RU2007113701A - С-арилгликозидные ингибиторы sglt2, содержащие их фармацевтические композиции и комбинации - Google Patents
С-арилгликозидные ингибиторы sglt2, содержащие их фармацевтические композиции и комбинации Download PDFInfo
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- RU2007113701A RU2007113701A RU2007113701/04A RU2007113701A RU2007113701A RU 2007113701 A RU2007113701 A RU 2007113701A RU 2007113701/04 A RU2007113701/04 A RU 2007113701/04A RU 2007113701 A RU2007113701 A RU 2007113701A RU 2007113701 A RU2007113701 A RU 2007113701A
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Abstract
1. Соединение формулы Iили его фармацевтически приемлемая соль, комплекс, стереоизомер, или пролекарственное соединение - сложный эфир.2. Фармацевтическая композиция, содержащая соединение формулы I и фармацевтически приемлемый носитель.3. Фармацевтическая комбинация, содержащая соединение формулы I и, по меньшей мере, один терапевтический агент, выбранный из группы, состоящей из антидиабетического агента, агента против ожирения, антигипертензивного агента, антиатеросклеротического агента и агента, понижающего содержание липидов.4. Фармацевтическая комбинация по п.3, содержащая соединение формулы I и, по меньшей мере, один антидиабетический агент.5. Комбинация по п.4, отличающаяся тем, что антидиабетический агент представляет собой, по меньшей мере, один агент, выбранный из группы, состоящей из бигуанида, сульфонилмочевины, ингибитора глюкозидаз, агониста PPAR-гамма, двойного агониста PPAR альфа/гамма, ингибитора аР2, ингибитора DPP4, сенсибилизатора инсулина, глюкагоноподобного пептида-1 (GLP- 1), ингибитора РТР1 В, ингибитора гликогенфосфорилазы, ингибитора глюкозо-6-фосфатазы, инсулина и меглитинида.6. Комбинация по п.4, отличающаяся тем, что антидиабетический агент представляет собой, по меньшей мере, один агент, выбранный из группы, состоящей из метформина, глибурида, глимепирида, глиперида, глипизида, хлорпропамида, гликлазида, акарбозы, миглитола, пиоглитазона, троглитазона, розиглитазона, инсулина, изоглитазона, репаглинида, натеглинида, мураглитазара и пелиглитазара.7. Комбинация по п.4, отличающаяся тем, что соединение формулы I присутствует в весовом соотношении к антидиабетическому агенту в интервале от 0.01 до 300:1
Claims (16)
1. Соединение формулы I
или его фармацевтически приемлемая соль, комплекс, стереоизомер, или пролекарственное соединение - сложный эфир.
2. Фармацевтическая композиция, содержащая соединение формулы I и фармацевтически приемлемый носитель.
3. Фармацевтическая комбинация, содержащая соединение формулы I и, по меньшей мере, один терапевтический агент, выбранный из группы, состоящей из антидиабетического агента, агента против ожирения, антигипертензивного агента, антиатеросклеротического агента и агента, понижающего содержание липидов.
4. Фармацевтическая комбинация по п.3, содержащая соединение формулы I и, по меньшей мере, один антидиабетический агент.
5. Комбинация по п.4, отличающаяся тем, что антидиабетический агент представляет собой, по меньшей мере, один агент, выбранный из группы, состоящей из бигуанида, сульфонилмочевины, ингибитора глюкозидаз, агониста PPAR-гамма, двойного агониста PPAR альфа/гамма, ингибитора аР2, ингибитора DPP4, сенсибилизатора инсулина, глюкагоноподобного пептида-1 (GLP- 1), ингибитора РТР1 В, ингибитора гликогенфосфорилазы, ингибитора глюкозо-6-фосфатазы, инсулина и меглитинида.
6. Комбинация по п.4, отличающаяся тем, что антидиабетический агент представляет собой, по меньшей мере, один агент, выбранный из группы, состоящей из метформина, глибурида, глимепирида, глиперида, глипизида, хлорпропамида, гликлазида, акарбозы, миглитола, пиоглитазона, троглитазона, розиглитазона, инсулина, изоглитазона, репаглинида, натеглинида, мураглитазара и пелиглитазара.
7. Комбинация по п.4, отличающаяся тем, что соединение формулы I присутствует в весовом соотношении к антидиабетическому агенту в интервале от 0.01 до 300:1.
8. Комбинация по п.3, отличающаяся тем, что агент против ожирения представляет собой, по меньшей мере, один агент, выбранный из группы, состоящей из бета-3 адренергического агониста, ингибитора липаз, ингибитора обратного захвата серотонина, бета- рецептора тиреоидных гормонов, агониста 5НТ2С, антагониста MCHR1, рецепторного агониста меланокортина, антагониста рецепторов меланин-концентрирующего гормона, модулятора галанин- рецепторных взаимодействий, антагониста орексина, агонистов ССК, антагониста NPY1 или NPY5, модулятора NPY2 и NPY4, агониста кортикотропин- высвобождающего фактора, модулятора рецептора- 3 (Н3) гистамина, ингибитора 11-бета-HSD-1, модулятора рецепторов адинопектина, ингибитора обратного захвата моноамина, цилиарного нейротрофического фактора, нейротрофического фактора головного мозга, лептина или рецепторных модуляторов лептина, антагониста рецепторов каннабиноида-1 и аноректика.
