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RU2005128551A - SUBSTITUTED N-ARILGETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR APPLICATION AS MEDICINES - Google Patents

SUBSTITUTED N-ARILGETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR APPLICATION AS MEDICINES Download PDF

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RU2005128551A
RU2005128551A RU2005128551/04A RU2005128551A RU2005128551A RU 2005128551 A RU2005128551 A RU 2005128551A RU 2005128551/04 A RU2005128551/04 A RU 2005128551/04A RU 2005128551 A RU2005128551 A RU 2005128551A RU 2005128551 A RU2005128551 A RU 2005128551A
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alkyl
independently
another
contain
nitrogen atom
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Лотар ШВИНК (DE)
Лотар ШВИНК
Зигфрид ШТЕНГЕЛИН (DE)
Зигфрид ШТЕНГЕЛИН
Маттиас ГОССЕЛЬ (DE)
Маттиас Госсель
Томас БЕМЕ (DE)
Томас Беме
Герхард ХЕССЛЕР (DE)
Герхард ХЕССЛЕР
Петра ШТАЛЬ (DE)
Петра Шталь
Дирк ГРЕТЦКЕ (DE)
Дирк Гретцке
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Санофи-Авентис Дойчланд Гмбх (De)
Санофи-Авентис Дойчланд Гмбх
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Claims (17)

1. Соединение формулы (I)1. The compound of formula (I)
Figure 00000001
Figure 00000001
 где R1, R2, независимо друг от друга, представляют собой H, (C1-C8)алкил, -(CR78R79)o-R12, (C1-C4)алкокси-(C1-C4)алкил, (C3-C8)алкенил, CO-(C1-C8)алкил, -CO-(CH2)o-R12, CO-арилокси-(C1-C4)алкил, COCH=CH(R13), COCC(R14), CO(C(R15)(R16))qN(R17)(R18), CO(C(R19)(R20))rCON(R21)(R22), CO(C(R23)(R24))sO(R25); или R1 и R2 образуют вместе с атомом азота, с которым они связаны, 4-10-членное моно-, би- или спироциклическое кольцо, которое, помимо атома азота, может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей кислород, азот и серу, где гетероциклическая кольцевая система может быть дополнительно замещена F, Cl, Br, CF3, (C1-C6)алкилом, O-(C1-C4)алкилом, (C1-C4)алкокси-(C1-C4)алкилом, гидрокси-(C1-C4)алкилом, (C0-C2)алкиленарилом, оксо, CO(R26), CON(R27)(R28), гидрокси, COO(R29), N(R30)CO(C1-C6)алкилом, N(R31)(R32) или SO2CH3;where R1, R2, independently of one another, are H, (C 1 -C 8 ) alkyl, - (CR78R79) o -R12, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, ( C 3 -C 8 ) alkenyl, CO- (C 1 -C 8 ) alkyl, -CO- (CH 2 ) o -R12, CO-aryloxy- (C 1 -C 4 ) alkyl, COCH = CH (R13), COCC (R14), CO (C (R15) (R16)) q N (R17) (R18), CO (C (R19) (R20)) r CON (R21) (R22), CO (C (R23) ( R24)) s O (R25); or R1 and R2 form, together with the nitrogen atom to which they are attached, a 4-10 membered mono-, bi- or spirocyclic ring, which, in addition to the nitrogen atom, may contain 0-2 additional heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, where the heterocyclic ring system may be further substituted with F, Cl, Br, CF 3 , (C 1 -C 6 ) alkyl, O- (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, (C 0 -C 2 ) alkylene aryl, oxo, CO (R26), CON (R27) (R28), hydroxy, COO (R29) , N (R30) CO (C 1 -C 6 ) alkyl, N (R31) (R32) or SO 2 CH 3 ; o имеет значение 0, 1, 2, 3, 4, 5, 6;o has the value 0, 1, 2, 3, 4, 5, 6; q, r, независимо друг от друга, имеют значение 1, 2, 3;q, r, independently of each other, have a value of 1, 2, 3; s имеет значение 0, 1, 2, 3, 4;s is 0, 1, 2, 3, 4; R13, R14, независимо друг от друга, представляют собой другое фенильное кольцо, которое может содержать 0-1 атом азота;R13, R14, independently of each other, represent another phenyl ring, which may contain 0-1 nitrogen atom; R15, R16, R17, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, независимо друг от друга, представляют собой H, (C1-C6)алкил;R15, R16, R17, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, independently of each other, are H, (C 1 -C 6 ) alkyl; R18 представляет собой H, (C1-C6)алкил, CO(R33); илиR18 represents H, (C 1 -C 6 ) alkyl, CO (R33); or R17 и R18, R21 и R22, R27 и R28, R31 и R32, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу;R17 and R18, R21 and R22, R27 and R28, R31 and R32, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0 -1 additional heteroatom selected from the group consisting of N- (C 1 -C 6) -alkyl, oxygen and sulfur; R33 представляет собой 5-10-членную ароматическую кольцевую систему, которая может содержать дополнительный гетероатом, выбранный из группы, включающей азот, кислород и серу, и может быть замещена F, Cl, (C1-C6)алкилом, O-(C1-C8)алкилом;R33 is a 5-10 membered aromatic ring system that may contain an additional heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, and may be substituted with F, Cl, (C 1 -C 6 ) alkyl, O- (C 1 -C 8 ) alkyl; R12 представляет собой OH, O-(C1-C6)алкил, O(C0-C8)алкиленарил, CN, S-(C1-C6)алкил, COO(R80), CON(R81)(R82), 3-12-членное моно-, би- или спироциклическое кольцо, которое может содержать один или несколько гетероатомов, выбранных из группы, включающей N, O и S, и указанное 3-12-членное кольцо может содержать дополнительные заместители, такие как F, Cl, Br, OH, CF3, CN, оксо, O-(C1-C6)алкил, (C1-C4)алкокси-(C1-C4)алкил, (C1-C6)алкил, O-(C0-C8)алкиленарил, (C0-C8)алкиленарил, N(R34)(R35), COCH=CH(R36), (C(R37)(R38))t(R39), CO(C(R37)(R38))t(R39), CO(C1-C6)алкил, COCOO(C1-C6)алкил, COO(R40), S(O)u(R41);R12 is OH, O- (C 1 -C 6 ) alkyl, O (C 0 -C 8 ) alkylenearyl, CN, S- (C 1 -C 6 ) alkyl, COO (R80), CON (R81) (R82 ), A 3-12 membered mono-, bi- or spirocyclic ring, which may contain one or more heteroatoms selected from the group consisting of N, O and S, and said 3-12-membered ring may contain additional substituents, such as F, Cl, Br, OH, CF 3 , CN, oxo, O- (C 1 -C 6 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, (C 1 -C 6 ) alkyl, O- (C 0 -C 8) alkylene-, (C 0 -C 8) alkylene-, N (R34) (R35) , COCH = CH (R36), (C (R37) (R38)) t (R39 ), CO (C (R37) (R38)) t (R39), CO (C 1 -C 6 ) alkyl, COCOO (C 1 -C 6 ) alkyl, COO (R40), S (O) u (R41) ; t имеет значение 0, 1, 2, 3, 4, 5, 6;t is 0, 1, 2, 3, 4, 5, 6; u имеет значение 0, 1, 2;u has the value 0, 1, 2; R34, R35, R37, R38, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR34, R35, R37, R38, independently of one another, are H, (C 1 -C 8 ) alkyl; or R34 и R35, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6 членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу, и может необязательно быть замещенным 1-2 оксогруппами;R34 and R35, optionally together with the nitrogen atom to which they are attached, form a 5-6 membered ring, which, in addition to the nitrogen atom, can also contain 0-1 additional heteroatoms selected from the group consisting of N- (C 1 -C 6 ) alkyl, oxygen and sulfur, and may optionally be substituted with 1-2 oxo groups; R36, R39, независимо друг от друга, представляют собой (C3-C8)циклоалкил, 5-10-членную ароматическую кольцевую систему, которая может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей азот, кислород и серу, и может быть замещена F, Cl, (C1-C6)алкилом, O-(C1-C8)алкилом;R36, R39, independently of each other, are (C 3 -C 8 ) cycloalkyl, a 5-10 membered aromatic ring system that may contain 0-2 additional heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and may be substituted with F, Cl, (C 1 -C 6) alkyl, O- (C 1 -C 8) alkyl; R40 представляет собой H, (C1-C8)алкил, (C2-C6)алкенил, (C0-C8)алкиленарил;R40 represents H, (C 1 -C 8 ) alkyl, (C 2 -C 6 ) alkenyl, (C 0 -C 8 ) alkylenearyl; R41 представляет собой (C1-C6)алкил, 5-10-членную ароматическую кольцевую систему, которая может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей азот, кислород и серу, и может быть замещена F, Cl, (C1-C6)алкилом, O-(C1-C8)алкилом;R41 represents a (C 1 -C 6) -alkyl, 5-10 membered aromatic ring system which may contain 0-2 additional heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur and may be substituted with F, Cl, ( C 1 -C 6 ) alkyl; O- (C 1 -C 8 ) alkyl; R78, R79, независимо друг от друга, представляют собой H, (C1-C8)алкил, гидрокси-(C1-C4)алкил, OH, (C1-C4)алкокси-(C1-C4)алкил;R78, R79, independently of one another, are H, (C 1 -C 8 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, OH, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl; R80, R81, независимо друг от друга, представляют собой H, (C1-C8)алкил;R80, R81, independently of one another, are H, (C 1 -C 8 ) alkyl; R3 представляет собой H, (C1-C6)алкил;R3 is H, (C 1 -C 6 ) alkyl; R4, R5, независимо друг от друга, представляют