RU2005104950A - Пробиотики для нервно-мышечной функции кишечника - Google Patents
Пробиотики для нервно-мышечной функции кишечника Download PDFInfo
- Publication number
- RU2005104950A RU2005104950A RU2005104950/13A RU2005104950A RU2005104950A RU 2005104950 A RU2005104950 A RU 2005104950A RU 2005104950/13 A RU2005104950/13 A RU 2005104950/13A RU 2005104950 A RU2005104950 A RU 2005104950A RU 2005104950 A RU2005104950 A RU 2005104950A
- Authority
- RU
- Russia
- Prior art keywords
- probiotic
- probiotics
- use according
- intestinal
- prevention
- Prior art date
Links
- 239000006041 probiotic Substances 0.000 title claims abstract 21
- 235000018291 probiotics Nutrition 0.000 title claims abstract 21
- 210000000936 intestine Anatomy 0.000 title claims 4
- 230000002232 neuromuscular Effects 0.000 title claims 2
- 239000000203 mixture Substances 0.000 claims abstract 10
- 239000003814 drug Substances 0.000 claims abstract 5
- 230000002265 prevention Effects 0.000 claims abstract 5
- 238000000855 fermentation Methods 0.000 claims abstract 2
- 230000004151 fermentation Effects 0.000 claims abstract 2
- 230000000529 probiotic effect Effects 0.000 claims 13
- 229940079593 drug Drugs 0.000 claims 4
- 235000013305 food Nutrition 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 230000000968 intestinal effect Effects 0.000 claims 3
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 3
- 244000052769 pathogen Species 0.000 claims 3
- 206010022678 Intestinal infections Diseases 0.000 claims 2
- 241000186605 Lactobacillus paracasei Species 0.000 claims 2
- 206010061296 Motor dysfunction Diseases 0.000 claims 2
- 238000010172 mouse model Methods 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000186000 Bifidobacterium Species 0.000 claims 1
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims 1
- 241001608472 Bifidobacterium longum Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims 1
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims 1
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 1
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 1
- 229940009289 bifidobacterium lactis Drugs 0.000 claims 1
- 229940009291 bifidobacterium longum Drugs 0.000 claims 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 1
- 229960002986 dinoprostone Drugs 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 208000018360 neuromuscular disease Diseases 0.000 claims 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000005856 abnormality Effects 0.000 abstract 2
- 208000004998 Abdominal Pain Diseases 0.000 abstract 1
- 208000002881 Colic Diseases 0.000 abstract 1
- 206010017999 Gastrointestinal pain Diseases 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (11)
1. Применение выбранного пробиотика или смеси выбранных пробиотиков для приготовления пищевой композиции или лекарственного средства для предупреждения или лечения боли кишечника или дискомфорта кишечника.
2. Применение выбранного пробиотика или смеси выбранных пробиотиков для приготовления пищевой композиции или лекарственного средства для предупреждения или лечения моторной дисфункции в кишечнике.
3. Применение выбранного пробиотика или смеси выбранных пробиотиков для приготовления пищевой композиции или лекарственного средства для предупреждения или лечения нервно-мышечных нарушений кишечника.
4. Применение выбранного пробиотика или смеси выбранных пробиотиков для приготовления пищевой композиции или лекарственного средства для предупреждения или лечения осложнений после инфекции кишечника.
5. Применение по любому из пп.1-3, где боль или дискомфорт кишечника, моторная дисфункция или нервно-мышечные нарушения обусловлены инфекциями кишечника патогенами.
6. Применение по любому из пп.1-4, в котором выбранный пробиотик является пробиотиком, который способен в мышиной модели действовать на индуцированную патогеном иммунную реакцию таким образом, что он значимо уменьшает количество высвобождаемых Th2 цитокинов.
7. Применение по любому из пп.1-4, в котором выбранный пробиотик является пробиотиком, который способен в мышиной модели действовать на индуцированное патогеном воспаление таким образом, что он значимо уменьшает экспрессию или концентрацию COX-2, TGF-β1 или PGE2 в продольной мышце мышечной оболочки кишечника.
8. Применение по любому из пп.1-4, в котором выбранным пробиотиком является Bifidobacterium.
9. Применение по любому из пп.1-4, в котором выбранным пробиотиком является Lactobacillus paracasei.
10. Применение по любому из пп.1-4, в котором пробиотик выбран из группы, состоящей из Bifidobacterium longum (CNCM I-2170), Bifidobacterium lactis (German Culture Collection: DSM20215), Lactobacillus paracasei (CNCM 1-2116, CNCM I-1292) и их смесей.
