RU2007110166A - Способы заживления ран введением il-18 человека - Google Patents
Способы заживления ран введением il-18 человека Download PDFInfo
- Publication number
- RU2007110166A RU2007110166A RU2007110166/14A RU2007110166A RU2007110166A RU 2007110166 A RU2007110166 A RU 2007110166A RU 2007110166/14 A RU2007110166/14 A RU 2007110166/14A RU 2007110166 A RU2007110166 A RU 2007110166A RU 2007110166 A RU2007110166 A RU 2007110166A
- Authority
- RU
- Russia
- Prior art keywords
- mucositis
- human
- wound
- patient
- group
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 14
- 230000035876 healing Effects 0.000 title claims 3
- 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 claims abstract 5
- 102000043959 human IL18 Human genes 0.000 claims abstract 4
- 206010056340 Diabetic ulcer Diseases 0.000 claims abstract 3
- 208000005230 Leg Ulcer Diseases 0.000 claims abstract 3
- 206010072170 Skin wound Diseases 0.000 claims abstract 3
- 208000002847 Surgical Wound Diseases 0.000 claims abstract 3
- 208000003265 stomatitis Diseases 0.000 claims abstract 3
- 206010028116 Mucosal inflammation Diseases 0.000 claims 8
- 201000010927 Mucositis Diseases 0.000 claims 8
- 206010052428 Wound Diseases 0.000 claims 6
- 208000027418 Wounds and injury Diseases 0.000 claims 6
- 238000007911 parenteral administration Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000000968 intestinal effect Effects 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 231100000516 lung damage Toxicity 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 206010064147 Gastrointestinal inflammation Diseases 0.000 abstract 1
- 102100039898 Interleukin-18 Human genes 0.000 abstract 1
- 208000004852 Lung Injury Diseases 0.000 abstract 1
- 206010069363 Traumatic lung injury Diseases 0.000 abstract 1
- 208000018925 gastrointestinal mucositis Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 231100000515 lung injury Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (13)
1. Способ заживления раны у пациента, нуждающегося в этом, включающий стадию введения пациенту терапевтически эффективного количества полипептида IL-18 человека (SEQ ID NO: 1).
2. Способ по п.2, где рана выбрана из группы ран на коже, хирургических ран, язв на ногах, диабетических язв, мукозита и повреждения легкого.
3. Способ по п.2, где IL-18 человека вводят посредством парентерального введения.
4. Способ по п.3, где парентеральное введение выбрано из группы подкожного, внутримышечного, внутривенного и интраназального введения.
5. Способ по п.2, где мукозит представляет собой мукозит полости рта.
6. Способ по п.2, где мукозит представляет собой мукозит кишечника.
7. Способ заживления раны у пациента, нуждающегося в этом, включающий стадию введения пациенту фармацевтической композиции, содержащей эффективное количество полипептида IL-18 человека (SEQ ID NO: 1) в сочетании с носителем.
8. Способ по п.5, где рана выбрана из группы ран на коже, хирургических ран, язв на ногах, диабетических язв, мукозита и повреждения легкого.
9. Способ по п.8, где мукозит представляет собой мукозит полости рта.
10. Способ по п.8, где мукозит представляет собой мукозит кишечника.
11. Способ по п.2, где фармацевтическую композицию вводят посредством парентерального введения.
12. Способ по п.11, где парентеральное введение выбрано из группы подкожного, внутримышечного, внутривенного и интраназального введения.
13. Способ по п.8, где рана представляет собой рану кожи, и, кроме того, где фармацевтическую композицию вводят пациенту местно.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60301204P | 2004-08-20 | 2004-08-20 | |
| US60/603,012 | 2004-08-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007110166A true RU2007110166A (ru) | 2008-09-27 |
| RU2387455C2 RU2387455C2 (ru) | 2010-04-27 |
Family
ID=35968167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007110166/14A RU2387455C2 (ru) | 2004-08-20 | 2005-08-18 | Способы заживления ран введением il-18 человека |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7595039B2 (ru) |
| EP (2) | EP1793859B1 (ru) |
| JP (1) | JP4912306B2 (ru) |
| KR (1) | KR20070050924A (ru) |
| CN (1) | CN101039696B (ru) |
| AT (2) | ATE526057T1 (ru) |
| AU (1) | AU2005277404A1 (ru) |
| BR (1) | BRPI0514445A (ru) |
| CA (1) | CA2577777A1 (ru) |
| CY (1) | CY1108991T1 (ru) |
| DE (1) | DE602005013542D1 (ru) |
| DK (1) | DK1793859T3 (ru) |
| ES (2) | ES2322605T3 (ru) |
| IL (1) | IL181286A0 (ru) |
| MX (1) | MX2007002134A (ru) |
| NO (1) | NO20071238L (ru) |
| NZ (1) | NZ552837A (ru) |
| PL (1) | PL1793859T3 (ru) |
| PT (1) | PT1793859E (ru) |
| RU (1) | RU2387455C2 (ru) |
| SI (1) | SI1793859T1 (ru) |
| WO (1) | WO2006023623A2 (ru) |
