RU2006101985A - Дозированные формы анестезирующих средств с с длительным высвобождением для обезболивания - Google Patents
Дозированные формы анестезирующих средств с с длительным высвобождением для обезболивания Download PDFInfo
- Publication number
- RU2006101985A RU2006101985A RU2006101985/15A RU2006101985A RU2006101985A RU 2006101985 A RU2006101985 A RU 2006101985A RU 2006101985/15 A RU2006101985/15 A RU 2006101985/15A RU 2006101985 A RU2006101985 A RU 2006101985A RU 2006101985 A RU2006101985 A RU 2006101985A
- Authority
- RU
- Russia
- Prior art keywords
- dosage form
- polymer
- sustained release
- anesthetic
- release dosage
- Prior art date
Links
- 230000007774 longterm Effects 0.000 title 1
- 239000002552 dosage form Substances 0.000 claims 41
- 229920000642 polymer Polymers 0.000 claims 31
- 238000013268 sustained release Methods 0.000 claims 31
- 239000012730 sustained-release form Substances 0.000 claims 31
- 230000003444 anaesthetic effect Effects 0.000 claims 23
- 239000002904 solvent Substances 0.000 claims 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 16
- 229920001577 copolymer Polymers 0.000 claims 10
- -1 levoropivacaine Chemical compound 0.000 claims 10
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 8
- 239000004310 lactic acid Substances 0.000 claims 8
- 235000014655 lactic acid Nutrition 0.000 claims 8
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 6
- 229960003150 bupivacaine Drugs 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 229920000249 biocompatible polymer Polymers 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims 2
- XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 claims 2
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims 2
- UYXTWWCETRIEDR-UHFFFAOYSA-N Tributyrin Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 claims 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N ethyl benzoate Chemical compound CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 239000001087 glyceryl triacetate Substances 0.000 claims 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229960002622 triacetin Drugs 0.000 claims 2
- DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical compound CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 1
- NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 1
- 229920002101 Chitin Polymers 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 239000004348 Glyceryl diacetate Substances 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229960002903 benzyl benzoate Drugs 0.000 claims 1
- 229930188620 butyrolactone Natural products 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940116333 ethyl lactate Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229940074076 glycerol formal Drugs 0.000 claims 1
- 235000019443 glyceryl diacetate Nutrition 0.000 claims 1
- 239000012456 homogeneous solution Substances 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 claims 1
- 229960004288 levobupivacaine Drugs 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims 1
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920001707 polybutylene terephthalate Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 239000000622 polydioxanone Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920001855 polyketal Polymers 0.000 claims 1
- 229920006324 polyoxymethylene Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 229960001549 ropivacaine Drugs 0.000 claims 1
- 239000011877 solvent mixture Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 150000003890 succinate salts Chemical class 0.000 claims 1
- 238000012385 systemic delivery Methods 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 1
- 229960002372 tetracaine Drugs 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 238000012384 transportation and delivery Methods 0.000 claims 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (36)
1. Дозированная форма анестезирующего средства с длительным высвобождением, содержащая гелевый носитель кратковременного действия, включающий биоэродируемый, биологически совместимый полимер с низкой молекулярной массой и несмешивающийся с водой растворитель, в количестве, эффективном для пластификации полимера и образования геля с вышеупомянутым полимером; анестезирующее средство, растворенное или диспергированное в гелевом носителе.
2. Дозированная форма с длительным высвобождением по п.1, дополнительно имеющая регулируемый коэффициент эффективности для достижения профиля высвобождения.
3. Дозированная форма с длительным высвобождением по п.2, где коэффициент эффективности находится приблизительно между 1 и 200, предпочтительно приблизительно между 5 и 100.
4. Дозированная форма с длительным высвобождением по п.1, где длительное высвобождение происходит за период, меньший или равный приблизительно четырнадцати дням, предпочтительно длительное высвобождение происходит за период, меньший или равный приблизительно семи дням и, более предпочтительно длительное высвобождение продолжается в течение периода приблизительно от 24 ч до семи дней.
5. Дозированная форма с длительным высвобождением по п.1, где анестезирующее средство выбрано из группы, состоящей из бупивакаина, левобупивакаина, ропивакаина, леворопивакаина, тетракаина, этидокаина, левоэтидокаина, декстроэтидокаина, левомепивакаина, и их комбинаций.
6. Дозированная форма с длительным высвобождением по п.1, где анестезирующее средство содержит бупивакаин.
7. Дозированная форма с длительным высвобождением по п.1, где растворитель имеет смешиваемость с водой, меньше или равную приблизительно 7 мас.% при 25°C.
8. Дозированная форма с длительным высвобождением по п.1, где дозированная форма не содержит растворителей, имеющих смешиваемость с водой более 7 мас.% при 25°C.
9. Дозированная форма с длительным высвобождением по п.1, где растворитель выбран из группы, состоящей из ароматического спирта, низших алкиловых эфиров ариловых кислот, низших аралкиловых эфиров ариловых кислот; арилкетонов, аралкилкетонов, низших алкилкетонов, низших алкиловых эфиров лимонной кислоты, и их комбинаций.
10. Дозированная форма с длительным высвобождением по п.1, где растворитель содержит компонент, выбранный из группы, состоящей из бензилового спирта, бензилбензоата, этилбензоата, триацетина и из смесей.
11. Дозированная форма с длительным высвобождением по п.1, где растворитель содержит составной растворитель, выбранный из группы, состоящей из триацетина, диацетина, трибутирина, триэтилцитрата, трибутилцитрата, ацетилтриэтилцитрата, ацетилтрибутилцитрата, триэтилглицеридов, триэтилфосфата, диэтилфталата, диэтилтартрата, минерального масла, полибутена, силиконовой жидкости, глицерина, этиленгликоля, полиэтиленгликоля, октанола, этиллактата, пропиленгликоля, пропиленкарбоната, этиленкарбоната, бутиролактона, этиленоксида, пропиленоксида, N-метил-2-пирролидона, 2-пирролидона, глицеролформаля, метилацетата, этилацетата, метилэтилкетона, диметилформамида, диметилсульфоксида, тетрагидрофурана, капролактама, децилметилсульфоксида, олеиновой кислоты и 1-додецилазациклогептан-2-она, и их комбинаций.
12. Дозированная форма с длительным высвобождением по п.1, где полимер содержит полимер на основе молочной кислоты или сополимер молочной кислоты и гликолевой кислоты (PLGA), или полимер на основе капролактона, или выбран из группы, состоящей из полилактидов, полигликолидов, поли(капролактона), полиангидридов, полиаминов, полиамидоэфиров, полиортоэфиров, полидиоксанонов, полиацеталей, поликеталей, поликарбонатов, полифосфоэфиров, полиэфиров, полибутилентерефталата, полиортокарбонатов, полифосфазенов, сукцинатов, поли(яблочной кислоты), поли(аминокислот), поливинилпирролидона, полиэтиленгликоля, полигидроксицеллюлозы, полисахаридов, хитина, хитозана, гиалуроновой кислоты и сополимеров, тройных сополимеров и их смесей.
13. Дозированная форма с длительным высвобождением по п.12, где полимер содержит сополимер молочной кислоты и гликолевой кислоты (PLGA), и где сополимер имеет соотношение мономеров молочной кислоты и гликолевой кислоты приблизительно 50:50.
14. Дозированная форма с длительным высвобождением по п.12 или 13, где полимер содержит эфирную концевую группу или концевую группу карбоновой кислоты.
15. Дозированная форма с длительным высвобождением по п.1, где полимер имеет среднюю молекулярную массу приблизительно между 3000 и 10000, предпочтительно полимер имеет среднюю молекулярную массу приблизительно между 3000 и 8000, более предпочтительно полимер имеет среднюю молекулярную массу приблизительно между 4000 и 6000, еще более предпочтительно полимер имеет среднюю молекулярную массу приблизительно 5000.
16. Дозированная форма с длительным высвобождением по п.1, где дозированная форма содержит от приблизительно 0,1 мас.% до приблизительно 50 мас.% анестезирующего средства, предпочтительно, дозированная форма содержит от приблизительно 0,5 до приблизительно 40 мас.% анестезирующего средства и более предпочтительно дозированная форма содержит от приблизительно 1 до приблизительно 30 мас.% анестезирующего средства.
