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RU2001123035A - Химические соединения - Google Patents

Химические соединения

Info

Publication number
RU2001123035A
RU2001123035A RU2001123035/14A RU2001123035A RU2001123035A RU 2001123035 A RU2001123035 A RU 2001123035A RU 2001123035/14 A RU2001123035/14 A RU 2001123035/14A RU 2001123035 A RU2001123035 A RU 2001123035A RU 2001123035 A RU2001123035 A RU 2001123035A
Authority
RU
Russia
Prior art keywords
glucopyranose
benzylidene
pharmaceutically acceptable
viruses
benzaldehyde derivative
Prior art date
Application number
RU2001123035/14A
Other languages
English (en)
Inventor
Бернт БЁРРЕТСЕН (NO)
Бернт БЁРРЕТСЕН
Видар МОЭН (NO)
Видар МОЭН
Рольф Олаф ЛАРСЕН (NO)
Рольф Олаф ЛАРСЕН
Эрик Олай ПЕТТЕРСЕН (NO)
Эрик Олай ПЕТТЕРСЕН
Камилла Бруно ДУНСЕД (NO)
Камилла Бруно ДУНСЕД
Гейр САГВОЛЬДЕН (NO)
Гейр САГВОЛЬДЕН
Original Assignee
Норск Хюдро АСА (NO)
Норск Хюдро Аса
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Норск Хюдро АСА (NO), Норск Хюдро Аса filed Critical Норск Хюдро АСА (NO)
Publication of RU2001123035A publication Critical patent/RU2001123035A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (6)

1. Применение 4,6-О-(бензилиден-d1)-D-глюкопиранозы, 4,6-O-бензилиден-L-глюкопиранозы и/или 4,6-О-(бензилиден-d1)-L-глюкопиранозы либо их фармацевтически приемлемой соли для производства фармацевтического препарата для профилактики и/или лечения рака печени, рака почек и рака поджелудочной железы.
2. Применение по п.1 для производства фармацевтического препарата для профилактического лечения раков, индуцируемых вирусами, такими как вирусы гепатита В и С, онкогенные вирусы папилломы и другие онкогенные вирусы.
3. Бензальдегидное производное, полезное в качестве терапевтического агента, представляющее собой 4,6-O-бензилиден-L-глюкопиранозу и/или 4,6-O-(бензилиден-d1)-L-глюкопиранозу либо их фармацевтически приемлемую соль.
4. Фармацевтическая композиция, содержащая бензальдегидное производное по любому из пп.1-3 и фармацевтически приемлемый носитель, разбавитель и/или эксципиент.
5. Способ производства фармацевтической композиции, при котором осуществляют стадию объединения бензальдегидного производного, как оно определено в любом из пп.1-4, с фармацевтически приемлемым носителем, разбавителем и/или эксципиентом.
6. Бензальдегидное производное, представляющее собой 4,6-O-бензилиден-L-глюкопиранозу, 4,6-O-(бензилиден-d2)-L-глюкопиранозу либо их фармацевтически приемлемую соль.
RU2001123035/14A 1999-02-19 2000-02-18 Химические соединения RU2001123035A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO990814A NO309305B1 (no) 1999-02-19 1999-02-19 Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
NO19990814 1999-02-19

Publications (1)

Publication Number Publication Date
RU2001123035A true RU2001123035A (ru) 2004-03-20

Family

ID=19902986

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2001123035/14A RU2001123035A (ru) 1999-02-19 2000-02-18 Химические соединения
RU2001123124/15A RU2001123124A (ru) 1999-02-19 2000-02-18 Химические соединения

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2001123124/15A RU2001123124A (ru) 1999-02-19 2000-02-18 Химические соединения

Country Status (15)

