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RU2003128961A - METHOD FOR PRODUCING POLYESTERS WITH FREE ACID FUNCTIONS INSIDE CHAINS - Google Patents

METHOD FOR PRODUCING POLYESTERS WITH FREE ACID FUNCTIONS INSIDE CHAINS Download PDF

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Publication number
RU2003128961A
RU2003128961A RU2003128961/04A RU2003128961A RU2003128961A RU 2003128961 A RU2003128961 A RU 2003128961A RU 2003128961/04 A RU2003128961/04 A RU 2003128961/04A RU 2003128961 A RU2003128961 A RU 2003128961A RU 2003128961 A RU2003128961 A RU 2003128961A
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RU
Russia
Prior art keywords
lactide
lactic acid
acid
chain
polyester
Prior art date
Application number
RU2003128961/04A
Other languages
Russian (ru)
Other versions
RU2282638C2 (en
Inventor
Жан-Бернар КАЗО (FR)
Жан-Бернар Казо
Шарль БРИГАТИ (FR)
Шарль БРИГАТИ
Александр ЛУШКОФФ (FR)
Александр ЛУШКОФФ
Original Assignee
Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.) (Fr)
Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.) (Fr), Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.) filed Critical Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.) (Fr)
Publication of RU2003128961A publication Critical patent/RU2003128961A/en
Application granted granted Critical
Publication of RU2282638C2 publication Critical patent/RU2282638C2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

The invention relates to a method for preparing polyesters A containing several mid-chain free acid functions by ring-opening polymerisation in the presence of a chain initiator: the benzyl diester of the tartaric acid, the phenyl radical of which is optionally substituted. A: aliphatic based on cyclic esters such as lactides and glycolides.

Claims (6)

1. Способ получения сложных полиэфиров, содержащих несколько функций свободной кислоты при расположении кислот в середине цепи, посредством полимеризации с раскрытием кольца в присутствии инициатора цепи: бензилового сложного диэфира винной кислоты, фенильный радикал которой необязательно замещен.1. A method for producing polyesters containing several free acid functions when the acids are located in the middle of the chain, by ring opening polymerization in the presence of a chain initiator: a benzyl tartaric acid diester, the phenyl radical of which is optionally substituted. 2. Способ по п. 1, отличающийся тем, что сложный полиэфир основан на одном из следующих соединений: L-молочная кислота, D-молочная кислота, DL-молочная кислота, ε-капролактон, п-диоксанон, ε-капроновая кислота, алкилен оксалат, циклоалкилен оксалат, алкилен сукцинат, β-гидроксибутират, замещенный или незамещенный триметиленкарбонат, 1,5-диоксепан-2-он, 1,4-диоксепан-2-он, гликолид, гликолевая кислота, L-лактид, D-лактид, DL-лактид, мезо-лактид; и все оптически активные изомеры, рацематы или сополимеры последнего.2. The method according to p. 1, characterized in that the polyester is based on one of the following compounds: L-lactic acid, D-lactic acid, DL-lactic acid, ε-caprolactone, p-dioxanone, ε-caproic acid, alkylene oxalate, cycloalkylene oxalate, alkylene succinate, β-hydroxybutyrate, substituted or unsubstituted trimethylene carbonate, 1,5-dioxepan-2-one, 1,4-dioxepan-2-one, glycolide, glycolic acid, L-lactide, D-lactide, DL-lactide, meso-lactide; and all optically active isomers, racemates or copolymers of the latter. 3. Способ по п. 1, отличающийся тем, что сложный полиэфир основан на одном из следующих соединений: L-молочная кислота, D-молочная кислота, DL-молочная кислота, ε-капролактон, п-диоксанон, ε-капроновая кислота, замещенный или незамещенный триметиленкарбонат, гликолид, гликолевая кислота, L-лактид, D-лактид, DL-лактид, мезо-лактид; и все оптически активные изомеры, рацематы или сополимеры последнего.3. The method according to p. 1, characterized in that the polyester is based on one of the following compounds: L-lactic acid, D-lactic acid, DL-lactic acid, ε-caprolactone, p-dioxanone, ε-caproic acid, substituted or unsubstituted trimethylene carbonate, glycolide, glycolic acid, L-lactide, D-lactide, DL-lactide, meso-lactide; and all optically active isomers, racemates or copolymers of the latter. 4. Способ по п. 3, отличающийся тем, что сложный полиэфир основан на одном из следующих соединений: L-молочная кислота, D-молочная кислота, DL-молочная кислота, гликолид, гликолевая кислота, L-лактид, D-лактид, DL-лактид, мезо-лактид; и все оптически активные изомеры, рацематы или сополимеры последнего.4. The method according to p. 3, characterized in that the polyester is based on one of the following compounds: L-lactic acid, D-lactic acid, DL-lactic acid, glycolide, glycolic acid, L-lactide, D-lactide, DL -lactide, meso-lactide; and all optically active isomers, racemates or copolymers of the latter. 5. Способ по одному из предыдущих пунктов, отличающийся тем, что инициатор цепи представляет бензиловый сложный диэфир винной кислоты.5. The method according to one of the preceding paragraphs, characterized in that the initiator of the chain is a benzyl complex diester of tartaric acid. 6. Способ по одному из предыдущих пунктов, включающий: получение сложного полиэфира посредством полимеризации с раскрытием кольца в присутствии инициатора цепи; удаление защитной группы с карбоксильных функций инициатора цепи.6. The method according to one of the preceding paragraphs, including: obtaining a complex polyester by polymerization with ring opening in the presence of a chain initiator; removal of the protective group from the carboxyl functions of the chain initiator.
RU2003128961/04A 2001-02-27 2002-02-22 Method for production of polyesters having free acid function within chain RU2282638C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR01/02630 2001-02-27
FR0102630A FR2821360B1 (en) 2001-02-27 2001-02-27 PROCESS FOR THE PREPARATION OF POLYESTERS WITH INTRACATENARY FREE ACID FUNCTIONS