17. Дозированная форма с длительным высвобождением по п.1, где соотношение между полимером и растворителем находится в диапазоне между приблизительно 5:95 и приблизительно 90:10, предпочтительно соотношение между полимером и растворителем находится в диапазоне между приблизительно 20:80 и приблизительно 80:20 и более предпочтительно соотношение между полимером и растворителем находится в диапазоне между приблизительно 30:70 и приблизительно 75:25.
18. Дозированная форма с длительным высвобождением по п.1, дополнительно содержащая по меньшей мере одно из следующего: наполнитель, эмульгирующее средство, порообразующее средство, модулятор растворимости для анестезирующего средства и вещество, изменяющее осмотическое давление.
19. Дозированная форма с длительным высвобождением по п.1, где анестезирующее средство содержит частицы, имеющие средний размер менее приблизительно 250 мкм, предпочтительно анестезирующее средство содержит частицы, имеющие средний размер от приблизительно 5 до 250 мкм, более предпочтительно средний размер частиц составляет от приблизительно 20 до приблизительно 125 мкм и более предпочтительно средний размер частиц составляет от приблизительно 38 до приблизительно 63 мкм.
20. Дозированная форма с длительным высвобождением по п.1, где полимер содержит полимер на основе молочной кислоты, а анестезирующее средство содержит бупивакаин, при этом дозированная форма дополнительно имеет регулируемый коэффициент эффективности для достижения профиля высвобождения; и где средняя молекулярная масса полимера на основе молочной кислоты находится приблизительно между 3000 и 10000.
21. Дозированная форма с длительным высвобождением по п.20, где полимер содержит сополимер молочной кислоты и гликолевой кислоты (PLGA).
22. Дозированная форма с длительным высвобождением по п.21, где сополимер имеет соотношение мономеров молочной кислоты к гликолевой кислоте приблизительно 50:50.
23. Дозированная форма с длительным высвобождением по п.21 или 22, где сополимер содержит поли(D,L-лактид-со-гликолид).
24. Дозированная форма с длительным высвобождением по п.21 или 22, где сополимер содержит поли(L-лактид-со-гликолид).
25. Применение анестезирующего средства в изготовлении дозированной формы с длительным высвобождением по п.1 для лечения локальной боли у субъекта.
26. Применение по п.25, в котором дозированная форма предназначена для однократного введения.
27. Применение по п.25, в котором дозированная форма предназначена для местного применения к очагу локальной боли, или дозированная форма предназначена для инъекции вблизи очага локальной боли, или дозированная форма предназначена для системной доставки анестезирующего средства, или дозированная форма предназначена для доставки анестезирующего средства к нескольким участкам.
28. Применение по п.27, в котором дозированная форма предназначена для инъекции в несколько участков вокруг очага локальной боли.
29. Применение по п.25, в котором дозированная форма предназначена для повторного введения.
30. Применение бупивакаина в изготовлении дозированной формы с длительным высвобождением, содержащей гелевый носитель кратковременного действия, включающий полимер с низкой молекулярной массой на основе молочной кислоты и несмешивающийся с водой растворитель, в количестве, эффективном для пластификации полимера и для образования геля с вышеупомянутым полимером; анестезирующее средство, содержащее бупивакаин, растворенный или диспергированный в гелевом носителе; и имеющей регулируемый коэффициент эффективности для достижения профиля высвобождения; где дозированная форма предназначена для лечения послеоперационной локальной боли у субъекта.
31. Применение по п.30, в котором полимер содержит сополимер молочной кислоты и гликолевой кислоты (PLGA).
32. Применение по п.31, в котором сополимер имеет соотношение мономеров молочной кислоты к гликолевой кислоте приблизительно 50:50.
33. Способ изготовления дозированной формы с длительным высвобождением, включающий приготовление гелевого носителя, который содержит биоэродируемый, биосовместимый полимер с низкой молекулярной массой и несмешивающийся с водой растворитель, в количестве, эффективном для пластификации полимера и для образования геля с вышеупомянутым полимером, с получением раствора или геля полимер/растворитель; уравновешивание смеси полимер/растворитель до получения прозрачного гомогенного раствора или геля; растворение или диспергирование анестезирующего средства в растворе или геле полимера/растворителя; смешивание анестезирующего средства и раствора или геля полимера/растворителя для образования дозированной формы с длительным высвобождением; и регулирование коэффициента эффективности для достижения профиля высвобождения.
34. Способ по п.33, в котором уравновешивание раствора или геля полимер/растворитель происходит при температуре в пределах от комнатной температуры до приблизительно 65°C.
35. Способ по п.33 или 34, в котором анестезирующее средство содержит бупивакаин.
36. Набор для введения анестезирующего средства с замедленным высвобождением субъекту с локальной болью, содержащий гелевый носитель кратковременного действия, который содержит биоэродируемый, биосовместимый полимер с низкой молекулярной массой и несмешивающийся с водой растворитель, в количестве, эффективном для пластификации полимера и для образования геля с вышеупомянутым полимером; анестезирующее средство, растворенное или диспергированное в гелевом носителе; и необязательно, одно или более из следующего: наполнитель; эмульгирующее средство; порообразующее средство; модулятор растворимости для анестезирующего средства, необязательно связанный с анестезирующим средством; и вещество, изменяющее осмотическое давление; в котором по меньшей мере анестезирующее средство, необязательно связанное с модулятором растворимости, сохраняется отдельно от растворителя до момента введения анестезирующего средства субъекту.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/606,969 | 2003-06-25 | ||
| US10/606,969 US20040001889A1 (en) | 2002-06-25 | 2003-06-25 | Short duration depot formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006101985A true RU2006101985A (ru) | 2006-07-27 |
| RU2332985C2 RU2332985C2 (ru) | 2008-09-10 |
Family
ID=34103124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006101985/15A RU2332985C2 (ru) | 2003-06-25 | 2003-10-31 | Дозированные формы анестезирующих средств с длительным высвобождением для обезболивания |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US20040001889A1 (ru) |
| EP (2) | EP1638519A2 (ru) |
| JP (1) | JP2007521225A (ru) |
| KR (1) | KR20060109816A (ru) |
| CN (1) | CN1822814A (ru) |
| AR (1) | AR045975A1 (ru) |
| AU (1) | AU2003286826A1 (ru) |
| BR (1) | BR0318373A (ru) |
| CA (1) | CA2530357A1 (ru) |
| IL (1) | IL172781A0 (ru) |
| MA (1) | MA27863A1 (ru) |
| MX (1) | MXPA05014193A (ru) |
| NO (1) | NO20060295L (ru) |
| PL (1) | PL379263A1 (ru) |
| RU (1) | RU2332985C2 (ru) |
| WO (1) | WO2005009408A2 (ru) |
| ZA (1) | ZA200600698B (ru) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
| US20070196415A1 (en) * | 2002-11-14 | 2007-08-23 | Guohua Chen | Depot compositions with multiple drug release rate controls and uses thereof |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| AU2003256849A1 (en) | 2002-07-31 | 2004-02-16 | Alza Corporation | Injectable multimodal polymer depot compositions and uses thereof |
| WO2004043432A2 (en) * | 2002-11-06 | 2004-05-27 | Alza Corporation | Controlled release depot formulations |
| CN101797221B (zh) | 2002-12-13 | 2013-06-12 | 杜雷科特公司 | 包含高粘度液体载体材料的口服递药系统 |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| MXPA05010605A (es) * | 2003-03-31 | 2005-11-23 | Alza Corp | Bomba osmotica con medios para disipar la presion interna. |
