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RU2001112869A - NEW MUTANT N-ACETYL GLUTAMATE SYNTHESIS AND METHOD FOR PRODUCING L-ARGININE - Google Patents

NEW MUTANT N-ACETYL GLUTAMATE SYNTHESIS AND METHOD FOR PRODUCING L-ARGININE

Info

Publication number
RU2001112869A
RU2001112869A RU2001112869/13A RU2001112869A RU2001112869A RU 2001112869 A RU2001112869 A RU 2001112869A RU 2001112869/13 A RU2001112869/13 A RU 2001112869/13A RU 2001112869 A RU2001112869 A RU 2001112869A RU 2001112869 A RU2001112869 A RU 2001112869A
Authority
RU
Russia
Prior art keywords
arginine
synthase
mutant
acetylglutamate synthase
producing
Prior art date
Application number
RU2001112869/13A
Other languages
Russian (ru)
Other versions
RU2215783C2 (en
Inventor
Леонид Романович Птицын
Ирина Борисовна Альтман
Сергей Васильевич Смирнов
Юлия Георгиевна Ростова
Татьяна Абрамовна Ямпольская
Татьяна Викторовна Леонова
Михаил Маркович Гусятинер
Original Assignee
Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика"
Filing date
Publication date
Application filed by Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" filed Critical Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика"
Priority claimed from RU2001112869/13A external-priority patent/RU2215783C2/en
Priority to RU2001112869/13A priority Critical patent/RU2215783C2/en
Priority to JP2001180219A priority patent/JP4682454B2/en
Priority to DE60106526T priority patent/DE60106526T2/en
Priority to EP01114572A priority patent/EP1170361B1/en
Priority to ES01114572T priority patent/ES2228699T3/en
Priority to US09/886,135 priority patent/US6790647B2/en
Priority to CNB011259191A priority patent/CN1180082C/en
Publication of RU2001112869A publication Critical patent/RU2001112869A/en
Publication of RU2215783C2 publication Critical patent/RU2215783C2/en
Application granted granted Critical
Priority to US10/891,122 priority patent/US7169586B2/en

Links

Claims (6)

1. Мутантная N-ацетилглутамат синтаза, отличающаяся тем, что последовательность аминокислот, соответствующая положениям с 15 по 19 в природной N-ацетилглутамат синтазе, заменена любой из последовательностей аминокислот под номерами 1-4 (SEQ ID NOS: 1-4) и ингибирование L-аргинином по типу обратной связи утрачено.1. Mutant N-acetylglutamate synthase, characterized in that the amino acid sequence corresponding to positions 15 to 19 in the natural N-acetylglutamate synthase is replaced by any of the amino acid sequences numbered 1-4 (SEQ ID NOS: 1-4) and inhibition of L -Arginine as feedback lost. 2. Мутантная N-ацетилглутамат синтаза по п. 1, отличающаяся тем, что природной N-ацетилглутамат синтазой является N-ацетилглутамат синтаза из Escherichia coli. 2. The mutant N-acetylglutamate synthase according to claim 1, characterized in that the natural N-acetylglutamate synthase is N-acetylglutamate synthase from Escherichia coli. 3. Мутантная N-ацетилглутамат синтаза по п. 1, отличающаяся тем, что такая синтаза содержит делеции, замены, вставки или добавления одной или нескольких аминокислот в одном или множестве положений, кроме положений с 15 по 19, и ингибирование L-аргинином такой синтазы по типу обратной связи утрачено. 3. The mutant N-acetylglutamate synthase according to claim 1, characterized in that such synthase contains deletions, substitutions, insertions or additions of one or more amino acids in one or many positions, except positions 15 to 19, and the inhibition of such synthase by L-arginine feedback type lost. 4. ДНК, кодирующая мутантную N-ацетилглутамат синтазу по любому из пп. 1-3. 4. DNA encoding the mutant N-acetylglutamate synthase according to any one of paragraphs. 1-3. 5. Бактерия, принадлежащая к роду Escherichia, отличающаяся тем, что такая бактерия трансформирована ДНК по п. 4 и обладает активностью по продукции L-аргинина. 5. A bacterium belonging to the genus Escherichia, characterized in that such a bacterium is transformed with DNA according to claim 4 and is active in the production of L-arginine. 6. Способ продуцирования L-аргинина, включающий стадии выращивания бактерии по п. 5 в питательной среде для продукции и накопления L-аргинина в питательной среде и сбора L-аргинина из культуральной жидкости. 6. A method for producing L-arginine, comprising the steps of growing a bacterium according to claim 5 in a culture medium for producing and accumulating L-arginine in a culture medium and collecting L-arginine from the culture fluid.
RU2001112869/13A 2000-06-28 2001-05-15 Mutant n-acetylglutamate synthase (variants), dna fragment, strain of microorganism escherichia coli as producer of arginine and method for preparing l-arginine RU2215783C2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
RU2001112869/13A RU2215783C2 (en) 2001-05-15 2001-05-15 Mutant n-acetylglutamate synthase (variants), dna fragment, strain of microorganism escherichia coli as producer of arginine and method for preparing l-arginine
JP2001180219A JP4682454B2 (en) 2000-06-28 2001-06-14 Process for producing novel mutant N-acetylglutamate synthase and L-arginine
ES01114572T ES2228699T3 (en) 2000-06-28 2001-06-18 NEW MUTANT OF N-ACETIGLTAMATE SYNTHEASE AND PROCEDURE FOR THE PRODUCTION OF ARGININE.
EP01114572A EP1170361B1 (en) 2000-06-28 2001-06-18 New mutant N-Acetylglutamate synthase and method for L-Arginine production
DE60106526T DE60106526T2 (en) 2000-06-28 2001-06-18 New N-acetylglutamate synthase mutant and a process for the production of L-arginine
US09/886,135 US6790647B2 (en) 2000-06-28 2001-06-22 Mutant N-acetylglutamate synthase and method for L-arginine production
CNB011259191A CN1180082C (en) 2000-06-28 2001-06-28 Production method of novel mutant N-acetylglutamate synthetase and L-arginine
US10/891,122 US7169586B2 (en) 2000-06-28 2004-07-15 Mutant N-acetylglutamate synthase and method for L-arginine production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2001112869/13A RU2215783C2 (en) 2001-05-15 2001-05-15 Mutant n-acetylglutamate synthase (variants), dna fragment, strain of microorganism escherichia coli as producer of arginine and method for preparing l-arginine

Related Parent Applications (1)

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RU2000116481/13A Substitution RU2000116481A (en) 2000-06-28 2000-06-28 MUTANT N-ACETYL GLUTAMATE SYNTHESIS, A BACTERIA BELONGING TO THE GENUS ESCHERICHIA, METHOD FOR PRODUCING L-ARGININE

Publications (2)

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RU2001112869A true RU2001112869A (en) 2003-03-20
RU2215783C2 RU2215783C2 (en) 2003-11-10

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WO2008102861A1 (en) 2007-02-22 2008-08-28 Ajinomoto Co., Inc. Method of producing l-amino acid
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