RU2002100058A - Кристаллические производные 1-метилкарбапенема - Google Patents
Кристаллические производные 1-метилкарбапенемаInfo
- Publication number
- RU2002100058A RU2002100058A RU2002100058/04A RU2002100058A RU2002100058A RU 2002100058 A RU2002100058 A RU 2002100058A RU 2002100058/04 A RU2002100058/04 A RU 2002100058/04A RU 2002100058 A RU2002100058 A RU 2002100058A RU 2002100058 A RU2002100058 A RU 2002100058A
- Authority
- RU
- Russia
- Prior art keywords
- methylcarbapenem
- derivative
- crystalline form
- formula
- prevention
- Prior art date
Links
- YKMONJZIUAOVEM-GDVGLLTNSA-N (5S)-4-methyl-1-azabicyclo[3.2.0]hept-2-en-7-one Chemical compound CC1C=CN2[C@H]1CC2=O YKMONJZIUAOVEM-GDVGLLTNSA-N 0.000 title claims 9
- 239000013078 crystal Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Claims (8)
1. Производное 1-метилкарбапенема формулы (I) или его фармацевтически приемлемая соль в кристаллической форме
2. Производное 1-метилкарбапенема формулы (I-1) в кристаллической форме
3. Производное 1-метилкарбапенема формулы (I-2) в кристаллической форме
4. Производное 1-метилкарбапенема формулы (I) в кристаллической форме 
5. Производное 1-метилкарбапенема формулы (I-3) в кристаллической форме
6. Фармацевтическая композиция для профилактики или лечения бактериальных инфекционных заболеваний, содержащая кристаллическую форму производного 1-метилкарбапенема или его фармацевтически приемлемой соли по любому из пп.1-5 в качестве активного ингредиента.
7. Применение кристаллической формы производного 1-метилкарбапенема или его фармацевтически приемлемой соли по любому из пп.1-5 в качестве активного ингредиента лекарственного средства для профилактики или лечения бактериальных инфекционных заболеваний.
8. Способ профилактики или лечения бактериальных инфекционных заболеваний, который включает введение теплокровному животному, нуждающемуся в такой профилактике или лечении, фармакологически эффективного количества кристаллической формы производного 1-метилкарбапенема или его фармацевтически приемлемой соли по любому из пп.1-5.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11/191368 | 1999-07-06 | ||
| JP19136899 | 1999-07-06 | ||
| JP11/191,368 | 1999-07-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2002100058A true RU2002100058A (ru) | 2003-06-27 |
| RU2214411C2 RU2214411C2 (ru) | 2003-10-20 |
Family
ID=16273433
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002100058/04A RU2214411C2 (ru) | 1999-07-06 | 2000-07-06 | Кристаллические производные 1-метилкарбапенема |
| RU2003118411/04A RU2003118411A (ru) | 1999-07-06 | 2003-06-18 | Кристаллические производные 1-метилкарбапенема |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003118411/04A RU2003118411A (ru) | 1999-07-06 | 2003-06-18 | Кристаллические производные 1-метилкарбапенема |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20020128254A1 (ru) |
| EP (1) | EP1193269A4 (ru) |
| JP (1) | JP3476420B2 (ru) |
| KR (1) | KR100750552B1 (ru) |
| CN (2) | CN101077869A (ru) |
| AU (1) | AU758190B2 (ru) |
| BR (1) | BR0012253A (ru) |
| CA (1) | CA2378483C (ru) |
| CZ (1) | CZ20014731A3 (ru) |
| HK (1) | HK1044768A1 (ru) |
| HU (1) | HUP0202255A3 (ru) |
| IL (2) | IL147214A0 (ru) |
| MX (1) | MXPA02000061A (ru) |
| NO (1) | NO327786B1 (ru) |