| DE602004015755D1 (de) * | 2003-03-31 | 2008-09-25 | Alza Corp | Nicht wässrige einphasige visköse vehikel und formulierungen die diese vehikel verwenden |
| WO2004089334A2 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
| US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| US9114198B2 (en) * | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
| US8425929B2 (en) * | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| AU2005287175B2 (en) | 2004-09-17 | 2011-12-01 | Durect Corporation | Sustained local anesthetic composition containing preferably a sugar ester such as SAIB |
| US20060142234A1 (en) * | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| KR101728868B1 (ko) | 2006-01-18 | 2017-05-02 | 포시 파마슈티컬스 컴퍼니 리미티드 | 안정성이 강화된 약학 조성물 |
| CA2651855C (en) | 2006-05-30 | 2011-08-02 | Intarcia Therapeutics, Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
| WO2008005371A2 (en) | 2006-06-29 | 2008-01-10 | Medtronic, Inc. | Poly(orthoester) polymers, and methods of making and using same |
| WO2008021133A2 (en) | 2006-08-09 | 2008-02-21 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
| US8599926B2 (en) | 2006-10-12 | 2013-12-03 | Qualcomm Incorporated | Combined run-length coding of refinement and significant coefficients in scalable video coding enhancement layers |
| EP1917971A1 (en) * | 2006-10-27 | 2008-05-07 | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) | Substained release formulations comprising very low molecular weight polymers |
| EP2117521B1 (en) | 2006-11-03 | 2012-06-27 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| ES2402172T3 (es) | 2007-04-23 | 2013-04-29 | Intarcia Therapeutics, Inc | Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos |
| US8470360B2 (en) * | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
| US8920843B2 (en) | 2007-11-07 | 2014-12-30 | Svip5 Llc | Slow release of organic salts of local anesthetics for pain relief |
| JP2011506319A (ja) | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 疼痛、関節炎症状、または慢性疾患に伴う炎症の治療に有用な方法 |
| DK2240155T3 (da) | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
| US8846068B2 (en) * | 2008-04-18 | 2014-09-30 | Warsaw Orthopedic, Inc. | Methods and compositions for treating post-operative pain comprising a local anesthetic |
| US8475823B2 (en) | 2008-04-18 | 2013-07-02 | Medtronic, Inc. | Baclofen formulation in a polyorthoester carrier |
| US20090263456A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Methods and Compositions for Reducing Preventing and Treating Adhesives |
| US8956642B2 (en) | 2008-04-18 | 2015-02-17 | Medtronic, Inc. | Bupivacaine formulation in a polyorthoester carrier |
| SI2291174T1 (sl) * | 2008-06-03 | 2015-05-29 | Tolmar Therapeutics, Inc. | Tekoči sestavek, ki vsebuje biokompatibilne sestavke oligomer-polimer |
| US20100016808A1 (en) * | 2008-07-17 | 2010-01-21 | Bioform Medical, Inc. | Thin-Walled Delivery System |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| US9095506B2 (en) * | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US20100203102A1 (en) * | 2009-02-10 | 2010-08-12 | Warsaw Orthopedic, Inc. | Compositions and methods for treating post-operative pain using bupivacaine and an anti-onflammatory agent |
| US20100228097A1 (en) * | 2009-03-04 | 2010-09-09 | Warsaw Orthopedic, Inc. | Methods and compositions to diagnose pain |
| LT2462246T (lt) | 2009-09-28 | 2017-11-27 | Intarcia Therapeutics, Inc | Esminio stacionaraus vaisto tiekimo greitas įgyvendinimas ir (arba) nutraukimas |
| EP2498783B1 (en) | 2009-11-09 | 2018-08-22 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| MX2012011261A (es) * | 2010-04-01 | 2012-12-05 | Pharmanest Ab | Composiciones bioadhesivas de anestesicos locales. |
| CA2826453A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| PT2717914T (pt) * | 2011-06-10 | 2019-12-18 | Ramscor Inc | Formulações de libertação sustentada para administração de proteínas ao olho e métodos de preparação das mesmas |
| CN103142458B (zh) * | 2013-01-22 | 2015-09-09 | 莱普德制药有限公司 | 无成瘾性镇痛缓释递药系统的组方与制备方法 |
| AU2014216112B2 (en) | 2013-02-15 | 2019-02-21 | Allergan, Inc. | Sustained drug delivery implant |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| KR101768843B1 (ko) | 2013-02-28 | 2017-08-17 | 미라 파마 코포레이션 | 주사가능 장기-작용 국소 마취제 반고체 제형 및 이의 조성물 |
| JP2016515523A (ja) | 2013-03-15 | 2016-05-30 | デュレクト コーポレーション | 溶解変動性を低減させるためのレオロジー改質剤を有する組成物 |
| ES2946767T3 (es) | 2013-09-11 | 2023-07-25 | Aim Targeted Therapies Inc | Composiciones terapéuticas antimicrobianas hipertónicas |
| US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
| US20170224726A1 (en) | 2014-02-18 | 2017-08-10 | Glenn Abrahmsohn | Compositions and methods for pain relief without numbness |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| CA2987766A1 (en) | 2015-06-03 | 2016-12-08 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| EP3375456B1 (en) | 2015-11-12 | 2023-05-03 | Terumo Kabushiki Kaisha | Sustained-release topically administered agent |
| US10501517B2 (en) | 2016-05-16 | 2019-12-10 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| AU2017292791B2 (en) | 2016-07-06 | 2023-05-25 | Orient Pharma Co., Ltd. | Oral dosage form with drug composition, barrier layer and drug layer |
| IL267736B2 (en) | 2017-01-03 | 2024-03-01 | Intarcia Therapeutics Inc | Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| IT201800001890A1 (it) * | 2018-01-25 | 2019-07-25 | Fidia Farm Spa | Composizioni farmaceutiche per il trattamento del dolore postoperatorio |
| EP4027979A4 (en) * | 2019-09-09 | 2023-10-04 | Pacira Therapeutics, Inc. | SUSTAINED RELEASE HEAT CURING GELS WITH SODIUM CHANNEL BLOCKERS AND METHOD FOR THE PRODUCTION THEREOF |
| CA3167217A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
| AU2021328260A1 (en) * | 2020-08-17 | 2023-03-09 | Humanwell Pharmaceutical US | Long acting in-situ forming/gelling compositions |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
| CN119235766B (zh) * | 2024-11-12 | 2026-02-10 | 北京博恩特药业有限公司 | 一种布比卡因缓释凝胶注射液及其制备方法和应用 |
Family Cites Families (343)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US557461A (en) * | 1896-03-31 | Andrew j | ||
| US2931802A (en) | 1958-04-30 | 1960-04-05 | Eastman Kodak Co | Mixed esters of glucose and sucrose |
| GB1088992A (en) | 1963-09-19 | 1967-10-25 | Squibb & Sons Inc | Protective dressings |
| GB1218430A (en) * | 1967-11-07 | 1971-01-06 | Burton Parsons Chemicals Inc | Composition for treatment of pruritis ani |
| US3412890A (en) | 1967-12-22 | 1968-11-26 | Clark Mfg Co J L | Hinged container closure |
| US4411890A (en) | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US3743398A (en) | 1971-03-22 | 1973-07-03 | Eastman Kodak Co | Motion picture projector |
| NO139560C (no) | 1972-04-29 | 1979-04-04 | Takeda Chemical Industries Ltd | Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater |
| US3797492A (en) * | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
| US3828389A (en) * | 1973-03-09 | 1974-08-13 | R Heisler | Unitary container having a hinged panel with a tray configuration |
| DK568274A (ru) | 1973-11-01 | 1975-06-23 | Wellcome Found | |
| US3923939A (en) | 1974-06-07 | 1975-12-02 | Alza Corp | Process for improving release kinetics of a monolithic drug delivery device |
| DE2438350C3 (de) | 1974-08-09 | 1979-06-13 | Hoechst Ag, 6000 Frankfurt | Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| DE2438352A1 (de) | 1974-08-09 | 1976-02-26 | Hoechst Ag | Peptidcyclopropylamide mit lh-rh/fshrh-wirkung |
