RU2002114343A - Новые соединения - Google Patents
Новые соединенияInfo
- Publication number
- RU2002114343A RU2002114343A RU2002114343/04A RU2002114343A RU2002114343A RU 2002114343 A RU2002114343 A RU 2002114343A RU 2002114343/04 A RU2002114343/04 A RU 2002114343/04A RU 2002114343 A RU2002114343 A RU 2002114343A RU 2002114343 A RU2002114343 A RU 2002114343A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- formula
- compound according
- therapy
- methyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 25
- 238000002560 therapeutic procedure Methods 0.000 claims abstract 6
- -1 (2) pyridinyl (3) thiophenyl (4) furanyl Chemical group 0.000 claims 4
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 4
- DOIULWAXABFBTR-UHFFFAOYSA-N 4-[(4-benzylpiperazin-1-yl)-(2,2-dimethyl-3h-1-benzofuran-7-yl)methyl]-n,n-diethylbenzamide;dihydrochloride Chemical compound Cl.Cl.C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=2OC(C)(C)CC=2C=CC=1)N1CCN(CC=2C=CC=CC=2)CC1 DOIULWAXABFBTR-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- LKPYPAVGPHAAHH-UHFFFAOYSA-N 4-[(2,2-dimethyl-3h-1-benzofuran-7-yl)-[4-(pyridin-3-ylmethyl)piperazin-1-yl]methyl]-n,n-diethylbenzamide;dihydrochloride Chemical compound Cl.Cl.C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=2OC(C)(C)CC=2C=CC=1)N1CCN(CC=2C=NC=CC=2)CC1 LKPYPAVGPHAAHH-UHFFFAOYSA-N 0.000 claims 2
- NGKCOTPJDXSDEZ-UHFFFAOYSA-N 4-[(2,2-dimethyl-3h-1-benzofuran-7-yl)-[4-[(4-iodophenyl)methyl]piperazin-1-yl]methyl]-n,n-diethylbenzamide;dihydrochloride Chemical compound Cl.Cl.C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=2OC(C)(C)CC=2C=CC=1)N1CCN(CC=2C=CC(I)=CC=2)CC1 NGKCOTPJDXSDEZ-UHFFFAOYSA-N 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- FMCIHHDGUHXTQG-UHFFFAOYSA-N 4-[(2,2-dimethyl-3h-1-benzofuran-7-yl)-[4-(pyridin-2-ylmethyl)piperazin-1-yl]methyl]-n,n-diethylbenzamide;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=2OC(C)(C)CC=2C=CC=1)N1CCN(CC=2N=CC=CC=2)CC1 FMCIHHDGUHXTQG-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical class [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical class [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 210000002820 sympathetic nervous system Anatomy 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Furan Compounds (AREA)
- Valve-Gear Or Valve Arrangements (AREA)
- Liquid Crystal (AREA)
Claims (18)
1. Соединение формулы
где R1 выбран из (1) фенила; (2) пиридинила
(3) тиофенила
(4) фуранила
(5) имидазолила
(6) триазолилиа
где каждое фенильное кольцо R1 и гетероароматическое кольцо R1 может быть возможно и независимо дополнительно замещено 1, 2 или 3 заместителями, выбранными из прямого и разветвленного C1-С6алкила, NO2, CF3, C1-С6алкокси, хлоро, фторо, бромо и йодо, замещения на фенильном кольце и на гетероароматическом кольце могут иметь место в любом положении на указанных кольцевых системах,
а также его фармацевтически приемлемые соли и его изомеры.
2. Соединение по п.1, где возможный(ые) заместитель(ли) на ароматическом или гетероароматическом кольце(ах) выбран(ы) любой из NO2, изобутила, CF3, метокси, метила или хлоро.
3. Соединение по п.1 или 2, выбранное из любого из
4-[(4-бензил-1-пиперазинил)(2,2-диметил-2,3-дигидро-1-бензофуран-7-ил)метил]-N,N-диэтилбензамида дигидрохлорида (соединение 6);
4-{(2,2-диметил-2,3-дигидро-1-бензофуран-7-ил)[4-(4-йодбензил)-1-пиперазинил]метил}-N,N-диэтилбензамида дигидрохлорида (соединение 7);
4-{(2,2-диметил-2,3-дигидро-1-бензофуран-7-ил)[4-(3-пиридинилметил)-1-пиперазинил]метил}-N,N-диэтилбензамида дигидрохлорида (соединение 8) и
4-{(2,2-диметил-2,3-дигидро-1-бензофуран-7-ил)[4-(2-пиридинилметил)-1-пиперазинил]метил}-N,N-диэтилбензамида дитрифторацетата (соединение 9).
4. Соединение по любому из пп.1-3, которое находится в виде (+)-энантиомера.
5. Соединение по любому из пп.1-3, которое находится в виде (-)-энантиомера.
6. Соединение по любому из пп.1-5 в форме его солей гидрохлорида, сульфата, тартрата или цитрата.
7. Соединение по любому из пп.1-6 для применения в терапии.
8. Соединение по п.7, где терапия представляет собой устранение боли.
9. Соединение по п.7, где терапия направлена на желудочно-кишечные расстройства.
10. Соединение по п.7, где терапия направлена на повреждения спинного мозга.
11. Соединение по п.7, где терапия направлена на расстройства симпатической нервной системы.
12. Применение соединения формулы I по п.1 для производства лекарства для применения при лечении боли.
13. Применение соединения формулы I по п.1 для производства лекарства для применения при лечении желудочно-кишечных расстройств.