| NZ (1) | NZ516310A (ru) |
| PL (1) | PL352296A1 (ru) |
| RU (2) | RU2214411C2 (ru) |
| TR (2) | TR200403436T2 (ru) |
| TW (1) | TWI250160B (ru) |
| WO (1) | WO2001002401A1 (ru) |
| ZA (1) | ZA200110413B (ru) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU760163B2 (en) | 1999-04-06 | 2003-05-08 | Sankyo Company Limited | Alpha-substituted carboxylic acid derivatives |
| US7041660B2 (en) * | 1999-07-06 | 2006-05-09 | Sankyo Company, Limited | Crystalline 1-methylcarbapenem derivatives |
| HK1049480B (en) * | 1999-09-30 | 2004-12-10 | Otsuka Kagaku Kabushiki Kaisha | 3-cephem derivative crystal and method for preparing the same |
| CN100358579C (zh) | 2000-06-21 | 2008-01-02 | 卡比斯特制药公司 | 提高抗微生物剂口服吸收的组合物和方法 |
| KR100451672B1 (ko) * | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
| EP1426376A4 (en) * | 2001-08-13 | 2004-12-22 | Eisai Co Ltd | PROCESS FOR THE PREPARATION OF CARBAPENEM-BASED ANTIBIOTICS |
| HRP20040264B1 (en) * | 2001-09-26 | 2012-07-31 | Merck@Sharp@@@Dohme@Corp | Process for making carbapenem compounds |
| BRPI0212411B8 (pt) * | 2001-09-26 | 2021-07-27 | Merck & Co Inc | ' processos para reduzir os níveis de solventes orgânicos em um sólido de carbapenem, e para fabricar um hidrato cristalino' |
| ITMI20012364A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Processo di sintesi della cefixima via alchil-o arilsolfonati |
| JP2005097278A (ja) * | 2003-08-25 | 2005-04-14 | Sankyo Co Ltd | １−メチルカルバペネム化合物の結晶 |
| BRPI0413842A (pt) | 2003-08-25 | 2006-10-24 | Sankyo Co | composto de 1-metil-carbapenem ou um seu sal farmacologicamente aceitável, etanolato e tetra-hidrato de composto de 1-metil-carbapenem, processo para a preparação da forma cristalina, processo para a preparação de um tri-hidrato de etanolato de composto de 1-metil-carbapenem, tri-hidrato de etanolato de composto de 1-metil-carbapenem, composição farmacêutica para prevenir ou tratar infecções bacterianas, e, uso da forma cristalina |
| WO2005118586A1 (en) * | 2004-06-02 | 2005-12-15 | Sandoz Ag | Meropenem intermediate in crystalline form |
| CA2602097A1 (en) * | 2005-03-22 | 2006-09-28 | Daiichi Sankyo Company, Limited | Process for producing carbapenem derivatives having 1-alkylpyrrolidine structure |
| NZ563271A (en) | 2005-04-29 | 2009-12-24 | Cubist Pharm Inc | Therapeutic compositions |
| EP1880997A4 (en) * | 2005-05-13 | 2009-03-11 | Daiichi Sankyo Co Ltd | CRYSTAL OF 1-METHYL CARBONENE COMPOUND |
| CN101328179B (zh) * | 2007-06-15 | 2011-01-12 | 山东轩竹医药科技有限公司 | 含有氧代氮杂环的巯基吡咯烷培南衍生物 |
| CN101412717B (zh) * | 2007-10-19 | 2011-01-12 | 山东轩竹医药科技有限公司 | 含有胍基烷酰胺基杂环的碳青霉烯衍生物 |
| WO2009091031A1 (ja) * | 2008-01-17 | 2009-07-23 | Dainippon Sumitomo Pharma Co., Ltd. | アデニン化合物の製造方法 |
| WO2011143935A1 (zh) * | 2010-05-21 | 2011-11-24 | 山东轩竹医药科技有限公司 | 碳青霉烯衍生物或其水合物的晶型及其制备方法与用途 |
| CN103025733B (zh) * | 2010-06-03 | 2015-11-25 | 山东轩竹医药科技有限公司 | 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途 |
| JP6364025B2 (ja) * | 2013-01-15 | 2018-07-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 骨関節炎を処置するためのアシルグアニジン |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260543A (en) | 1978-07-03 | 1981-04-07 | Merck & Co., Inc. | Crystalline N-formimidoyl thienamycin |
| US4748238A (en) | 1984-03-14 | 1988-05-31 | Merck & Co., Inc. | Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid |
| US4713451A (en) | 1984-04-09 | 1987-12-15 | Merck & Co., Inc. | Crystalline dimethyliminothienamycin |
| IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
| US4866171A (en) | 1987-04-11 | 1989-09-12 | Lederle (Japan), Ltd. | (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate |
| CA2036163C (en) * | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Novel beta-lactam compounds and their production |
| TW209220B (ru) * | 1991-11-27 | 1993-07-11 | Manyu Seiyaku Kk | |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| ES2131560T3 (es) | 1992-11-17 | 1999-08-01 | Sankyo Co | Derivado de carbapenem cristalino. |
| JPH06336483A (ja) * | 1993-05-26 | 1994-12-06 | Banyu Pharmaceut Co Ltd | アミノアルキルピロリジニルチオカルバペネム誘導体 |
| JPH07291973A (ja) * | 1994-04-27 | 1995-11-07 | Banyu Pharmaceut Co Ltd | 新規な２−ピロリジニルチオカルバペネム誘導体 |
| JPH09110869A (ja) * | 1995-10-23 | 1997-04-28 | Lederle Japan Ltd | カルバペネム化合物 |
| CA2241092C (en) * | 1995-12-21 | 2004-04-27 | Sankyo Company, Limited | 1-methylcarbapenem derivatives |
| JP2955276B2 (ja) * | 1997-06-19 | 1999-10-04 | 三共株式会社 | １−メチルカルバペネム誘導体を含有する抗菌剤 |
-
2000
- 2000-07-05 TW TW089113337A patent/TWI250160B/zh not_active IP Right Cessation
- 2000-07-06 NZ NZ516310A patent/NZ516310A/en not_active IP Right Cessation
- 2000-07-06 CA CA002378483A patent/CA2378483C/en not_active Expired - Fee Related
- 2000-07-06 KR KR1020027000117A patent/KR100750552B1/ko not_active Expired - Fee Related
- 2000-07-06 CN CNA2007101096355A patent/CN101077869A/zh active Pending
- 2000-07-06 RU RU2002100058/04A patent/RU2214411C2/ru not_active IP Right Cessation
- 2000-07-06 AU AU58487/00A patent/AU758190B2/en not_active Ceased
- 2000-07-06 JP JP2000204430A patent/JP3476420B2/ja not_active Expired - Fee Related
- 2000-07-06 CN CNB008124558A patent/CN100360530C/zh not_active Expired - Fee Related
- 2000-07-06 TR TR2004/03436T patent/TR200403436T2/xx unknown
- 2000-07-06 TR TR2002/00100T patent/TR200200100T2/xx unknown
- 2000-07-06 IL IL14721400A patent/IL147214A0/xx unknown
- 2000-07-06 WO PCT/JP2000/004496 patent/WO2001002401A1/ja not_active Ceased
- 2000-07-06 CZ CZ20014731A patent/CZ20014731A3/cs unknown
- 2000-07-06 PL PL00352296A patent/PL352296A1/xx not_active Application Discontinuation
- 2000-07-06 HK HK02106273.3A patent/HK1044768A1/en unknown
- 2000-07-06 BR BR0012253-0A patent/BR0012253A/pt not_active Application Discontinuation
- 2000-07-06 EP EP00944289A patent/EP1193269A4/en not_active Withdrawn
- 2000-07-06 MX MXPA02000061A patent/MXPA02000061A/es active IP Right Grant
- 2000-07-06 HU HU0202255A patent/HUP0202255A3/hu unknown
-
2001
- 2001-12-19 ZA ZA200110413A patent/ZA200110413B/xx unknown
- 2001-12-20 IL IL147214A patent/IL147214A/en not_active IP Right Cessation
- 2001-12-28 US US10/034,548 patent/US20020128254A1/en not_active Abandoned
-
2002
- 2002-01-04 NO NO20020030A patent/NO327786B1/no not_active IP Right Cessation
-
2003
- 2003-01-27 US US10/351,944 patent/US6924279B2/en not_active Expired - Fee Related
- 2003-04-03 US US10/407,546 patent/US20030232803A1/en not_active Abandoned
- 2003-06-18 RU RU2003118411/04A patent/RU2003118411A/ru not_active Application Discontinuation
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