| US4131648A (en) | 1975-01-28 | 1978-12-26 | Alza Corporation | Structured orthoester and orthocarbonate drug delivery devices |
| US4180646A (en) | 1975-01-28 | 1979-12-25 | Alza Corporation | Novel orthoester polymers and orthocarbonate polymers |
| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| JPS5194273A (ru) | 1975-02-15 | 1976-08-18 | ||
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4079038A (en) | 1976-03-05 | 1978-03-14 | Alza Corporation | Poly(carbonates) |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| US4360019A (en) | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
| JPS55154991A (en) | 1979-05-23 | 1980-12-02 | Hisamitsu Pharmaceut Co Inc | Beta-d-fructopyranoside derivative |
| NZ194405A (en) | 1979-08-02 | 1982-05-25 | Dut Pty Ltd | Producing liquid hydrocarbon streams by hydrogenation of fossil-based feedstock |
| US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
| US4304767A (en) | 1980-05-15 | 1981-12-08 | Sri International | Polymers of di- (and higher functionality) ketene acetals and polyols |
| US4322323A (en) | 1980-12-01 | 1982-03-30 | Alza Corporation | Erodible device comprising surfactant for modifying the rate of erosion of the device |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| LU83485A1 (fr) * | 1981-07-09 | 1983-02-04 | Metallurgie Hoboken | Procede et installation pour couler une bande a oreilles en saillie laterale |
| US4443340A (en) * | 1981-10-09 | 1984-04-17 | Betz Laboratories, Inc. | Control of iron induced fouling in water systems |
| US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| DE3716302C2 (de) | 1987-05-15 | 1996-02-01 | Henkel Kgaa | Verbesserte resorbierbare Knochenwachse und ihre Verwendung |
| US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| JPS59210024A (ja) | 1983-05-13 | 1984-11-28 | Taiyo Kagaku Kk | トコフエロ−ル乳化物 |
| US4725442A (en) | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4568559A (en) | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| US4623588A (en) | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
| US4708861A (en) | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
| US6217911B1 (en) * | 1995-05-22 | 2001-04-17 | The United States Of America As Represented By The Secretary Of The Army | sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres |
| US4891225A (en) | 1984-05-21 | 1990-01-02 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| GB8416234D0 (en) | 1984-06-26 | 1984-08-01 | Ici Plc | Biodegradable amphipathic copolymers |
| US4549010A (en) | 1984-06-27 | 1985-10-22 | Merck & Co., Inc. | Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal |
| US4985404A (en) * | 1984-10-04 | 1991-01-15 | Monsanto Company | Prolonged release of biologically active polypeptides |
| US4725852A (en) | 1985-05-09 | 1988-02-16 | Burlington Industries, Inc. | Random artificially perturbed liquid apparatus and method |
| JPS62419A (ja) | 1985-06-26 | 1987-01-06 | Shiseido Co Ltd | 脂溶性ビタミン含有水溶性剤 |
| US4780319A (en) | 1985-07-08 | 1988-10-25 | Merck & Co., Inc. | Organic acids as catalysts for the erosion of polymers |
| US4931279A (en) * | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
| US4668506A (en) * | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
| US4713244A (en) | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
| US4865845A (en) * | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4780320A (en) | 1986-04-29 | 1988-10-25 | Pharmetrix Corp. | Controlled release drug delivery system for the periodontal pocket |
| ATE107857T1 (de) | 1986-06-10 | 1994-07-15 | Euro Celtique Sa | Zusammensetzung mit kontrollierter freisetzung von dihydrocodein. |
| US4861598A (en) | 1986-07-18 | 1989-08-29 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| US4970075A (en) | 1986-07-18 | 1990-11-13 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| GB8626098D0 (en) | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
| US4853218A (en) * | 1987-02-24 | 1989-08-01 | Schering Corporation | Zinc-protamine-alpha interferon complex |
| US5391381A (en) | 1987-06-25 | 1995-02-21 | Alza Corporation | Dispenser capable of delivering plurality of drug units |
| US4795641A (en) | 1987-08-20 | 1989-01-03 | Eastman Kodak Company | Polymer blends having reverse phase morphology for controlled delivery of bioactive agents |
| US4866050A (en) * | 1988-04-27 | 1989-09-12 | Ben Amoz Daniel | Ultrasonic transdermal application of steroid compositions |
| US5350741A (en) | 1988-07-30 | 1994-09-27 | Kanji Takada | Enteric formulations of physiologically active peptides and proteins |
| US4957998A (en) | 1988-08-22 | 1990-09-18 | Pharmaceutical Delivery Systems, Inc. | Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages |
| US5181914A (en) * | 1988-08-22 | 1993-01-26 | Zook Gerald P | Medicating device for nails and adjacent tissue |
| JPH0296516A (ja) | 1988-09-29 | 1990-04-09 | Dainippon Pharmaceut Co Ltd | 粒剤およびその製造方法 |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5632727A (en) * | 1988-10-03 | 1997-05-27 | Atrix Laboratories, Inc. | Biodegradable film dressing and method for its formation |
| US5725491A (en) | 1988-10-03 | 1998-03-10 | Atrix Laboratories, Inc. | Method of forming a biodegradable film dressing on tissue |
| US4987893A (en) | 1988-10-12 | 1991-01-29 | Rochal Industries, Inc. | Conformable bandage and coating material |
| US5085866A (en) * | 1988-12-02 | 1992-02-04 | Southern Research Institute | Method of producing zero-order controlled-released devices |
| US5059423A (en) | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
| US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
| US5324520A (en) | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
| US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US4946931A (en) | 1989-06-14 | 1990-08-07 | Pharmaceutical Delivery Systems, Inc. | Polymers containing carboxy-ortho ester and ortho ester linkages |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| US5112614A (en) * | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
| GB8926612D0 (en) | 1989-11-24 | 1990-01-17 | Erba Farmitalia | Pharmaceutical compositions |
| US5300295A (en) * | 1990-05-01 | 1994-04-05 | Mediventures, Inc. | Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH |
| IT1240643B (it) | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
| US5110685A (en) | 1990-05-18 | 1992-05-05 | Exxon Chemical Patents, Inc. | Low friction, abrasion resistant polymer coating |
| US5252318A (en) * | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| US5234693A (en) * | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5234692A (en) * | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| NZ239370A (en) | 1990-08-22 | 1994-04-27 | Merck & Co Inc | Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone |
| US5149543A (en) | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| US5620700A (en) * | 1990-10-30 | 1997-04-15 | Alza Corporation | Injectable drug delivery system and method |
| ZA918526B (en) | 1990-10-30 | 1992-08-26 | Alza Corp | Drug delivery system and method |
| US6117425A (en) | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| GB9027422D0 (en) * | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| IE920040A1 (en) | 1991-01-09 | 1992-07-15 | Alza Corp | Bioerodible devices and compositions for diffusional release¹of agents |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| ES2176189T3 (es) * | 1991-02-01 | 2002-12-01 | Massachusetts Inst Technology | Mezlas de polimeros biodegradables para uso medicamentosos. |
| JPH05508266A (ja) | 1991-04-03 | 1993-11-18 | イーストマン・コダック・カンパニー | ＧａＡｓをドライエッチングするための高耐久性マスク |