собой H, (C1-C6)алкил, OH, O-(C1-C6)алкил, O-CO(C1-C6)алкил, S-(C1-C6)алкил;R4, R5, independently of one another, are H, (C 1 -C 6 ) alkyl, OH, O- (C 1 -C 6 ) alkyl, O-CO (C 1 -C 6 ) alkyl, S- ( C 1 -C 6 ) alkyl; R6, R7, R8, R9 представляют собой H; илиR6, R7, R8, R9 are H; or R6 и R7, R8 и R9, независимо друг от друга, необязательно, представляют собой оксо;R6 and R7, R8 and R9, independently of one another, are optionally oxo; n имеет значение 1;n is 1; m имеет значение 1;m is 1; A, B, D, G, независимо друг от друга, представляет собой N, C(R42); илиA, B, D, G, independently of each other, represents N, C (R42); or группы A и B или группы D и G, каждая, представляет собой C(R42) и вместе образуют ортофениленовое звено, в целом образуя 1,4-бизамещенную нафталиновую систему;groups A and B or groups D and G each represent C (R42) and together form an orthophenylene unit, generally forming a 1,4-bisubstituted naphthalene system; R42 представляет собой H, F, Cl, Br, CF3, CN, O-(C1-C6)алкил, O-(C1-C4)алкокси-(C1-C4)алкил, S-(C1-C6)алкил, (C1-C6)алкил, (С0-С8)алкиленарил, O-(C0-C8)алкиленарил, N(R43)(R44), SO2-CH3, CON(R45)(R46), N(R47)CO(R48), CO(R51), -(CR84R85)x-O(R86);R42 represents H, F, Cl, Br, CF 3 , CN, O- (C 1 -C 6 ) alkyl, O- (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, S- ( C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkyl, (C 0 -C 8 ) alkylene aryl, O- (C 0 -C 8 ) alkylene aryl, N (R43) (R44), SO 2 -CH 3 , CON (R45) (R46), N (R47) CO (R48), CO (R51), - (CR84R85) x- O (R86); R43, R44, R45, R46, R47, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR43, R44, R45, R46, R47, independently of one another, are H, (C 1 -C 8 ) alkyl; or R43 и R44, R45 и R46, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу;R43 and R44, R45 and R46, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group including N- (C 1 -C 6 ) alkyl, oxygen and sulfur; R48, R50, R51, независимо друг от друга, представляют собой H, (C1-C8)алкил, арил;R48, R50, R51, independently of one another, are H, (C 1 -C 8 ) alkyl, aryl; R84, R85 представляют собой H;R84, R85 are H; R86 представляет собой H, (C1-C6)алкил;R86 is H, (C 1 -C 6 ) alkyl; x имеет значение 0, 1, 2;x has the value 0, 1, 2; R10 представляет собой H, (C1-C8)алкил;R10 represents H, (C 1 -C 8 ) alkyl; X представляет собой N(R52), связь, C=C, C(R53)(R54), СН2-СН2;X represents N (R52), a bond, C = C, C (R53) (R54), CH 2 —CH 2 ; Y представляет собой O, S, N(R89);Y represents O, S, N (R89); R89 представляет собой H, (C1-C8)алкил;R89 represents H, (C 1 -C 8 ) alkyl; R52, R53, R54, независимо друг от друга, представляют собой H, (C1-C8)алкил;R52, R53, R54, independently of one another, are H, (C 1 -C 8 ) alkyl; E выбран из группы, включающейE is selected from the group including
Figure 00000002
Figure 00000002
Figure 00000003
Figure 00000003
 которые могут необязательно содержать заместители, выбранные из группы, включающей H, F, Cl, Br, OH, CF3, NO2, OCF3, O-(C1-C6)алкил, (C1-C6)алкил, (C2-C6)алкенил, N(R57)(R58), SO2-CH3, CO(R65);which can optionally contain substituents selected from the group consisting of H, F, Cl, Br, OH, CF 3, NO 2, OCF 3, O- (C 1 -C 6) alkyl, (C 1 -C 6) alkyl, (C 2 -C 6 ) alkenyl, N (R57) (R58), SO 2 -CH 3 , CO (R65); R57, R58, независимо друг от друга, представляют собой H, (C1-C8)алкил;R57, R58, independently of one another, are H, (C 1 -C 8 ) alkyl; R65, независимо друг от друга, представляют собой H, (C1-C8)алкил, арил;R65, independently of one another, are H, (C 1 -C 8 ) alkyl, aryl; K представляет собой связь, O, OCH2, CH2O, S, SO, SO2, N(R66), N(R67)CO, CON(R68), (C(R69)(R70))v, CO, C=C, C≡C, SCH2, SO2CH2;K is a bond, O, OCH 2, CH 2 O, S, SO, SO 2, N (R66), N ( R67) CO, CON (R68), (C (R69) (R70)) v, CO, C = C, C≡C, SCH 2 , SO 2 CH 2 ; v имеет значение 1, 2, 3, 4v is 1, 2, 3, 4 R66, R67, R68, R69, R70, независимо друг от друга, представляют собой H, (C1-C8)алкил;R66, R67, R68, R69, R70, independently of one another, are H, (C 1 -C 8 ) alkyl; R11 представляет собой H, (C1-C8)алкил, (C1-C4)алкокси-(C1-C4)алкил, (C3-C8)алкенил, (C3-C8)алкинил, 3-10-членное моно-, би-, три- или спироциклическое кольцо, которое может содержать 0-4 гетероатома, выбранных из группы, включающей кислород, азот и серу, где указанная кольцевая система может быть дополнительно замещена F, Cl, Br, CF3, CN, (C1-C6)алкилом, O-(C1-C8)алкилом, (C1-C4)алкокси-(C1-C4)алкилом, гидрокси-(С1-С4)алкилом, -(C0-C8)алкиленарилом, оксо, CO(R71), CON(R72)(R73), гидрокси, COO(R74), N(R75)CO(C1-C6)алкилом, N(R76)(R77) или SO2CH3;R11 represents H, (C 1 -C 8 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, (C 3 -C 8 ) alkenyl, (C 3 -C 8 ) alkynyl, 3-10 membered mono-, bi-, tri- or spirocyclic ring, which may contain 0-4 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, where this ring system may be further substituted by F, Cl, Br, CF 3 , CN, (C 1 -C 6 ) alkyl, O- (C 1 -C 8 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, - (C 0 -C 8 ) alkylene aryl, oxo, CO (R71), CON (R72) (R73), hydroxy, COO (R74), N (R75) CO (C 1 -C 6 ) alkyl, N (R76) (R77) or SO 2 CH 3 ; R71, R72, R73, R74, R75, R76, R77, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR71, R72, R73, R74, R75, R76, R77, independently of one another, are H, (C 1 -C 8 ) alkyl; or R72 и R73, R76 и R77, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу, илиR72 and R73, R76 and R77, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group consisting of N- (C 1 -C 6) -alkyl, oxygen and sulfur, or их N-оксиды и физиологически приемлемые соли.their N-oxides and physiologically acceptable salts. 2. Соединение формулы (I) по п.1,2. The compound of formula (I) according to claim 1, где R1, R2, независимо друг от друга, представляют собой H, (C1-C8)алкил, -(CR78R79)o-R12, (C1-C4)алкокси-(C1-C4)алкил, CO-(C1-C8)алкил, -CO-(CH2)o-R12, COCH=CH(R13), COCC(R14), CO(C(R15)(R16))qN(R17)(R18), CO(C(R23)(R24))sO(R25); или R1 и R2 образуют вместе с атомом азота, с которым они связаны, 4-10-членное моно- или бициклическое кольцо, которое, помимо атома азота, может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей кислород, азот и серу, где гетероциклическая кольцевая система может быть дополнительно замещена F, Cl, CF3, (C1-C6)алкилом, O-(C1-C4)алкилом, (C1-C4)алкокси-(C1-C4)алкилом, (C0-C2)алкиленарилом, оксо, CO(R26), гидрокси, N(R31)(R32) или SO2CH3;wherein R1, R2, independently, represent H, (C 1 -C 8) -alkyl, - (CR78R79) o -R12, (C 1 -C 4) alkoxy- (C 1 -C 4) alkyl, CO - (C 1 -C 8 ) alkyl, -CO- (CH 2 ) o -R12, COCH = CH (R13), COCC (R14), CO (C (R15) (R16)) q N (R17) (R18 ), CO (C (R23) (R24)) s O (R25); or R1 and R2 form, together with the nitrogen atom to which they are attached, a 4-10 membered mono- or bicyclic ring, which, in addition to the nitrogen atom, may contain 0-2 additional heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur where the heterocyclic ring system may be further substituted with F, Cl, CF 3 , (C 1 -C 6 ) alkyl, O- (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, (C 0 -C 2 ) alkylene aryl, oxo, CO (R26), hydroxy, N (R31) (R32) or SO 2 CH 3 ; o имеет значение 0, 1, 2, 3, 4;o has the value 0, 1, 2, 3, 4; q имеет значение 1 или 2;q is 1 or 2; s имеет значение 0, 1, 2, 3;s is 0, 1, 2, 3; R13, R14, независимо друг от друга, представляют собой другое фенильное кольцо, которое может содержать 0-1 атом азота;R13, R14, independently of each other, represent another phenyl ring, which may contain 0-1 nitrogen atom; R15, R16, R17, R23, R24, R26, R31, R32, независимо друг от друга, представляют собой H, (C1-C6)алкил;R15, R16, R17, R23, R24, R26, R31, R32, independently of one another, are H, (C 1 -C 6 ) alkyl; R18 представляет собой H, (C1-C6)алкил, CO(C1-C6)алкил; илиR18 represents H, (C 1 -C 6 ) alkyl, CO (C 1 -C 6 ) alkyl; or R17 и R18, R31 и R32, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, выбранное из пирролидина, пиперидина, N-метилпиперазина, морфолина;R17 and R18, R31 and R32, independently of each other, optionally together with the nitrogen atom to which they are attached, form a 5-6 membered ring selected from pyrrolidine, piperidine, N-methylpiperazine, morpholine; R12 представляет собой OH, O-(C1-C6)алкил, O(C0-C8)алкиленарил, CN, 3-10-членное моно- или бициклическое кольцо, которое может содержать 1-3 гетероатома, выбранных из группы, включающей N, O и