RU2003107668A - Новое оксабиспидиновое соединение, полезное при лечении сердечных аритмий - Google Patents
Новое оксабиспидиновое соединение, полезное при лечении сердечных аритмий Download PDFInfo
- Publication number
- RU2003107668A RU2003107668A RU2003107668/04A RU2003107668A RU2003107668A RU 2003107668 A RU2003107668 A RU 2003107668A RU 2003107668/04 A RU2003107668/04 A RU 2003107668/04A RU 2003107668 A RU2003107668 A RU 2003107668A RU 2003107668 A RU2003107668 A RU 2003107668A
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- compound according
- arrhythmia
- oxa
- diazabicyclo
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Claims (10)
1. Соль 4-({3-[7-(3,3-диметил-2-оксобутил)-9-окса-3,7-диазабицикло-[3.3.1]нон-3-ил]пропил}амино)бензонитрила с бензолсульфоновой кислотой.
2. Моногидрат соли 4-({3-[7-(3,3-диметил-2-оксобутил)-9-окса-3,7-диазабицикло[3.3.1]нон-3-ил]пропил}амино)бензонитрила с бензолсульфоновой кислотой.
3. Фармацевтический препарат, включающий в себя соединение по п.1 или 2, в смеси с фармацевтически приемлемым адъювантом, разбавителем или носителем.
4. Фармацевтический препарат для применения при профилактике или лечении аритмии, содержащий соединение по п.1 или 2.
5. Соединение по п.1 или 2 для применения в качестве фармацевтического препарата.
6. Соединение по п.1 или 2 для применения при профилактике или лечении аритмии.
7. Применение соединения по п.1 или п.2 в качестве активного ингредиента для производства лекарства для применения при профилактике или лечении аритмии.
8. Применение по п.7, где аритмия представляет собой предсердную или желудочковую аритмию.
9. Способ профилактики или лечения аритмии, при котором субъекту, страдающему от такого состояния или подверженному такому состоянию, вводят терапевтически эффективное количество соединения по п.1 или 2.
10. Способ получения соединения по п.1 или 2, при котором:
а) осуществляют взаимодействие бензолсульфоновой кислоты с 4-({3-[7-(3,3-диметил-2-оксобутил)-9-окса-3,7-диазабицикло[3.3.1]нон-3-ил]пропил}-амино)бензонитрилом; или б) осуществляют взаимодействие 3-(4-цианоанилино)пропилбензол-сульфоната с 3,3-диметил-1-(9-окса-3,7-диазабицикло[3.3.1]нон-3-ил)-2-бутаноном.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PH12000002701 | 2000-10-02 | ||
| PH1-2000-02701 | 2000-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2003107668A true RU2003107668A (ru) | 2004-11-27 |
Family
ID=52573779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003107668/04A RU2003107668A (ru) | 2000-10-02 | 2001-10-01 | Новое оксабиспидиновое соединение, полезное при лечении сердечных аритмий |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US6936712B1 (ru) |
| EP (3) | EP1900741A1 (ru) |
| JP (2) | JP4248873B2 (ru) |
| KR (2) | KR20030032060A (ru) |
| CN (3) | CN1243754C (ru) |
| AR (1) | AR030756A1 (ru) |
| AU (3) | AU2001292504B2 (ru) |
| BR (2) | BR0114366A (ru) |
| CA (2) | CA2421776A1 (ru) |
| CZ (1) | CZ294217B6 (ru) |
| EE (1) | EE200300131A (ru) |
| HU (1) | HUP0302288A3 (ru) |
| IL (3) | IL154802A0 (ru) |
| IS (1) | IS6744A (ru) |
| MX (2) | MXPA03002759A (ru) |
| NO (2) | NO20031413L (ru) |
| NZ (2) | NZ524574A (ru) |
| PL (1) | PL364047A1 (ru) |
| RU (1) | RU2003107668A (ru) |
| SK (1) | SK3862003A3 (ru) |
| WO (2) | WO2002028863A1 (ru) |
| ZA (2) | ZA200301757B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903759D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