9. Комбинация по п.8, отличающаяся тем, что агент против ожирения представляет собой, по меньшей мере, один агент, выбранный из группы, состоящей из римонабанта, орлистата, сибутрамина, топирамата, дексамфетамина, фентермина, фенйлпропаноламина и мазиндола.
10. Комбинация по п.3, отличающаяся тем, что агент, понижающий содержание липидов, представляет собой, по меньшей мере, один агент, выбранный из группы, состоящей из ингибитора МТР, ингибитора СЕТР, ингибитора HMG СоА редуктазы, ингибитора скваленсинтетазы, производного фибриновой кислоты, позитивного регулятора ("апрегулятора") ЛПНП (LDL) рецепторной активности, ингибитора липоксигеназ и ингибитора АСАТ.
11. Комбинация по п.10, отличающаяся тем, что агент, понижающий содержание липидов, представляет собой, по меньшей мере, один агент, выбранный из группы, состоящей из правастатина, ловастатина, симвастатина, аторвастатина, церивастатина, флувастатина, нисвастатина, визастатина (visastatin), атавастатина, розувастатина, фенофибрата, гемфиброзила, клофибрата и авазимиба.
12. Комбинация по п.10, отличающаяся тем, что соединение формулы I присутствует в весовом соотношении к агенту, понижающему содержание липидов, в интервале от 0,01 до 300:1.
13. Способ лечения или замедления прогрессирования или начала диабета, диабетической ретинопатии, диабетической нейропатии, диабетической нефропатии, замедленного заживления ран, устойчивости к инсулину, гипергликемии, гиперинсулинемии, повышенных уровней жирных кислот или глицерина в крови, гиперлипидемии, ожирения, гиперглицеридемии, синдрома X, диабетических осложнений, атеросклероза или гипертензии, или повышения уровня липопротеинов высокой плотности, заключающийся во введении терапевтически эффективного количества соединения формулы I.
14. Способ по п.13, дополнительно включающий введение, одновременно или последовательно, терапевтически эффективного количества, по меньшей мере, одного дополнительного терапевтического агента, выбранного из группы, состоящей из антидиабетического агента, агента против ожирения, антигипертензивного агента, антиатеросклеротического агента и агента, снижающего содержание липидов.
15. Способ лечения диабета типа II, заключающийся во введении терапевтически эффективного количества соединения формулы I, самостоятельно или в комбинации, по меньшей мере, с одним терапевтическим агентом, выбранным из группы, состоящей из антидиабетического агента, агента для лечения осложнений диабета, агента против ожирения, антигипертензивного агента, антитромбоцитарного агента, антиатеросклеротического агента и гиполипидемического агента.
16. Соединение, имеющее структуру
Applications Claiming Priority (2)
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| US61259904P | 2004-09-23 | 2004-09-23 | |
| US60/612,599 | 2004-09-23 |
Publications (1)
| Publication Number | Publication Date |
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| RU2007113701A true RU2007113701A (ru) | 2008-10-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2007113701/04A RU2007113701A (ru) | 2004-09-23 | 2005-09-23 | С-арилгликозидные ингибиторы sglt2, содержащие их фармацевтические композиции и комбинации |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7589193B2 (ru) |
| EP (1) | EP1791852B8 (ru) |
| JP (1) | JP4945450B2 (ru) |
| KR (1) | KR20070054672A (ru) |
| CN (1) | CN101065391B (ru) |
| AR (1) | AR051446A1 (ru) |
| AT (1) | ATE419260T1 (ru) |
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2005
- 2005-09-21 AR ARP050103981A patent/AR051446A1/es unknown
- 2005-09-23 ES ES05814242T patent/ES2318570T3/es not_active Expired - Lifetime
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- 2005-09-23 WO PCT/US2005/034359 patent/WO2006034489A2/en not_active Ceased
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- 2005-09-23 DE DE602005012126T patent/DE602005012126D1/de not_active Expired - Lifetime
- 2005-09-23 SI SI200530586T patent/SI1791852T1/sl unknown
- 2005-09-23 DK DK05814242T patent/DK1791852T3/da active
- 2005-09-23 CA CA002581673A patent/CA2581673A1/en not_active Abandoned
- 2005-09-23 JP JP2007533695A patent/JP4945450B2/ja not_active Expired - Fee Related
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- 2005-09-23 KR KR1020077006539A patent/KR20070054672A/ko not_active Ceased
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- 2005-09-23 UA UAA200704433A patent/UA88647C2/ru unknown
- 2005-09-23 AU AU2005286608A patent/AU2005286608A1/en not_active Abandoned
- 2005-09-23 AT AT05814242T patent/ATE419260T1/de active
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2625795C2 (ru) * | 2012-04-10 | 2017-07-19 | Теракос Саб, ЛЛК | Способ получения бензилбензольных ингибиторов sglt2 |
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