S, и указанное 3-10 членное кольцо может содержать дополнительные заместители, такие как F, Cl, Br, OH, CF3, CN, оксо, O-(C1-C6)алкил, (C1-C4)алкокси-(C1-C4)алкил, (C1-C6)алкил, (C0-C2)алкиленарил, N(R34)(R35), CO(C1-C6)алкил;R12 represents OH, O- (C 1 -C 6 ) alkyl, O (C 0 -C 8 ) alkylenearyl, CN, a 3-10 membered mono- or bicyclic ring, which may contain 1-3 heteroatoms selected from the group including N, O and S, and the specified 3-10 membered ring may contain additional substituents, such as F, Cl, Br, OH, CF 3 , CN, oxo, O- (C 1 -C 6 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, (C 1 -C 6 ) alkyl, (C 0 -C 2 ) alkylene aryl, N (R34) (R35), CO (C 1 -C 6 ) alkyl; t имеет значение 0, 1, 2, 3, 4, 5, 6;t is 0, 1, 2, 3, 4, 5, 6; u имеет значение 0 или 2;u has a value of 0 or 2; R34, R35, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR34, R35, independently of one another, are H, (C 1 -C 8 ) alkyl; or R34 и R35, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу, и может быть замещенным 1-2 оксогруппами;R34 and R35, optionally together with the nitrogen atom to which they are attached, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group consisting of N- (C 1 -C 6 ) alkyl, oxygen and sulfur, and may be substituted with 1-2 oxo groups; R78, R79, независимо друг от друга, представляют собой H, (C1-C8)алкил, гидрокси-(C1-C4)алкил, OH, (C1-C4)алкокси-(C1-C4)алкил;R78, R79, independently of one another, are H, (C 1 -C 8 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, OH, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl; R3 представляет собой H;R3 represents H; R4, R5, независимо друг от друга, представляют собой H, (C1-C6)алкил, OH, O-(C1-C6)алкил, O-CO(C1-C6)алкил;R4, R5, independently of one another, are H, (C 1 -C 6 ) alkyl, OH, O- (C 1 -C 6 ) alkyl, O-CO (C 1 -C 6 ) alkyl; R6, R7, R8, R9 представляют собой H;R6, R7, R8, R9 are H; n имеет значение 1;n is 1; m имеет значение 1;m is 1; A, B, D, G: В представляет собой N, C(R42); и A, D, G представляют собой C(R42);A, B, D, G: B represents N, C (R42); and A, D, G are C (R42); R42 представляет собой H, F, Cl, Br, CF3, CN, O-(C1-C6)алкил, (C1-C6)алкил, SO2-CH3, CON(R45)(R46), N(R47)CO(R48), CO(R51), -(CR84R85)x-O(R86);R42 is H, F, Cl, Br, CF 3 , CN, O- (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkyl, SO 2 -CH 3 , CON (R45) (R46), N (R47) CO (R48) , CO (R51), - (CR84R85) x -O (R86); R45, R46, R47, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR45, R46, R47, independently of one another, are H, (C 1 -C 8 ) alkyl; or R45 и R46, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу;R45 and R46, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group consisting of N- (C 1 -C 6 ) alkyl, oxygen and sulfur; R48, R51, независимо друг от друга, представляют собой H, (C1-C8)алкил;R48, R51, independently of one another, are H, (C 1 -C 8 ) alkyl; R84, R85 представляют собой H;R84, R85 are H; R86 представляет собой H, (C1-C6)алкил;R86 is H, (C 1 -C 6 ) alkyl; x имеет значение 0, 1;x has the value 0, 1; R10 представляет собой H, (C1-C8)алкил;R10 represents H, (C 1 -C 8 ) alkyl; X представляет собой N(R52), связь, C=C, C(R53)(R54), СН2-СН2;X represents N (R52), a bond, C = C, C (R53) (R54), CH 2 —CH 2 ; R52, R53, R54, независимо друг от друга, представляют собой H, (C1-C8)алкил;R52, R53, R54, independently of one another, are H, (C 1 -C 8 ) alkyl; E выбран из группы, включающейE is selected from the group including
Figure 00000004
Figure 00000004
 которые могут необязательно содержать заместители, выбранные из группы, включающей H, F, Cl, Br, OH, CF3, NO2, OCF3, O-(C1-C6)алкил, (C1-C6)алкил, (C2-C6)алкенил, N(R57)(R58), SO2-CH3, CO(R65);which may optionally contain substituents selected from the group consisting of H, F, Cl, Br, OH, CF 3 , NO 2 , OCF 3 , O- (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, N (R57) (R58), SO 2 -CH 3 , CO (R65); R57, R58, независимо друг от друга, представляют собой H, (C1-C8)алкил;R57, R58, independently of one another, are H, (C 1 -C 8 ) alkyl; R65, независимо друг от друга, представляют собой H, (C1-C8)алкил;R65, independently of one another, are H, (C 1 -C 8 ) alkyl; K представляет собой связь, O, OCH2, CH2O, N(R66), CON(R68), (C(R69)(R70))v, CO, C≡C, SCH2;K represents a bond, O, OCH 2 , CH 2 O, N (R66), CON (R68), (C (R69) (R70)) v , CO, C≡C, SCH 2 ; v имеет значение 1, 2, 3;v has a value of 1, 2, 3; R66, R68, R69, R70, независимо друг от друга, представляют собой H, (C1-C8)алкил;R66, R68, R69, R70, independently of one another, are H, (C 1 -C 8 ) alkyl; R11 представляет собой (C1-C8)алкил, (C1-C4)алкокси-(C1-C4)алкил, 3-10-членное моно-, би-, три- или спироциклическое кольцо, которое может содержать 0-3 гетероатома, выбранных из группы, включающей кислород, азот и серу, где указанная кольцевая система может быть дополнительно замещена F, Cl, Br, CF3, CN, (C1-C6)алкилом, O-(C1-C8)алкилом, -(C0-C2)алкиленарилом, оксо, CO(R71), CON(R72)(R73), гидрокси, N(R75)CO(C1-C6)алкилом, N(R76)(R77) или SO2CH3;R11 is a (C 1 -C 8 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, 3-10 membered mono-, bi-, tri- or spirocyclic ring, which may contain 0-3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, wherein said ring system may be further substituted with F, Cl, Br, CF 3 , CN, (C 1 -C 6 ) alkyl, O- (C 1 - C 8 ) alkyl, - (C 0 -C 2 ) alkylene aryl, oxo, CO (R71), CON (R72) (R73), hydroxy, N (R75) CO (C 1 -C 6 ) alkyl, N (R76) (R77) or SO 2 CH 3 ; R71, R72, R73, R75, R76, R77, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR71, R72, R73, R75, R76, R77, independently of one another, are H, (C 1 -C 8 ) alkyl; or R72 и R73, R76 и R77, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу; илиR72 and R73, R76 and R77, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group including N- (C 1 -C 6 ) alkyl, oxygen and sulfur; or их N-оксиды и физиологически приемлемые соли.their N-oxides and physiologically acceptable salts. 3. Соединение формулы (I) по п.1,3. The compound of formula (I) according to claim 1, где R1, R2, независимо друг от друга, представляют собой H, (C1-C8)алкил, -(CR78R79)o-R12, (C1-C4)алкокси-(C1-C4)алкил, CO-(C1-C8)алкил, -CO-(CH2)o-R12, O(C(R15)(R16))qN(R17)(R18); или R1 и R2 образуют вместе с атомом азота, с которым они связаны, 4-10-членное моно- или бициклическое кольцо, которое, помимо атома азота, может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей кислород и азот, где гетероциклическая кольцевая система может быть дополнительно замещена F, (C1-C6)алкилом, (C1-C4)алкокси-(C1-C4)алкилом, оксо, CO(R26), гидрокси, N(R31)(R32);where R1, R2, independently of one another, are H, (C 1 -C 8 ) alkyl, - (CR78R79) o -R12, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, CO - (C 1 -C 8 ) alkyl, -CO- (CH 2 ) o -R12, O (C (R15) (R16)) q N (R17) (R18); or R1 and R2 form, together with the nitrogen atom to which they are bonded, a 4-10 membered mono- or bicyclic ring, which, in addition to the nitrogen atom, may contain 0-2 additional heteroatoms selected from the group consisting of oxygen and nitrogen, where the heterocyclic ring system may be further substituted with F, (C 1 -C 6 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, oxo, CO (R26), hydroxy, N (R31) ( R32); o имеет значение 0, 1, 2, 3;o has a value of 0, 1, 2, 3; q имеет значение 1 или 2;q is 1 or 2; R15, R16, R17, R26, R31, R32, независимо друг от друга, представляют собой H, (C1-C6)алкил;R15, R16, R17, R26, R31, R32, independently of one another, are H, (C 1 -C 6 ) alkyl; R18 представляет собой H, (C1-C6)алкил; илиR18 represents H, (C 1 -C 6 ) alkyl; or R17 и R18, R21 и R22, R27 и R28, R31 и R32, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, выбранное из пирролидина, пиперидина, N-метилпиперазина, морфолина;R17 and R18, R21 and R22, R27 and R28, R31 and R32, independently of each other, optionally together with the nitrogen atom to which they are attached, form a 5-6 membered ring selected from pyrrolidine, piperidine, N-methylpiperazine, morpholine; R12 представляет собой OH, O-(C1-C6)алкил, 3-10-членное моно- или бициклическое кольцо, которое может содержать 1-2 гетероатома, выбранных из группы, включающей N, O и S, и указанное 3-10-членное кольцо может содержать дополнительные заместители, такие как F, OH, оксо, (C1-C6)алкил, CO(C1-C6)алкил,;R12 represents OH, O- (C 1 -C 6 ) alkyl, a 3-10 