Publications (2)

Publication Number Publication Date
RU2003128961A true RU2003128961A (en) 2005-03-10
RU2282638C2 RU2282638C2 (en) 2006-08-27

Family

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RU2003128961/04A RU2282638C2 (en) 2001-02-27 2002-02-22 Method for production of polyesters having free acid function within chain

Country Status (12)

Country Link
US (1) US7094862B2 (en)
EP (1) EP1366105B1 (en)
JP (1) JP4106271B2 (en)
AT (1) ATE302228T1 (en)
CA (1) CA2437520C (en)
DE (1) DE60205594T2 (en)
DK (1) DK1366105T3 (en)
ES (1) ES2246388T3 (en)
FR (1) FR2821360B1 (en)
NO (1) NO330434B1 (en)
RU (1) RU2282638C2 (en)
WO (1) WO2002068499A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1367080A1 (en) 2002-05-29 2003-12-03 Hycail B.V. Hyperbranched poly(hydroxycarboxylic acid) polymers
US9180229B2 (en) * 2005-05-19 2015-11-10 Ethicon, Inc. Antimicrobial polymer compositions and the use thereof
US9149558B2 (en) 2005-05-19 2015-10-06 Ethicon, Inc. Antimicrobial polymer compositions and the use thereof
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
RU2355694C2 (en) * 2007-04-20 2009-05-20 Игорь Леонидович Федюшкин Polylactide obtainment catalyst and method of its synthesis
WO2010012770A1 (en) * 2008-07-31 2010-02-04 Purac Biochem Bv Process for the continuous production of polyesters
US8501875B2 (en) 2010-10-28 2013-08-06 Covidien Lp Surface induced ring-opening polymerization and medical devices formed therefrom
HUE025611T2 (en) * 2011-02-18 2016-03-29 Sulzer Chemtech Ag A method for producing polyhydroxy carboxylic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1507766A1 (en) * 1986-11-10 1989-09-15 Предприятие П/Я В-8469 Method of producing poly-caprolactonepolyols
SU1685952A1 (en) * 1989-04-12 1991-10-23 Предприятие П/Я А-7629 Method for preparation of complex polyesters
IL126422A (en) * 1996-04-23 2004-02-19 Kinerton Ltd Biodegradable acidic polylactic polymers and methods for their preparation
US6867181B1 (en) * 1997-06-02 2005-03-15 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
ES2234325T3 (en) * 1998-12-15 2005-06-16 Takeda Pharmaceutical Company Limited PROCEDURE TO PRODUCE BIODEGRADABLE POLYESTERS.

Also Published As

Publication number Publication date
RU2282638C2 (en) 2006-08-27
DK1366105T3 (en) 2005-12-27
JP4106271B2 (en) 2008-06-25
NO330434B1 (en) 2011-04-11
JP2004533494A (en) 2004-11-04
WO2002068499A1 (en) 2002-09-06
NO20033783D0 (en) 2003-08-26
DE60205594D1 (en) 2005-09-22
ATE302228T1 (en) 2005-09-15
NO20033783L (en) 2003-08-26
ES2246388T3 (en) 2006-02-16
US20040127676A1 (en) 2004-07-01
EP1366105A1 (en) 2003-12-03
FR2821360A1 (en) 2002-08-30
US7094862B2 (en) 2006-08-22
EP1366105B1 (en) 2005-08-17
CA2437520C (en) 2011-08-30
CA2437520A1 (en) 2002-09-06
DE60205594T2 (en) 2006-05-18
FR2821360B1 (en) 2003-05-30

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Effective date: 20130223