RU2009115364A - Антагонисты рецепторов для лечения метастатического рака - Google Patents
Антагонисты рецепторов для лечения метастатического рака Download PDFInfo
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- RU2009115364A RU2009115364A RU2009115364/15A RU2009115364A RU2009115364A RU 2009115364 A RU2009115364 A RU 2009115364A RU 2009115364/15 A RU2009115364/15 A RU 2009115364/15A RU 2009115364 A RU2009115364 A RU 2009115364A RU 2009115364 A RU2009115364 A RU 2009115364A
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- pdgfrα
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- 239000002464 receptor antagonist Substances 0.000 title claims 2
- 229940044551 receptor antagonist Drugs 0.000 title claims 2
- 208000037819 metastatic cancer Diseases 0.000 title 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 46
- 102000001393 Platelet-Derived Growth Factor alpha Receptor Human genes 0.000 claims abstract 27
- 108010068588 Platelet-Derived Growth Factor alpha Receptor Proteins 0.000 claims abstract 27
- 239000005557 antagonist Substances 0.000 claims abstract 16
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims abstract 10
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims abstract 10
- 208000018084 Bone neoplasm Diseases 0.000 claims abstract 8
- 206010028980 Neoplasm Diseases 0.000 claims abstract 8
- 230000004614 tumor growth Effects 0.000 claims abstract 6
- 239000003098 androgen Substances 0.000 claims abstract 4
- 239000003112 inhibitor Substances 0.000 claims abstract 4
- 230000003834 intracellular effect Effects 0.000 claims abstract 4
- 210000004881 tumor cell Anatomy 0.000 claims abstract 4
- 206010006187 Breast cancer Diseases 0.000 claims abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 claims abstract 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims abstract 2
- 206010060862 Prostate cancer Diseases 0.000 claims abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims abstract 2
- 230000001419 dependent effect Effects 0.000 claims abstract 2
- 239000012634 fragment Substances 0.000 claims abstract 2
- 239000003102 growth factor Substances 0.000 claims abstract 2
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960002411 imatinib Drugs 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 201000005202 lung cancer Diseases 0.000 claims abstract 2
- 208000020816 lung neoplasm Diseases 0.000 claims abstract 2
- 208000011581 secondary neoplasm Diseases 0.000 claims abstract 2
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Abstract
1. Способ лечения субъекта, имеющего опухоль кости, который включает введение эффективного количества антагониста PDGFRα. ! 2. Способ ингибирования роста опухоли кости, который включает введение эффективного количества антагониста PDGFRα. ! 3. Способ по п. 1 или 2, где опухоль кости представляет собой первичную опухоль. ! 4. Способ по п. 1 или 2, где опухоль кости представляет собой вторичную опухоль. ! 5. Способ по п. 1 или 2, где рост опухолевых клеток является андроген-зависимым. ! 6. Способ по п. 1 или 2, где рост опухолевых клеток является андроген-независимым. ! 7. Способ по п. 1 или 2, где опухоль метастазирует из рака предстательной железы. ! 8. Способ по п. 1 или 2, где опухоль метастазирует из рака молочной железы. ! 9. Способ по п. 1 или 2, где опухоль метастазирует из рака легких. ! 10. Способ по п. 1 или 2, где антагонист PDGFRα представляет собой антитело или фрагмент антитела. ! 11. Способ по п.10, где антитело или фрагмент антитела конкурирует за связывание с PDGFRα с антителом, включающим тяжелую цепь вариабельного домена, имеющую SEQ ID NO:8, и легкую цепь вариабельного домена, имеющую SEQ ID NO:16. ! 12. Способ по п. 1 или 2, где антагонист PDGFRα представляет собой внутриклеточный ингибитор PDGFRα. ! 13. Способ по п.12, где внутриклеточный ингибитор PDGFRα выбран из группы, состоящей из AG1296, STI-571 и SU11248. ! 14. Способ по п.10, где антитело или фрагмент антитела представляют собой антитело или фрагмент антитела человека. ! 15. Способ по п. 10, где антитело или фрагмент антитела являются гуманизованными. ! 16. Способ по п.10, где антитело или фрагмент антитела является химерным. ! 17. Способ по п. 1 или 2, где антагонист PDGFRα ингибирует связывание тромбоцитарного фактора роста с PDGFRα. !
Claims (29)
1. Способ лечения субъекта, имеющего опухоль кости, который включает введение эффективного количества антагониста PDGFRα.
2. Способ ингибирования роста опухоли кости, который включает введение эффективного количества антагониста PDGFRα.
3. Способ по п. 1 или 2, где опухоль кости представляет собой первичную опухоль.
4. Способ по п. 1 или 2, где опухоль кости представляет собой вторичную опухоль.
5. Способ по п. 1 или 2, где рост опухолевых клеток является андроген-зависимым.
6. Способ по п. 1 или 2, где рост опухолевых клеток является андроген-независимым.
7. Способ по п. 1 или 2, где опухоль метастазирует из рака предстательной железы.
8. Способ по п. 1 или 2, где опухоль метастазирует из рака молочной железы.