membered mono- or bicyclic ring, which may contain 1-2 heteroatoms selected from the group consisting of N, O and S, and said 3- The 10 membered ring may contain additional substituents, such as F, OH, oxo, (C 1 -C 6 ) alkyl, CO (C 1 -C 6 ) alkyl ,; R78, R79, независимо друг от друга, представляют собой H, (C1-C8)алкил, гидрокси-(C1-C4)алкил, OH, (C1-C4)алкокси-(C1-C4)алкил;R78, R79, independently of one another, are H, (C 1 -C 8 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, OH, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl; R3 представляет собой H;R3 represents H; R4, R5, независимо друг от друга, представляют собой H, OH, O-(C1-C6)алкил;R4, R5, independently of one another, are H, OH, O- (C 1 -C 6 ) alkyl; R6, R7, R8, R9, представляют собой H;R6, R7, R8, R9 are H; n имеет значение 1;n is 1; m имеет значение 1;m is 1; A, B, D, G представляют собой C(R42);A, B, D, G are C (R42); R42 представляет собой H, F, Cl, CF3, CN, (C1-C6)алкил, -(CR84R85)x-O(R86);R42 represents H, F, Cl, CF 3 , CN, (C 1 -C 6 ) alkyl, - (CR84R85) x —O (R86); R84, R85 представляют собой H;R84, R85 are H; R86 представляет собой H, (C1-C6)алкил;R86 is H, (C 1 -C 6 ) alkyl; x имеет значение 0, 1, 2; предпочтительно, 0, 1; особенно предпочтительно 1;x has the value 0, 1, 2; preferably 0, 1; particularly preferably 1; R10 представляет собой H, (C1-C8)алкил;R10 represents H, (C 1 -C 8 ) alkyl; X представляет собой связь, C=C, C(R53)(R54), СН2-СН2;X is a bond, C = C, C (R53) (R54), CH 2 —CH 2 ; R53, R54, независимо друг от друга, представляют собой H, (C1-C8)алкил;R53, R54, independently of one another, are H, (C 1 -C 8 ) alkyl; E выбран из группы, включающейE is selected from the group including
Figure 00000005
Figure 00000005
 которые могут необязательно содержать заместители, выбранные из группы, включающей H, F, Cl, Br, OH, CF3, NO2, OCF3, O-(C1-C6)алкил, (C1-C6)алкил, (C2-C6)алкенил, N(R57)(R58), SO2-CH3, CO(R65);which may optionally contain substituents selected from the group consisting of H, F, Cl, Br, OH, CF 3 , NO 2 , OCF 3 , O- (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, N (R57) (R58), SO 2 -CH 3 , CO (R65); R57, R58, независимо друг от друга, представляют собой H, (C1-C8)алкил;R57, R58, independently of one another, are H, (C 1 -C 8 ) alkyl; R65, независимо друг от друга, представляют собой H, (C1-C8)алкил;R65, independently of one another, are H, (C 1 -C 8 ) alkyl; K представляет собой связь, O, OCH2, CH2O, CON(R68), (C(R69)(R70))v, CO, C≡C;K is a bond, O, OCH 2 , CH 2 O, CON (R68), (C (R69) (R70)) v , CO, C≡C; v имеет значение 1, 2;v has a value of 1, 2; R68, R69, R70, независимо друг от друга, представляют собой H, (C1-C8)алкил;R68, R69, R70, independently of one another, are H, (C 1 -C 8 ) alkyl; R11 представляет собой (C1-C8)алкил, (C1-C4)алкокси-(C1-C4)алкил, 3-10-членное моно- или бициклическое кольцо, которое может содержать 0-2 гетероатома, выбранных из группы, включающей кислород, азот и серу, где указанная кольцевая система может быть дополнительно замещена F, Cl, Br, CF3, CN, (C1-C6)алкилом, O-(C1-C8)алкилом, оксо, CO(R71), CON(R72)(R73), N(R75)CO(C1-C6)алкилом или SO2CH3;R11 is a (C 1 -C 8 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, 3-10 membered mono- or bicyclic ring, which may contain 0-2 heteroatoms selected from the group comprising oxygen, nitrogen and sulfur, where the specified ring system may be further substituted by F, Cl, Br, CF 3 , CN, (C 1 -C 6 ) alkyl, O- (C 1 -C 8 ) alkyl, oxo , CO (R71), CON (R72) (R73), N (R75) CO (C 1 -C 6 ) alkyl or SO 2 CH 3 ; R71, R72, R75, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR71, R72, R75, independently of one another, are H, (C 1 -C 8 ) alkyl; or R72 и R73, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу, илиR72 and R73, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group consisting of N- (C 1 -C 6 ) alkyl, oxygen and sulfur, or их N-оксиды и физиологически приемлемые соли.their N-oxides and physiologically acceptable salts. 4. Соединение по п.1, отличающееся тем, что имеет формулу (Ia)4. The compound according to claim 1, characterized in that it has the formula (Ia)
Figure 00000006
Figure 00000006
 R1, R2, независимо друг от друга, представляют собой H, (C1-C8)алкил, -(CR78R79)o-R12, (C1-C4)алкокси-(C1-C4)алкил, или R1 и R2 образуют вместе с атомом азота, с которым они связаны, 4-10-членное моно-, би- или спироциклическое кольцо, которое, помимо атома азота, может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей кислород, азот и серу, где гетероциклическая кольцевая система может быть дополнительно замещена F, (C1-C6)алкилом, О-(С1-С4)алкилом, (C1-C4)алкокси-(C1-C4)алкилом, гидрокси-(C1-C4)алкилом, (C0-C2)алкиленарилом, оксо, CO(R26), CON(R27)(R28), гидрокси, N(R31)(R32) или SO2CH3; где R1 и R2 оба не являются СО(R26);R1, R2, independently of one another, are H, (C 1 -C 8 ) alkyl, - (CR78R79) o-R12, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, or R1 and R2 form, together with the nitrogen atom to which they are bonded, a 4-10 membered mono-, bi- or spirocyclic ring, which, in addition to the nitrogen atom, may contain 0-2 additional heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, where the heterocyclic ring system may be further substituted with F, (C 1 -C 6 ) alkyl, O- (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, hydroxy (C 1 -C 4) alkyl, (C 0 -C 2) alkilenarilom, oxo, CO (R26), CON ( R27) (R28), idroksi, N (R31) (R32) or SO 2 CH 3; where R 1 and R 2 are not both CO (R26); o имеет значение 0, 1, 2, 3, 4;o has the value 0, 1, 2, 3, 4; q имеет значение 1, 2, 3;q is 1, 2, 3; s имеет значение 0, 1, 2;s is 0, 1, 2; R15, R16, R17, R18, R23, R24, R25, R26, R27, R28, R31, R32, независимо друг от друга, представляют собой H, (C1-C6)алкил; илиR15, R16, R17, R18, R23, R24, R25, R26, R27, R28, R31, R32, independently of one another, are H, (C1-C6) alkyl; or R17 и R18, R27 и R28, R31 и R32, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу;R17 and R18, R27 and R28, R31 and R32, independently of each other, optionally together with the nitrogen atom to which they are attached form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatom selected from the group comprising N- (C 1 -C 6 ) alkyl, oxygen and sulfur; R12 представляет собой OH, O-(C1-C6)алкил, O(C0-C2)алкиленарил, CN, S-(C1-C6)алкил, 3-12 членное моно-, би- или спироциклическое кольцо, которое может содержать 1-3 гетероатома, выбранных из группы, включающей N, O и S, и указанное 3-12 членное кольцо может содержать дополнительные заместители, такие как F, OH, CF3, CN, оксо, (C1-C6)алкил, (C0-C2)алкиленарил, N(R34)(R35), COO(R40), CO(C1-C6)алкил;R12 is OH, O- (C 1 -C 6 ) alkyl, O (C 0 -C 2 ) alkylene aryl, CN, S- (C 1 -C 6 ) alkyl, 3-12 membered mono-, bi- or spirocyclic a ring which may contain 1-3 heteroatoms selected from the group consisting of N, O and S, and said 3-12 membered ring may contain additional substituents, such as F, OH, CF 3 , CN, oxo, (C 1 - C 6 ) alkyl, (C 0 -C 2 ) alkylenearyl, N (R34) (R35), COO (R40), CO (C 1 -C 6 ) alkyl; R34, R35, независимо друг от друга, представляют собой H, (C1-C4)алкил;R34, R35, independently of one another, are H, (C 1 -C 4 ) alkyl; R40 представляет собой H, (C1-C6)алкил, (C0-C2)алкиленарил;R40 represents H, (C 1 -C 6 ) alkyl, (C 0 -C 2 ) alkylene aryl; R78, R79, независимо друг от друга, представляют собой H, (C1-C8)алкил, гидрокси-(C1-C4)алкил, OH, (C1-C4)алкокси-(C1-C4)алкил;R78, R79, independently of one another, are H, (C 1 -C 8 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, OH, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl; R42, R42', независимо друг от друга, представляют собой H, F, Cl, Br, CF3, CN, (C1-C6)алкил;R42, R42 ', independently of one another, are H, F, Cl, Br, CF 3 , CN, (C 1 -C 6 ) alkyl; R10 представляет собой H, (C1-C8)алкил;R10 represents H, (C 1 -C 8 ) alkyl; X представляет собой N(R52), связь, C=C, C(R53)(R54), СН2СН2;X represents N (R52), a bond, C = C, C (R53) (R54), CH 2 CH 2 ; R52, R53, R54, независимо друг от друга, представляют собой H, (C1-C8)алкил;R52, R53, R54, independently of one another, are H, (C 1 -C 8 ) alkyl; E выбран из группы, включающейE is selected from the group including
Figure 00000004
Figure 00000004