14. Применение соединения формулы I по п.1 для производства лекарства для применения при лечении повреждений спинного мозга.
15. Фармацевтическая композиция, содержащая соединение формулы I по п.1 в качестве активного ингредиента вместе с фармакологически и фармацевтически приемлемым носителем.
16. Способ лечения боли, при котором субъекту, нуждающемуся в устранении боли, вводят эффективное количество соединения формулы I по п.1.
17. Способ лечения желудочно-кишечных расстройств, при котором субъекту, страдающему указанным желудочно-кишечным расстройством, вводят эффективное количество соединения формулы I по п.1.
18. Способ лечения повреждений спинного мозга, при котором субъекту, страдающему указанным повреждением спинного мозга, вводят эффективное количество соединения формулы I по п.1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904674-0 | 1999-12-20 | ||
| SE9904674A SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002114343A true RU2002114343A (ru) | 2004-01-10 |
| RU2258703C2 RU2258703C2 (ru) | 2005-08-20 |
Family
ID=20418210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002114343/04A RU2258703C2 (ru) | 1999-12-20 | 2000-12-15 | Новые соединения |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US6680318B2 (ru) |
| EP (1) | EP1242410B1 (ru) |
| JP (1) | JP2003522741A (ru) |
| KR (2) | KR20070090050A (ru) |
| CN (1) | CN1608064A (ru) |
| AT (1) | ATE275143T1 (ru) |
| AU (1) | AU780799B2 (ru) |
| BG (1) | BG65457B1 (ru) |
| BR (1) | BR0016591A (ru) |
| CA (1) | CA2395300A1 (ru) |
| CZ (1) | CZ20022124A3 (ru) |
| DE (1) | DE60013486T2 (ru) |
| DK (1) | DK1242410T3 (ru) |
| EE (1) | EE200200337A (ru) |
| ES (1) | ES2225289T3 (ru) |
| HK (1) | HK1048308B (ru) |
| HU (1) | HUP0300020A3 (ru) |
| IL (2) | IL150125A0 (ru) |
| IS (1) | IS2143B (ru) |
| MX (1) | MXPA02006063A (ru) |
| NO (1) | NO322432B1 (ru) |
| NZ (1) | NZ519986A (ru) |
| PL (1) | PL356780A1 (ru) |
| PT (1) | PT1242410E (ru) |
| RU (1) | RU2258703C2 (ru) |
| SE (1) | SE9904674D0 (ru) |
| SI (1) | SI1242410T1 (ru) |
| SK (1) | SK8832002A3 (ru) |
| UA (1) | UA71650C2 (ru) |
| WO (1) | WO2001046174A1 (ru) |
| ZA (1) | ZA200204255B (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040067950A1 (en) * | 1998-07-27 | 2004-04-08 | Schering-Plough Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| SE9904674D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| AR035974A1 (es) * | 2001-05-18 | 2004-07-28 | Astrazeneca Ab | Derivados de diarilmetil piperazina, procesos para su preparacion, uso de estos derivados para la elaboracion de medicamentos y composicion farmaceutica |
| JP4892654B2 (ja) * | 2001-10-29 | 2012-03-07 | マウント クック ファーマ，インコーポレーテッド | デルタレセプターアゴニスト化合物によるうつ病の治療方法 |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| US7196100B2 (en) | 2003-12-12 | 2007-03-27 | Eli Lilly And Company | Opioid receptor antagonists |
| SE0400027D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| HRP20120343T1 (hr) | 2004-08-02 | 2012-05-31 | Astrazeneca Ab | Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba |
| US20080262229A1 (en) * | 2005-02-28 | 2008-10-23 | Astrazeneca Ab | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof |
| GB0606876D0 (en) * | 2006-04-05 | 2006-05-17 | Glaxo Group Ltd | Compounds |
| EP2296657A4 (en) * | 2008-05-20 | 2011-12-14 | Astrazeneca Ab | METHOD FOR TREATING HEAVY DEPRESSION WITH FEARING STATES |
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| CH585209A5 (ru) | 1973-06-29 | 1977-02-28 | Cermol Sa | |
| DE2900810A1 (de) | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
| IT1140978B (it) | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
| GB8320701D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
| IT1196150B (it) | 1984-06-19 | 1988-11-10 | Poli Ind Chimica Spa | Derivati di 1-(bis-(4-fluorofenil)metil)-4-(3-fenil-2-propenil)-esaidro-1h-1,4-diazepina ad attivita' calcio antagonista,sua preparazione e composizioni che lo contengono |
| SE8500573D0 (sv) | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| US5028610A (en) | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
| US4829065A (en) | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| US4826844A (en) | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| ES2053208T3 (es) | 1989-11-22 | 1994-07-16 | Janssen Pharmaceutica Nv | Metodo para prevenir o limitar el daño por reperfusion. |
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| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
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| FR2696744B1 (fr) | 1992-10-12 | 1994-12-30 | Logeais Labor Jacques | Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique. |
| DK148292D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Forbindelser |
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| JP3352184B2 (ja) | 1993-11-12 | 2002-12-03 | 株式会社アズウェル | ピペラジン不飽和脂肪酸誘導体 |
| US5693843A (en) * | 1995-12-22 | 1997-12-02 | E. I. Du Pont De Nemours And Company | Process for hydrocyanation of diolefins and isomerization of nonconjugated 2 alkyl-3-monoalkenenitriles |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| JP4754068B2 (ja) | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類 |
| SE9904674D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
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