Country Link
EP (2) EP1150690A1 (ru)
JP (2) JP2002537263A (ru)
CN (2) CN1347323A (ru)
AU (2) AU2834100A (ru)
BR (2) BR0008302A (ru)
CA (2) CA2363670A1 (ru)
CZ (2) CZ20012966A3 (ru)
HU (2) HUP0105280A2 (ru)
IL (2) IL144895A0 (ru)
MX (2) MXPA01008346A (ru)
NO (1) NO309305B1 (ru)
PL (2) PL350520A1 (ru)
RU (2) RU2001123035A (ru)
SK (2) SK11602001A3 (ru)
WO (2) WO2000048610A1 (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4182218B2 (ja) * 2001-05-30 2008-11-19 学校法人東京理科大学 アポトーシスを誘導する新規なグルコース誘導体、その製造方法及び医薬としてのその用途
DE10261807A1 (de) * 2002-12-19 2004-07-01 Turicum Drug Development Ag Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel
NZ565078A (en) * 2005-07-26 2010-03-26 Nycomed Gmbh Deuterated proton pump inhibitors such as omeprazole
EP1912947A1 (en) * 2005-07-26 2008-04-23 Nycomed GmbH Isotopically substituted pantoprazole
JP2009511481A (ja) * 2005-10-06 2009-03-19 オースペックス・ファーマシューティカルズ・インコーポレイテッド 増強された治療特性を持つ、胃Ｈ＋，Ｋ＋−ＡＴＰａｓｅの重水素化阻害剤
CN101157711B (zh) * 2007-09-28 2010-12-08 西安交通大学 一种具有抗肿瘤活性的化合物及其用途
JP2011516478A (ja) * 2008-04-03 2011-05-26 コグネイト ３，エルエルシー 免疫療法のための組成物および方法
CN101735284B (zh) * 2008-11-24 2012-05-23 上海医药工业研究院 一种4,6-o-苄叉-d-吡喃葡萄糖的制备方法
PL3076967T3 (pl) 2013-12-03 2021-12-20 Intra-Cellular Therapies, Inc. Metody leczenia objawów rezydualnych schizofrenii
MX388258B (es) 2014-04-04 2025-03-19 Intra Cellular Therapies Inc Gamma-carbolinas fusionadas con heterociclos sustituidas con deuterio.
JP6898072B2 (ja) * 2015-08-27 2021-07-07 秀行 佐谷 １４−３−３タンパク質活性調節剤
PL3407889T3 (pl) 2016-03-25 2021-11-22 Intra-Cellular Therapies, Inc. Związki organiczne i ich zastosowanie w leczeniu lub zapobieganiu zaburzeniom ośrodkowego układu nerwowego
US11331316B2 (en) 2016-10-12 2022-05-17 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
KR20240141212A (ko) 2017-03-24 2024-09-25 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 조성물 및 방법
EP3843729A4 (en) 2018-08-29 2022-06-01 Intra-Cellular Therapies, Inc. NEW COMPOSITIONS AND METHODS
CN118873536A (zh) 2018-08-31 2024-11-01 细胞内治疗公司 新方法
WO2020047407A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
EP4134101A1 (en) 2019-07-07 2023-02-15 Intra-Cellular Therapies, Inc. Deuterated lumateperone for the treatment of the bipolar ii disorder
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods

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GB811510A (en) * 1954-12-20 1959-04-08 Gyogyszeripari Ki New nitrogen-containing derivatives of polyhydroxy compounds and process for the preparation thereof
JPS6112623A (ja) * 1984-06-28 1986-01-21 Kaken Pharmaceut Co Ltd エンケフアリナ−ゼ阻害剤
JPS6256423A (ja) * 1985-09-06 1987-03-12 Kaken Pharmaceut Co Ltd 悪液質治療改善剤
GB8705780D0 (en) * 1987-03-11 1987-04-15 Norsk Hydro As Anticancer compounds
JPH07145191A (ja) * 1993-11-24 1995-06-06 Japan Tobacco Inc ガラクトシルホスフォネート誘導体

Also Published As

Publication number Publication date
BR0008297A (pt) 2002-05-28
WO2000048610A1 (en) 2000-08-24
PL350520A1 (en) 2002-12-16
CA2363670A1 (en) 2000-08-24
NO990814L (no) 2000-08-21
JP2002537264A (ja) 2002-11-05
EP1150690A1 (en) 2001-11-07
SK11602001A3 (sk) 2002-02-05
HUP0105280A2 (hu) 2002-04-29
HUP0105281A2 (hu) 2002-05-29
BR0008302A (pt) 2002-08-27
CN1347322A (zh) 2002-05-01
AU2834100A (en) 2000-09-04
CA2362306A1 (en) 2000-08-24
AU2834200A (en) 2000-09-04
IL144896A0 (en) 2002-06-30
NO309305B1 (no) 2001-01-15
EP1150689A1 (en) 2001-11-07
CN1347323A (zh) 2002-05-01
SK11612001A3 (sk) 2002-04-04
JP2002537263A (ja) 2002-11-05
IL144895A0 (en) 2002-06-30
PL350519A1 (en) 2002-12-16
MXPA01008347A (es) 2004-03-10
CZ20012965A3 (cs) 2002-03-13
NO990814D0 (no) 1999-02-19
WO2000048609A1 (en) 2000-08-24
RU2001123124A (ru) 2004-02-20
MXPA01008346A (es) 2003-06-06
CZ20012966A3 (cs) 2002-03-13

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