 которые могут необязательно содержать заместители, выбранные из группы, включающей H, F, Cl, Br, OH, CF3, NO2, OCF3, O-(C1-C6)алкил, (C1-C6)алкил, (C2-C6)алкенил, N(R57)(R58), SO2-CH3, CO(R65);which may optionally contain substituents selected from the group consisting of H, F, Cl, Br, OH, CF 3 , NO 2 , OCF 3 , O- (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, N (R57) (R58), SO 2 -CH 3 , CO (R65); R57, R58, независимо друг от друга, представляют собой H, (C1-C8)алкил;R57, R58, independently of one another, are H, (C 1 -C 8 ) alkyl; R65 представляют собой H, (C1-C8)алкил;R65 is H, (C 1 -C 8 ) alkyl; K представляет собой связь, O, OCH2, CH2O, S, SO2, N(R66), N(R67)CO, CON(R68), (C(R69)(R70))v, CO, C≡C, SCH2, SO2CH2;K is a bond, O, OCH 2 , CH 2 O, S, SO 2 , N (R66), N (R67) CO, CON (R68), (C (R69) (R70)) v , CO, C≡ C, SCH 2 , SO 2 CH 2 ; v имеет значение 1, 2, 3;v has a value of 1, 2, 3; R66, R67, R68, R69, R70, независимо друг от друга, представляют собой H, (C1-C8)алкил;R66, R67, R68, R69, R70, independently of one another, are H, (C 1 -C 8 ) alkyl; R11 представляет собой (C1-C8)алкил, (C1-C4)алкокси-(C1-C4)алкил, 3-10-членное моно-, би-, три- или спироциклическое кольцо, которое может содержать 0-4 гетероатома, выбранных из группы, включающей кислород, азот и серу, где указанная кольцевая система может быть дополнительно замещена F, Cl, Br, CF3, CN, (C1-C6)алкилом, O-(C1-C8)алкилом, оксо, CO(R71), гидрокси, N(R75)CO(C1-C6)алкилом или SO2CH3;R11 represents a (C 1 -C 8) alkyl, (C 1 -C 4) alkoxy- (C 1 -C 4) -alkyl, 3-10 membered mono-, bi-, tri- or spirocyclic ring which may comprise 0-4 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, wherein said ring system may be further substituted with F, Cl, Br, CF 3 , CN, (C 1 -C 6 ) alkyl, O- (C 1 - C 8 ) alkyl, oxo, CO (R71), hydroxy, N (R75) CO (C 1 -C 6 ) alkyl or SO 2 CH 3 ; R71, R72, R73, R74, R75, R76, R77, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR71, R72, R73, R74, R75, R76, R77, independently of one another, are H, (C 1 -C 8 ) alkyl; or R72 и R73, R76 и R77, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу, илиR72 and R73, R76 and R77, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group including N- (C 1 -C 6 ) alkyl, oxygen and sulfur, or их N-оксиды и физиологически приемлемые соли.their N-oxides and physiologically acceptable salts. 5. Соединение по п.1, отличающееся тем, что имеет формулу (Ib)5. The compound according to claim 1, characterized in that it has the formula (Ib)
Figure 00000007
Figure 00000007
 где R1, R2, независимо друг от друга, представляют собой H, (C1-C8)алкил, -(CR78R79)o-R12, (C1-C4)алкокси-(C1-C4)алкил, (C3-C8)алкенил, CO-(C1-C8)алкил, -CO-(CH2)o-R12, CO-арилокси-(C1-C4)алкил, COCH=CH(R13), COCC(R14), CO(C(R15)(R16))qN(R17)(R18), CO(C(R19)(R20))rCON(R21)(R22), CO(C(R23)(R24))sO(R25); или R1 и R2 образуют вместе с атомом азота, с которым они связаны, 4-10-членное моно-, би- или спироциклическое кольцо, которое, помимо атома азота, может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей кислород, азот и серу, где гетероциклическая кольцевая система может быть дополнительно замещена F, Cl, CF3, (C1-C6)алкилом, O-(C1-C4)алкилом, (C1-C4)алкокси-(C1-C4)алкилом, гидрокси-(C1-C4)алкилом, (C0-C2)алкиленарилом, оксо, CO(R26), CON(R27)(R28), гидрокси, COO(R29), N(R30)CO(C1-C6)алкилом, N(R31)(R32) или SO2CH3, где R1 и R2 оба не являются CO(R26);where R1, R2, independently of one another, are H, (C 1 -C 8 ) alkyl, - (CR78R79) o -R12, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, ( C 3 -C 8 ) alkenyl, CO- (C 1 -C 8 ) alkyl, -CO- (CH 2 ) o -R12, CO-aryloxy- (C 1 -C 4 ) alkyl, COCH = CH (R13), COCC (R14), CO (C (R15) (R16)) q N (R17) (R18), CO (C (R19) (R20)) r CON (R21) (R22), CO (C (R23) ( R24)) s O (R25); or R1 and R2 form, together with the nitrogen atom to which they are attached, a 4-10 membered mono-, bi- or spirocyclic ring, which, in addition to the nitrogen atom, may contain 0-2 additional heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, where the heterocyclic ring system may be further substituted with F, Cl, CF 3 , (C 1 -C 6 ) alkyl, O- (C 1 -C 4 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, (C 0 -C 2 ) alkylene aryl, oxo, CO (R26), CON (R27) (R28), hydroxy, COO (R29), N (R30) CO (C 1 -C 6 ) alkyl, N (R31) (R32) or SO 2 CH 3 , where R1 and R2 are not both CO (R26); o имеет значение 0, 1, 2, 3, 4, 5, 6;o has the value 0, 1, 2, 3, 4, 5, 6; q, r, независимо друг от друга, имеют значение 1, 2, 3;q, r, independently of each other, have a value of 1, 2, 3; s имеет значение 0, 1, 2, 3, 4;s is 0, 1, 2, 3, 4; R13, R14, независимо друг от друга, представляют собой другое фенильное кольцо, которое может содержать 0-1 атом азота;R13, R14, independently of each other, represent another phenyl ring, which may contain 0-1 nitrogen atom; R15, R16, R17, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, независимо друг от друга, представляют собой H, (C1-C6)алкил;R15, R16, R17, R19, R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, independently of each other, are H, (C 1 -C 6 ) alkyl; R18 представляет собой H, (C1-C6)алкил, СО-(C1-C6)алкил, CO(R33); илиR18 represents H, (C 1 -C 6 ) alkyl, CO- (C 1 -C 6 ) alkyl, CO (R33); or R17 и R18, R21 и R22, R27 и R28, R31 и R32, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу;R17 and R18, R21 and R22, R27 and R28, R31 and R32, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0 -1 an additional heteroatom selected from the group consisting of N- (C 1 -C 6 ) alkyl, oxygen and sulfur; R33 представляет собой 5-10-членную ароматическую кольцевую систему, которая может содержать дополнительный гетероатом, выбранный из группы, включающей азот, кислород и серу, и может быть замещена F, Cl, (C1-C6)алкилом, O-(C1-C8)алкилом;R33 represents a 5-10 membered aromatic ring system which may contain an additional heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and may be substituted with F, Cl, (C 1 -C 6) alkyl, O- (C 1 -C 8 ) alkyl; R12 представляет собой OH, O-(C1-C6)алкил, O(C0-C8)алкиленарил, CN, S-(C1-C6)алкил, COO(R80), CON(R81)(R82), 3-12 членное моно-, би- или спироциклическое кольцо, которое может содержать один или несколько гетероатомов, выбранных из группы, включающей N, O и S, и указанное 3-12 членное кольцо может содержать дополнительные заместители, такие как F, Cl, Br, OH, CF3, CN, оксо, O-(C1-C6)алкил, (C1-C4)алкокси-(C1-C4)алкил, (C1-C6)алкил, O-(C0-C8)алкиленарил, (C0-C8)алкиленарил, N(R34)(R35), COCH=CH(R36), (C(R37)(R38))t(R39), CO(C(R37)(R38))t(R39), CO(C1-C6)алкил, COCOO(C1-C6)алкил, COO(R40), S(O)u(R41);R12 is OH, O- (C 1 -C 6 ) alkyl, O (C 0 -C 8 ) alkylenearyl, CN, S- (C 1 -C 6 ) alkyl, COO (R80), CON (R81) (R82 ), A 3-12 membered mono-, bi- or spirocyclic ring, which may contain one or more heteroatoms selected from the group consisting of N, O and S, and said 3-12 membered ring may contain additional substituents, such as F, Cl, Br, OH, CF 3 , CN, oxo, O- (C 1 -C 6 ) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, (C 1 -C 6 ) alkyl , O- (C 0 -C 8 ) alkylene aryl, (C 0 -C 8 ) alkylene aryl, N (R34) (R35), COCH = CH (R36), (C (R37) (R38)) t (R39), CO (C (R37) (R38)) t (R39), CO (C 1 -C 6 ) alkyl, COCOO (C 1 -C 6 ) alkyl, COO (R40), S (O) u (R41); t имеет значение 0, 1, 2, 3, 4, 5, 6;t is 0, 1, 2, 3, 4, 5, 6; u имеет значение 0, 1, 2;u has the value 0, 1, 2; R34, R35, R37, R38, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR34, R35, R37, R38, independently of one another, are H, (C 1 -C 8 ) alkyl; or R34 и R35 необязательно вместе с атомом азота, с которым они связаны, образуют 5-6 членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу, и может необязательно быть замещенным 1-2 оксогруппами;R34 and R35 optionally together with the nitrogen atom to which they are bonded form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group consisting of N- (C 1 -C 6 ) alkyl, oxygen and sulfur, and may optionally be substituted with 1-2 oxo groups; R36, R39, независимо друг от друга, представляет собой (C3-C8)циклоалкил, 5-10-членную ароматическую кольцевую систему, которая может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей азот, кислород и серу, и может быть замещена F, Cl, (C1-C6)алкилом, O-(C1-C8)алкилом;R36, R39, independently of one another, is a (C 3 -C 8 ) cycloalkyl, 5-10 membered aromatic ring system which may contain 0-2 additional heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and may be substituted