| US5137727A (en) * | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| US5211951A (en) | 1991-07-24 | 1993-05-18 | Merck & Co., Inc. | Process for the manufacture of bioerodible poly (orthoester)s and polyacetals |
| JP3313124B2 (ja) | 1991-07-31 | 2002-08-12 | 森下仁丹株式会社 | 親水性物質を内容物とするシームレスカプセルおよびその製法 |
| EP0601053B1 (en) | 1991-08-26 | 2000-10-25 | Abbott Laboratories | Compositions and methods for the sublingual or buccal administration of therapeutic agents |
| US5487898A (en) | 1991-08-26 | 1996-01-30 | Abbott Laboratories | Compositions and method for the sublingual or buccal administration therapeutic agents |
| US5288214A (en) * | 1991-09-30 | 1994-02-22 | Toshio Fukuda | Micropump |
| YU87892A (sh) | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
| IL103275A0 (en) | 1991-10-01 | 1993-02-21 | Lilly Co Eli | Injectable extended release formulations and methods |
| AU2605592A (en) | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5545408A (en) | 1991-10-21 | 1996-08-13 | Peptide Technology Limited | Biocompatible implant for the timing of ovulation in mares |
| US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| DK0542364T3 (da) * | 1991-11-13 | 1996-03-11 | Glaxo Canada | Anordning til reguleret frigivelse |
| US5266331A (en) | 1991-11-27 | 1993-11-30 | Euroceltique, S.A. | Controlled release oxycodone compositions |
| US5656295A (en) | 1991-11-27 | 1997-08-12 | Euro-Celtique, S.A. | Controlled release oxycodone compositions |
| AU3125193A (en) | 1991-12-05 | 1993-06-28 | Pitman-Moore, Inc. | A carbohydrate glass matrix for the sustained release of a therapeutic agent |
| CA2125483A1 (en) | 1991-12-11 | 1993-06-24 | Mary Ann Hunter | Cetylpyridinium chloride and domiphen bromide in organic solvent |
| FI933471L (fi) * | 1991-12-19 | 1993-08-05 | Mitsui Toatsu Chemicals | Polyhydroxikarboxylsyra och foerfarande foer dess framstaellning |
| US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5308348A (en) * | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5209746A (en) * | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5656297A (en) * | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| EP0560014A1 (en) | 1992-03-12 | 1993-09-15 | Atrix Laboratories, Inc. | Biodegradable film dressing and method for its formation |
| AU3941493A (en) * | 1992-03-30 | 1993-11-08 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
| ZA932273B (en) | 1992-03-30 | 1993-11-26 | Alza Corp | Additives for bioerodible polymers to regulate degradation |
| GB9211268D0 (en) | 1992-05-28 | 1992-07-15 | Ici Plc | Salts of basic peptides with carboxyterminated polyesters |
| DK0659073T3 (da) | 1992-09-10 | 2002-03-11 | Childrens Medical Center | Bionedbrydelige polymermatrixer med vedvarerende afgivelse af lokalanæstetika |
| US5922340A (en) * | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| US5700485A (en) * | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| DK0661045T3 (da) * | 1992-09-18 | 2002-10-28 | Yamanouchi Pharma Co Ltd | Hydrogelpræparat med forsinket frigivelse |
| US5242910A (en) | 1992-10-13 | 1993-09-07 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
| AU670168B2 (en) * | 1992-12-02 | 1996-07-04 | Alkermes Controlled Therapeutics, Inc. | Controlled release growth hormone containing microspheres |
| MY113268A (en) | 1992-12-29 | 2002-01-31 | Insite Vision Incorporated | Plasticized bioerodible controlled delivery system |
| JPH08505138A (ja) | 1992-12-29 | 1996-06-04 | インサイト・ビジョン・インコーポレイテッド | 生体内崩壊性徐放性薬剤供給系 |
| RU2146128C1 (ru) | 1993-01-06 | 2000-03-10 | Кинертон Лимитед | Ионный конъюгат с длительным периодом высвобождения пептида, способ синтезирования ионного конъюгата, способ синтезирования микрочастиц |
| US5340572A (en) | 1993-02-08 | 1994-08-23 | Insite Vision Incorporated | Alkaline ophthalmic suspensions |
| US5340614A (en) * | 1993-02-11 | 1994-08-23 | Minnesota Mining And Manufacturing Company | Methods of polymer impregnation |
| JP3987963B2 (ja) | 1993-03-17 | 2007-10-10 | スリーエム カンパニー | エステルー，アミド−又はメルカプトエステル−誘導分散促進剤を含むエーロゾル配合物 |
| JPH08507792A (ja) | 1993-03-17 | 1996-08-20 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | ジオール−二酸から誘導される分散助剤を含むエーロゾル配合物 |
| DK44193D0 (da) | 1993-04-20 | 1993-04-20 | Euromed I S | Saarforbinding og klaebemiddel til en saarforbinding eller lignende |
| US5330452A (en) * | 1993-06-01 | 1994-07-19 | Zook Gerald P | Topical medicating device |
| US5447725A (en) | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
| IL110014A (en) | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| JP3189175B2 (ja) | 1993-07-02 | 2001-07-16 | 出光興産株式会社 | 芳香族ビニル化合物共重合体の製造方法 |
| US5415866A (en) * | 1993-07-12 | 1995-05-16 | Zook; Gerald P. | Topical drug delivery system |
| JP3257750B2 (ja) | 1993-07-20 | 2002-02-18 | エチコン・インコーポレーテツド | ε−カプロラクトンおよびラクチドの液状コポリマー |
| US5879705A (en) | 1993-07-27 | 1999-03-09 | Euro-Celtique S.A. | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
| JPH0753356A (ja) | 1993-08-16 | 1995-02-28 | Morishita Jintan Kk | 酸化され易い油性物質を内容物とするシームレスカプセルおよびその製造方法 |
| JPH07112940A (ja) | 1993-08-26 | 1995-05-02 | Takeda Chem Ind Ltd | 徐放性非経口投与製剤およびその製造方法 |
| US5578137A (en) | 1993-08-31 | 1996-11-26 | E. I. Du Pont De Nemours And Company | Azeotropic or azeotrope-like compositions including 1,1,1,2,3,4,4,5,5,5-decafluoropentane |
| AU5895994A (en) | 1993-10-04 | 1995-05-01 | Mark Chasin | Controlled release microspheres |
| GB9321061D0 (en) | 1993-10-13 | 1993-12-01 | Chiroscience Ltd | Analgestic agent and its use |
| DK0723445T3 (da) * | 1993-10-13 | 1997-10-06 | Chiroscience Ltd | Analgetisk middel samt anvendelse deraf |
| US5849763A (en) | 1993-10-13 | 1998-12-15 | Darwin Discovery Limited | Use of levobupivacaine as an anesthetic agent |
| US5681873A (en) | 1993-10-14 | 1997-10-28 | Atrix Laboratories, Inc. | Biodegradable polymeric composition |
| JPH07115901A (ja) | 1993-10-28 | 1995-05-09 | Fuji Bibaretsuji:Kk | ドコサヘキサエン酸高含有乳化組成物及び飲料 |
| BR9408072A (pt) | 1993-11-16 | 1997-08-12 | Depotech Corp | Vesículas com liberação controlada de ativos |
| DE69429820T3 (de) | 1993-11-19 | 2013-02-28 | Alkermes Controlled Therapeutics, Inc. | Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel |
| WO1995017901A1 (en) | 1993-12-29 | 1995-07-06 | Matrix Pharmaceutical, Inc. | Methods and compositions for the treatment of a host with a cellular proliferative disease |
| US5760077A (en) * | 1994-01-14 | 1998-06-02 | Shahinian, Jr.; Lee | Topical ophthalmic analgesic preparations for sustained and extended corneal analgesia |
| JPH09510961A (ja) * | 1994-01-14 | 1997-11-04 | ジュニア シャヒニアン，リー | 持続性および長期間の角膜鎮痛の方法 |
| RU2056843C1 (ru) * | 1994-02-22 | 1996-03-27 | Лопырев Валентин Александрович | Анестезирующее и гемостатическое средство и способ его получения |
| US5556905A (en) | 1994-03-30 | 1996-09-17 | Reilly Industries, Inc. | Physically-modified degradable thermoplastic compositions |
| EP0754064B1 (en) | 1994-04-08 | 2003-05-28 | Atrix Laboratories, Inc. | An adjunctive polymer system for use with medical device |
| WO1995027481A1 (en) * | 1994-04-08 | 1995-10-19 | Atrix Laboratories, Inc. | Liquid delivery compositions |
| US5633000A (en) | 1994-06-23 | 1997-05-27 | Axxia Technologies | Subcutaneous implant |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5599534A (en) * | 1994-08-09 | 1997-02-04 | University Of Nebraska | Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use |
| US5786484A (en) | 1994-09-23 | 1998-07-28 | Chiroscience Limited | Racemization and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