| GB0223712D0 (en) * | 2002-10-14 | 2002-11-20 | Astrazeneca Ab | Chemical intermediate |
| SE0401539D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| SE0401540D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| AR057064A1 (es) | 2005-06-13 | 2007-11-14 | Astrazeneca Ab | Compuestos para el tratamiento de arritmias cardiacas, formulacion farmaceutica y preparacion del compuesto |
| BRPI0611839A2 (pt) * | 2005-06-20 | 2016-08-30 | Astrazeneca Ab | processos para a preparação de um sal de ácido sulfônico e para a preparação de um composto, e, mistura |
| US20100160626A1 (en) * | 2005-06-20 | 2010-06-24 | Astrazeneca Ab | Process For The Preparation Of 3,7-Dihydroxy-1,5-Diazacyclooctanes |
| AR053901A1 (es) * | 2005-06-20 | 2007-05-23 | Astrazeneca Ab | Formas fisicas de oxabispidinas n,n'- disustituidas |
| AU2006259938B2 (en) * | 2005-06-20 | 2010-07-01 | Astrazeneca Ab | Process for the preparation of sulfonic acid salts of oxabispidines |
| CN103319423B (zh) * | 2013-06-28 | 2015-10-28 | 江苏师范大学 | 一种3,7-双芳基-1,5-二氧-3,7-二氮杂环辛烷的合成方法 |
| KR20150082070A (ko) | 2014-01-06 | 2015-07-15 | (주)신비넷 | 위치 인식 시스템 및 그 시스템에서의 위치 인식을 위한 장치 및 방법 |
| EP3059229A1 (en) | 2015-02-17 | 2016-08-24 | Evonik Degussa GmbH | Method for the epoxidation of an olefin with hydrogen peroxide |
| CN115054728B (zh) * | 2022-07-18 | 2023-11-07 | 中国科学院大学宁波华美医院 | 一种仿生骨组织工程支架材料及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3503939A (en) * | 1967-03-29 | 1970-03-31 | Du Pont | Polyamides from heterocyclic diamines |
| DE2428792A1 (de) * | 1974-06-14 | 1976-01-02 | Knoll Ag | Neue antiarrhythmika |
| DE3112055A1 (de) * | 1981-03-27 | 1982-10-07 | Basf Ag, 6700 Ludwigshafen | Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel |
| DE3234697A1 (de) * | 1982-09-18 | 1984-03-22 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Neue diazabicyclo-(3,3,1)-nonane |
| DE3732094A1 (de) * | 1987-09-24 | 1989-04-06 | Basf Ag | Bispidinderivate als klasse iii-antiarrhythmika |
| DE3902357A1 (de) | 1989-01-27 | 1990-08-02 | Hoechst Ag | Verwendung von rheniumorganischen verbindungen zur oxidation von c-c-mehrfachbindungen, darauf basierende oxidationsverfahren und neue rheniumorganische verbindungen |
| US5140033A (en) * | 1989-04-03 | 1992-08-18 | Bayer Aktiengesellschaft | Antibacterial 5-alkylquinolonecarboxylic acids |
| US5110933A (en) | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
| US5468858A (en) * | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
| US5831099A (en) | 1995-03-10 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Army | Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same |
| US5939568A (en) | 1997-01-31 | 1999-08-17 | The Scripps Research Institute | Accelerated catalysis of olefinic epoxidations |
| SE9704709D0 (sv) * | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
| WO2000061569A1 (en) * | 1999-04-09 | 2000-10-19 | Astrazeneca Ab | Adamantane derivatives |
| AUPQ274199A0 (en) | 1999-09-09 | 1999-09-30 | Ericsson Australia Pty Ltd | Information transmission rate control across a core network |
| SE9903759D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
| GB0223712D0 (en) * | 2002-10-14 | 2002-11-20 | Astrazeneca Ab | Chemical intermediate |
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2001
- 2001-09-18 AR ARP010104406A patent/AR030756A1/es unknown