with F, Cl, (C 1 -C 6 ) alkyl, O- (C 1 -C 8 ) alkyl; R40 представляет собой H, (C1-C8)алкил, (C2-C6)алкенил, (C0-C8)алкиленарил;R40 represents H, (C 1 -C 8 ) alkyl, (C 2 -C 6 ) alkenyl, (C 0 -C 8 ) alkylenearyl; R41 представляет собой (C1-C6)алкил, 5-10-членную ароматическую кольцевую систему, которая может содержать 0-2 дополнительных гетероатома, выбранных из группы, включающей азот, кислород и серу, и может быть замещена F, Cl, (C1-C6)алкилом, O-(C1-C8)алкилом;R41 is a (C 1 -C 6 ) alkyl, 5-10 membered aromatic ring system that may contain 0-2 additional heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and may be substituted with F, Cl, ( C 1 -C 6 ) alkyl; O- (C 1 -C 8 ) alkyl; R78, R79, независимо друг от друга, представляют собой H, (C1-C8)алкил, гидрокси-(C1-C4)алкил, OH, (C1-C4)алкокси-(C1-C4)алкил;R78, R79, independently of one another, are H, (C 1 -C 8 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, OH, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl; R80, R81, независимо друг от друга, представляют собой H, (C1-C8)алкил;R80, R81, independently of one another, are H, (C 1 -C 8 ) alkyl; R10 представляет собой H, (C1-C8)алкил;R10 represents H, (C 1 -C 8 ) alkyl; E выбран из группы, включающейE is selected from the group including
Figure 00000004
Figure 00000004
 которые могут необязательно содержать заместители, выбранные из группы, включающей H, F, Cl, Br, OH, CF3, NO2, OCF3, O-(C1-C6)алкил, (C1-C6)алкил, (C2-C6)алкенил, N(R57)(R58), SO2-CH3, CO(R65);which may optionally contain substituents selected from the group consisting of H, F, Cl, Br, OH, CF 3 , NO 2 , OCF 3 , O- (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkyl, (C 2 -C 6 ) alkenyl, N (R57) (R58), SO 2 -CH 3 , CO (R65); R57, R58, независимо друг от друга, представляют собой H, (C1-C8)алкил;R57, R58, independently of one another, are H, (C 1 -C 8 ) alkyl; R65, независимо друг от друга, представляют собой H, (C1-C8)алкил, арил;R65, independently of one another, are H, (C 1 -C 8 ) alkyl, aryl; K представляет собой связь, O, OCH2, CH2O, S, SO, SO2, N(R66), N(R67)CO, CON(R68), (C(R69)(R70))v, CO, С=С, C≡C, SCH2, SO2CH2;K is a bond, O, OCH 2, CH 2 O, S, SO, SO 2, N (R66), N ( R67) CO, CON (R68), (C (R69) (R70)) v, CO, C = C, C≡C, SCH 2 , SO 2 CH 2 ; v имеет значение 1, 2, 3, 4;v is 1, 2, 3, 4; R66, R67, R68, R69, R70, независимо друг от друга, представляют собой H, (C1-C8)алкил;R66, R67, R68, R69, R70, independently of one another, are H, (C 1 -C 8 ) alkyl; R11 представляет собой (C1-C8)алкил, (C1-C4)алкокси-(C1-C4)алкил, (С3-С8)алкенил, (С3-С8)алкинил, 3-10-членное моно-, би-, три- или спироциклическое кольцо, которое может содержать 0-4 гетероатома, выбранных из группы, включающей кислород, азот и серу, где указанная кольцевая система может быть дополнительно замещена F, Cl, Br, CF3, CN, (C1-C6)алкилом, O-(C1-C8)алкилом, (С1-С4)алкокси-(С1-С4)алкилом, гидрокси-(С1-С4)алкилом, (С0-С8)алкиленарилом, оксо, CO(R71), CON(R73)(R73), гидрокси, COO(R74), N(R75)CO(C1-C6)алкилом, N(R76)(R77) или SO2CH3;R11 is (C1-C8) alkyl, (C1-C4) alkoxy- (C1-C4) alkyl, (C 3 -C 8 ) alkenyl, (C 3 -C 8 ) alkynyl, 3-10 membered mono, a bi-, tri- or spirocyclic ring, which may contain 0-4 heteroatoms selected from the group comprising oxygen, nitrogen and sulfur, where said ring system may be further substituted by F, Cl, Br, CF 3 , CN, (C1- C6) alkyl, O- (C1-C8) alkyl, (C 1 -C 4 ) alkoxy- (C 1 -C 4 ) alkyl, hydroxy- (C 1 -C 4 ) alkyl, (C 0 -C 8 ) alkylene aryl oxo, CO (R71), CON (R73) (R73), hydroxy, COO (R74), N (R75) CO (C1-C6) alkyl, N (R76) (R77) or SO 2 CH 3 ; R71, R72, R73, R74, R75, R76, R77, независимо друг от друга, представляют собой H, (C1-C8)алкил; илиR71, R72, R73, R74, R75, R76, R77, independently of one another, are H, (C1-C8) alkyl; or R72 и R73, R76 и R77, независимо друг от друга, необязательно вместе с атомом азота, с которым они связаны, образуют 5-6-членное кольцо, которое, помимо атома азота, может также содержать 0-1 дополнительный гетероатом, выбранный из группы, включающей N-(C1-C6)алкил, кислород и серу, илиR72 and R73, R76 and R77, independently of each other, optionally together with the nitrogen atom to which they are bonded, form a 5-6 membered ring, which, in addition to the nitrogen atom, may also contain 0-1 additional heteroatoms selected from the group including N- (C1-C6) alkyl, oxygen and sulfur, or их N-оксиды и физиологически приемлемые соли.their N-oxides and physiologically acceptable salts. 6. Лекарственное средство, включающее одно или несколько соединений по пп.1-5.6. A medicine comprising one or more compounds according to claims 1-5. 7. Лекарственное средство, включающее одно или несколько соединений по пп.1-5 и один или несколько анорексически активных ингредиентов.7. A medicament comprising one or more compounds according to claims 1-5 and one or more anorexic active ingredients. 8. Соединение формулы (I) по пп.1-5 для применения в качестве лекарственного средства для профилактики и лечения ожирения.8. The compound of formula (I) according to claims 1-5 for use as a medicine for the prevention and treatment of obesity. 9. Соединение формулы (I) по пп.1-5 для применения в качестве лекарственного средства для профилактики и лечения диабета типа II.9. The compound of formula (I) according to claims 1-5 for use as a medicine for the prevention and treatment of type II diabetes. 10. Соединение формулы (I) по пп.1-5 в сочетании с по меньшей мере одним дополнительным анорексически активным ингредиентом для применения в качестве лекарственного средства для профилактики и лечения ожирения.10. The compound of formula (I) according to claims 1-5 in combination with at least one additional anorexic active ingredient for use as a medicament for the prevention and treatment of obesity. 11. Соединение формулы (I) по пп.1-5 в сочетании с по меньшей мере одним дополнительным анорексически активным ингредиентом для применения в качестве лекарственного средства для профилактики и лечения диабета типа II.11. The compound of formula (I) according to claims 1-5 in combination with at least one additional anorexic active ingredient for use as a medicament for the prevention and treatment of type II diabetes. 12. Способ получения лекарственного средства, включающего одно или несколько соединений формулы (I) по пп.1-5, который включает смешивание активного ингредиента с фармацевтически приемлемым носителем и преобразование полученной смеси в форму, подходящую для введения.12. A method for producing a medicament comprising one or more compounds of formula (I) according to claims 1-5, which comprises mixing the active ingredient with a pharmaceutically acceptable carrier and converting the resulting mixture into a form suitable for administration. 13. Применение соединения формулы (I) по пп.1-5 для получения лекарственного средства для снижения массы у млекопитающих.13. The use of the compounds of formula (I) according to claims 1-5 for the preparation of a medicament for weight loss in mammals. 14. Применение соединения формулы (I) по пп.1-5 для получения лекарственного средства для профилактики и лечения ожирения.14. The use of the compounds of formula (I) according to claims 1-5 for the manufacture of a medicament for the prevention and treatment of obesity. 15. Применение соединения формулы (I) по пп.1-5 для получения лекарственного средства для профилактики и лечения диабета типа II.15. The use of the compounds of formula (I) according to claims 1-5 for the manufacture of a medicament for the prevention and treatment of type II diabetes. 16. Применение соединения формулы (I) по пп.1-5 для получения лекарственного средства для лечения тревожности и других психиатрических показаний, для лечения расстройств, связанных с циркадным ритмом, и для лечения злоупотребления лекарственными средствами.16. The use of the compounds of formula (I) according to claims 1-5 for the manufacture of a medicament for the treatment of anxiety and other psychiatric indications, for the treatment of circadian rhythm disorders, and for the treatment of drug abuse. 17. Применение соединения формулы (I) по пп.1-5 для получения лекарственного средства, обладающего активностью антагониста МСН-рецептора.17. The use of the compounds of formula (I) according to claims 1-5 for the preparation of a medicament having an MCH receptor antagonist activity.