| US5599852A (en) | 1994-10-18 | 1997-02-04 | Ethicon, Inc. | Injectable microdispersions for soft tissue repair and augmentation |
| DE69531624T2 (de) | 1994-10-25 | 2004-06-17 | Darwin Discovery Ltd., Slough | Verfahren zur herstellung von levobupivacaine und analoge |
| CA2200355C (en) | 1994-10-25 | 2007-03-06 | Marianne Langston | Crystallisation of levobupivacaine and analogues thereof |
| US5660817A (en) * | 1994-11-09 | 1997-08-26 | Gillette Canada, Inc. | Desensitizing teeth with degradable particles |
| US5607686A (en) | 1994-11-22 | 1997-03-04 | United States Surgical Corporation | Polymeric composition |
| US6333021B1 (en) * | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| AU4652596A (en) | 1995-01-09 | 1996-07-31 | Atrix Laboratories, Inc. | Liquid polymer delivery system |
| US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
| GB9501071D0 (en) | 1995-01-18 | 1995-03-08 | Chiroscience Ltd | Racemisation |
| US5614206A (en) * | 1995-03-07 | 1997-03-25 | Wright Medical Technology, Inc. | Controlled dissolution pellet containing calcium sulfate |
| US5492253A (en) * | 1995-03-24 | 1996-02-20 | Proshan; Mary-Elizabeth | Cap attachment for small neck plastic bottle of liquid |
| US5972326A (en) | 1995-04-18 | 1999-10-26 | Galin; Miles A. | Controlled release of pharmaceuticals in the anterior chamber of the eye |
| US6322548B1 (en) | 1995-05-10 | 2001-11-27 | Eclipse Surgical Technologies | Delivery catheter system for heart chamber |
| US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US5968542A (en) | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| ATE287673T1 (de) | 1995-06-07 | 2005-02-15 | Southern Biosystems Inc | Kontrolliertes zuführsystem mit einer flüssigkeit von hoher viskosität |
| DE69632569T2 (de) | 1995-06-09 | 2005-08-18 | Euroceltique S.A. | Formulierungen und verfahren für eine verlängerte lokalanästhesie |
| US5897880A (en) | 1995-09-29 | 1999-04-27 | Lam Pharmaceuticals, Llc. | Topical drug preparations |
| US5942253A (en) | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| US5787175A (en) * | 1995-10-23 | 1998-07-28 | Novell, Inc. | Method and apparatus for collaborative document control |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US5968543A (en) | 1996-01-05 | 1999-10-19 | Advanced Polymer Systems, Inc. | Polymers with controlled physical state and bioerodibility |
| CN100493647C (zh) | 1996-02-02 | 2009-06-03 | 精达制药公司 | 利用可植入系统持续释放活性物质 |
| US6245351B1 (en) | 1996-03-07 | 2001-06-12 | Takeda Chemical Industries, Ltd. | Controlled-release composition |
| IT1283252B1 (it) | 1996-03-15 | 1998-04-16 | Pulitzer Italiana | Soluzioni di piroxicam iniettabili per via parenterale |
| US5747060A (en) * | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
| JP3263399B2 (ja) * | 1996-05-23 | 2002-03-04 | サムヤン コーポレーション | 局所投与型生分解性徐放型歯周炎用薬剤組成物及びその製造方法 |
| JPH11511763A (ja) | 1996-06-24 | 1999-10-12 | ユーロ―セルティーク，エス．エイ． | 安全な局所麻酔の提供方法 |
| CA2180601C (en) * | 1996-07-05 | 2007-12-18 | Chun Keung Mak | Heated nozzle manifolds in a common plane interconnected through connector manifolds |
| EP1024833A1 (en) * | 1996-07-11 | 2000-08-09 | Farmarc Nederland B.V. | Pharmaceutical composition containing acid addition salt of basic drug |
| US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| US6106301A (en) * | 1996-09-04 | 2000-08-22 | Ht Medical Systems, Inc. | Interventional radiology interface apparatus and method |
| US6046187A (en) * | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| US5747051A (en) | 1996-09-27 | 1998-05-05 | Elizabeth Arden Co., Division Of Conopco, Inc. | Skin care compositions containing an amide of a hydroxy fatty acid and a retinoid |
| US5766637A (en) * | 1996-10-08 | 1998-06-16 | University Of Delaware | Microencapsulation process using supercritical fluids |
| US6572880B2 (en) | 1996-10-24 | 2003-06-03 | Pharmaceutical Applications Associates Llc | Methods and transdermal compositions for pain relief |
| US6479074B2 (en) | 1996-10-24 | 2002-11-12 | Pharmaceutical Applications Associates Llc | Methods and transdermal compositions for pain relief |
| EP0949905B1 (en) | 1996-12-20 | 2001-07-18 | Alza Corporation | Injectable depot gel composition and method of preparing the composition |
| US6203813B1 (en) | 1997-01-13 | 2001-03-20 | Lance L. Gooberman | Pharmaceutical delivery device and method of preparation therefor |
| US5993856A (en) | 1997-01-24 | 1999-11-30 | Femmepharma | Pharmaceutical preparations and methods for their administration |
| US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| GB9704351D0 (en) * | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| DE19714765A1 (de) | 1997-04-10 | 1998-10-15 | Merck Patent Gmbh | Verwendung von niedermolekularen, oligomeren Estern von alpha-Hydroxysäuren und/oder aromatischen o-Hydroxysäuren in kosmetischen Formulierungen |
| US5919473A (en) | 1997-05-12 | 1999-07-06 | Elkhoury; George F. | Methods and devices for delivering opioid analgesics to wounds via a subdermal implant |
| US20020039594A1 (en) * | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| US5840329A (en) | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| US6051558A (en) | 1997-05-28 | 2000-04-18 | Southern Biosystems, Inc. | Compositions suitable for controlled release of the hormone GnRH and its analogs |
| US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| US6004295A (en) | 1997-06-26 | 1999-12-21 | An-Go-Gen Inc. | Catheters |
| US6248345B1 (en) * | 1997-07-02 | 2001-06-19 | Euro-Celtique, S.A. | Prolonged anesthesia in joints and body spaces |
| US20010004644A1 (en) * | 1997-07-21 | 2001-06-21 | Levin Bruce H. | Compositions, kits, apparatus, and methods for inhibiting cephalic inflammation |
| US6432986B2 (en) | 1997-07-21 | 2002-08-13 | Bruce H. Levin | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches |
| ATE239474T1 (de) * | 1997-07-22 | 2003-05-15 | Darwin Discovery Ltd | Verwendung von levobupivacain |
| EP0999825B1 (en) | 1997-07-29 | 2003-10-01 | Alcon Laboratories, Inc. | Ophthalmic compositions containing galactomannan polymers and borate |
| US6306166B1 (en) * | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| EP1014946B1 (en) | 1997-09-18 | 2010-04-07 | Pacira Pharmaceuticals, Inc. | Sustained-release liposomal anesthetic compositions |
| US6183444B1 (en) | 1998-05-16 | 2001-02-06 | Microheart, Inc. | Drug delivery module |
| US6193991B1 (en) * | 1997-10-29 | 2001-02-27 | Atul J. Shukla | Biodegradable delivery systems of biologically active substances |
| ES2384094T3 (es) | 1997-11-14 | 2012-06-29 | Pacira Pharmaceuticals, Inc. | Producción de liposomas multivesiculares |
| AU740914B2 (en) | 1997-11-19 | 2001-11-15 | Darwin Discovery Limited | Anaesthetic formulation |
| AU737661B2 (en) | 1997-11-27 | 2001-08-23 | Nihon Seikan Kabushiki Kaisha | Metallic can and method of manufacture of same, and can cover with integral scraper |
| US6050986A (en) * | 1997-12-01 | 2000-04-18 | Scimed Life Systems, Inc. | Catheter system for the delivery of a low volume liquid bolus |
| IT1298574B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione |
| CA2324265C (en) | 1998-03-19 | 2008-08-05 | Merck & Co., Inc. | Liquid polymeric compositions for controlled release of bioactive substances |
| AU3212199A (en) * | 1998-03-31 | 1999-10-18 | Scimed Life Systems, Inc. | Temperature controlled solute delivery system |
| US6261547B1 (en) * | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
| US7128927B1 (en) | 1998-04-14 | 2006-10-31 | Qlt Usa, Inc. | Emulsions for in-situ delivery systems |
| US6103266A (en) * | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