9. Способ по п. 1 или 2, где опухоль метастазирует из рака легких.
10. Способ по п. 1 или 2, где антагонист PDGFRα представляет собой антитело или фрагмент антитела.
11. Способ по п.10, где антитело или фрагмент антитела конкурирует за связывание с PDGFRα с антителом, включающим тяжелую цепь вариабельного домена, имеющую SEQ ID NO:8, и легкую цепь вариабельного домена, имеющую SEQ ID NO:16.
12. Способ по п. 1 или 2, где антагонист PDGFRα представляет собой внутриклеточный ингибитор PDGFRα.
13. Способ по п.12, где внутриклеточный ингибитор PDGFRα выбран из группы, состоящей из AG1296, STI-571 и SU11248.
14. Способ по п.10, где антитело или фрагмент антитела представляют собой антитело или фрагмент антитела человека.
15. Способ по п. 10, где антитело или фрагмент антитела являются гуманизованными.
16. Способ по п.10, где антитело или фрагмент антитела является химерным.
17. Способ по п. 1 или 2, где антагонист PDGFRα ингибирует связывание тромбоцитарного фактора роста с PDGFRα.
18. Способ по п. 1 или 2, где антагонист PDGFRα нейтрализует активацию PDGFRα.
19. Способ по п. 1 или 2, где антагонист PDGFRα уменьшает концентрацию поверхностного рецептора PDGFRα.
20. Способ по п. 1 или 2, где антагонист PDGFRα представляет собой антитело, которое связывается с IGF-IR с Kd, составляющей примерно 10-9М-1 или менее.
21. Способ по п. 1 или 2, где антагонист PDGFRα ингибирует фосфорилирование сигнальной молекулы в прямом направлении от PDGFRα.
22. Способ по п. 1 или 2, где антагонист PDGFRα ингибирует активацию Akt, индуцированную костным мозгом.
23. Способ по п. 1 или 2, дополнительно включающий совместное введение второго антагониста рецептора тирозинкиназы.
24. Способ по п. 1 или 2, где антагонист PDGFRα представляет собой биспецифическое антитело.
25. Способ по п.24, где биспецифическое антитело является специфическим в отношении IGF-IR и EGFR.
26. Способ по п. 1 или 2, дополнительно включающий введение эффективного количества противоопухолевого средства.
27. Способ по п. 26, где противоопухолевое средство представляет собой доцетаксел.
28. Способ по п. 26, где противоопухолевое средство представляет собой доксорубицин.
29. Способ по п.26, где противоопухолевое средство представляет собой облучение.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69192005P | 2005-06-17 | 2005-06-17 | |
| US60/691,920 | 2005-06-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008101772/14A Division RU2008101772A (ru) | 2005-06-17 | 2006-06-19 | Антагонисты рецепторов для лечения метастатического рака |
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| Publication Number | Publication Date |
|---|---|
| RU2009115364A true RU2009115364A (ru) | 2010-10-27 |
| RU2502523C2 RU2502523C2 (ru) | 2013-12-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2008101772/14A RU2008101772A (ru) | 2005-06-17 | 2006-06-19 | Антагонисты рецепторов для лечения метастатического рака |
| RU2009115364/15A RU2502523C2 (ru) | 2005-06-17 | 2006-06-19 | АНТИТЕЛА ПРОТИВ PDGFRα ДЛЯ ЛЕЧЕНИЯ ВТОРИЧНОЙ ОПУХОЛИ КОСТИ |
| RU2009115363A RU2455026C3 (ru) | 2005-06-17 | 2009-04-22 | Антагонисты рецепторов для лечения метастатического рака |
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| RU2008101772/14A RU2008101772A (ru) | 2005-06-17 | 2006-06-19 | Антагонисты рецепторов для лечения метастатического рака |
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| RU2009115363A RU2455026C3 (ru) | 2005-06-17 | 2009-04-22 | Антагонисты рецепторов для лечения метастатического рака |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8128929B2 (ru) |
| EP (4) | EP2505205A1 (ru) |
| JP (4) | JP2009501141A (ru) |
| KR (3) | KR101246428B1 (ru) |
| CN (3) | CN101500597A (ru) |
| BR (2) | BRPI0622073A8 (ru) |
| CA (3) | CA2680945C (ru) |
| CY (3) | CY1114603T1 (ru) |
| DK (2) | DK2100618T3 (ru) |
| ES (2) | ES2452115T3 (ru) |
| HU (1) | HUS1700015I1 (ru) |
| IL (3) | IL188151A0 (ru) |
| LT (1) | LTC2100614I2 (ru) |
| LU (1) | LUC00012I2 (ru) |
| NL (1) | NL300869I2 (ru) |
| PL (2) | PL2100618T3 (ru) |
| PT (2) | PT2100618E (ru) |
| RU (3) | RU2008101772A (ru) |
| SI (2) | SI2100618T1 (ru) |
| WO (1) | WO2006138729A2 (ru) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2680945C (en) * | 2005-06-17 | 2014-03-18 | Imclone Systems Incorporated | Anti-pdgfralpha antibodies |
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