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Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
EP2251343A1 (en) 2003-05-15 2010-11-17 Arqule, Inc. Imidazothiazoles as p38-kinase-inhibitors
EP1867644B1 (en) * 2003-07-24 2009-05-20 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
EP1648879B1 (en) 2003-07-24 2008-10-22 Euro-Celtique S.A. Heteroaryl-tetrahydropyridyl compounds useful for treating or preventing pain
EP2426120A1 (en) * 2003-08-18 2012-03-07 Fujifilm Finechemicals Co., Ltd. Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them
US7592373B2 (en) 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
DE10360745A1 (en) * 2003-12-23 2005-07-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg New amide compounds having MCH antagonist activity and medicaments containing these compounds
DE102004003812A1 (en) * 2004-01-25 2005-08-11 Aventis Pharma Deutschland Gmbh Aryl-substituted heterocycles, methods of their preparation and their use as pharmaceuticals
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
WO2006010082A1 (en) * 2004-07-08 2006-01-26 Arqule, Inc. 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase
WO2006022442A1 (en) * 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. Novel heterocyclic amide derivatives having dihydroorotate dehydrogenase inhibiting activity
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
CN101084211A (en) * 2004-09-20 2007-12-05 泽农医药公司 Heterocyclic derivatives and their use as therapeutic agents
CA2582327A1 (en) * 2004-10-01 2006-04-13 Takao Suzuki 2-arylcarboxamide-nitrogeneous heterocycle compound
MX2007004661A (en) 2004-10-18 2007-06-22 Lilly Co Eli 1-(hetero)aryl-3-amino-pyrollidine derivatives for use as mglur3 receptor antagonists.
CA2584368A1 (en) 2004-10-19 2006-04-27 Arqule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
DE102004051277A1 (en) 2004-10-21 2006-04-27 Merck Patent Gmbh Heterocyclic carbonyl compounds
US8084492B2 (en) * 2004-11-19 2011-12-27 The New Industry Research Organization Benzofuran compound and pharmaceutical composition containing the same
EA012589B1 (en) 2004-12-30 2009-10-30 Янссен Фармацевтика Н.В. Derivatives of 4-(benzyl)piperazine carboxylic acid phenylamide and associated compounds as fatty acid amide hydrolase inhibitors for the treatment of anxiety, pain and other disorders
TWI444187B (en) * 2005-01-25 2014-07-11 Synta Pharmaceuticals Corp Thiophene compounds for inflammation and immune-related uses
AU2006298852A1 (en) 2005-09-30 2007-04-12 F. Hoffmann-La Roche Ag Indane derivatives as MCH receptor antagonists
CN101379060B (en) 2006-02-10 2012-05-23 转化技术制药公司 Benzoxazole Derivatives, Compositions and Methods of Use as Aurora Kinase Inhibitors
CA2636605A1 (en) * 2006-02-15 2007-08-23 Lothar Schwink Novel azacycly-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments
CA2636879A1 (en) * 2006-02-15 2007-08-23 Sanofi-Aventis Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments
AR059898A1 (en) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS
EP2009005A4 (en) * 2006-04-19 2010-06-02 Astellas Pharma Inc Azolecarboxamide derivative
SI2010528T1 (en) 2006-04-19 2018-02-28 Novartis Ag 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling
UA93548C2 (en) 2006-05-05 2011-02-25 Айерем Елелсі Compounds and compositions as hedgehog pathway modulators
US8278307B2 (en) 2006-05-08 2012-10-02 Ariad Pharmaceuticals, Inc. Monocyclic Heteroaryl compounds
KR20090018104A (en) * 2006-05-08 2009-02-19 어리어드 파마슈티칼스, 인코포레이티드 Acetylene Heteroaryl Compound
JP2010500300A (en) 2006-08-08 2010-01-07 サノフィ−アベンティス Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for their preparation, agents containing these compounds, and uses thereof
RU2009110254A (en) 2006-08-24 2010-09-27 Новартис АГ (CH) 2- (PYRAZIN-2-IL) THIAZOLE DERIVATIVES AND 2- (1H-PYRAZOL-3-IL) THYRAZOL AND COMPOUNDS CONNECTED WITH IT AS STEAROIL-SOA INHIBERATOUS AND SMOKE
PE20081368A1 (en) 2006-09-11 2008-11-19 Glaxo Group Ltd DERIVATIVES OF AZABICYCLE [4.1.0] HEPTANE AS INHIBITORS OF THE RECAPTATION OF SEROTONIN, DOPAMINE AND NOREPINEPHRINE
JP2010504362A (en) * 2006-09-25 2010-02-12 アレテ セラピューティクス， インコーポレイテッド Soluble epoxide hydrolase inhibitor
AR063311A1 (en) * 2006-10-18 2009-01-21 Novartis Ag ORGANIC COMPOUNDS
WO2008086014A2 (en) * 2007-01-09 2008-07-17 Amgen Inc. Bis-aryl amide derivatives useful for the treatment of cancer
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
GB0706793D0 (en) * 2007-04-05 2007-05-16 Evotec Ag Compounds
CN101678019B (en) * 2007-06-08 2016-03-30 詹森药业有限公司 Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine/Piperazine derivatives
AU2008258549B2 (en) 2007-06-08 2013-11-14 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
ES2483898T3 (en) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Piperidine / Piperazine Derivatives
TWI452044B (en) 2007-06-15 2014-09-11 Mitsubishi Tanabe Pharma Corp Morpholine derivative
TW200918521A (en) * 2007-08-31 2009-05-01 Astrazeneca Ab Heterocyclic amides and methods of use thereof
AU2008297877C1 (en) 2007-09-14 2013-11-07 Addex Pharma S.A. 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones
DE602008004794D1 (en) 2007-09-14 2011-03-10 Addex Pharmaceuticals Sa 1 ', 3'-DISUBSTITUTED 4-PHENYL-3,4,5,6-TETRAHYDRO-2H, 1'H-Ä1,4'-UPBIPYRIDINYL-2'-ONE
KR20100065191A (en) 2007-09-14 2010-06-15 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
HRP20110953T1 (en) * 2007-10-17 2012-01-31 Sanofi SUBSTITUTED N-PHENYLBIPYROLIDINKARBOXAMIDES AND THEIR USE IN THERAPY
NZ584691A (en) * 2007-10-17 2011-09-30 Sanofi Aventis Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators
PT2212283E (en) * 2007-10-17 2011-11-03 Sanofi Sa Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof
PL2215058T3 (en) * 2007-10-17 2012-04-30 Sanofi Sa Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof
KR101504787B1 (en) 2007-10-24 2015-03-20 아스테라스 세이야쿠 가부시키가이샤 Azolecarboxamide compound or salt thereof
US8785486B2 (en) 2007-11-14 2014-07-22 Janssen Pharmaceuticals, Inc. Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
EP2070925A1 (en) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft New 2-substituted tiazol-4-carboxylic acid derivatives, their manufacture and use as medicine
EP2070916A1 (en) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft 2-Arylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine
EP2070924A1 (en) 2007-12-10 2009-06-17 Bayer Schering Pharma Aktiengesellschaft New 2 hetarylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine
RU2364597C1 (en) * 2007-12-14 2009-08-20 Андрей Александрович Иващенко HETEROCYCLIC INHIBITORS OF Hh-SYGNAL CASCADE, BASED ON THEM MEDICINAL COMPOSITIONS AND METHOD OF TREATING DISEASES INDUCED BY ABBARANT ACTIVITY OF Hh-SIGNAL SYSTEM
ES2617619T3 (en) 2008-06-05 2017-06-19 Janssen Pharmaceutica, N.V. Drug combinations comprising a DGAT inhibitor and a PPAR agonist
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
CA2737699A1 (en) * 2008-09-16 2010-03-25 Merck Sharp & Dohme Corp. Phthalimide derivative metabotropic glutamate r4 ligands
JP2012006837A (en) * 2008-09-30 2012-01-12 Mochida Pharmaceut Co Ltd 2-indoleacrylamide analogue
CN102186477B (en) 2008-10-16 2013-07-17 奥梅-杨森制药有限公司 Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
AU2009314631B2 (en) 2008-11-12 2014-07-31 Takeda Pharmaceutical Company Limited Pyrazinopyrazines and derivatives as kinase inhibitors
CN102232074B (en) 2008-11-28 2014-12-03 奥梅-杨森制药有限公司 Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
AR074466A1 (en) * 2008-12-05 2011-01-19 Sanofi Aventis PIPERIDINE ESPIRO PIRROLIDINONA AND PIPERIDINONA REPLACED AND ITS THERAPEUTIC USE IN DISEASES MEDIATED BY THE MODULATION OF H3 RECEPTORS.