| ZA (1) | ZA200700524B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL151044A0 (en) * | 2000-02-10 | 2003-04-10 | Abbott Lab | Antibodies that bind human interleukin-18 and methods of making and using |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| RU2423971C1 (ru) * | 2010-06-01 | 2011-07-20 | Закрытое акционерное общество "Биологические исследования и системы" | Способ ускорения заживления кожных повреждений, вызванных денервацией и нарушением кровоснабжения |
| EP2718456B1 (en) | 2011-06-13 | 2019-04-24 | Neumedicines, Inc. | Mitigation of cutaneous injury with il-12 |
| PH12016500425B1 (en) * | 2013-09-05 | 2022-07-29 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in inflammatory diseases |
| JP7274259B2 (ja) | 2015-03-05 | 2023-05-16 | エイビー２ バイオ ソシエテアノニム | 炎症性疾患におけるｉｌ－１８結合タンパク質（ｉｌ－１８ｂｐ）および抗体 |
| MX2020002542A (es) | 2017-09-06 | 2020-07-20 | Univ Yale | Variantes de interleucina-18 y metodos de uso. |
| AU2023226512A1 (en) | 2022-02-23 | 2024-08-29 | Bright Peak Therapeutics Ag | Immune antigen specific il-18 immunocytokines and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0692536B1 (en) | 1994-07-14 | 2000-11-22 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | IFN-Y production inducing protein and monoclonal antibody of the same |
| JP4004088B2 (ja) | 1995-09-26 | 2007-11-07 | 株式会社林原生物化学研究所 | 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質 |
| TW464656B (en) | 1994-11-15 | 2001-11-21 | Hayashibara Biochem Lab | Interferon-gamma production inducing polypeptide monoclonal antibody, and agent for interferon-gamma susceptive disease |
| US5680795A (en) | 1995-07-05 | 1997-10-28 | Norco Inc. | Mechanical drive assembly incorporating counter-spring biassed radially-adjustable rollers |
| JP4024366B2 (ja) * | 1996-11-29 | 2007-12-19 | 株式会社林原生物化学研究所 | ポリペプチド |
| AU6636098A (en) * | 1998-03-07 | 1999-09-20 | Dae Woong Pharmaceutical Co., Ltd. | Topical composition containing human epidermal growth factor |
| TWI227136B (en) * | 1998-05-21 | 2005-02-01 | Smithkline Beecham Corp | Novel pharmaceutical composition for the prevention and/or treatment of cancer |
| JP2004514652A (ja) * | 2000-06-02 | 2004-05-20 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−１８およびｉｌ−１８組み合わせを用いるウイルス疾患の治療法 |
| PL208592B1 (pl) * | 2000-06-15 | 2011-05-31 | Smithkline Beecham Corp | Sposób wytwarzania aktywnego ludzkiego polipeptydu IL-18 z ludzkiego polipeptydu prekursora IL-18 |
| WO2003005811A1 (fr) * | 2001-07-12 | 2003-01-23 | Nakanishi, Kenji | Animal transgenique il-18 |
| ATE497778T1 (de) * | 2002-09-16 | 2011-02-15 | Agennix Inc | Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus |
| AU2003295331A1 (en) * | 2002-09-19 | 2004-04-23 | Centocor, Inc. | Method of inducing maturation of dendritic cells and uses therefor |
| WO2005018542A2 (en) * | 2003-07-10 | 2005-03-03 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
-
2005
- 2005-08-18 ES ES05789011T patent/ES2322605T3/es not_active Expired - Lifetime
- 2005-08-18 RU RU2007110166/14A patent/RU2387455C2/ru not_active IP Right Cessation
- 2005-08-18 JP JP2007528002A patent/JP4912306B2/ja not_active Expired - Lifetime
- 2005-08-18 KR KR1020077003853A patent/KR20070050924A/ko not_active Withdrawn
- 2005-08-18 PL PL05789011T patent/PL1793859T3/pl unknown
- 2005-08-18 AT AT09155870T patent/ATE526057T1/de not_active IP Right Cessation
- 2005-08-18 DE DE602005013542T patent/DE602005013542D1/de not_active Expired - Lifetime
- 2005-08-18 PT PT05789011T patent/PT1793859E/pt unknown
- 2005-08-18 MX MX2007002134A patent/MX2007002134A/es active IP Right Grant
- 2005-08-18 DK DK05789011T patent/DK1793859T3/da active
- 2005-08-18 CA CA002577777A patent/CA2577777A1/en not_active Abandoned
- 2005-08-18 EP EP05789011A patent/EP1793859B1/en not_active Expired - Lifetime
- 2005-08-18 AT AT05789011T patent/ATE426410T1/de active
- 2005-08-18 WO PCT/US2005/029358 patent/WO2006023623A2/en not_active Ceased
- 2005-08-18 SI SI200530665T patent/SI1793859T1/sl unknown
- 2005-08-18 NZ NZ552837A patent/NZ552837A/en not_active IP Right Cessation
- 2005-08-18 EP EP09155870A patent/EP2161032B1/en not_active Expired - Lifetime
- 2005-08-18 AU AU2005277404A patent/AU2005277404A1/en not_active Abandoned
- 2005-08-18 BR BRPI0514445-0A patent/BRPI0514445A/pt not_active IP Right Cessation
- 2005-08-18 ES ES09155870T patent/ES2372728T3/es not_active Expired - Lifetime
- 2005-08-18 CN CN2005800338197A patent/CN101039696B/zh not_active Expired - Fee Related
- 2005-08-19 US US11/207,847 patent/US7595039B2/en active Active
-
2007
- 2007-01-18 ZA ZA200700524A patent/ZA200700524B/en unknown
- 2007-02-12 IL IL181286A patent/IL181286A0/en unknown
- 2007-03-07 NO NO20071238A patent/NO20071238L/no not_active Application Discontinuation
-
2009
- 2009-05-07 CY CY20091100489T patent/CY1108991T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20110819 |