| GB9808720D0 (en) | 1998-04-23 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
| US5939453A (en) | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
| MXPA00012767A (es) | 1998-06-29 | 2002-08-09 | Pharmaceuticals Applic Asociat | Metodos y composiciones transdermicas para el alivio del dolor. |
| US6312717B1 (en) | 1998-07-07 | 2001-11-06 | Bristol-Myers Squibb Company | Method for treatment of anxiety and depression |
| US6261583B1 (en) | 1998-07-28 | 2001-07-17 | Atrix Laboratories, Inc. | Moldable solid delivery system |
| US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| US7662409B2 (en) * | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US6955819B2 (en) | 1998-09-29 | 2005-10-18 | Zars, Inc. | Methods and apparatus for using controlled heat to regulate transdermal and controlled release delivery of fentanyl, other analgesics, and other medical substances |
| US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| US6102235A (en) | 1998-12-18 | 2000-08-15 | Stern; Max M. | Lid with integral paint roller tray |
| DE19858891A1 (de) | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Verbesserte Knochensiegel |
| US6451346B1 (en) | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
| US6498153B1 (en) | 1998-12-31 | 2002-12-24 | Akzo Nobel N.V. | Extended release growth promoting two component composition |
| US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
| AU779277B2 (en) | 1999-06-04 | 2005-01-13 | Alza Corporation | Implantable gel compositions and method of manufacture |
| AU5025300A (en) | 1999-06-18 | 2001-01-09 | Southern Biosystems, Inc. | Compositions for controlled release of the hormone gnrh and its analogs |
| DE19932157A1 (de) | 1999-07-13 | 2001-01-18 | Pharmasol Gmbh | Verfahren zur schonenden Herstellung von hochfeinen Mikropartikeln und Nanopartikeln |
| US6423818B1 (en) * | 1999-07-30 | 2002-07-23 | Takehisa Matsuda | Coumarin endcapped absorbable polymers |
| US6352667B1 (en) * | 1999-08-24 | 2002-03-05 | Absorbable Polymer Technologies, Inc. | Method of making biodegradable polymeric implants |
| US6528086B2 (en) * | 1999-09-28 | 2003-03-04 | Zars, Inc. | Methods and apparatus for drug delivery involving phase changing formulations |
| US6432415B1 (en) * | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
| US6566345B2 (en) * | 2000-04-28 | 2003-05-20 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
| US6899731B2 (en) * | 1999-12-30 | 2005-05-31 | Boston Scientific Scimed, Inc. | Controlled delivery of therapeutic agents by insertable medical devices |
| DE10190041D2 (de) | 2000-01-11 | 2002-12-05 | Roland Bodmeier | Implantate, Partikel |
| FR2804066B1 (fr) | 2000-01-25 | 2002-05-31 | Franpin | Bac a peinture a moyens de maintien de rouleau |
| US6447604B1 (en) | 2000-03-13 | 2002-09-10 | Advanced Technology Materials, Inc. | Method for achieving improved epitaxy quality (surface texture and defect density) on free-standing (aluminum, indium, gallium) nitride ((al,in,ga)n) substrates for opto-electronic and electronic devices |
| RU2177314C2 (ru) * | 2000-03-22 | 2001-12-27 | Кривошеин Юрий Семенович | Состав с антисептическими, репаративными и болеутоляющими свойствами |
| BR0002246A (pt) | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
| IL152360A0 (en) | 2000-04-19 | 2003-05-29 | Genentech Inc | Sustained release formulations |
| WO2001082863A2 (en) * | 2000-04-28 | 2001-11-08 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
| US6613355B2 (en) * | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| DK1280558T3 (da) | 2000-05-11 | 2005-12-27 | Ap Pharma Inc | Halvfast indgivelsesvehikel og farmaceutiske sammensætninger |
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| EP1299048A4 (en) | 2000-06-28 | 2005-09-28 | Atul J Shukla | BIODEGRADABLE VEHICLES AND SYSTEMS FOR DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES |
| US6545011B2 (en) | 2000-07-13 | 2003-04-08 | Guilford Pharmaceuticals Inc. | Substituted 4,9-dihydrocyclopenta[imn]phenanthridine-5-ones, derivatives thereof and their uses |
| US20020045668A1 (en) * | 2000-07-17 | 2002-04-18 | Wenbin Dang | Compositions for sustained release of analgesic agents, and methods of making and using the same |
| WO2002010436A2 (en) | 2000-07-28 | 2002-02-07 | The Brigham And Women's Hospital, Inc. | Prognostic classification of breast cancer |
| US6362308B1 (en) * | 2000-08-10 | 2002-03-26 | Alkermes Controlled Therapeutics Inc. Ii | Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content |
| US6543081B1 (en) * | 2000-08-15 | 2003-04-08 | Sheldon C. Cohen | Flip-up wringer sponge mop |
| DE10044545A1 (de) | 2000-09-05 | 2002-04-04 | Roland Bodmeier | Retardpartikeldispersion |
| FR2814308B1 (fr) | 2000-09-15 | 2003-03-14 | France Telecom | Procede de gestion de l'usage d'une ligne de telecommunication et systeme de mise en oeuvre |
| US6823084B2 (en) * | 2000-09-22 | 2004-11-23 | Sri International | Method and apparatus for portably recognizing text in an image sequence of scene imagery |
| CN100518827C (zh) | 2000-10-30 | 2009-07-29 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
| WO2002038185A2 (en) | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
| US20020141966A1 (en) | 2000-11-16 | 2002-10-03 | Wenbin Dang | Compositions for treatment of malignant effusions, and methods of making and using the same |
| KR100446101B1 (ko) | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
| US20030152637A1 (en) | 2001-01-25 | 2003-08-14 | Mark Chasin | Local anesthetic, and method of use |
| US6375659B1 (en) * | 2001-02-20 | 2002-04-23 | Vita Licensing, Inc. | Method for delivery of biocompatible material |
| JP4724354B2 (ja) | 2001-02-23 | 2011-07-13 | ジェネンテック， インコーポレイテッド | 注射用の崩壊性ポリマー |
| US20040018238A1 (en) | 2001-02-26 | 2004-01-29 | Shukla Atul J | Biodegradable vehicles and delivery systems of biolgically active substances |
| US20020148846A1 (en) | 2001-04-12 | 2002-10-17 | Ropak Corporation | Container lid having gasketless liquid seal |
| US20020176844A1 (en) | 2001-05-11 | 2002-11-28 | Ng Steven Y. | Bioerodible polyorthoesters containing hydrogen bonding groups |
| US6590059B2 (en) | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
| US20030152630A1 (en) | 2001-05-11 | 2003-08-14 | Ng Steven Y. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
| IL159048A0 (en) | 2001-06-21 | 2004-05-12 | Genentech Inc | Sustained release formulation |
| WO2003041685A1 (en) * | 2001-11-14 | 2003-05-22 | Alza Corporation | Injectable depot composition |
| MXPA04004665A (es) | 2001-11-14 | 2004-09-10 | Alza Corp | Composiciones de deposito inyectable y uso de los mismos. |
| NZ533435A (en) | 2001-11-14 | 2007-10-26 | Alza Corp | Injectable depot compositions and uses thereof |
| US6524606B1 (en) | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| US6833139B1 (en) | 2002-01-09 | 2004-12-21 | Ferndale Laboratories, Inc. | Composition and method for the treatment of anorectal disorders |
| US7074426B2 (en) | 2002-03-27 | 2006-07-11 | Frank Kochinke | Methods and drug delivery systems for the treatment of orofacial diseases |
| FR2838349B1 (fr) | 2002-04-15 | 2004-06-25 | Laurence Paris | Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication |
| US7736665B2 (en) | 2002-05-31 | 2010-06-15 | Titan Pharmaceuticals, Inc. | Implantable polymeric device for sustained release of buprenorphine |
| TWI353854B (en) | 2002-06-25 | 2011-12-11 | Alza Corp | Short duration depot formulations |
| US20040109893A1 (en) | 2002-06-25 | 2004-06-10 | Guohua Chen | Sustained release dosage forms of anesthetics for pain management |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| JP4417039B2 (ja) | 2002-06-28 | 2010-02-17 | 太陽化学株式会社 | 水中油滴型乳化組成物 |