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
UA103918C2 (en) 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
JP5642661B2 (en) 2009-03-05 2014-12-17 塩野義製薬株式会社 Piperidine and pyrrolidine derivatives having NPYY5 receptor antagonistic activity
WO2010101247A1 (en) 2009-03-05 2010-09-10 塩野義製薬株式会社 Cyclohexane derivative having npy y5 receptor antagonism
WO2010130422A1 (en) 2009-05-12 2010-11-18 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
AR076861A1 (en) 2009-05-12 2011-07-13 Addex Pharma Sa DERIVATIVES OF 1,2,4-TRIAZOLO (4,3-A) PIRIDINE AND ITS USE AS POSITIVE ALOSTERIC MODULATORS OF MGLUR2 RECEIVERS
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
KR20120060207A (en) 2009-08-26 2012-06-11 사노피 Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011060026A1 (en) 2009-11-12 2011-05-19 Jansen Pharmaceutica Nv Piperazinecarboxamide derivative useful as a modulator of fatty acid amide hydrolase (faah)
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
UA108233C2 (en) 2010-05-03 2015-04-10 Fatty acid amide hydrolysis activity modulators
JP2013526529A (en) * 2010-05-11 2013-06-24 サノフイ Substituted N-heteroarylbipyrrolidinecarboxamides, their preparation and therapeutic use
EP2569280B1 (en) * 2010-05-11 2015-02-25 Sanofi Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
JP5833105B2 (en) * 2010-05-11 2015-12-16 サノフイ Substituted N-heteroaryl spirolactam bipyrrolidines, their preparation and therapeutic use
UY33469A (en) 2010-06-29 2012-01-31 Irm Llc Y Novartis Ag COMPOSITIONS AND METHODS TO MODULATE THE WNT SIGNALING ROAD
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
ES2552455T3 (en) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
CA2814998C (en) 2010-11-08 2019-10-29 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2766349B1 (en) 2011-03-08 2016-06-01 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120055A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120051A1 (en) 2011-03-08 2012-09-13 Sanofi Benzyl-oxathiazine derivates substituted with adamantane or noradamantane, medicaments containing said compounds and use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683702B1 (en) 2011-03-08 2014-12-24 Sanofi New substituted phenyl oxathiazine derivatives, method for their manufacture, medicines containing these compounds and their application
EP2683701B1 (en) 2011-03-08 2014-12-24 Sanofi Oxathiazine derivatives substituted with benzyl or heteromethylene groups, method for their preparation, their usage as medicament, medicament containing same and its use
WO2012120056A1 (en) 2011-03-08 2012-09-13 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120057A1 (en) 2011-03-08 2012-09-13 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
US8957093B2 (en) 2011-06-06 2015-02-17 The Scripps Research Institute N-biphenylmethylindole modulators of PPARG
WO2012170561A1 (en) * 2011-06-06 2012-12-13 The Scripps Research Institute (T.S.R.I.) N-benzylindole modulators of pparg
WO2013078240A1 (en) 2011-11-22 2013-05-30 Ripka Amy S N-biphenylmethylbenzimidazole modulators of pparg
US9102669B2 (en) 2011-12-06 2015-08-11 Janssen Pharmaceutica Nv Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors
WO2013085954A1 (en) 2011-12-06 2013-06-13 Janssen Pharmaceutica Nv Substituted piperidinyl-carboxamide derivatives useful as scd 1 inhibitors
WO2013170113A1 (en) * 2012-05-11 2013-11-14 Abbvie Inc. Nampt inhibitors
JP6293770B2 (en) * 2012-11-05 2018-03-14 ナント ホールディングス アイピー，エルエルシー Cyclic sulfonamide-containing derivatives as hedgehog signaling pathway inhibitors
AR094929A1 (en) 2013-02-28 2015-09-09 Bristol Myers Squibb Co DERIVATIVES OF PHENYLPIRAZOL AS POWERFUL INHIBITORS OF ROCK1 AND ROCK2
EP2961746B1 (en) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6, 7- dihydropyrazolu [5,1-a] pyrazine-4 (5 hands) -on compounds and their use as negative excretory regulators of Miglore 2 receptors.
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
SMT201900545T1 (en) 2014-01-21 2019-11-13 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
PH12019500127B1 (en) 2014-01-21 2022-05-04 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
WO2015161108A1 (en) 2014-04-16 2015-10-22 The Scripps Research Institute Pparg modulators for treatment of osteoporosis
RU2017104856A (en) * 2014-07-16 2018-08-16 Новоджен Лтд FUNCTIONALIZED AND SUBSTITUTED INDOLES AS ANTI-CANCER AGENTS
ES2838573T3 (en) 2014-08-21 2021-07-02 Bristol Myers Squibb Co Benzamide derivatives linked as potent ROCK inhibitors
CA2960274A1 (en) * 2014-09-10 2016-03-17 Epizyme, Inc. Isoxazole carboxamide compounds
EA201890330A1 (en) * 2015-08-28 2018-07-31 Гленмарк Фармасьютикалс С.А. NEW CARBOCYCLIC CONNECTIONS AS ROR-GAMMA MODULATORS
PT3430010T (en) 2016-03-17 2020-09-10 Hoffmann La Roche 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
CN108815167B (en) * 2017-05-24 2021-04-13 四川晶华生物科技有限公司 Application of compound in preparing medicine for treating tumor
TW202136238A (en) * 2020-01-06 2021-10-01 大陸商廣東東陽光藥業有限公司 ROR[gamma]T inhibitor, preparation method therefor and use thereof
WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof
CN115160269A (en) * 2021-04-02 2022-10-11 北京大学 Arylcarboxamide derivatives as positive allosteric modulators of NMDAR
CA3248924A1 (en) 2022-01-18 2023-07-27 Maze Therapeutics, Inc. Apol1 inhibitors and methods of use

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663336B1 (en) 1990-06-18 1992-09-04 Adir NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
PT788498E (en) * 1994-10-26 2002-02-28 Upjohn Co ANTIMICROBIAL COMPOUNDS OF PHENYLXAZOLIDINONE
CA2241567A1 (en) 1996-01-17 1997-07-24 Novo Nordisk A/S Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
KR100556067B1 (en) 1996-08-30 2006-03-07 노보 노르디스크 에이/에스 Glp-1 derivatives
IL127296A (en) 1996-12-31 2003-01-12 Reddy Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
DE19726167B4 (en) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, process for its preparation and pharmaceutical preparation containing it
RU2215004C2 (en) 1997-07-16 2003-10-27 Ново Нордиск А/С Condensed derivative of 1,2,4-thiadiazine, pharmaceutical composition and method for preparing medicine
CO4970713A1 (en) 1997-09-19 2000-11-07 Sanofi Synthelabo DERIVATIVES OF CARBOXAMIDOTIAZOLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
JP2001522836A (en) * 1997-11-07 2001-11-20 シェーリング コーポレイション Phenyl-alkyl-imidazoles as H3 receptor antagonists
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
DE19845405C2 (en) 1998-10-02 2000-07-13 Aventis Pharma Gmbh Aryl-substituted propanolamine derivatives and their use
AU3126700A (en) 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
GB9900416D0 (en) 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
MXPA01008142A (en) * 1999-02-10 2003-07-21 Welfide Corp Amide compounds and medicinal use thereof.
HUP0202214A3 (en) * 1999-04-09 2002-12-28 Astrazeneca Ab Adamantane derivatives, preparation and use thereof
EP1173438A1 (en) 1999-04-16 2002-01-23 Novo Nordisk A/S Substituted imidazoles, their preparation and use
CA2371271A1 (en) 1999-04-30 2000-11-09 Neurogen Corporation 9h-pyrimido[4,5-b]indole derivatives: crf1 specific ligands
GB9911863D0 (en) 1999-05-21 1999-07-21 Knoll Ag Therapeutic agents
SE9901875D0 (en) * 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds
DE60029446T2 (en) 1999-06-18 2007-02-08 Merck & Co., Inc. ARYLTHIAZOLIDEINDIONE AND ARYLOXAZOIDIDE DERIVATIVES
US6967201B1 (en) 1999-07-29 2005-11-22 Eli Lilly And Company Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists
CA2383781A1 (en) 1999-09-01 2001-03-08 Aventis Pharma Deutschland Gmbh Sulfonyl carboxamide derivatives, method for their production and their use as medicaments
WO2001083451A1 (en) 2000-04-28 2001-11-08 Asahi Kasei Kabushiki Kaisha Novel bicyclic compounds
WO2001085695A1 (en) 2000-05-11 2001-11-15 Bristol-Myers Squibb Co. Tetrahydroisoquinoline analogs useful as growth hormone secretagogues
WO2001091752A1 (en) 2000-05-30 2001-12-06 Merck & Co., Inc. Melanocortin receptor agonists
US6525202B2 (en) * 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
HUP0302918A2 (en) * 2000-07-17 2003-12-29 Ranbaxy Laboratories Limited Antimicrobial oxazolidinone derivatives, and pharmaceutical compositions containing the same and process for preparation of compounds
KR20030059084A (en) * 2000-07-31 2003-07-07 스미스크라인 비참 피.엘.시. Carboxamide compounds and their use as antagonists of a human 11cby receptor
JO2654B1 (en) * 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Polyarylcarboxamides useful as lipid lowering agents
JO2409B1 (en) * 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Biphenylcarboxamides useful as lipid lowering agents
JP2002338537A (en) * 2001-05-16 2002-11-27 Mitsubishi Pharma Corp Amide compounds and their pharmaceutical uses
WO2002098839A1 (en) * 2001-06-01 2002-12-12 Tanabe Seiyaku Co., Ltd. Biphenylcarboxamides and process for preparation thereof
WO2002098871A1 (en) * 2001-06-01 2002-12-12 Tanabe Seiyaku Co., Ltd. Phenylcarboxamides and process for preparation thereof
AU2002346048A1 (en) * 2001-06-07 2002-12-16 Merck And Co., Inc. Benzodiazepine bradykinin antagonists
DE10142734A1 (en) 2001-08-31 2003-03-27 Aventis Pharma Gmbh New (((oxazolylalkyl)-cycloalkyl)-alkyl)-benzoic acid derivatives, are peroxisome proliferator activated receptor agonists or antagonists used e.g. for treating lipid metabolism disorders, type II diabetes, syndrome X and obesity
KR20040097375A (en) * 2002-04-23 2004-11-17 시오노기 앤드 컴파니, 리미티드 Pyrazolo[1, 5-a]pyrimidine derivative and NAD(P)H oxidase inhibitor containing the same
JP2004175739A (en) * 2002-11-28 2004-06-24 Tanabe Seiyaku Co Ltd Pharmaceutical composition

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