | 2011-11-28 |
| KR20140088228A (ko) | 2014-07-09 |
| CN101528229B (zh) | 2012-07-04 |
| CA2665024C (en) | 2015-04-07 |
| US8772317B2 (en) | 2014-07-08 |
| JP5250551B2 (ja) | 2013-07-31 |
| BRPI0718429A2 (pt) | 2013-11-12 |
| KR101491965B1 (ko) | 2015-02-10 |
| UA95989C2 (ru) | 2011-09-26 |
| JP2010507566A (ja) | 2010-03-11 |
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