- 2001-10-01 MX MXPA03002759A patent/MXPA03002759A/es active IP Right Grant
- 2001-10-01 IL IL15480201A patent/IL154802A0/xx unknown
- 2001-10-01 NZ NZ524574A patent/NZ524574A/en unknown
- 2001-10-01 AU AU2001292504A patent/AU2001292504B2/en not_active Ceased
- 2001-10-01 IL IL15480301A patent/IL154803A0/xx active IP Right Grant
- 2001-10-01 JP JP2002532447A patent/JP4248873B2/ja not_active Expired - Fee Related
- 2001-10-01 SK SK386-2003A patent/SK3862003A3/sk not_active Application Discontinuation
- 2001-10-01 BR BR0114366-2A patent/BR0114366A/pt not_active IP Right Cessation
- 2001-10-01 US US10/381,900 patent/US6936712B1/en not_active Expired - Fee Related
- 2001-10-01 CZ CZ2003923A patent/CZ294217B6/cs not_active IP Right Cessation
- 2001-10-01 PL PL01364047A patent/PL364047A1/xx not_active Application Discontinuation
- 2001-10-01 BR BR0114367-0A patent/BR0114367A/pt not_active IP Right Cessation
- 2001-10-01 EP EP07121849A patent/EP1900741A1/en not_active Withdrawn
- 2001-10-01 AU AU2001292503A patent/AU2001292503A1/en not_active Abandoned
- 2001-10-01 KR KR10-2003-7004638A patent/KR20030032060A/ko not_active Withdrawn
- 2001-10-01 KR KR1020037004639A patent/KR100812920B1/ko not_active Expired - Fee Related
- 2001-10-01 EE EEP200300131A patent/EE200300131A/xx unknown
- 2001-10-01 CA CA002421776A patent/CA2421776A1/en not_active Abandoned
- 2001-10-01 US US10/398,171 patent/US20040039199A1/en not_active Abandoned
- 2001-10-01 EP EP01972865A patent/EP1330461A1/en not_active Withdrawn
- 2001-10-01 CN CNB018167225A patent/CN1243754C/zh not_active Expired - Fee Related
- 2001-10-01 AU AU9250401A patent/AU9250401A/xx active Pending
- 2001-10-01 CA CA002422810A patent/CA2422810A1/en not_active Abandoned
- 2001-10-01 EP EP01972866A patent/EP1330462A1/en not_active Withdrawn
- 2001-10-01 WO PCT/SE2001/002129 patent/WO2002028863A1/en not_active Ceased
- 2001-10-01 WO PCT/SE2001/002130 patent/WO2002028864A1/en not_active Ceased
- 2001-10-01 CN CNA2005100035779A patent/CN1793146A/zh active Pending
- 2001-10-01 CN CNA018167217A patent/CN1468244A/zh active Pending
- 2001-10-01 MX MXPA03002679A patent/MXPA03002679A/es not_active Application Discontinuation
- 2001-10-01 HU HU0302288A patent/HUP0302288A3/hu unknown
- 2001-10-01 NZ NZ524573A patent/NZ524573A/en unknown
- 2001-10-01 JP JP2002532446A patent/JP2004510775A/ja active Pending
- 2001-10-01 RU RU2003107668/04A patent/RU2003107668A/ru not_active Application Discontinuation
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2003
- 2003-03-03 ZA ZA200301757A patent/ZA200301757B/en unknown
- 2003-03-06 IL IL154803A patent/IL154803A/en not_active IP Right Cessation
- 2003-03-13 IS IS6744A patent/IS6744A/is unknown
- 2003-03-18 ZA ZA200302202A patent/ZA200302202B/en unknown
- 2003-03-27 NO NO20031413A patent/NO20031413L/no not_active Application Discontinuation
- 2003-03-27 NO NO20031414A patent/NO20031414L/no not_active Application Discontinuation
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2005
- 2005-03-25 US US11/089,325 patent/US7439355B2/en not_active Expired - Fee Related
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2008
- 2008-09-15 US US12/232,293 patent/US20090036675A1/en not_active Abandoned
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2009
- 2009-03-06 US US12/382,068 patent/US20090240051A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20051208 |