11. Применение по любому из пп.1-4, в котором этот пробиотик включает мертвые пробиотические бактерии, ферментационный субстрат и/или полученный из пробиотиков материал.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02078064A EP1384483A1 (en) | 2002-07-23 | 2002-07-23 | Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function |
| EP02078064.9 | 2002-07-23 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008132327/10A Division RU2490325C2 (ru) | 2002-07-23 | 2003-07-23 | Применение lactobacillus paracasei cncm i-2116 для лечения синдрома раздраженного кишечника |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005104950A true RU2005104950A (ru) | 2005-12-10 |
| RU2346036C2 RU2346036C2 (ru) | 2009-02-10 |
Family
ID=29797269
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008132327/10A RU2490325C2 (ru) | 2002-07-23 | 2003-07-23 | Применение lactobacillus paracasei cncm i-2116 для лечения синдрома раздраженного кишечника |
| RU2005104950/13A RU2346036C2 (ru) | 2002-07-23 | 2003-07-23 | Пробиотики для нервно-мышечной функции кишечника |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008132327/10A RU2490325C2 (ru) | 2002-07-23 | 2003-07-23 | Применение lactobacillus paracasei cncm i-2116 для лечения синдрома раздраженного кишечника |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8021656B2 (ru) |
| EP (2) | EP1384483A1 (ru) |
| JP (1) | JP2005538087A (ru) |
| KR (1) | KR20050025978A (ru) |
| CN (1) | CN100480370C (ru) |
| AT (1) | ATE534396T1 (ru) |
| AU (1) | AU2003250149B2 (ru) |
| BR (1) | BR0313185A (ru) |
| CA (1) | CA2493255A1 (ru) |
| ES (1) | ES2376664T3 (ru) |
| IL (1) | IL166442A0 (ru) |
| MX (1) | MXPA05000880A (ru) |
| NO (1) | NO20050896L (ru) |
| NZ (1) | NZ538335A (ru) |
| PT (1) | PT1531841E (ru) |
| RU (2) | RU2490325C2 (ru) |
| WO (1) | WO2004009103A1 (ru) |
| ZA (1) | ZA200501559B (ru) |
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|---|---|---|---|---|
| JP2006518191A (ja) * | 2003-01-09 | 2006-08-10 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | 細菌ワクチンベクターの免疫原性を強化するための組成物、方法、及びキット |
| US8192733B2 (en) | 2003-08-29 | 2012-06-05 | Cobb & Associates | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| US7749509B2 (en) * | 2003-08-29 | 2010-07-06 | Cobb And Company, Llp | Treatment of autism using probiotic composition |
| US7731976B2 (en) * | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
| US7759105B2 (en) * | 2003-08-29 | 2010-07-20 | Cobb & Company, Llp | Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions |
| MY143693A (en) | 2004-03-24 | 2011-06-30 | Nestec Sa | Shelf stable product wih living micro-organisms |
| PT2351492E (pt) * | 2005-02-28 | 2014-12-02 | Nutricia Nv | Composição nutricional com probióticos |
| EP1903894A1 (en) * | 2005-07-20 | 2008-04-02 | Unilever N.V. | Edible product containing beneficial moulds and/or yeasts |
| US8246946B2 (en) * | 2005-09-27 | 2012-08-21 | Cobb & Associates | Treatment of bipolar disorder utilizing anti-fungal compositions |
| WO2007093619A1 (en) | 2006-02-15 | 2007-08-23 | Nestec S.A. | Use of bifidobacterium longum for the prevention and treatment of inflammation |
| US9005682B2 (en) | 2006-03-07 | 2015-04-14 | Nestec S.A. | Synbiotic mixture |
| JP2009538342A (ja) * | 2006-05-26 | 2009-11-05 | ネステク ソシエテ アノニム | トウチ抽出物の使用方法及び栄養組成物 |
| CN101454440B (zh) | 2006-05-28 | 2013-05-29 | 西普拉梅德普罗研究与发展有限公司 | 益生菌株以及从其衍生的抗微生物肽 |
| US7374924B2 (en) * | 2006-06-05 | 2008-05-20 | Biogaia Ab | Use of selected lactic acid bacteria for reducing infantile colic |