| JP4712380B2 (ja) | 2002-07-26 | 2011-06-29 | 三笠製薬株式会社 | 外用剤 |
| NZ537955A (en) | 2002-07-31 | 2007-10-26 | Alza Corp | Injectable depot compositions and uses thereof |
| AU2003256849A1 (en) | 2002-07-31 | 2004-02-16 | Alza Corporation | Injectable multimodal polymer depot compositions and uses thereof |
| US7070582B2 (en) | 2002-08-09 | 2006-07-04 | Boston Scientific Scimed, Inc. | Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents |
| CN1849110A (zh) | 2002-10-25 | 2006-10-18 | 辉瑞产品公司 | 新型储库型注射剂 |
| JP2006505579A (ja) | 2002-10-25 | 2006-02-16 | ファイザー・プロダクツ・インク | 懸濁形態でのアリール複素環活性薬物の蓄積製剤 |
| AU2003286796A1 (en) | 2002-10-31 | 2004-06-07 | Umd, Inc. | Therapeutic compositions for drug delivery to and through covering epithelia |
| WO2004043432A2 (en) | 2002-11-06 | 2004-05-27 | Alza Corporation | Controlled release depot formulations |
| US6863782B2 (en) | 2002-11-15 | 2005-03-08 | A.P. Pharma, Inc. | Method of preparing di(ketene acetals) |
| US7045589B2 (en) | 2002-11-15 | 2006-05-16 | A.P. Pharma, Inc. | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
| US7491234B2 (en) | 2002-12-03 | 2009-02-17 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agents |
| CN101797221B (zh) | 2002-12-13 | 2013-06-12 | 杜雷科特公司 | 包含高粘度液体载体材料的口服递药系统 |
| US20040224903A1 (en) | 2002-12-19 | 2004-11-11 | Stephen Berry | Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device |
| DK2526996T3 (da) | 2002-12-20 | 2019-12-02 | Xeris Pharmaceuticals Inc | Formulering til intrakutan injektion |
| AU2004219595A1 (en) | 2003-03-11 | 2004-09-23 | Qlt Usa Inc. | Formulations for cell- schedule dependent anticancer agents |
| DE10312346A1 (de) | 2003-03-20 | 2004-09-30 | Bayer Healthcare Ag | Kontrolliertes Freisetzungssystem |
| DE10322469A1 (de) | 2003-05-19 | 2004-12-16 | Bayer Healthcare Ag | Heterocyclische Verbindungen |
| KR20060023140A (ko) | 2003-05-30 | 2006-03-13 | 알자 코포레이션 | 이식성 탄성중합체 데포 조성물, 이의 용도 및 이의제조방법 |
| US20050171052A1 (en) | 2003-11-14 | 2005-08-04 | Cook Phillip M. | Sucrose acetate isobutyrate formulation |
| US20050106304A1 (en) | 2003-11-14 | 2005-05-19 | Cook Phillip M. | Sucrose acetate isobutyrate formulation |
| US20050232876A1 (en) | 2004-04-19 | 2005-10-20 | Robin Lynn Minga | Skin care compositions |
| US20080023261A1 (en) | 2004-05-14 | 2008-01-31 | Yanmar Co., Ltd. | Noise Proof Structure of Cabin |
| US20050266087A1 (en) | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| US7269958B2 (en) | 2004-09-10 | 2007-09-18 | Pratt & Whitney Canada Corp. | Combustor exit duct |
| AU2005287175B2 (en) | 2004-09-17 | 2011-12-01 | Durect Corporation | Sustained local anesthetic composition containing preferably a sugar ester such as SAIB |
| WO2006084139A2 (en) | 2005-02-03 | 2006-08-10 | Intarcia Therapeutics, Inc. | An implantable interferon-containing device |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| JP5194273B2 (ja) | 2007-09-20 | 2013-05-08 | 三菱電機株式会社 | 半導体装置 |
| SE531980C2 (sv) | 2008-01-17 | 2009-09-22 | Avtech Sweden Ab | Flygstyrningsförfarande samt datorprogram och datorprogramprodukt för att genomföra förfarandet |
| US8980317B2 (en) | 2008-12-23 | 2015-03-17 | Warsaw Orthopedic, Inc. | Methods and compositions for treating infections comprising a local anesthetic |
-
2003
- 2003-06-25 US US10/606,969 patent/US20040001889A1/en not_active Abandoned
- 2003-10-31 RU RU2006101985/15A patent/RU2332985C2/ru not_active IP Right Cessation
- 2003-10-31 AU AU2003286826A patent/AU2003286826A1/en not_active Abandoned
- 2003-10-31 EP EP03778041A patent/EP1638519A2/en not_active Withdrawn
- 2003-10-31 CA CA002530357A patent/CA2530357A1/en not_active Abandoned
- 2003-10-31 EP EP09001701A patent/EP2067468A1/en not_active Withdrawn
- 2003-10-31 JP JP2005504650A patent/JP2007521225A/ja active Pending
- 2003-10-31 MX MXPA05014193A patent/MXPA05014193A/es unknown
- 2003-10-31 PL PL379263A patent/PL379263A1/pl not_active Application Discontinuation
- 2003-10-31 CN CNA2003801103931A patent/CN1822814A/zh active Pending
- 2003-10-31 BR BRPI0318373-4A patent/BR0318373A/pt not_active IP Right Cessation
- 2003-10-31 WO PCT/US2003/034763 patent/WO2005009408A2/en not_active Ceased
- 2003-10-31 KR KR1020057024815A patent/KR20060109816A/ko not_active Ceased
- 2003-12-10 AR ARP030104542A patent/AR045975A1/es not_active Application Discontinuation
-
2005
- 2005-12-22 IL IL172781A patent/IL172781A0/en unknown
- 2005-12-23 MA MA28682A patent/MA27863A1/fr unknown
-
2006
- 2006-01-20 NO NO20060295A patent/NO20060295L/no not_active Application Discontinuation
- 2006-01-24 ZA ZA200600698A patent/ZA200600698B/xx unknown
- 2006-04-03 US US11/278,472 patent/US20060165800A1/en not_active Abandoned
-
2010
- 2010-09-27 US US12/924,441 patent/US8278330B2/en not_active Expired - Fee Related
-
2016
- 2016-09-15 US US15/267,070 patent/US10201496B2/en not_active Expired - Lifetime
-
2018
- 2018-12-28 US US16/235,889 patent/US10471001B2/en not_active Expired - Fee Related
-
2019
- 2019-03-08 US US16/297,509 patent/US10471002B2/en not_active Expired - Fee Related
- 2019-09-26 US US16/584,698 patent/US11179326B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2332985C2 (ru) | 2008-09-10 |
| US20200129425A1 (en) | 2020-04-30 |
| KR20060109816A (ko) | 2006-10-23 |
| PL379263A1 (pl) | 2006-08-07 |
| CN1822814A (zh) | 2006-08-23 |
| JP2007521225A (ja) | 2007-08-02 |
| BR0318373A (pt) | 2006-07-25 |
| ZA200600698B (en) | 2007-04-25 |
| US11179326B2 (en) | 2021-11-23 |
| US20110046181A1 (en) | 2011-02-24 |
| US10201496B2 (en) | 2019-02-12 |
| US10471001B2 (en) | 2019-11-12 |
| US20040001889A1 (en) | 2004-01-01 |
| MXPA05014193A (es) | 2006-02-24 |
| IL172781A0 (en) | 2006-06-11 |
| US10471002B2 (en) | 2019-11-12 |
| US20060165800A1 (en) | 2006-07-27 |
| EP2067468A1 (en) | 2009-06-10 |
| AR045975A1 (es) | 2005-11-23 |
| US20190269610A1 (en) | 2019-09-05 |
| MA27863A1 (fr) | 2006-04-03 |
| US8278330B2 (en) | 2012-10-02 |
| CA2530357A1 (en) | 2005-02-03 |
| EP1638519A2 (en) | 2006-03-29 |
| US20170087086A1 (en) | 2017-03-30 |
| WO2005009408A2 (en) | 2005-02-03 |
| WO2005009408A3 (en) | 2006-01-19 |
| AU2003286826A1 (en) | 2005-02-14 |
| NO20060295L (no) | 2006-03-03 |
| US20190183791A1 (en) | 2019-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2006101985A (ru) | Дозированные формы анестезирующих средств с с длительным высвобождением для обезболивания | |
| WO2005009408B1 (en) | Sustained release dosage forms of anesthetics for pain management | |
| RU2005117164A (ru) | Композиции пролонгированного действия с контролируемым высвобождением | |
| JP4686653B2 (ja) | 低い初期薬物噴出性を有する制御放出性液状デリバリー組成物 | |
| EP2394663B1 (en) | Compositions for injectable in-situ biodegradable implants | |
| US5736152A (en) | Non-polymeric sustained release delivery system | |
| KR101784330B1 (ko) | 항정신병약물 주사 가능한 데포 조성물 | |
| US20040109893A1 (en) | Sustained release dosage forms of anesthetics for pain management | |
| JP2006508127A5 (ru) | ||
| US20090181068A1 (en) | Low Viscosity Liquid Polymeric Delivery System | |
| CA2624088A1 (en) | Sustained release small molecule drug formulation | |
| CA2275525A1 (en) | Gel composition and methods | |
| NZ574443A (en) | Short duration depot formulations | |
| ES2370377T3 (es) | Sistema de administración de un líquido polimérico de baja viscosidad. | |
| OA16256A (en) | Antipsychotic injectable depot composition. | |
| HK1094649A (en) | Sustained release dosage forms of anesthetics for pain management |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20121101 |