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| PL2072053T3 (pl) * | 2007-12-21 | 2013-02-28 | Gervais Danone Sa | Sposób zmniejszania obwodu brzucha przez podawanie bakterii bifidobacterium |
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| TR201807143T4 (tr) | 2009-08-25 | 2018-06-21 | Nestec Sa | Bifidobacterium longum ve fonksiyonel gastrointestinal bozukluklar. |
| KR101840239B1 (ko) * | 2010-01-28 | 2018-03-20 | 에이비－바이오틱스, 에스.에이. | 장 염증의 치료에 사용하기 위한 프로바이오틱 조성물 |
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| US20130251829A1 (en) | 2012-03-23 | 2013-09-26 | Mead Johnson Nutrition Company | Probiotic derived non-viable material for infection prevention and treatment |
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| DE60231809D1 (ru) * | 2001-02-19 | 2009-05-14 | Nestle Sa | |
| PE20030283A1 (es) * | 2001-07-26 | 2003-05-01 | Alimentary Health Ltd | Cepas de lactobacillus casei |
| PE20030284A1 (es) * | 2001-07-26 | 2003-05-01 | Alimentary Health Ltd | Cepas de bifidobacterium |
| US20040208863A1 (en) * | 2003-01-30 | 2004-10-21 | James Versalovic | Anti-inflammatory activity from lactic acid bacteria |
-
2002
- 2002-07-23 EP EP02078064A patent/EP1384483A1/en not_active Withdrawn
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2003
- 2003-07-23 MX MXPA05000880A patent/MXPA05000880A/es active IP Right Grant
- 2003-07-23 KR KR1020057001239A patent/KR20050025978A/ko not_active Ceased
- 2003-07-23 PT PT03765107T patent/PT1531841E/pt unknown
- 2003-07-23 NZ NZ538335A patent/NZ538335A/en unknown
- 2003-07-23 EP EP03765107A patent/EP1531841B1/en not_active Revoked
- 2003-07-23 CA CA002493255A patent/CA2493255A1/en not_active Abandoned
- 2003-07-23 AU AU2003250149A patent/AU2003250149B2/en not_active Ceased
- 2003-07-23 IL IL16644203A patent/IL166442A0/xx unknown
- 2003-07-23 US US10/522,295 patent/US8021656B2/en not_active Expired - Fee Related
- 2003-07-23 ES ES03765107T patent/ES2376664T3/es not_active Expired - Lifetime
- 2003-07-23 AT AT03765107T patent/ATE534396T1/de active
- 2003-07-23 JP JP2004522568A patent/JP2005538087A/ja not_active Withdrawn
- 2003-07-23 RU RU2008132327/10A patent/RU2490325C2/ru not_active IP Right Cessation
- 2003-07-23 BR BR0313185-8A patent/BR0313185A/pt not_active Application Discontinuation
- 2003-07-23 RU RU2005104950/13A patent/RU2346036C2/ru not_active IP Right Cessation
- 2003-07-23 WO PCT/EP2003/008076 patent/WO2004009103A1/en not_active Ceased
- 2003-07-23 CN CNB038200031A patent/CN100480370C/zh not_active Expired - Fee Related
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2005
- 2005-02-18 NO NO20050896A patent/NO20050896L/no not_active Application Discontinuation
- 2005-02-22 ZA ZA200501559A patent/ZA200501559B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0313185A (pt) | 2005-06-21 |
| NZ538335A (en) | 2007-04-27 |
| ES2376664T3 (es) | 2012-03-15 |
| RU2008132327A (ru) | 2010-02-10 |
| AU2003250149A1 (en) | 2004-02-09 |
| EP1531841B1 (en) | 2011-11-23 |
| IL166442A0 (en) | 2006-01-15 |
| CA2493255A1 (en) | 2004-01-29 |
| ATE534396T1 (de) | 2011-12-15 |
| JP2005538087A (ja) | 2005-12-15 |
| MXPA05000880A (es) | 2006-01-24 |
| CN100480370C (zh) | 2009-04-22 |
| RU2346036C2 (ru) | 2009-02-10 |
| US20070128178A1 (en) | 2007-06-07 |
| NO20050896L (no) | 2005-04-18 |
| AU2003250149B2 (en) | 2009-01-22 |
| WO2004009103A1 (en) | 2004-01-29 |
| EP1531841A1 (en) | 2005-05-25 |
| EP1384483A1 (en) | 2004-01-28 |
| ZA200501559B (en) | 2006-05-31 |
| PT1531841E (pt) | 2012-02-01 |
| RU2490325C2 (ru) | 2013-08-20 |
| CN1678329A (zh) | 2005-10-05 |
| US8021656B2 (en) | 2011-09-20 |
| KR20050025978A (ko) | 2005-03-14 |
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